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1. 发明授权

US08691718B2 Diphosphine ligand and transition metal complex using the same 有权
标题翻译：二膦配体和过渡金属络合物使用它们
公开(公告)号：US08691718B2
公开(公告)日：2014-04-08
申请号：US11992167
申请日：2006-09-20
申请人： Mitsuhisa Yamano , Mitsutaka Goto , Shinji Kawaguchi , Masatoshi Yamada , Jun-ichi Kawakami
发明人： Mitsuhisa Yamano , Mitsutaka Goto , Shinji Kawaguchi , Masatoshi Yamada , Jun-ichi Kawakami
IPC分类号： B01J31/24 , C07F15/00 , C07F1/08
CPC分类号： C07F9/572 , B01J31/2452 , B01J2531/80 , C07B53/00 , C07F9/5022 , C07F9/5027 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008
摘要： The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions.A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).
摘要翻译：本发明提供了由下式表示的新型配位体和具有配位体的新型过渡金属络合物，其在各种不对称合成反应中表现出优异的对映体选择性和催化效率，特别高的催化剂活性。一种具有下式表示的化合物作为配体的过渡金属配合物，其中R 4为氢原子或任选具有取代基的C 1-6烷基，R 5和R 6各自为任选具有取代基，或式为由下式表示的基团：其中环B为任选具有取代基的3-至8-元环。

2. 发明申请

US20060094887A1 Transition metal complex having diphosphine compound as ligand 有权
公开(公告)号：US20060094887A1
公开(公告)日：2006-05-04
申请号：US10536731
申请日：2003-12-04
申请人： Mitsutaka Goto , Mitsuhisa Yamano , Shinji Kawaguchi
发明人： Mitsutaka Goto , Mitsuhisa Yamano , Shinji Kawaguchi
IPC分类号： C07F15/00 , C07F9/09 , C07C69/66 , C07D301/06 , C07D307/02
CPC分类号： C07D263/58 , C07B53/00 , C07B2200/07 , C07C67/31 , C07C231/18 , C07D301/26 , C07D303/48 , C07D307/28 , C07F9/5027 , C07F9/5045 , C07C69/732 , C07C233/47
摘要： A transition metal complex having 2,2′-bis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-1,1′-binaphthyl as a ligand. The presence of the transition metal complex in the reaction system of an asymmetric reaction system allows the preparation of an objective compound having an objective absolute configuration with improved efficiency.

3. 发明申请

US20110015399A1 STABLE VINAMIDINIUM SALT AND NITROGEN-CONTAINING HETEROCYCLIC RING SYNTHESIS USING THE SAME 有权
标题翻译：稳定的盐酸和含氮杂环化合物的合成
公开(公告)号：US20110015399A1
公开(公告)日：2011-01-20
申请号：US12934801
申请日：2009-03-27
申请人： Mitsuhisa Yamano , Yasuhiro Sawai , Masahiro Mizuno
发明人： Mitsuhisa Yamano , Yasuhiro Sawai , Masahiro Mizuno
IPC分类号： C07D215/38 , C07C251/12 , C07C251/16 , C09K3/00
CPC分类号： C07C251/30 , C07D215/38
摘要： Disclosed is a vinamidinium salt represented by the formula (I): [wherein R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or the like; R2 and R3 are the same or different and each represents a lower alkyl group, or alternatively R2 and R3 may combine together to form a ring; R4 and R5 are the same or different and each represents a lower alkyl group, or alternatively R4 and R5 may combine together to form a ring; X and Y are the same or different and each represents a bromine atom or a chlorine atom; n represents a number of not less than 2; and m represents 0 or n], which can be used as a general purpose reagent useful for synthesis of various nitrogen-containing heteroaromatic rings having a substituent. The vinamidinium salt has excellent storage stability and reaction selectivity. A method for synthesizing a nitrogen-containing heteroaromatic ring compound using the vinamidinium salt is also disclosed.
摘要翻译：公开了由式（I）表示的缬氨酸盐：其中R1表示氢原子，卤素原子，任选取代的烃基等; R2和R3相同或不同，各自表示低级烷基，或者R2和R3可以结合在一起形成环; R4和R5相同或不同，各自表示低级烷基，或者R4和R5可以结合在一起形成环; X和Y相同或不同，各自表示溴原子或氯原子; n表示不小于2的数; m表示0或n]，可用作合成具有取代基的各种含氮杂芳环的通用试剂。缬氨酸盐具有优异的储存稳定性和反应选择性。还公开了使用缬氨酸盐合成含氮杂芳环化合物的方法。

4. 发明申请

US20070161805A1 Process for Preparation of Diphosphine Compounds and Intermediates for the Process 有权
标题翻译：二膦化合物和中间体的制备方法
公开(公告)号：US20070161805A1
公开(公告)日：2007-07-12
申请号：US11682630
申请日：2007-03-06
申请人： Mitsutaka Goto , Mitsuhisa Yamano
发明人： Mitsutaka Goto , Mitsuhisa Yamano
IPC分类号： C07F9/02
CPC分类号： C07F9/65517 , C07F9/5027 , C07F9/5045 , C07F9/505
摘要： A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
摘要翻译：由下式表示的化合物的制备方法其中R 1a，R 1b，R 1c，R 1d， R 1，R 1，R 2，R 2b，R 2b，R 2c， R 2d，R 2e和R 2f相同或不同，各自为氢原子等，R“ R 4，R 4，R 5，R 6，R 7，R 7， 8，R 9和R 10相同或不同，各自为氢原子等，或其盐，其包括使化合物其中X为离去基团，其它符号如上所定义，或其盐与下式表示的膦 - 硼烷配合物或其盐，其中符号如上所定义，或其盐在溶剂中提供了胺和镍催化剂的存在。

5. 发明申请

US20090270635A1 Diphosphine Ligand and Transition Metal Complex Using the Same 有权
标题翻译：二膦配体和过渡金属络合物使用它
公开(公告)号：US20090270635A1
公开(公告)日：2009-10-29
申请号：US11992167
申请日：2006-09-20
申请人： Mitsuhisa Yamano , Mitsutaka Goto , Shinji Kawaguchi , Masatoshi Yamada , Jun-ichi Kawakami
发明人： Mitsuhisa Yamano , Mitsutaka Goto , Shinji Kawaguchi , Masatoshi Yamada , Jun-ichi Kawakami
IPC分类号： C07F15/00 , C07F9/28 , C07F9/572
CPC分类号： C07F9/572 , B01J31/2452 , B01J2531/80 , C07B53/00 , C07F9/5022 , C07F9/5027 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008
摘要： The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions.A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).
摘要翻译：本发明提供了由下式表示的新型配位体和具有配位体的新型过渡金属络合物，其在各种不对称合成反应中表现出优异的对映体选择性和催化效率，特别高的催化剂活性。一种具有下式表示的化合物作为配体的过渡金属配合物，其中R 4为氢原子或任选具有取代基的C 1-6烷基，R 5和R 6各自为任选具有取代基，或式为由下式表示的基团：其中环B为任选具有取代基的3-至8-元环。

6. 发明授权

US07541498B2 Process for production of phosphine-borane complexes 有权
标题翻译：膦 - 硼烷配合物的制备方法
公开(公告)号：US07541498B2
公开(公告)日：2009-06-02
申请号：US10556499
申请日：2004-05-18
申请人： Mitsuhisa Yamano , Mitsutaka Goto , Masatoshi Yamada
发明人： Mitsuhisa Yamano , Mitsutaka Goto , Masatoshi Yamada
IPC分类号： C07F9/50 , C07F5/02
CPC分类号： C07F9/5045
摘要： A process for the production of phosphine-borane complexes represented by the general formula: or salts thereof: [wherein R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heterocyclic group (with the proviso that R1 and R2 together with the adjacent phosphorus atom may form a 4- to 6-membered ring)], characterized by converting a compound represented by the general formula: in a solvent in the presence of a borane reagent: [wherein each symbol is as defined above].
摘要翻译：制备由以下通式表示的膦 - 硼烷配合物的方法：或其盐：[其中R 1，R 2和R 3各自独立地为氢原子，卤素原子，任选取代的烷基，任选取代的环烷基，任选取代的芳基或任选取代的杂环基（条件是R 1和R 2与相邻的磷原子一起可以形成4-至6-元环）]，其特征在于将通式为：在硼烷试剂存在下的溶剂中：[其中每个符号如上所定义]。

7. 发明授权

US07208633B2 Process for preparation of diphosphine compounds and intermediates for the process 有权
标题翻译：制备二膦化合物和中间体的方法
公开(公告)号：US07208633B2
公开(公告)日：2007-04-24
申请号：US10497808
申请日：2002-12-05
申请人： Mitsutaka Goto , Mitsuhisa Yamano
发明人： Mitsutaka Goto , Mitsuhisa Yamano
IPC分类号： C07F5/02 , C07F9/50
CPC分类号： C07F9/65517 , C07F9/5027 , C07F9/5045 , C07F9/505
摘要： A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
摘要翻译：由下式表示的化合物的制备方法其中R 1a，R 1b，R 1c，R 1d， R 1，R 1，R 2，R 2b，R 2b，R 2c， R 2d，R 2e和R 2f相同或不同，各自为氢原子等，R“ R 4，R 4，R 5，R 6，R 7，R 7， 8，R 9和R 10相同或不同，各自为氢原子等，或其盐，其包括使化合物其中X为离去基团，其它符号如上定义，或其盐与下式表示的膦 - 硼烷配合物或其盐，其中符号如上所定义，或其盐在溶剂中提供了胺和镍催化剂的存在。

8. 发明申请

US20060241145A1 Piperidine derivative crystal, process for producing the same, and use 审中-公开
标题翻译：哌啶衍生物晶体，其制备方法和用途
公开(公告)号：US20060241145A1
公开(公告)日：2006-10-26
申请号：US11407209
申请日：2006-04-20
申请人： Yoshinori Ikeura , Tadatoshi Hashimoto , Junya Shirai , Yoshikawa Takeshi , Hiroshi Nakatani , Mitsuhisa Yamano , Masahiro Mizuno , Hiroyuki Irie
发明人： Yoshinori Ikeura , Tadatoshi Hashimoto , Junya Shirai , Yoshikawa Takeshi , Hiroshi Nakatani , Mitsuhisa Yamano , Masahiro Mizuno , Hiroyuki Irie
IPC分类号： A61K31/454 , C07D403/02
CPC分类号： C07D211/74 , C07D211/56 , C07D401/12 , C07D401/14
摘要： The present invention provides a piperidine derivative having antagonistic action for tachykinin receptors and the like, a crystal thereof, and an agent for the prophylaxis or treatment of diseases including lower urinary tract disease and the like, which contains the derivative. Specifically, the present invention provides an optically active compound represented by the formula (I): wherein each symbol is as defined in the specification, and a salt thereof.
摘要翻译：本发明提供对速激肽受体等具有拮抗作用的哌啶衍生物及其结晶，以及含有该衍生物的预防或治疗包括下尿路疾病等的疾病的药剂。具体地，本发明提供由式（I）表示的光学活性化合物：其中每个符号如说明书中所定义，及其盐。

9. 发明申请

US20060199968A1 Process for production of phosphine-borane complexes 有权
标题翻译：膦 - 硼烷配合物的制备方法
公开(公告)号：US20060199968A1
公开(公告)日：2006-09-07
申请号：US10556499
申请日：2004-05-18
申请人： Mitsuhisa Yamano , Mitsutaka Goto , Masatoshi Yamada
发明人： Mitsuhisa Yamano , Mitsutaka Goto , Masatoshi Yamada
IPC分类号： C07F9/02
CPC分类号： C07F9/5045
摘要： A process for the production of phosphine-borane complexes represented by the general formula: or salts thereof: [wherein R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heterocyclic group (with the proviso that R1 and R2 together with the adjacent phosphorus atom may form a 4- to 6-membered ring)], characterized by converting a compound represented by the general formula: in a solvent in the presence of a borane reagent: [wherein each symbol is as defined above].
摘要翻译：由通式表示的膦 - 硼烷配合物的制备方法：或其盐：[其中R 1，R 2，R 3和R 3 各自独立地为氢原子，卤素原子，任选取代的烷基，任选取代的环烷基，任选取代的芳基或任选取代的杂环基（条件是R 1，和R 2与相邻的磷原子一起形成4-至6-元环）]，其特征在于：在溶剂中，在硼烷试剂存在下，将通式表示的化合物：[其中每个符号如上所定义]。

10. 发明授权

US08952185B2 Production method of optically active dihydrobenzofuran derivative 有权
标题翻译：光学活性二氢苯并呋喃衍生物的制备方法
公开(公告)号：US08952185B2
公开(公告)日：2015-02-10
申请号：US13985395
申请日：2012-02-16
申请人： Mitsuhisa Yamano , Mitsutaka Goto , Takahiro Konishi
发明人： Mitsuhisa Yamano , Mitsutaka Goto , Takahiro Konishi
IPC分类号： C07D307/86 , C07D307/80 , C07C215/32 , C07C315/04 , C07C317/18 , C07C211/27 , B01J31/22 , C07F9/50 , C07F15/00 , C07F17/02 , C07F9/572 , C07F9/6568
CPC分类号： B01J31/2295 , C07B2200/07 , C07C211/27 , C07C215/32 , C07C315/04 , C07C317/18 , C07D307/80 , C07D307/86 , C07F9/5004 , C07F9/5018 , C07F9/5022 , C07F9/5027 , C07F9/5031 , C07F9/572 , C07F9/5728 , C07F9/65683 , C07F15/006 , C07F17/02
摘要： Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like.
摘要翻译：提供光学活性二氢苯并呋喃衍生物的制备方法。由下式表示的化合物的光学活性形式的制备方法：其中每个符号如说明书中所定义，或其盐等。

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