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1. 发明申请

US20100113442A1 TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES 有权
标题翻译：作为磷酸二酯酶抑制剂治疗牙齿疾病的三唑吡啶
公开(公告)号：US20100113442A1
公开(公告)日：2010-05-06
申请号：US12595922
申请日：2008-04-16
申请人： Jakob Felding , Morten Dahl Sornesen
发明人： Jakob Felding , Morten Dahl Sornesen
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , A61K31/497 , A61P35/00 , A61P17/02 , A61P17/10
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention relates to a compound according to formula (I), wherein X and Y are either C and N or N and C; Z is CH2, CH2—CH2, CH2—NH, or NH; R1 is halogen, or R1 is alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, cycloalkyl, alkoxycarbonyl, aryl, all of which are optionally substituted; R2 is hydrogen, or R2 is alkyl, cycloalkyl, alkoxy, heterocycloalkyl, aryl, heteroaryl, alkoxycarbonyl, aminocarbonyl, amino, all of which are optionally substituted; A is aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl or heterocycloalkenyl, all of which are optionally substituted; and pharmaceutically acceptable salts, hydrates, or solvates hereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments, in particular for the treatment of dermal diseases.
摘要翻译：本发明涉及式（I）化合物，其中X和Y为C和N或N和C; Z是CH 2，CH 2 -CH 2，CH 2 -NH或NH; R1是卤素，或R1是烷基，烯基，炔基，卤代烷基，烷氧基，环烷基，烷氧基羰基，芳基，它们都是任选被取代的; R2是氢，或R2是烷基，环烷基，烷氧基，杂环烷基，芳基，杂芳基，烷氧基羰基，氨基羰基，氨基，它们都是任选被取代的; A是芳基，环烷基，环烯基，杂芳基，杂环烷基或杂环烯基，它们都是任选被取代的; 和其药学上可接受的盐，水合物或溶剂合物。本发明还涉及用于治疗的所述化合物，包含所述化合物的药物组合物，治疗疾病的方法，例如，所述化合物的皮肤病，以及所述化合物在制备药物中的用途，特别是用于治疗真皮疾病。

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