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1. 发明申请

US20100047259A1 FOLLISTATIN DOMAIN CONTAINING PROTEINS 审中-公开
标题翻译：包含蛋白质的蛋白质域
公开(公告)号：US20100047259A1
公开(公告)日：2010-02-25
申请号：US12476489
申请日：2009-06-02
申请人： JENNIFER J. HILL , NEIL M. WOLFMAN
发明人： JENNIFER J. HILL , NEIL M. WOLFMAN
IPC分类号： A61K39/00 , A61K38/22 , A61P21/00
CPC分类号： A61K38/39 , A61K38/00 , C07K14/47 , C07K14/4743
摘要： The present invention relates to the use of proteins comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, the invention relates to the use of proteins comprising at least one follistatin domain, excluding follistatin itself, for treating disorders that are related to modulation of the level or activity of GDF-8. The invention is useful for treating muscular diseases and disorders, particularly those in which an increase in muscle tissue would be therapeutically beneficial. The invention is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration.
摘要翻译：本发明涉及包含至少一个卵泡抑素结构域的蛋白质调节生长和分化因子-8（GDF-8）的水平或活性的用途。更具体地，本发明涉及包含至少一种卵泡抑素结构域（不包括卵泡抑素本身）的蛋白质用于治疗与调节GDF-8的水平或活性相关的疾病的用途。本发明可用于治疗肌肉疾病和病症，特别是肌肉组织增加在治疗上有益的那些。本发明也可用于治疗与代谢，脂肪组织和骨变性相关的疾病和病症。

2. 发明申请

US20100021462A1 GASP1: A FOLLISTATIN DOMAIN CONTAINING PROTEIN 失效
标题翻译： GASP1：含有蛋白质的蛋白质域
公开(公告)号：US20100021462A1
公开(公告)日：2010-01-28
申请号：US12540606
申请日：2009-08-13
申请人： Jennifer J. Hill , Neil M. Wolfman
发明人： Jennifer J. Hill , Neil M. Wolfman
IPC分类号： A61K39/395 , A61K38/16 , A61P21/00
CPC分类号： A61K38/1709 , Y10S435/81
摘要： The present invention relates to the use of a protein, GASP1, comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, the invention relates to the use of GASP1 for treating disorders that are related to modulation of the level or activity of GDF-8. The invention is useful for treating muscular diseases and disorders, particularly those in which an increase in muscle tissue would be therapeutically beneficial. The invention is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration.
摘要翻译：本发明涉及包含至少一个卵泡抑素结构域的蛋白质GASP1在调节生长和分化因子-8（GDF-8）的水平或活性中的用途。更具体地，本发明涉及GASP1用于治疗与调节GDF-8的水平或活性相关的疾病的用途。本发明可用于治疗肌肉疾病和病症，特别是肌肉组织增加在治疗上有益的那些。本发明也可用于治疗与代谢，脂肪组织和骨变性相关的疾病和病症。

3. 发明申请

US20090142806A1 INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR 审中-公开
标题翻译：白细胞介素-17F抗体及其他IL-17F信号拮抗剂及其用途
公开(公告)号：US20090142806A1
公开(公告)日：2009-06-04
申请号：US12196117
申请日：2008-08-21
申请人： BEATRIZ M. CARRENO , MARY COLLINS , JILL F. WRIGHT , NEIL M. WOLFMAN , MAYA ARAI , KENNETH JACOBS , ZHIJIAN LU , YONGJING GUO , YONGCHANG QIU
发明人： BEATRIZ M. CARRENO , MARY COLLINS , JILL F. WRIGHT , NEIL M. WOLFMAN , MAYA ARAI , KENNETH JACOBS , ZHIJIAN LU , YONGJING GUO , YONGCHANG QIU
IPC分类号： C12P21/04 , C07K14/54
CPC分类号： C07K16/244 , A61K38/00 , A61K2039/505 , A61K2039/55527 , C07K14/54 , C07K14/7155 , C07K16/2866 , C07K2317/76 , C07K2319/30 , C12N15/1138 , G01N33/6869
摘要： The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling.
摘要翻译：本发明提供与IL-17F信号通路相关的分离和纯化的多核苷酸和多肽。本发明还提供了对IL-17F同源二聚体和IL-17A / IL-17F异二聚体的抗体，以及从天然来源分离和纯化IL-17家族成员（包括IL-17A / IL-17F异源二聚体）的方法。本发明还涉及用于诊断，预后，监测与IL-17F信号传导相关的疾病的进展和/或预防的新方法，即IL-17F相关疾病，包括但不限于炎性诸如自身免疫性疾病（例如关节炎（包括类风湿性关节炎），牛皮癣，系统性红斑狼疮和多发性硬化症），呼吸系统疾病（例如COPD，囊性纤维化，哮喘，过敏），移植排斥（包括实体器官移植排斥）和炎症性肠病或疾病（IBD，例如溃疡性结肠炎，克罗恩病）。本发明还涉及新的治疗和治疗靶标，以及筛选和评估用于干预（治疗）的试验化合物和预防与IL-17F信号传导相关的紊乱的方法。

4. 发明授权

US6027919A BMP-12 and BMP-13 proteins and DNA encoding them 失效
标题翻译： BMP-12和BMP-13蛋白和编码它们的DNA
公开(公告)号：US6027919A
公开(公告)日：2000-02-22
申请号：US333576
申请日：1994-11-02
申请人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61L27/22 , A61L27/36 , A61P1/02 , A61P5/00 , A61P19/04 , A61P43/00 , C07H21/04 , C07K14/51 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475
CPC分类号： A61L27/227 , A61L27/38 , C07K14/51 , A61K38/00 , C07K2319/02
摘要： The present invention relates to a novel family of purified proteins, and compositions containing such proteins, which compositions are useful for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair. The present invention further relates to DNA molecules, vectors and host cells useful for production of such proteins.
摘要翻译：本发明涉及一种纯化蛋白质的新家族，以及含有这些蛋白质的组合物，该组合物可用于诱导腱/类韧带组织形成，伤口愈合和韧带以及其它组织修复。本发明还涉及可用于生产这种蛋白质的DNA分子，载体和宿主细胞。

5. 发明授权

US08710202B2 Isolated nucleic acid molecule encoding an antibody that reduces GDF-8 activity 有权
标题翻译：编码降低GDF-8活性的抗体的分离的核酸分子
公开(公告)号：US08710202B2
公开(公告)日：2014-04-29
申请号：US13346042
申请日：2012-01-09
申请人： Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C07H21/04 , A61K39/395
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译：本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。

6. 发明授权

US08222384B2 Modified and stabilized GDF propeptides and uses thereof 有权
标题翻译：改良和稳定的GDF前肽及其用途
公开(公告)号：US08222384B2
公开(公告)日：2012-07-17
申请号：US12434758
申请日：2009-05-04
申请人： Neil M. Wolfman , Soo-Peang Khor , Kathleen N. Tomkinson
发明人： Neil M. Wolfman , Soo-Peang Khor , Kathleen N. Tomkinson
IPC分类号： A61K48/00 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译：公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病，依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。

7. 发明申请

US20120107928A1 Antibody Inhibitors of GDF-8 and Uses Thereof 有权
标题翻译： GDF-8抗体抑制剂及其用途
公开(公告)号：US20120107928A1
公开(公告)日：2012-05-03
申请号：US13346042
申请日：2012-01-09
申请人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C12N15/13 , C12N5/16
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译：本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。

8. 发明授权

US08092798B2 Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8 有权
标题翻译：通过针对GDF-8的抗体在有需要的患者中增加小梁骨密度的方法
公开(公告)号：US08092798B2
公开(公告)日：2012-01-10
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , William J. Dunham, legal representative , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译：本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。

9. 发明申请

US20110020372A1 FOLLISTATIN DOMAIN CONTAINING PROTEINS 审中-公开
标题翻译：包含蛋白质的蛋白质域
公开(公告)号：US20110020372A1
公开(公告)日：2011-01-27
申请号：US12884371
申请日：2010-09-17
申请人： Jennifer J. Hill , Neil M. Wolfman
发明人： Jennifer J. Hill , Neil M. Wolfman
IPC分类号： A61K39/395 , A61K38/02 , A61K38/17 , A61K38/38 , A61P21/00
CPC分类号： A61K38/39 , A61K38/00 , C07K14/47 , C07K14/4743
摘要： The present invention relates to the use of proteins comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, the invention relates to the use of proteins comprising at least one follistatin domain, excluding follistatin itself, for treating disorders that are related to modulation of the level or activity of GDF-8. The invention is useful for treating muscular diseases and disorders, particularly those in which an increase in muscle tissue would be therapeutically beneficial. The invention is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration.
摘要翻译：本发明涉及包含至少一个卵泡抑素结构域的蛋白质调节生长和分化因子-8（GDF-8）的水平或活性的用途。更具体地，本发明涉及包含至少一种卵泡抑素结构域（不包括卵泡抑素本身）的蛋白质用于治疗与调节GDF-8的水平或活性相关的疾病的用途。本发明可用于治疗肌肉疾病和病症，特别是肌肉组织增加在治疗上有益的那些。本发明也可用于治疗与代谢，脂肪组织和骨变性相关的疾病和病症。

10. 发明授权

US07737116B2 Modified and stabilized GDF propeptides and uses thereof 失效
标题翻译：改良和稳定的GDF前肽及其用途
公开(公告)号：US07737116B2
公开(公告)日：2010-06-15
申请号：US11614702
申请日：2006-12-21
申请人： Neil M. Wolfman , Soo-Peang Khor , Kathleen N. Tomkinson
发明人： Neil M. Wolfman , Soo-Peang Khor , Kathleen N. Tomkinson
IPC分类号： A61K38/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译：公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病，依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。

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