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1. 发明授权

US08656204B2 Security device meant to be connected to a processing unit for audio/video signal and method using such a device 有权
标题翻译：安全设备意图连接到用于音频/视频信号的处理单元和使用这种设备的方法
公开(公告)号：US08656204B2
公开(公告)日：2014-02-18
申请号：US12801804
申请日：2010-06-25
申请人： Karl Osen , Nicolas Fischer
发明人： Karl Osen , Nicolas Fischer
IPC分类号： G06F1/04 , G06F15/177
CPC分类号： G06K19/07 , G06K7/10297 , G06K19/073 , G06K19/07733
摘要： Example embodiments relate to a security device having two communication interfaces sharing at least one pin, each interface being capable of operating according to either of two predetermined communication protocols. The security device may further include a frequency detector to detect the frequency of a clock signal on the shared pin. Depending on the value of the detected frequency, and to which of a plurality of predetermined frequency ranges the detected frequency pertains, the security device may function according to one of the two predetermined communication protocols, operating at two different frequencies.
摘要翻译：示例性实施例涉及具有共享至少一个引脚的两个通信接口的安全设备，每个接口能够根据两个预定通信协议中的任一个进行操作。安全装置还可以包括频率检测器，用于检测共享引脚上的时钟信号的频率。根据所检测的频率的值以及所检测的频率所属的多个预定频率范围中的哪一个，安全设备可以根据两个预定通信协议中的一个在两个不同的频率下工作。

2. 发明授权

US08176331B2 Method to secure data exchange between a multimedia processing unit and a security module 有权
标题翻译：确保多媒体处理单元与安全模块之间数据交换的方法
公开(公告)号：US08176331B2
公开(公告)日：2012-05-08
申请号：US11591555
申请日：2006-11-02
申请人： Guy Moreillon , Nicolas Fischer , Nikolai Keychenko , Joel Wenger
发明人： Guy Moreillon , Nicolas Fischer , Nikolai Keychenko , Joel Wenger
IPC分类号： G06F21/00
CPC分类号： H04N21/4181 , H04N7/163 , H04N21/26613 , H04N21/4367
摘要： A method for protecting multimedia data exchanged between a multimedia processing device and a security module managed by a management center, the multimedia processing device receiving an encrypted multimedia data, decrypting the encrypted multimedia data and converting the decrypted multimedia data, said multimedia processing device including a personal key, the method comprising obtaining an identifier pertaining to an entity representing a group of multimedia processing devices, calculating a security key formed by a one-way function based on the personal key of the processing multimedia device and the entity identifier, transmitting this security key and the entity identifier to the security module connected to said multimedia processing device, calculating the security key using a one-way function based on the personal key of said multimedia processing device and the entity identifier, and using the calculated security key to secure the data exchanged between the multimedia processing device and the security module.
摘要翻译：一种用于保护在多媒体处理设备和由管理中心管理的安全模块之间交换的多媒体数据的方法，所述多媒体处理设备接收加密的多媒体数据，解密加密的多媒体数据和转换解密的多媒体数据，所述多媒体处理设备包括个人密钥，所述方法包括获得与表示一组多媒体处理设备的实体有关的标识符，基于处理多媒体设备的个人密钥和实体标识符计算由单向功能形成的安全密钥，以及传送该安全性密钥和实体标识符连接到所述多媒体处理装置的安全模块，使用基于所述多媒体处理装置的个人密钥和实体标识符的单向功能计算安全密钥，并使用所计算的安全密钥来确保多媒体过程之间交换数据 ssing设备和安全模块。

3. 发明授权

US08168617B2 Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use 失效
标题翻译：复方泛酸酯新戊酰磺酰酯环化释放前药的acamprosate，其组合物和使用方法
公开(公告)号：US08168617B2
公开(公告)日：2012-05-01
申请号：US12205031
申请日：2008-09-05
申请人： Bernd Jandeleit , Yunxiao Li , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
发明人： Bernd Jandeleit , Yunxiao Li , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
IPC分类号： A61K31/66 , A61K31/255 , C07F9/02 , C07C309/04
CPC分类号： C07C309/15
摘要： Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.
摘要翻译：公开了阿卡波酸的泛酸酯新戊基磺酰酯前药，包含这些前药的药物组合物，以及使用这些前药及其组合物治疗疾病的方法。特别地，表现出增强的口服生物利用度的阿坎酸酯前药和使用阿坎酸类前药治疗神经变性疾病，精神病性障碍，情绪障碍，焦虑症，躯体形式障碍，运动障碍，物质滥用障碍，暴饮暴食症，皮质扩张抑郁症相关疾病，耳鸣的方法，睡眠障碍，多发性硬化和疼痛。

4. 发明申请

US20100183554A1 Anti-CD3 Antibodies and Methods of Use Thereof 有权
标题翻译：抗CD3抗体及其使用方法
公开(公告)号：US20100183554A1
公开(公告)日：2010-07-22
申请号：US12750385
申请日：2010-03-30
申请人： Bernard Mach , Yann Dean , Marie Kosco-Vilbois , Greg Elson , Nicolas Fischer , Olivier Leger
发明人： Bernard Mach , Yann Dean , Marie Kosco-Vilbois , Greg Elson , Nicolas Fischer , Olivier Leger
IPC分类号： A61K39/395 , A61K38/21 , C07K16/28
CPC分类号： C07K16/2809 , A61K39/3955 , A61K45/06 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/74
摘要： The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译：本发明涉及针对抗原CD3的抗体和这种抗体的用途。特别地，本发明提供了完全针对CD3的人单克隆抗体。编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，被提供。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

5. 发明授权

US07697686B2 Unit for managing audio/video data and access control method for said data 有权
标题翻译：用于管理音频/视频数据的单元和用于所述数据的访问控制方法
公开(公告)号：US07697686B2
公开(公告)日：2010-04-13
申请号：US11284101
申请日：2005-11-22
申请人： Jean-Michel Puiatti , André Nicoulin , Nicolas Fischer , Guy Moreillon , Fabien Gremaud , Michael John Hill
发明人： Jean-Michel Puiatti , André Nicoulin , Nicolas Fischer , Guy Moreillon , Fabien Gremaud , Michael John Hill
IPC分类号： H04N7/167
CPC分类号： H04N5/913 , H04N7/163 , H04N7/1675 , H04N21/26613 , H04N21/4181 , H04N21/4405 , H04N21/4408 , H04N21/4627 , H04N21/835 , H04N2005/91364
摘要： Example embodiments are directed to a digital audio/video (AV) data processing unit and a method of controlling access to the digital AV data. The processing unit of AV digital data includes a deciphering unit of the AV data, a decompression unit, an input/output interface of the processed AV data and communication device towards a security module. The deciphering and decompression units respectively include an encryption unit and a decryption unit, each having at least one personal key and a common encryption key. Deciphering the AV data using the control words and re-encrypting the deciphered AV data occurs only after a successful verification of the control word and the common key. After temporary storage, the re-encrypted AV data cannot be decrypted by the decryption unit unless the common key has been positively verified by the security module by way of a random number generated by the decryption unit.
摘要翻译：示例性实施例涉及数字音频/视频（AV）数据处理单元和控制对数字AV数据的访问的方法。 AV数字数据的处理单元包括AV数据的解密单元，解压缩单元，经处理的AV数据的输入/输出接口和通信设备朝向安全模块。解密和解压缩单元分别包括加密单元和解密单元，每个加密单元和解密单元具有至少一个个人密钥和公共加密密钥。使用控制字对AV数据进行解密并对解密的AV数据重新进行加密，只有在成功地验证了控制字和公用密钥之后才发生。在临时存储之后，重新加密的AV数据不能被解密单元解密，除非通过安全模块通过由解密单元生成的随机数来肯定地验证了公共密钥。

6. 发明申请

US20090099253A1 Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use 审中-公开
标题翻译：内在掩蔽的新戊基磺酰酯环化释放Acamprosate，其组成及其使用方法
公开(公告)号：US20090099253A1
公开(公告)日：2009-04-16
申请号：US12252167
申请日：2008-10-15
申请人： Yunxiao Li , Bernd Jandeleit , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
发明人： Yunxiao Li , Bernd Jandeleit , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
IPC分类号： A61K31/35 , C07C233/00 , A61K31/16 , C07D309/00
CPC分类号： C07D311/76 , C07D307/33 , C07D307/88 , C07D309/30 , C07D317/32 , C07D317/36 , C07D333/64
摘要： Internally masked neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.
摘要翻译：本发明公开了含有阿坎酸盐的内部掩蔽的新戊基磺酰基酯前体药物，包含这些前药的药物组合物，以及使用这些前药及其组合物治疗疾病的方法。特别地，表现出增强的口服生物利用度的阿坎酸酯前药和使用阿坎酸类前药治疗神经变性疾病，精神病性障碍，情绪障碍，焦虑症，躯体形式障碍，运动障碍，物质滥用障碍，暴饮暴食症，皮质扩张抑郁症相关疾病，耳鸣的方法，睡眠障碍，多发性硬化和疼痛。

7. 发明申请

US20090082464A1 EXTERNALLY MASKED NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE 审中-公开
标题翻译：外用苯丙醇磺酸酯环化酶释放丙酸钠，其组合物及其使用方法
公开(公告)号：US20090082464A1
公开(公告)日：2009-03-26
申请号：US12205275
申请日：2008-09-05
申请人： Bernd Jandeleit , Yunxiao Li , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
发明人： Bernd Jandeleit , Yunxiao Li , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
IPC分类号： A61K31/16 , C07C233/00
CPC分类号： C07C309/15
摘要： Masked nitrogen-substituted and oxygen-substituted neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.
摘要翻译：本发明公开了阿卡波酸的掩蔽的氮取代和氧取代的新戊基磺酰酯前药，包含这些前药的药物组合物，以及使用这些前药及其组合物治疗疾病的方法。特别地，表现出增强的口服生物利用度的阿坎酸酯前药和使用阿坎酸类前药治疗神经变性疾病，精神病性障碍，情绪障碍，焦虑症，躯体形式障碍，运动障碍，物质滥用障碍，暴饮暴食症，皮质扩张抑郁症相关疾病，耳鸣的方法，睡眠障碍，多发性硬化和疼痛。

8. 发明授权

US07433473B2 Data transmission method between a broadcasting center and a multimedia unit 有权
标题翻译：广播中心与多媒体单元之间的数据传输方法
公开(公告)号：US07433473B2
公开(公告)日：2008-10-07
申请号：US11214833
申请日：2005-08-31
申请人： André Kudelski , Christophe Nicolas , Nicolas Fischer
发明人： André Kudelski , Christophe Nicolas , Nicolas Fischer
IPC分类号： H04L9/00
CPC分类号： H04N21/26606 , H04N21/25816
摘要： The aim of this invention is to propose a flexible solution to the risk represented by the interception of data by an unauthorized party during the transmission of said data between a broadcast center and a specialized decryption/decompression circuit such as is used in a Pay-TV decoder. This aim is achieved by a data transmission method involving a broadcast center or diffusion center, a management center and a multimedia unit, the latter comprising at least one unique key and a security module having a transport key.
摘要翻译：本发明的目的是提出一种在广播中心和专用解密/解压缩电路（例如在付费电视机中使用的）之间传输所述数据期间由未授权方截取数据所代表的风险的灵活解决方案解码器。该目的通过涉及广播中心或扩散中心，管理中心和多媒体单元的数据传输方法来实现，后者包括至少一个唯一密钥和具有传输密钥的安全模块。

9. 发明申请

US20080031449A1 Security device intended to be connected to a processing unit for an audio/video signal and process using such a device 有权
标题翻译：旨在连接到用于音频/视频信号的处理单元和使用这种设备的处理的安全设备
公开(公告)号：US20080031449A1
公开(公告)日：2008-02-07
申请号：US11802662
申请日：2007-05-24
申请人： Karl Osen , Nicolas Fischer
发明人： Karl Osen , Nicolas Fischer
IPC分类号： H04N7/167 , H04N7/12
CPC分类号： G06K19/07733 , G06K7/10297 , G06K19/07 , G06K19/073
摘要： The invention relates to a security device intended to be connected to a processing unit for an audio/video signal. This device comprises means to decrypt an audio/video stream, an interface of the ISO 7816 type and an interface of the USB type. It is characterised in that it includes a clock frequency detection module connected to a clock input of the 7816 interface, this detection module comprising means to distinguish the input frequency according to at least two different frequency ranges, one of said frequency ranges activating the USB function. The invention also concerns a process for processing an audio/video signal by means of a security device comprising means to decrypt an audio/video stream, an interface of the ISO 7816 type and an interface of the USB type. The process is characterised in that it includes the following steps: sending of a clock signal to a clock input of the ISO 7816 interface according to a preset frequency; determination of a frequency range to which said preset frequency belongs; determination of the operating mode of the security device according to the determined clock frequency range; processing the data according to the determined operating mode.
摘要翻译：本发明涉及一种旨在连接到用于音频/视频信号的处理单元的安全装置。该设备包括用于解密音频/视频流，ISO 7816类型的接口和USB类型的接口的装置。其特征在于，它包括连接到7816接口的时钟输入的时钟频率检测模块，该检测模块包括用于根据至少两个不同频率范围区分输入频率的装置，所述频率范围中的一个激活USB功能。本发明还涉及一种通过安全设备来处理音频/视频信号的过程，该安全设备包括解密音频/视频流的装置，ISO 7816类型的接口和USB类型的接口。该过程的特征在于它包括以下步骤：根据预设频率将时钟信号发送到ISO 7816接口的时钟输入; 确定所述预设频率所属的频率范围; 根据确定的时钟频率范围确定安全设备的操作模式; 根据确定的操作模式处理数据。

10. 发明申请

US20060263363A1 Anti-interferon gamma antibodies and methods of use thereof 有权
标题翻译：抗干扰素γ抗体及其使用方法
公开(公告)号：US20060263363A1
公开(公告)日：2006-11-23
申请号：US11342020
申请日：2006-01-27
申请人： Walter Ferlin , Nicolas Fischer , Greg Elson , Olivier Leger
发明人： Walter Ferlin , Nicolas Fischer , Greg Elson , Olivier Leger
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/249 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hIFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFN-γ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune-related disorders and in the amelioration of a symptom associated with an immune-related disorder.
摘要翻译：本发明涉及与人类干扰素γ（hIFNgamma）结合的完全人抗体及其片段，从而调节IFNγ与其受体之间的相互作用，IFNγ-R和/或调节IFN-γ的生物学活性。本发明还涉及这种抗-γ-抗原γ抗体在预防或治疗免疫相关病症中以及改善与免疫相关病症相关症状的用途。

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