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1. 发明申请

US20100184724A1 COMPOSITIONS FOR TREATING AND/OR PREVENTING DISEASES CHARACTERIZED BY THE PRESENCE OF METAL IONS 有权
标题翻译：用于治疗和/或预防由金属离子存在而引起的疾病的组合物
公开(公告)号：US20100184724A1
公开(公告)日：2010-07-22
申请号：US12567678
申请日：2009-09-25
申请人： Orrie Friedman , Ivan Correia , Toby J. Sommer , David Alan Kew
发明人： Orrie Friedman , Ivan Correia , Toby J. Sommer , David Alan Kew
IPC分类号： A61K31/695 , A61P25/28
CPC分类号： A61K31/695 , Y10S514/879
摘要： The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e.g., fluorescently or radioactively) in certain instances. In some embodiments, the composition, or a portion thereof, may sequester aluminum, copper, iron or other ions, for example, by electrostatically binding to the ions. The composition may also include other functionalities such as amines, certain alkyl and/or aryl moieties (including substituted alkyls and/or aryls), or hydrophobic moieties, for example, to facilitate transport of the organosilicon compound through the blood-brain barrier.
摘要翻译：本发明一般涉及通过使用包括有机硅化合物的某些组合来治疗和/或预防阿尔茨海默病，其他神经变性疾病和/或特征为某些金属离子的存在的疾病。本发明的组合物可以施用于哺乳动物，例如人。在一些情况下，组合物可以包括硅烷醇，硅烷醇，硅烷三醇或环状有机硅烷，和/或能够在暴露于例如在血液中发现的生理条件下形成硅烷醇，硅烷醇或硅烷醇，在胃和/或胃肠道，或在脑或其他器官中。在某些情况下，有机硅化合物可以结合到能够通过血脑屏障转运到脑中的部分，例如氨基酸，肽，蛋白质，病毒等。有机硅化合物也可以在某些情况下被标记（例如，荧光或放射性）。在一些实施方案中，组合物或其一部分可以螯合铝，铜，铁或其它离子，例如通过静电结合离子。组合物还可以包括其它官能团，例如胺，某些烷基和/或芳基部分（包括取代的烷基和/或芳基）或疏水部分，例如有助于有机硅化合物通过血脑屏障的转运。

2. 发明授权

US07595308B2 Compositions for treating and/or preventing diseases characterized by the presence of metal ions 有权
标题翻译：用于治疗和/或预防以金属离子存在为特征的疾病的组合物
公开(公告)号：US07595308B2
公开(公告)日：2009-09-29
申请号：US11132170
申请日：2005-05-17
申请人： Orrie Friedman , Ivan Correia , Toby Sommer , David Alan Kew
发明人： Orrie Friedman , Ivan Correia , Toby Sommer , David Alan Kew
IPC分类号： A01N55/00
CPC分类号： A61K31/695 , Y10S514/879
摘要： The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e.g., fluorescently or radioactively) in certain instances. In some embodiments, the composition, or a portion thereof, may sequester aluminum, copper, iron or other ions, for example, by electrostatically binding to the ions. The composition may also include other functionalities such as amines, certain alkyl and/or aryl moieties (including substituted alkyls and/or aryls), or hydrophobic moieties, for example, to facilitate transport of the organosilicon compound through the blood-brain barrier.
摘要翻译：本发明一般涉及通过使用包括有机硅化合物的某些组合来治疗和/或预防阿尔茨海默病，其他神经变性疾病和/或特征为某些金属离子的存在的疾病。本发明的组合物可以施用于哺乳动物，例如人。在一些情况下，组合物可以包括硅烷醇，硅烷醇，硅烷三醇或环状有机硅烷，和/或能够在暴露于例如在血液中发现的生理条件下形成硅烷醇，硅烷醇或硅烷醇，在胃和/或胃肠道，或在脑或其他器官中。在某些情况下，有机硅化合物可以结合到能够通过血脑屏障转运到脑中的部分，例如氨基酸，肽，蛋白质，病毒等。有机硅化合物也可以在某些情况下被标记（例如，荧光或放射性）。在一些实施方案中，组合物或其一部分可以螯合铝，铜，铁或其它离子，例如通过静电结合离子。组合物还可以包括其它官能团，例如胺，某些烷基和/或芳基部分（包括取代的烷基和/或芳基）或疏水部分，例如有助于有机硅化合物通过血脑屏障的转运。

3. 发明申请

US20060040897A1 Compositions for treating and/or preventing diseases characterized by the presence of metal ions 有权
公开(公告)号：US20060040897A1
公开(公告)日：2006-02-23
申请号：US11132170
申请日：2005-05-17
申请人： Orrie Friedman , Ivan Correia , Toby Sommer , David Kew
发明人： Orrie Friedman , Ivan Correia , Toby Sommer , David Kew
IPC分类号： A61K31/695
CPC分类号： A61K31/695 , Y10S514/879
摘要： The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e.g., fluorescently or radioactively) in certain instances. In some embodiments, the composition, or a portion thereof, may sequester aluminum, copper, iron or other ions, for example, by electrostatically binding to the ions. The composition may also include other functionalities such as amines, certain alkyl and/or aryl moieties (including substituted alkyls and/or aryls), or hydrophobic moieties, for example, to facilitate transport of the organosilicon compound through the blood-brain barrier.

4. 发明授权

US08273726B2 Compositions for treating and/or preventing diseases characterized by the presence of metal ions 有权
标题翻译：用于治疗和/或预防以金属离子存在为特征的疾病的组合物
公开(公告)号：US08273726B2
公开(公告)日：2012-09-25
申请号：US12567678
申请日：2009-09-25
申请人： Orrie Friedman , Ivan Correia , Toby J. Sommer , David Alan Kew
发明人： Orrie Friedman , Ivan Correia , Toby J. Sommer , David Alan Kew
IPC分类号： A01N55/00 , A61K31/695
CPC分类号： A61K31/695 , Y10S514/879
摘要： The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e.g., fluorescently or radioactively) in certain instances. In some embodiments, the composition, or a portion thereof, may sequester aluminum, copper, iron or other ions, for example, by electrostatically binding to the ions. The composition may also include other functionalities such as amines, certain alkyl and/or aryl moieties (including substituted alkyls and/or aryls), or hydrophobic moieties, for example, to facilitate transport of the organosilicon compound through the blood-brain barrier.
摘要翻译：本发明一般涉及通过使用包括有机硅化合物的某些组合来治疗和/或预防阿尔茨海默病，其他神经变性疾病和/或特征为某些金属离子的存在的疾病。本发明的组合物可以施用于哺乳动物，例如人。在一些情况下，组合物可以包括硅烷醇，硅烷醇，硅烷三醇或环状有机硅烷，和/或能够在暴露于例如在血液中发现的生理条件下形成硅烷醇，硅烷醇或硅烷醇，在胃和/或胃肠道，或在脑或其他器官中。在某些情况下，有机硅化合物可以结合到能够通过血脑屏障转运到脑中的部分，例如氨基酸，肽，蛋白质，病毒等。有机硅化合物也可以在某些情况下被标记（例如，荧光或放射性）。在一些实施方案中，组合物或其一部分可以螯合铝，铜，铁或其它离子，例如通过静电结合离子。组合物还可以包括其它官能团，例如胺，某些烷基和/或芳基部分（包括取代的烷基和/或芳基）或疏水部分，例如有助于有机硅化合物通过血脑屏障的转运。

5. 发明申请

US20090203644A1 Compositions for treating and/or preventing diseases characterized by the presence of metal ions 审中-公开
标题翻译：用于治疗和/或预防以金属离子存在为特征的疾病的组合物
公开(公告)号：US20090203644A1
公开(公告)日：2009-08-13
申请号：US11665793
申请日：2005-10-24
申请人： Orrie Friedman , Thomas C. Pochapsky , Julie Yu Wei
发明人： Orrie Friedman , Thomas C. Pochapsky , Julie Yu Wei
IPC分类号： A61K31/695 , A61P25/28
CPC分类号： A61K31/695
摘要： The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including silicon-amino compounds. In some cases, a silicon-amino compound of the invention may be bidentate, tridentate, or otherwise polydentate, and in certain instances, the silicon-amino compound, or a portion thereof, may sequester aluminum or other ions, for example, by electrostatically binding the ions. Further aspects of the invention relate to methods of making and using such compositions of the invention, as well as articles and kits associated with the compositions.
摘要翻译：本发明一般涉及通过使用包括硅 - 氨基化合物的某些组合来治疗和/或预防阿尔茨海默氏病，其他神经变性疾病和/或特征为某些金属离子的存在的疾病。在一些情况下，本发明的硅 - 氨基化合物可以是二齿，三齿或其它多齿，并且在某些情况下，硅 - 氨基化合物或其一部分可以螯合铝或其它离子，例如通过静电结合离子。本发明的其它方面涉及制备和使用本发明的这些组合物的方法，以及与组合物相关的制品和试剂盒。

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