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1. 发明申请

US20120271130A1 METHOD AND APPARATUS FOR DETERMINING AN OXYGEN DESATURATION EVENT 审中-公开
标题翻译：用于测定氧气脱硫事件的方法和装置
公开(公告)号：US20120271130A1
公开(公告)日：2012-10-25
申请号：US13444509
申请日：2012-04-11
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/1455 , A61B5/0205
CPC分类号： A61B5/14551 , A61B2503/045
摘要： A method and apparatus for determining an index indicative of a subject's response to an oxygen desaturation condition is provided. The method includes the steps of: a) providing a NIRS tissue sensor, a pulse oximetry sensor, and a processor in communication with the NIRS tissue sensor and the pulse oximetry sensor; b) sensing the subject's tissue using the NIRS tissue sensor and producing first signals; c) sensing the subject's tissue using the pulse oximetry sensor and producing second signals; d) processing the first signals to determine a change in tissue oxygen saturation values, processing the second signals to determine a change in arterial oxygen saturation values; and e) determining the index indicative of the subject's response to the oxygen desaturation condition using the change in tissue oxygen saturation values and the change in arterial oxygen saturation values.
摘要翻译：提供了一种用于确定指示对象对氧去饱和状态的反应的指标的方法和装置。该方法包括以下步骤：a）提供与NIRS组织传感器和脉搏血氧饱和度传感器通信的NIRS组织传感器，脉搏血氧饱和度传感器和处理器; b）使用NIRS组织传感器感测被检者的组织并产生第一信号; c）使用脉搏血氧测定传感器感测被检者的组织并产生第二信号; d）处理第一信号以确定组织氧饱和度值的变化，处理第二信号以确定动脉血氧饱和度值的变化; 以及e）使用组织氧饱和度值的变化和动脉血氧饱和度值的变化来确定指示受试者对氧气去饱和状态的反应的指标。

2. 发明申请

US20110028812A1 METHOD FOR SPECTROPHOTOMETRIC BLOOD OXYGENATION MONITORING 审中-公开
标题翻译：分光光度法血液氧化监测方法
公开(公告)号：US20110028812A1
公开(公告)日：2011-02-03
申请号：US12851977
申请日：2010-08-06
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/1455
CPC分类号： A61B5/14553 , A61B5/1495
摘要： A method and apparatus for non-invasively determining a blood oxygenation level within a subject's tissue is provided. The method includes the steps of: a) providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; b) inputting into the sensor at least one of the subject's age, weight, brain development, and head size; c) spectrophotometrically sensing the subject's tissue along a plurality of wavelengths using the sensor, and producing signal data from sensing the subject's tissue; and d) processing the signal data utilizing the at least one of the subject's age, weight, brain development, and head size, to determine the blood oxygen saturation level within the subject's tissue using a difference in attenuation between the wavelengths.
摘要翻译：提供了一种用于非侵入性地确定受试者组织内的血氧水平水平的方法和装置。该方法包括以下步骤：a）提供分光光度传感器，其可操作以将光透射到受试者的组织中并感测光; b）将至少一个受试者的年龄，体重，大脑发育和头部大小输入传感器; c）使用所述传感器分光光度测量沿着多个波长的对象的组织，并且产生来自感测对象的组织的信号数据; 以及d）利用所述受试者的年龄，体重，大脑发育和头大小中的至少一个来处理所述信号数据，以使用所述波长之间的衰减差来确定所述受试者组织内的血氧饱和度水平。

3. 发明申请

US20100087719A1 METHOD AND APPARATUS FOR DETERMINING CEREBRAL DESATURATION IN PATIENTS UNDERGOING DEEP HYPOTHERMIC CIRCULATORY ARREST 有权
标题翻译：用于确定深层热电循环系统的患者的脑缺血的方法和装置
公开(公告)号：US20100087719A1
公开(公告)日：2010-04-08
申请号：US12574412
申请日：2009-10-06
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/1455
CPC分类号： A61B5/7275 , A61B5/14553 , G06F19/00
摘要： A method and apparatus for determining cerebral oxygen saturation in a subject is provided. The method comprises the steps of: a) determining tissue oxygen saturation values using a NIRS type oximeter over a period of time; b) modeling a rate of change in the tissue oxygen saturation values; and c) determining an amount of time until a predetermined tissue oxygen saturation value is reached using the modeling of the tissue oxygen saturation values.
摘要翻译：提供了一种用于确定受试者中的脑氧饱和度的方法和装置。该方法包括以下步骤：a）使用NIRS型血氧计在一段时间内确定组织氧饱和度值; b）对组织氧饱和度值的变化率进行建模; 以及c）使用所述组织氧饱和度值的建模来确定达到预定组织氧饱和度值的时间量。

4. 发明授权

US09364175B2 Method for spectrophotometric blood oxygenation monitoring of organs in the body 有权
标题翻译：分光光度法血氧监测身体器官的方法
公开(公告)号：US09364175B2
公开(公告)日：2016-06-14
申请号：US13511928
申请日：2010-11-24
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/4836 , A61B5/4848 , A61B5/7246 , A61B5/7271 , A61B5/7278 , A61B5/746 , A61B2562/0233
摘要： A method and apparatus for non-invasively determining a blood oxygen saturation level within an organ of a subject using direct application of a near infrared spectrophotometric sensor is provided. The method includes the steps of: a) transmitting a light signal directly into the subject's organ using the sensor; b) sensing a first intensity of the light signal and a second intensity of the light signal, after the light signal travels a predetermined distance through the organ of the subject; c) determining an attenuation of the light signal along multiple different wavelengths using the sensed first intensity and sensed second intensity; d) determining a difference in attenuation of the light signal between wavelengths; and e) determining the blood oxygen saturation level within the subject's organ using the difference in attenuation between wavelengths.
摘要翻译：提供了一种使用近红外分光光度传感器直接应用非侵入性地确定受试者器官内的血氧饱和度水平的方法和装置。该方法包括以下步骤：a）使用传感器将光信号直接发送到被检者的器官; b）在光信号经过预定距离通过被摄体的器官之后感测光信号的第一强度和光信号的第二强度; c）使用感测到的第一强度和感测的第二强度来确定沿着多个不同波长的光信号的衰减; d）确定波长之间的光信号的衰减差; 以及e）使用波长之间的衰减差来确定受试者器官内的血氧饱和度水平。

5. 发明申请

US20100105998A1 METHOD AND APPARATUS FOR SPECTROPHOTOMETRIC BASED OXIMETRY OF SPINAL TISSUE 审中-公开
标题翻译：用于基于分光光度法测定的脊髓组织的方法和装置
公开(公告)号：US20100105998A1
公开(公告)日：2010-04-29
申请号：US12607648
申请日：2009-10-28
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/407 , A61B5/6846 , A61B5/6865 , A61B2562/0242
摘要： A near infrared spectrophotometric sensor for non-invasive monitoring of blood oxygenation levels in a subject's spinal cord tissue and spinal cord blood vessels is provided. The sensor includes at least one light source and at least one light detector. The light source is operative to emit near infrared light signals of a plurality of different wavelengths. The light detector is operative to sense light signals emitted from the light source and passed through the subject's spinal tissue, and to produce a sensor signal representative of the sensed light signals The light source is separated from the light detector by a distance representative of a distance from a first vertebrae structure of a human spine to a second vertebrae structure of the human spine, to permit alignment of the light source and detector with the first and second vertebrae structure.
摘要翻译：提供了一种用于无创监测受试者的脊髓组织和脊髓血管中的血氧水平的近红外分光光度传感器。传感器包括至少一个光源和至少一个光检测器。光源可操作地发射多个不同波长的近红外光信号。光检测器可操作以感测从光源发射并穿过被检者的脊髓组织的光信号，并产生表示感测到的光信号的传感器信号。光源与光检测器分离距离，该距离表示距离从人脊椎的第一椎骨结构到人脊椎的第二椎骨结构，以允许光源和检测器与第一和第二椎骨结构对准。

6. 发明申请

US20090281403A1 METHOD FOR SPECTROPHOTOMETRIC BLOOD OXYGENATION MONITORING 有权
标题翻译：分光光度法血液氧化监测方法
公开(公告)号：US20090281403A1
公开(公告)日：2009-11-12
申请号：US11914074
申请日：2006-05-10
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/0261 , A61B5/14546 , A61B5/14552 , A61B5/14553 , A61B5/1495 , A61B5/6814 , G01N21/359 , G01N21/49 , G01N2021/3144
摘要： According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method comprises the steps of: 1) providing a near infrared spectrophotometric sensor operable to transmit light along a plurality of wavelengths into the subject's tissue; 2) sensing the light transmitted into the subject's tissue using the sensor, and producing signal data representative of the light sensed from the subject's tissue; 3) processing the signal data to account for physical characteristics of the subject; and 4) determining the blood oxygen saturation level within the subject's tissue using a difference in attenuation between the wavelengths. The apparatus includes a sensor having a light source and at least one light detector, which sensor is operably connected to a processor. The sensor is operable to transmit light along a plurality of wavelengths into the subject's tissue, and produce signal data representative of the light sensed from the subject's tissue. The algorithm is operable to process the signal data to account for the physical characteristics of the subject being sensed.
摘要翻译：根据本发明，提供了用于非侵入性地确定受试者组织内的血氧饱和度水平的方法和装置。该方法包括以下步骤：1）提供近红外分光光度传感器，可操作以将多个波长的光透射到被检者的组织中; 2）使用传感器感测传播到被检者组织的光，并且产生代表从被检者组织感测的光的信号数据; 3）处理信号数据以解决被摄体的物理特征; 以及4）使用所述波长之间的衰减差来确定所述受试者组织内的血氧饱和度水平。该装置包括具有光源和至少一个光检测器的传感器，该传感器可操作地连接到处理器。传感器可操作以将多个波长的光传输到被检者的组织中，并且产生表示从受检者组织感测的光的信号数据。该算法可操作以处理信号数据以考虑被感测对象的物理特性。

7. 发明申请

US20080017800A1 LASER DIODE OPTICAL TRANSDUCER ASSEMBLY FOR NON-INVASIVE SPECTROPHOTOMETRIC BLOOD OXYGENATION 审中-公开
标题翻译：激光二极管光学传感器组件用于非入射光谱法血液氧化
公开(公告)号：US20080017800A1
公开(公告)日：2008-01-24
申请号：US11864203
申请日：2007-09-28
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： G01J3/02
CPC分类号： A61B5/14553 , A61B5/14552 , A61B5/6814 , A61B2560/0242
摘要： An infrared spectrometric monitoring transducer includes a shielded cable, a fiber optic light guide, a transducer housing, a light source, and at least one light detector. The light source is mounted in the transducer housing and is operable to produce a light signal along a plurality of discrete wavelengths. The at least one light detector is mounted in the housing and is operable to receive light energy corresponding to the light signal. The at least one light detector is mounted in the transducer housing spaced a distance apart from the light source along a straight line extending the light source and the at least one light detector. The shielded cable and the fiber optic light guide are disposed adjacent the light source and the transducer has an “L” shape formed by the shielded cable and the fiber optic light guide extending outwardly from the transducer housing in a direction substantially perpendicular to the line between the extending the light source and the at least one light detector.
摘要翻译：红外光谱监测传感器包括屏蔽电缆，光纤光导，传感器外壳，光源和至少一个光检测器。光源安装在换能器壳体中并且可操作以沿着多个离散波长产生光信号。所述至少一个光检测器安装在壳体中并且可操作以接收对应于光信号的光能。至少一个光检测器安装在换能器壳体中，沿着延伸光源和至少一个光检测器的直线与光源隔开一段距离。屏蔽电缆和光纤光导被设置在光源附近，并且换能器具有由屏蔽电缆形成的“L”形状，并且光纤光导从换能器壳体向外延伸，基本上垂直于线之间的线延伸光源和至少一个光检测器。

8. 发明申请

US20060195024A1 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation 有权
公开(公告)号：US20060195024A1
公开(公告)日：2006-08-31
申请号：US11384615
申请日：2006-03-20
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14552 , A61B5/6814 , A61B2560/0242
摘要： A non-invasive near infrared spectrophotometric monitoring transducer assembly includes a housing member, which is adhered directly on a patient's skin. The housing member contains a prism coupled to a flexible and lightweight single core optical light guide, which provides a means of transferring narrow spectral bandwidth light from multiple distant laser diodes of different wavelengths by use of a multi-fiber optic light combining assembly. Different wavelengths are needed to monitor the level of blood oxygenation in the patient. The assembly also contains a planar light guide mounted on the prism located in the housing member, which light guide contacts the patient's skin when the housing member is adhered to the patient's skin. The light guide controls the spacing between the prism and the patient's skin, and therefore controls the intensity of the area on the patient's skin which is illuminated by the laser light. The housing member contains a photodiode assembly, which detects the infrared light at a second location on the skin to determine light absorption. The photodiode assembly is preferably shielded from ambient electromagnetic interference (EMI) by an optically transparent EMI attenuating window. This rigid window placed over the photodiode also provides a planar interface between the assembly and the skin, improving optical coupling and stability as well as reducing the capacitive coupling between skin and the photodiode resulting in further EMI attenuation. The housing may be associated with a disposable sterile hydrogel coated adhesive envelope, or pad, which when applied to the patient's skin will adhere the housing to the patient's skin. The transducer assembly will thus be reusable, and skin-contacting part of the device, i.e., the envelope or pad can be discarded after a single use. The assembly also includes a laser safety interlock means, which is operable to turn off the laser light output in the event that the assembly accidentally becomes detached from the patient's skin.

9. 发明申请

US20060189861A1 Method for spectrophotometric blood oxygenation monitoring 有权
标题翻译：分光光度血氧监测方法
公开(公告)号：US20060189861A1
公开(公告)日：2006-08-24
申请号：US11376894
申请日：2006-03-16
申请人： Bo Chen , Paul Benni
发明人： Bo Chen , Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/14553
摘要： A method and apparatus for non-invasively determining the blood oxygenation within a subject's tissue is provided that utilizes a near infrared spectrophotometric (NIRS) sensor capable of transmitting a light signal into the tissue of a subject and sensing the light signal once it has passed through the tissue via transmittance or reflectance.
摘要翻译：提供了一种用于非侵入性地确定受试者组织内的血氧饱和的方法和装置，其利用能够将光信号传输到对象的组织中的近红外分光光度计（NIRS）传感器，并且一旦其通过就感测光信号组织通过透光率或反射率。

10. 发明授权

US08391942B2 Method and apparatus for determining cerebral desaturation in patients undergoing deep hypothermic circulatory arrest 有权
标题翻译：用于确定深度低温循环阻滞患者脑缺血的方法和装置
公开(公告)号：US08391942B2
公开(公告)日：2013-03-05
申请号：US12574412
申请日：2009-10-06
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/7275 , A61B5/14553 , G06F19/00
摘要： A method and apparatus for determining cerebral oxygen saturation in a subject is provided. The method comprises the steps of: a) determining tissue oxygen saturation values using a NIRS type oximeter over a period of time; b) modeling a rate of change in the tissue oxygen saturation values; and c) determining an amount of time until a predetermined tissue oxygen saturation value is reached using the modeling of the tissue oxygen saturation values.
摘要翻译：提供了一种用于确定受试者中的脑氧饱和度的方法和装置。该方法包括以下步骤：a）使用NIRS型血氧计在一段时间内确定组织氧饱和度值; b）对组织氧饱和度值的变化率进行建模; 以及c）使用所述组织氧饱和度值的建模来确定达到预定组织氧饱和度值的时间量。

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