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1. 发明授权

US09451887B2 Systems and methods for measuring electromechanical delay of the heart 有权
标题翻译：用于测量心脏机电延迟的系统和方法
公开(公告)号：US09451887B2
公开(公告)日：2016-09-27
申请号：US12751814
申请日：2010-03-31
申请人： James N. Watson , Paul Stanley Addison , Robert Stoughton
发明人： James N. Watson , Paul Stanley Addison , Robert Stoughton
IPC分类号： A61B5/02 , A61B5/024 , A61B5/022 , A61B5/0402 , A61B5/00
CPC分类号： A61B5/02416 , A61B5/022 , A61B5/0402 , A61B5/6814 , A61B5/6816 , A61B5/6823 , A61B5/6824 , A61B5/6826
摘要： Systems and methods are disclosed herein for measuring the electromechanical delay of the heart of a patient. An electrocardiogram (EKG) signal may be used to detect heart electrical activity. Photoplethysmograph (PPG) signals may be used to detect heart mechanical activity. The electromechanical delay may be calculated based at least in part on the timing of an EKG signal and at least two PPG signals.
摘要翻译：本文公开了用于测量患者心脏的机电延迟的系统和方法。可以使用心电图（EKG）信号来检测心脏电活动。 Photoplethysmograph（PPG）信号可用于检测心脏机械活动。可以至少部分地基于EKG信号的定时和至少两个PPG信号来计算机电延迟。

2. 发明授权

US09241646B2 System and method for determining stroke volume of a patient 有权
标题翻译：用于确定患者的行程体积的系统和方法
公开(公告)号：US09241646B2
公开(公告)日：2016-01-26
申请号：US13609566
申请日：2012-09-11
申请人： Paul Stanley Addison , James Nicholas Watson
发明人： Paul Stanley Addison , James Nicholas Watson
IPC分类号： A61B5/02 , A61B5/029 , A61B5/024 , A61B8/02 , A61B5/1455
CPC分类号： A61B5/029 , A61B5/024 , A61B5/02416 , A61B5/02427 , A61B5/0261 , A61B5/14551 , A61B5/742 , A61B8/02
摘要： A PPG system for determining a stroke volume of a patient includes a PPG sensor configured to be secured to an anatomical portion of the patient. The PPG sensor is configured to sense a physiological characteristic of the patient. The PPG system may include a monitor operatively connected to the PPG sensor. The monitor receives a PPG signal from the PPG sensor. The monitor includes a pulse trending module determining a slope transit time of an upslope of a primary peak of the PPG signal. The pulse trending module determines a stroke volume of the patient as a function of the slope transit time.
摘要翻译：用于确定患者的行程体积的PPG系统包括被配置为固定到患者的解剖部分上的PPG传感器。 PPG传感器被配置为感测患者的生理特征。 PPG系统可以包括可操作地连接到PPG传感器的监视器。监视器从PPG传感器接收PPG信号。监视器包括确定PPG信号的主峰的上坡的斜率通过时间的脉冲趋势模块。脉冲趋势模块根据斜率通过时间确定患者的搏动量。

3. 发明授权

US09220460B2 Method of analyzing and processing signals 有权
标题翻译：信号分析处理方法
公开(公告)号：US09220460B2
公开(公告)日：2015-12-29
申请号：US13590111
申请日：2012-08-20
申请人： Paul Stanley Addison , James Nicholas Watson
发明人： Paul Stanley Addison , James Nicholas Watson
IPC分类号： A61B5/02 , A61B5/00 , A61B5/024 , A61B5/08 , A61B5/1455 , G01N21/31
CPC分类号： A61B5/726 , A61B5/0002 , A61B5/0082 , A61B5/02416 , A61B5/02438 , A61B5/0816 , A61B5/14551 , A61B5/14552 , A61B5/4818 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6896 , A61B5/7207 , A61B5/7214 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B2503/06 , G01N21/3151 , G06F19/00
摘要： A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.
摘要翻译：公开了一种生理测量系统，其可以从患者获取诸如光谱体积图的脉搏血氧测定信号，然后分析该信号以测量生理参数，包括呼吸，脉搏，氧饱和度和运动。该系统包括脉搏血氧计，其包括发光装置和可附接到对象的光电检测器，以获得脉搏血氧饱和度信号; 模拟数字转换器装置，被布置成将所述脉搏血氧测定信号转换成数字脉搏血氧饱和度信号; 信号处理装置，适于接收所述数字脉搏血氧饱和度信号，并被布置成通过小波变换装置分解该信号; 特征提取装置，被布置成从分解信号中导出生理信息; 分析器组件，被布置成从特征提取装置收集信息; 以及数据输出装置，被布置成与分析器组件通信。

4. 发明授权

US09220459B2 Method of analyzing and processing signals 有权
标题翻译：信号分析处理方法
公开(公告)号：US09220459B2
公开(公告)日：2015-12-29
申请号：US13590100
申请日：2012-08-20
申请人： Paul Stanley Addison , James Nicholas Watson
发明人： Paul Stanley Addison , James Nicholas Watson
IPC分类号： A61B5/02 , A61B5/00 , A61B5/024 , A61B5/08 , A61B5/1455 , G01N21/31
CPC分类号： A61B5/726 , A61B5/0002 , A61B5/0082 , A61B5/02416 , A61B5/02438 , A61B5/0816 , A61B5/14551 , A61B5/14552 , A61B5/4818 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6896 , A61B5/7207 , A61B5/7214 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B2503/06 , G01N21/3151 , G06F19/00
摘要： A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyze the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyzer component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyzer component.
摘要翻译：公开了一种生理测量系统，其可以从患者获取诸如光谱体积图的脉搏血氧测定信号，然后分析该信号以测量生理参数，包括呼吸，脉搏，氧饱和度和运动。该系统包括脉搏血氧计，其包括发光装置和可附接到对象的光电检测器，以获得脉搏血氧饱和度信号; 模拟数字转换器装置，被布置成将所述脉搏血氧测定信号转换成数字脉搏血氧饱和度信号; 信号处理装置，适于接收所述数字脉搏血氧饱和度信号，并被布置成通过小波变换装置分解该信号; 特征提取装置，被布置成从分解信号中导出生理信息; 分析器组件，被布置成从特征提取装置收集信息; 以及数据输出装置，被布置成与分析器组件通信。

5. 发明授权

US09138183B2 Combined physiological sensor systems and methods 有权
标题翻译：组合生理传感器系统和方法
公开(公告)号：US09138183B2
公开(公告)日：2015-09-22
申请号：US13020704
申请日：2011-02-03
申请人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison
发明人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/01 , A61B5/0205 , A61B5/024 , A61B5/16
CPC分类号： A61B5/02055 , A61B5/01 , A61B5/0205 , A61B5/02433 , A61B5/14552 , A61B5/165 , A61B5/6814 , A61B5/6826 , A61B5/6838 , A61B5/7203 , A61B5/7257 , A61B5/726
摘要： A combined physiological sensor and methods for detecting one or more physiological characteristics of a subject are provided. The combined sensor (e.g., a forehead sensor) may be used to detect and/or calculate at least one of a pulse blood oxygen saturation level, a regional blood oxygen saturation level, a respiration rate, blood pressure, an electrical physiological signal (EPS), a pulse transit time (PTT), body temperature associated with the subject, a depth of consciousness (DOC) measurement, any other suitable physiological parameter, and any suitable combination thereof. The combined sensor may include a variety of individual sensors, such as electrodes, optical detectors, optical emitters, temperature sensors, and/or other suitable sensors. The sensors may be advantageously positioned in accordance with a number of different geometries. The combined sensor may also be coupled to a monitoring device, which may receive and/or process one or more output signals from the individual sensors to display information about the medical condition of the subject. In addition, several techniques may be employed to prevent or limit interference between the individual sensors and their associated input and/or output signals.
摘要翻译：提供组合的生理传感器和用于检测受试者的一种或多种生理特征的方法。组合的传感器（例如，前额传感器）可用于检测和/或计算脉搏血氧饱和度水平，区域血氧饱和度水平，呼吸速率，血压，电生理信号（EPS ），脉搏传播时间（PTT），与受试者相关的体温，意识深度（DOC）测量，任何其它合适的生理参数及其任何合适的组合。组合的传感器可以包括各种单独的传感器，例如电极，光学检测器，光发射器，温度传感器和/或其它合适的传感器。可以根据多个不同的几何形状有利地定位传感器。组合的传感器还可以耦合到监视设备，监视设备可以接收和/或处理来自各个传感器的一个或多个输出信号以显示关于对象的医疗状况的信息。此外，可以采用几种技术来防止或限制各个传感器及其相关的输入和/或输出信号之间的干扰。

6. 发明申请

US20140081098A1 SENSOR SYSTEM 审中-公开
标题翻译：传感器系统
公开(公告)号：US20140081098A1
公开(公告)日：2014-03-20
申请号：US13618227
申请日：2012-09-14
申请人： Kristi Cohrs , James Nicholas Watson , Paul Stanley Addison , Mark Su
发明人： Kristi Cohrs , James Nicholas Watson , Paul Stanley Addison , Mark Su
IPC分类号： A61B5/024
CPC分类号： A61B5/02444 , A61B5/02028 , A61B5/02125 , A61B5/029 , A61B5/14552 , A61B5/6816 , A61B5/6822
摘要： A sensor system is provided for determining a pulse transit time measurement of a patient. The sensor system includes a carotid sensor device configured to be positioned on a neck of the patient over a carotid artery of the patient. The carotid sensor device is configured to detect a plethysmograph waveform from the carotid artery. The sensor system includes a temporal sensor device that is operatively connected to the carotid sensor device. The temporal sensor device is configured to be positioned on the patient over a temporal artery of the patient. The temporal sensor device is configured to detect a plethysmograph waveform from the temporal artery.
摘要翻译：提供了用于确定患者的脉搏传播时间测量的传感器系统。传感器系统包括颈动脉传感器装置，其被配置为位于患者的颈部上方位于患者的颈动脉上。颈动脉传感器装置被配置为检测来自颈动脉的体积描记器波形。传感器系统包括可操作地连接到颈动脉传感器装置的时间传感器装置。时间传感器装置被配置为在患者的颞动脉上定位在患者身上。时间传感器装置被配置为从颞动脉检测体积描记器波形。

7. 发明申请

US20140066782A1 SYSTEM AND METHOD FOR DETERMINING A RESTING HEART RATE OF AN INDIVIDUAL 审中-公开
标题翻译：用于确定个体的静态心率的系统和方法
公开(公告)号：US20140066782A1
公开(公告)日：2014-03-06
申请号：US13598953
申请日：2012-08-30
申请人： Paul Stanley Addison , Rui Wang , James Nicholas Watson
发明人： Paul Stanley Addison , Rui Wang , James Nicholas Watson
IPC分类号： A61B5/024
CPC分类号： A61B5/024 , A61B5/02416 , A61B5/0245 , A61B5/0456 , A61B5/7239 , A61B7/00
摘要： A system to determine a resting heart rate (HR) of an individual. The system may include a monitor that is configured to be operatively connected to a sensor that obtains physiological signals from an individual. The monitor is configured to receive the physiological signals from the sensor. The monitor may include a validation module that is configured to analyze the physiological signals to identify valid heart beats from the physiological signals. The monitor may also include a rate-determining module that is configured to determine an HR signal that is based on the valid heart beats. The HR signal includes a series of data points. The monitor may also include an analysis module that is configured to analyze the HR signal and identify baseline data points from the series of data points. The analysis module is configured to calculate the resting HR based on the baseline data points.
摘要翻译：确定个体静息心率（HR）的系统。该系统可以包括被配置为可操作地连接到从个人获得生理信号的传感器的监视器。监视器被配置为从传感器接收生理信号。监视器可以包括验证模块，其被配置为分析生理信号以从生理信号识别有效心跳。监视器还可以包括速率确定模块，其被配置为基于有效的心脏跳动来确定HR信号。 HR信号包括一系列数据点。监视器还可以包括分析模块，其被配置为分析HR信号并从所述一系列数据点识别基准数据点。分析模块被配置为基于基线数据点计算静息HR。

8. 发明授权

US08660625B2 Signal processing systems and methods for analyzing multiparameter spaces to determine physiological states 有权
标题翻译：用于分析多参数空间以确定生理状态的信号处理系统和方法
公开(公告)号：US08660625B2
公开(公告)日：2014-02-25
申请号：US12242915
申请日：2008-10-01
申请人： Paul Stanley Addison , James Nicholas Watson , Edward M. McKenna
发明人： Paul Stanley Addison , James Nicholas Watson , Edward M. McKenna
IPC分类号： A61B5/026 , A61B5/0452
CPC分类号： G06K9/00536 , A61B5/14551 , A61B5/7207 , A61B5/726 , G06K9/00516 , G16H50/20
摘要： The present disclosure relates to signal processing systems and methods, and more particularly, to systems and methods for analyzing multiparameter spaces to determine changes in a physiological state. In embodiments, a first signal and a second signal may be obtained, from which a first plurality of values of a physiological parameter may be determined. At least one of the signals also may be used to generate a scalogram derived at least in part from the signal. A second plurality of values may be determined based at least in part on a feature in the scalogram. The first and second plurality of values may then be associated, and a physiological state may be analyzed using the associated first and second values. In an embodiment, the signals may be PPG signals and the associated first and second values may include a parameter scatter plot that may permit a user to determine changes in a patient's ventilation state over time.
摘要翻译：本公开涉及信号处理系统和方法，更具体地，涉及用于分析多参数空间以确定生理状态的变化的系统和方法。在实施例中，可以获得可以确定生理参数的第一多个值的第一信号和第二信号。信号中的至少一个也可用于产生至少部分地从该信号导出的标尺图。可以至少部分地基于缩放图中的特征来确定第二多个值。然后可以将第一和第二多个值相关联，并且可以使用相关联的第一和第二值分析生理状态。在一个实施例中，信号可以是PPG信号，并且相关联的第一和第二值可以包括参数散点图，其可以允许用户随时间确定患者通气状态的变化。

9. 发明授权

US08628477B2 Systems and methods for non-invasive determination of blood pressure 有权
标题翻译：用于非侵入性测定血压的系统和方法
公开(公告)号：US08628477B2
公开(公告)日：2014-01-14
申请号：US12533224
申请日：2009-07-31
申请人： Paul Stanley Addison , James Watson
发明人： Paul Stanley Addison , James Watson
IPC分类号： A61B5/02
CPC分类号： A61B5/726 , A61B5/02225 , A61B5/7203 , A61B5/7225
摘要： Methods and systems for determining blood pressure from a pressure signal are disclosed. A patient's blood pressure may be determined by analyzing features of a wavelet transformation of a pressure signal obtained during an occlusion procedure. Ridges in a scalogram of the transformed signal may be identified and used to determine an envelope of a pressure oscillation signal, to which oscillometric blood pressure determination techniques may be applied.
摘要翻译：公开了一种用于从压力信号测定血压的方法和系统。可以通过分析在闭塞过程中获得的压力信号的小波变换的特征来确定患者的血压。变换信号的标尺中的脊可以被识别并用于确定压力振荡信号的包络，可应用示波器血压测定技术。

10. 发明授权

US08412295B2 Systems and methods for monitoring pain management 有权
标题翻译：用于监测疼痛管理的系统和方法
公开(公告)号：US08412295B2
公开(公告)日：2013-04-02
申请号：US12750944
申请日：2010-03-31
申请人： Rakesh Sethi , Paul Stanley Addison , James N. Watson , Paul A. Edney
发明人： Rakesh Sethi , Paul Stanley Addison , James N. Watson , Paul A. Edney
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/02125 , A61B5/4824 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223
摘要： The present disclosure relates to systems and methods for monitoring pain management using measurements of physiological parameters based on a PPG signal. A reference physiological parameter may be compared against a later measurement to identify a change in condition that may indicate a pain management problem.
摘要翻译：本公开涉及使用基于PPG信号的生理参数测量来监测疼痛管理的系统和方法。可以将参考生理参数与稍后的测量进行比较以识别可能指示疼痛管理问题的状况变化。

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