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1. 发明授权

US10335444B2 Method for extracting high content of chlorogenic acids from green coffee beans 有权
公开(公告)号：US10335444B2
公开(公告)日：2019-07-02
申请号：US15100055
申请日：2015-06-10
申请人： Pawan Kumar Goel
发明人： Dalip Uppal , Ashok Sharma , Kiran Tewari
IPC分类号： A61K36/74 , A23F5/02 , A23L33/105
摘要： An extract from green coffee beans is disclosed which contains polyphenols and bioactive compounds e.g. Chlorogenic acids in a significantly higher concentration (70-80%) than in extracts of prior art methods (40-50%). The extract has greater ability to quench oxidative stress and destroy free radicals and offers health benefits due to its anti-obesity, anti-diabetic, antihypertensive, anti-tumor and anti-acid properties. The higher concentration of bioactive compounds has been achieved by use of polar solvents having polarity less than that of alcohols used for extraction. The use of such solvents of lower polarity such as n-Butyl alcohol, ethyl acetate or acetone results in extraction of enriched Chlorogenic acid fractions into the extract, leaving polar impurities behind in aqueous medium. The extract obtained has significantly higher content of polyphenols and chlorogenic acids ranging from 70-80% and a distinctive HPLC profile.

2. 发明申请

US20170252391A1 SINGLE HERB EXTRACT FOR THE TREATMENT OF PCOS (POLY CYSTIC OVARIAN SYNDROME) 审中-公开
公开(公告)号：US20170252391A1
公开(公告)日：2017-09-07
申请号：US15524757
申请日：2015-02-11
申请人： PAWAN KUMAR GOEL
发明人： Ashok SHARMA , Kiran TEWARI
IPC分类号： A61K36/48 , A61K9/48 , A61K31/7048 , A61K9/00
CPC分类号： A61K36/48 , A61K9/0053 , A61K9/48 , A61K31/7048
摘要： Discloses is a single herb extract for the treatment of PCOS (Poly Cystic Ovarian Syndrome) when given in oral dosage form as capsules of 500 mg, twice a day for period of time ranging from 30-90 days, The extract is obtained from fenugreek seeds using a specific method of extraction and comprises five furostanolicsaponins present in synergistic ratios as in Table 1 and having analytical profile as in FIG. 1.

3. 发明申请

US20210093686A1 SINGLE HERB EXTRACT FOR THE TREATMENT OF PCOS (POLY CYSTIC OVARIAN SYNDROME) 有权
公开(公告)号：US20210093686A1
公开(公告)日：2021-04-01
申请号：US17007180
申请日：2020-08-31
申请人： PAWAN KUMAR GOEL
发明人： Ashok SHARMA , Kiran TEWARI
IPC分类号： A61K36/48 , A61K9/00 , A61K9/48 , A61K31/7048
摘要： Discloses is a single herb extract for the treatment of PCOS (Poly Cystic Ovarian Syndrome) when given in oral dosage form as capsules of 500 mg, twice a day for period of time ranging from 30-90 days. The extract is obtained from fenugreek seeds using a specific method of extraction and comprises five furostanolicsaponins present in synergistic ratios as in Table 1 and having analytical profile as in FIG. 1.

4. 发明授权

US08217165B2 Process for the extraction of furostanolic saponins from fenugreek seeds 有权
标题翻译：从葫芦巴种子中提取呋喃维生素皂苷的方法
公开(公告)号：US08217165B2
公开(公告)日：2012-07-10
申请号：US12665279
申请日：2008-09-03
申请人： Pawan Kumar Goel
发明人： Pawan Kumar Goel
IPC分类号： C07H1/06 , C07H1/08
CPC分类号： C07J71/0031 , A61K36/48
摘要： A novel, commercially viable process for the extraction of high purity (>70%), bioactive furostanolic saponins including protodioscin (>30%), from the seeds of fenugreek (Trigonella foenumgraecum) comprising essentially the steps of powdering of the natural material followed by a first extraction, an ion-exchange chromatographic purification and a second extraction using a novel composite solvent and drying of the product under defined conditions, the entire process being carried out at essentially neutral pH and low temperatures of less than 80° C.
摘要翻译：一种用于从葫芦巴（Trigonella foenumgraecum）的种子中提取高纯度（> 70％），包括原花青素（> 30％）的生物活性呋喃糖醇皂苷的新颖的商业上可行的方法，其基本上包括以下步骤：粉碎天然材料，第一次萃取，离子交换色谱纯化和使用新型复合溶剂的第二次萃取，并在规定的条件下干燥产物，整个过程在基本上中性的pH值和低于80℃的低温下进行。

5. 发明申请

US20120071427A1 NOVEL ANTIDIABETIC FUROSTANOLIC SAPONIN RICH (FSR) FRACTION FROM FENUGREEK SEEDS 审中-公开
标题翻译：来自蕨类植物的新型抗真菌SAP藜皂苷（FSR）
公开(公告)号：US20120071427A1
公开(公告)日：2012-03-22
申请号：US13322460
申请日：2010-05-28
申请人： Pawan Kumar Goel
发明人： Pawan Kumar Goel
IPC分类号： A61K31/7048 , A61P3/10
CPC分类号： A61K36/48
摘要： The present invention discloses a novel anti-diabetic composition extracted from fenugreek seeds. The same comprises a furostanolic-saponin-rich fraction (>70%) with approximately 30% protodioscin as one of the bioactive components. Pre-clinical studies in rats indicated significant glucose lowering effect of the fraction (31.5%) as compared to control after two weeks of oral treatment. Clinical studies in human volunteers indicated suitability of a dosage form of 500 mg given once or twice daily as anti-diabetic agent either alone or in combination with standard, synthetic anti-diabetic drugs such as metformin and glipizide in controlling plasma glucose levels.
摘要翻译：本发明公开了从葫芦巴种子提取的新型抗糖尿病组合物。其中含有富含富鲁丝酵素 - 富含皂苷的级分（> 70％），其中约30％原生质蛋白作为生物活性成分之一。大鼠的临床前研究表明，两周口服治疗后，与对照组相比，该组分（31.5％）具有显着的葡萄糖降低作用。人类志愿者的临床研究表明500mg给药剂量的适用性，每日给予一次或两次，作为抗糖尿病药，单独使用或与标准的合成抗糖尿病药物如二甲双胍和格列吡嗪组合以控制血浆葡萄糖水平。

6. 发明申请

US20170007658A1 GREEN COFFEE BEAN EXTRACT AND METHOD THEREOF 审中-公开
标题翻译：绿咖啡豆提取物及其方法
公开(公告)号：US20170007658A1
公开(公告)日：2017-01-12
申请号：US15100055
申请日：2015-06-10
申请人： Pawan Kumar Goel
发明人： Dalip Uppal , Ashok Sharma , Kiran Tewari
IPC分类号： A61K36/74 , A23L33/105 , A23F5/02
CPC分类号： A61K36/74 , A23F5/02 , A23L33/105 , A23V2002/00 , A61K2236/00 , A61K2236/15 , A61K2236/33
摘要： An extract from green coffee beans is disclosed which contains polyphenols and bioactive compounds e.g. Chlorogenic acids in a significantly higher concentration (70-80%) than in extracts of prior art methods (40-50%). The extract has greater ability to quench oxidative stress and destroy free radicals and offers health benefits due to its anti-obesity, anti-diabetic, antihypertensive, anti-tumor and anti-acid properties. The higher concentration of bioactive compounds has been achieved by use of polar solvents having polarity less than that of alcohols used for extraction. The use of such solvents of lower polarity such as n-Butyl alcohol, ethyl acetate or acetone results in extraction of enriched Chlorogenic acid fractions into the extract, leaving polar impurities behind in aqueous medium. The extract obtained has significantly higher content of polyphenols and chlorogenic acids ranging from 70-80% and a distinctive HPLC profile.
摘要翻译：公开了一种来自生咖啡豆的提取物，其中含有多酚和生物活性化合物，绿原酸浓度显着高于现有技术提取物（40-50％）浓度（70-80％）。提取物具有较强的抗氧化应激能力和破坏自由基的功能，并且由于其抗肥胖，抗糖尿病，抗高血压，抗肿瘤和抗酸性质而具有健康益处。通过使用极性小于用于萃取的醇的极性溶剂的极性溶剂，已经实现了更高浓度的生物活性化合物。使用较低极性的溶剂如正丁醇，乙酸乙酯或丙酮导致将富集的绿原酸馏分萃取到萃取物中，在水介质中留下极性杂质。所提取的提取物具有显着更高的多酚和绿原酸含量，范围为70-80％和独特的HPLC谱。

7. 发明申请

US20100160616A1 NOVEL PROCESS FOR THE EXTRACTION OF FUROSTANOLIC SAPONINS FROM FENUGREEK SEEDS 有权
标题翻译：从蕨类植物提取糠醛芸香苷的新方法
公开(公告)号：US20100160616A1
公开(公告)日：2010-06-24
申请号：US12665279
申请日：2008-09-03
申请人： Pawan Kumar Goel
发明人： Pawan Kumar Goel
IPC分类号： C07H1/08 , C07H15/24
CPC分类号： C07J71/0031 , A61K36/48
摘要： A novel, commercially viable process for the extraction of high purity (>70%), bioactive furostanolic saponins including protodioscin (>30%), from the seeds of fenugreek (Trigonella foenumgraecum) comprising essentially the steps of powdering of the natural material followed by a first extraction, an ion-exchange chromatographic purification and a second extraction using a novel composite solvent and drying of the product under defined conditions, the entire process being carried out at essentially neutral pH and low temperatures of less than 80° C.
摘要翻译：一种用于从葫芦巴（Trigonella foenumgraecum）的种子中提取高纯度（> 70％），包括原花青素（> 30％）的生物活性呋喃糖醇皂苷的新颖的商业上可行的方法，其基本上包括以下步骤：粉碎天然材料，第一次萃取，离子交换色谱纯化和使用新型复合溶剂的第二次萃取，并在规定的条件下干燥产物，整个过程在基本上中性的pH值和低于80℃的低温下进行。

8. 发明授权

US10730869B2 Process for extracting alpha yohimbine (rauwolscine) from Rauwolfia species 有权
公开(公告)号：US10730869B2
公开(公告)日：2020-08-04
申请号：US16406422
申请日：2019-05-08
申请人： Pawan Kumar Goel
发明人： Kiran Tewari , Ashok Sharma
IPC分类号： C07D459/00 , A61K36/24 , B01D11/02
摘要： Present invention discloses a novel, commercially viable process for extraction of Alpha yohimbine from the bark, stem and leaves of Rauwolfia species. The extract is obtained by a precipitation method involving alternate steps of acidification and alkalization along with use of specific organic solvents. The extract gives higher yield of 7-8 fold as compared to other processes and without use of any column chromatography at all. Yield of alpha yohimbine from roots and leaves of Rauwolfia canescens by process of present invention was 0.017% and 0.4% respectively, indicating that leaves are a much better source. The HPLC analysis of the compound obtained indicated a purity of >90%.

9. 发明申请

US20190330203A1 NOVEL PROCESS FOR EXTRACTING ALPHA YOHIMBINE (RAUWOLSCINE) FROM RAUWOLFIA SPECIES 审中-公开
公开(公告)号：US20190330203A1
公开(公告)日：2019-10-31
申请号：US16406422
申请日：2019-05-08
申请人： Pawan Kumar GOEL
发明人： Kiran TEWARI , Ashok SHARMA
IPC分类号： C07D459/00 , B01D11/02
摘要： Present invention discloses a novel, commercially viable process for extraction of Alpha yohimbine from the bark, stem and leaves of Rauwolfia species. The extract is obtained by a precipitation method involving alternate steps of acidification and alkalization along with use of specific organic solvents. The extract gives higher yield of 7-8 fold as compared to other processes and without use of any column chromatography at all. Yield of alpha yohimbine from roots and leaves of Rauwolfia canescens by process of present invention was 0.017% and 0.4% respectively, indicating that leaves are a much better source. The HPLC analysis of the compound obtained indicated a purity of >90%.

10. 发明授权

US08754205B2 Extract obtained by a commercially viable process for the extraction of furostanolic saponins from fenugreek seeds, in which one of the compounds in the extract is protodioscin 有权
标题翻译：通过商业上可行的从葫芦巴种子提取呋喃维生素皂苷获得的提取物，其中提取物中的一种化合物是原花青素
公开(公告)号：US08754205B2
公开(公告)日：2014-06-17
申请号：US13474594
申请日：2012-05-17
申请人： Pawan Kumar Goel
发明人： Pawan Kumar Goel
IPC分类号： C07H1/06 , C07H1/08
CPC分类号： C07J71/0031 , A61K36/48
摘要： Disclosed is an extract obtained by a commercially viable process for the extraction of furostanolic saponins from fenugreek seeds, in which one of the compounds in the extract is protodioscin. The process includes providing plurality of fenugreek seeds and crushing the same by milling and grinding; performing a primary extraction on the prepared fenugreek seeds using a first hydrophilic polar solvent which is a lower primary aliphatic alcohol followed by ion-exchange chromatography; performing a secondary extraction after ion-exchange chromatography using a composite solvent; and decolorizing the final extract by use of activated charcoal concentration of the extract by heating and vacuum drying sieving the final powdered product.
摘要翻译：公开了通过商业上可行的从葫芦巴种子提取呋喃维生素皂苷的提取物，其中提取物中的一种化合物是原二糖蛋白。该方法包括提供多个葫芦巴种子并通过研磨和研磨将其破碎; 使用第一亲水极性溶剂（其为低级伯脂肪醇，然后进行离子交换色谱法）对所制备的葫芦巴种子进行初次提取; 使用复合溶剂进行离子交换层析后的二次萃取; 并通过加热和真空干燥筛分最终粉末产品，通过使用提取物的活性炭浓度使最终提取物脱色。

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