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1. 发明授权

US08088715B2 Detection of circulating tumor cells in peripheral blood with an automated scanning fluorescence microscope 有权
标题翻译：用自动扫描荧光显微镜检测外周血中的循环肿瘤细胞
公开(公告)号：US08088715B2
公开(公告)日：2012-01-03
申请号：US12270820
申请日：2008-11-13
申请人： Sir Walter Bodmer , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
发明人： Sir Walter Bodmer , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
IPC分类号： C40B30/04
CPC分类号： G06K9/00127 , G01N21/6458
摘要： An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.
摘要翻译：一种使用自动显微镜识别和列举血液和其他液体中稀有癌细胞的自动化，高灵敏度，特异性和潜在的定量检测方法。

2. 发明申请

US20110129138A1 SYSTEM FOR DETECTING INFECTIOUS AGENTS USING COMPUTER-CONTROLLED AUTOMATED IMAGE ANALYSIS 失效
标题翻译：使用计算机控制自动图像分析检测感染性代理的系统
公开(公告)号：US20110129138A1
公开(公告)日：2011-06-02
申请号：US13022348
申请日：2011-02-07
申请人： Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras
发明人： Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras
IPC分类号： G06K9/00
CPC分类号： G06K9/00147 , C12Q1/04 , G01N15/1475 , G06K9/00127 , G06T7/0012 , G06T2207/30024
摘要： A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of the image pixel corresponding to the same location where the candidate object is found in the fractal map may be compared to a threshold value. If the pixel value is greater than the threshold value, the candidate object is recognized as a valid object.
摘要翻译：公开了一种用于识别图像中的对象的方法，其中通过估计图像中每个像素的分形维数来生成图像的分形图。可以通过阈值分割分形图并确定候选对象的位置。可以将对应于在分形图中找到候选对象的相同位置的图像像素的像素值与阈值进行比较。如果像素值大于阈值，则候选对象被识别为有效对象。

3. 发明授权

US07640112B2 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 有权
公开(公告)号：US07640112B2
公开(公告)日：2009-12-29
申请号：US10091360
申请日：2002-03-04
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G06F19/00 , G06K9/20 , G06K9/78 , G06K9/00
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

4. 发明申请

US20080131064A1 DEVICE AND METHOD FOR DETECTING AND LOCALIZING CELLS BY MEANS OF PHOTOSENSITIVE WAVEGUIDES 失效
标题翻译：通过感光波形检测和定位细胞的装置和方法
公开(公告)号：US20080131064A1
公开(公告)日：2008-06-05
申请号：US11691989
申请日：2007-03-27
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G02B6/02
CPC分类号： G02B1/045 , G01N21/7703 , G01N2021/1725 , G01N2021/7783 , G02B6/02033 , G02B6/1221
摘要： The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.
摘要翻译：本发明提供用于在使用光敏波导的样品中检测诸如生物细胞的颗粒的装置和方法。响应于控制从颗粒发射的辐射，光敏波导以可检测的方式改变其透射率。在优选实施例中，波导是二维的，并且颗粒的位置以及它们的存在是通过在两个非平行方向扫描波导而获得的。所提供的装置优选用于定位标记的细胞。本发明还包括使用所提供的设备来检测和定位单元的控制系统和方法。

5. 发明申请

US20060072805A1 Method and apparatus for computer controlled cell based diagnosis 有权
公开(公告)号：US20060072805A1
公开(公告)日：2006-04-06
申请号：US11264273
申请日：2005-11-01
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G06K9/00
CPC分类号： G01N1/312 , G01N15/1475 , G01N2001/282 , G01N2001/317 , G01N2015/1006 , G01N2015/1472 , G01N2015/1477 , G01N2015/1488 , G01N2800/36 , G06K9/00127
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

6. 发明申请

US20060068377A1 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 失效
公开(公告)号：US20060068377A1
公开(公告)日：2006-03-30
申请号：US11273229
申请日：2005-11-14
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

7. 发明申请

US20060056016A1 System and method for increasing the contrast of an image produced by an epifluorescence microscope 失效
公开(公告)号：US20060056016A1
公开(公告)日：2006-03-16
申请号：US11225460
申请日：2005-09-13
申请人： Triantafyllos Tafas , Petros Tsipouras
发明人： Triantafyllos Tafas , Petros Tsipouras
IPC分类号： G02B21/00
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.

8. 发明授权

US06221607B1 Automated fluorescence in situ hybridization detection of genetic abnormalities 失效
标题翻译：自动荧光原位杂交检测遗传异常
公开(公告)号：US06221607B1
公开(公告)日：2001-04-24
申请号：US09594624
申请日：2000-06-15
申请人： Petros Tsipouras , Triantafyllos P. Tafas
发明人： Petros Tsipouras , Triantafyllos P. Tafas
IPC分类号： C12Q168
CPC分类号： G02B21/365 , G01N15/1475
摘要： Automated sample analysis is performed by a computer-implemented apparatus and method for distinguishing objects of interest in an optical field from other objects and background in the optical field, collectively called background. Once an object has been identified, the color comprised of a combination of the red, green and blue components of the pixels occupied by the image of the object of interest, or another parameter of interest relative to that object can be measured and stored. This computer-implemented analysis apparatus and method is performed on objects of interest in the sample which are tagged using fluorescent tags. The sample may be a cell sample containing a nucleic acid target and the tagging achieved by fluorescence in situ hybridization.
摘要翻译：通过计算机实现的设备和方法来执行自动样本分析，该装置和方法用于将光场中的感兴趣对象与光场中的其他对象和背景区分开，统称为背景。一旦已经识别出物体，就可以测量和存储由感兴趣对象的图像所占据的像素的红色，绿色和蓝色分量与感兴趣的另一参数组合的颜色。该计算机实现的分析装置和方法对使用荧光标签进行标记的样品中感兴趣的对象进行。样品可以是含有核酸靶的细胞样品，并且通过荧光原位杂交获得标记。

9. 发明授权

US08445411B2 Detection of circulating tumor cells in peripheral blood with an automated scanning fluorescence microscope 有权
标题翻译：用自动扫描荧光显微镜检测外周血中的循环肿瘤细胞
公开(公告)号：US08445411B2
公开(公告)日：2013-05-21
申请号：US13337823
申请日：2011-12-27
申请人： Sir Walter Bodmer , Triantafyllos P. Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
发明人： Sir Walter Bodmer , Triantafyllos P. Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
IPC分类号： C40B30/04
CPC分类号： G06K9/00127 , G01N21/6458
摘要： An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.
摘要翻译：一种使用自动显微镜识别和列举血液和其他液体中稀有癌细胞的自动化，高灵敏度，特异性和潜在的定量检测方法。

10. 发明授权

US07991213B2 System for detecting infectious agents using computer-controlled automated image analysis 失效
标题翻译：使用计算机控制的自动图像分析检测感染因子的系统
公开(公告)号：US07991213B2
公开(公告)日：2011-08-02
申请号：US13022348
申请日：2011-02-07
申请人： Triantafyllos P. Tafas , Michael Kilpatrick , Petros Tsipouras
发明人： Triantafyllos P. Tafas , Michael Kilpatrick , Petros Tsipouras
IPC分类号： G06K9/00 , C12Q1/00 , A61B5/00 , A61B8/00 , A61B10/00
CPC分类号： G06K9/00147 , C12Q1/04 , G01N15/1475 , G06K9/00127 , G06T7/0012 , G06T2207/30024
摘要： A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of the image pixel corresponding to the same location where the candidate object is found in the fractal map may be compared to a threshold value. If the pixel value is greater than the threshold value, the candidate object is recognized as a valid object.
摘要翻译：公开了一种用于识别图像中的对象的方法，其中通过估计图像中每个像素的分形维数来生成图像的分形图。可以通过阈值分割分形图并确定候选对象的位置。可以将对应于在分形图中找到候选对象的相同位置的图像像素的像素值与阈值进行比较。如果像素值大于阈值，则候选对象被识别为有效对象。

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