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1. 发明授权

US06756044B1 Antigenic complexes and methods 有权
标题翻译：抗原复合物和方法
公开(公告)号：US06756044B1
公开(公告)日：2004-06-29
申请号：US09617569
申请日：2000-07-17
申请人： Petrus W. Roelvink , Joseph T. Bruder , Imre Kovesdi , Thomas J. Wickham
发明人： Petrus W. Roelvink , Joseph T. Bruder , Imre Kovesdi , Thomas J. Wickham
IPC分类号： A61K4500
CPC分类号： C40B40/02 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , C12N15/1037 , C12N2799/022
摘要： The present invention provides a complex that includes a virion having a ligand that recognizes an epitope present on an immune effector cell surface and at least a first nucleic acid encoding a first non-native antigen. The invention also provides a library including a plurality of such complexes, in which antigens of at least two of the plurality are different. Using such reagents, the invention provides a method of precipitating an immune response within an immune effector cell, wherein such a complex is delivered to the cell under conditions sufficient for the cell to mount an immune response to the antigen. When applied in vivo, the method can serve to immunize an animal from the pathogen. Moreover, using a library including a plurality of complexes, which contains at least one test antigen, the invention provides a method of assessing the antigenicity of the test antigen.
摘要翻译：本发明提供了一种复合物，其包括具有识别存在于免疫效应细胞表面上的表位的配体和至少编码第一非天然抗原的第一核酸的病毒粒子。本发明还提供了包含多个这样的复合物的文库，其中至少两个的抗原是不同的。使用这样的试剂，本发明提供了在免疫效应细胞内沉淀免疫应答的方法，其中这种复合物在足以使细胞对抗原产生免疫应答的条件下递送至细胞。当应用于体内时，该方法可用于从病原体免疫动物。此外，使用包含至少一种测试抗原的多个复合物的文库，本发明提供了评估测试抗原的抗原性的方法。

2. 发明授权

US6057155A Targeting adenovirus with use of constrained peptide motifs 有权
公开(公告)号：US6057155A
公开(公告)日：2000-05-02
申请号：US130225
申请日：1998-08-06
申请人： Thomas J. Wickham , Petrus W. Roelvink , Imre Kovesdi
发明人： Thomas J. Wickham , Petrus W. Roelvink , Imre Kovesdi
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07K14/075 , C12N5/10 , C12N15/34 , C12N15/861 , C12P21/04 , C12R1/92 , C12N15/86
CPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/405 , C12N2810/60
摘要： The present invention provides a chimeric adenovirus fiber protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence in a conformationally-restrained manner. Such a chimeric adenovirus fiber protein according to the invention is able to direct entry into cells of a vector comprising the chimeric fiber protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus fiber protein rather than the chimeric adenovirus fiber protein. The nonnative amino acid sequences encodes a peptide motif that comprises an epitope for an antibody, or a ligand for a cell surface receptor, that can be employed in cell targeting. The present invention also pertains to vectors comprising such a chimeric adenovirus fiber protein, and to methods of using such vectors.

3. 发明授权

US06455314B1 Alternatively targeted adenovirus 有权
标题翻译：或者靶向腺病毒
公开(公告)号：US06455314B1
公开(公告)日：2002-09-24
申请号：US09393627
申请日：1999-09-10
申请人： Thomas J. Wickham , Imre Kovesdi , Petrus W. Roelvink , Joseph T. Bruder
发明人： Thomas J. Wickham , Imre Kovesdi , Petrus W. Roelvink , Joseph T. Bruder
IPC分类号： C12N1586
CPC分类号： C07K14/005 , A61K48/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/405 , C12N2810/6018 , C12N2830/008
摘要： The present invention provides a recombinant protein having an amino terminus of an adenoviral fiber protein and having a trimerization domain. A fiber incorporating such a protein exhibits reduced affinity for a native substrate than does a wild-type adenoviral fiber trimer. The present invention further provides an adenovirus incorporating the recombinant protein of the present invention.
摘要翻译：本发明提供具有腺病毒纤维蛋白的氨基末端并具有三聚结构域的重组蛋白质。与野生型腺病毒纤维三聚体相比，掺入这种蛋白质的纤维对天然底物的亲和性降低。本发明还提供了并入本发明的重组蛋白的腺病毒。

4. 发明授权

US5962311A Short-shafted adenoviral fiber and its use 失效
标题翻译：短轴腺病毒纤维及其用途
公开(公告)号：US5962311A
公开(公告)日：1999-10-05
申请号：US700846
申请日：1996-08-21
申请人： Thomas J. Wickham , Petrus W. Roelvink , Imre Kovesdi
发明人： Thomas J. Wickham , Petrus W. Roelvink , Imre Kovesdi
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07K14/075 , C07K14/705 , C12N7/00 , C12N7/01 , C12N15/34 , C12N15/861 , C12N15/866 , C12N15/87 , C12P21/02 , C12N15/86
CPC分类号： C12N15/86 , C07K14/005 , C07K14/70546 , C12N15/87 , C12N7/00 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/14043 , C12N2710/14143 , C12N2810/40 , C12N2810/405 , C12N2810/60 , C12N2810/6018 , C12N2810/855 , C12N2810/856 , C12N2810/859
摘要： The present invention provides a short-shafted adenoviral fiber, a recombinant adenovirus comprising a short-shafted fiber, a vector comprising a short-shafted adenoviral fiber gene, and a method of targeting attachment of a short-shafted recombinant adenovirus to a cell so as to effect entry of the short-shafted recombinant adenovirus into the cell.
摘要翻译：本发明提供一种短轴型腺病毒纤维，包含短轴纤维的重组腺病毒，包含短轴腺病毒纤维基因的载体以及将短轴重组腺病毒连接至细胞的方法，以便以使短轴重组腺病毒进入细胞。

5. 发明授权

US08993530B2 RNAi expression constructs 有权
标题翻译： RNAi表达构建体
公开(公告)号：US08993530B2
公开(公告)日：2015-03-31
申请号：US13293359
申请日：2011-11-10
申请人： Petrus W. Roelvink , David A. Suhy , Alexander A. Kolykhalov , Linda Couto
发明人： Petrus W. Roelvink , David A. Suhy , Alexander A. Kolykhalov , Linda Couto
IPC分类号： C12N15/113 , C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/51 , C12N2310/53 , C12N2310/531 , C12N2330/30 , C12N2770/24211
摘要： The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
摘要翻译：本发明提供适用于在体外和体内表达1-x RNAi试剂以针对感兴趣的细胞，组织或器官中的基因或基因的组合物和方法，以便治疗疾病或病症。

6. 发明授权

US08076471B2 RNAi expression constructs 有权
标题翻译： RNAi表达构建体
公开(公告)号：US08076471B2
公开(公告)日：2011-12-13
申请号：US11883645
申请日：2006-02-03
申请人： Petrus W. Roelvink , David A. Suhy , Alexander A. Kolykhalov , Linda Couto
发明人： Petrus W. Roelvink , David A. Suhy , Alexander A. Kolykhalov , Linda Couto
IPC分类号： C07H21/04 , C12N15/00 , A61K31/70
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/51 , C12N2310/53 , C12N2310/531 , C12N2330/30 , C12N2770/24211
摘要： The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
摘要翻译：本发明提供适用于在体外和体内表达1-x RNAi试剂以针对感兴趣的细胞，组织或器官中的基因或基因的组合物和方法，以便治疗疾病或病症。

7. 发明授权

US06576456B2 Chimeric adenovirus fiber protein 有权
标题翻译：嵌合腺病毒纤维蛋白
公开(公告)号：US06576456B2
公开(公告)日：2003-06-10
申请号：US09326447
申请日：1999-06-04
申请人： Thomas J. Wickham , Erik Falck-Pedersen , Petrus W. Roelvink , Joseph T. Bruder , Jason Gall , Imre Kovesdi
发明人： Thomas J. Wickham , Erik Falck-Pedersen , Petrus W. Roelvink , Joseph T. Bruder , Jason Gall , Imre Kovesdi
IPC分类号： C12N701
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/405 , C12N2810/6018 , C12N2830/00 , C12N2830/60
摘要： The invention provides a chimeric adenovirus fiber protein including a nonnative amino acid sequence, and a chimeric adenovirus fiber protein lacking a native amino acid receptor-binding sequence. The chimeric protein trimerizes when produced in a mammalian cell.
摘要翻译：本发明提供了包含非氨基酸序列的嵌合腺病毒纤维蛋白和缺乏天然氨基酸受体结合序列的嵌合腺病毒纤维蛋白。当在哺乳动物细胞中产生时，嵌合蛋白质三聚体。

8. 发明申请

US20110003378A1 MULTIPLE PROMOTER EXPRESSION CASSETTES FOR SIMULTANEOUS DELIVERY OF RNAi AGENTS 有权
标题翻译：用于同时递送RNAi试剂的多种促进剂表达载体
公开(公告)号：US20110003378A1
公开(公告)日：2011-01-06
申请号：US12723466
申请日：2010-03-12
申请人： PETRUS W. ROELVINK , DAVID A. SUHY , ALEXANDER A. KOLYKHALOV
发明人： PETRUS W. ROELVINK , DAVID A. SUHY , ALEXANDER A. KOLYKHALOV
IPC分类号： C12N15/63
CPC分类号： C12N15/85 , A61K38/00 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30
摘要： The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo.
摘要翻译：本发明提供用于在体内同时递送RNAi，优选哺乳动物细胞的多重启动子表达盒。

9. 发明授权

US07727970B2 Multiple promoter expression cassettes for simultaneous delivery of RNAi agents targeted to Hepatitis C virus 有权
标题翻译：用于同时递送针对丙型肝炎病毒的RNAi试剂的多个启动子表达盒
公开(公告)号：US07727970B2
公开(公告)日：2010-06-01
申请号：US11072592
申请日：2005-03-04
申请人： Petrus W. Roelvink , David A. Suhy , Alexander A. Kolykhalov
发明人： Petrus W. Roelvink , David A. Suhy , Alexander A. Kolykhalov
IPC分类号： A61K31/70
CPC分类号： C12N15/85 , A61K38/00 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30
摘要： The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo.
摘要翻译：本发明提供用于在体内同时递送RNAi，优选哺乳动物细胞的多重启动子表达盒。

10. 发明授权

US5846782A Targeting adenovirus with use of constrained peptide motifs 失效
公开(公告)号：US5846782A
公开(公告)日：1998-12-08
申请号：US701124
申请日：1996-08-21
申请人： Thomas J. Wickham , Petrus W. Roelvink , Imre Kovesdi
发明人： Thomas J. Wickham , Petrus W. Roelvink , Imre Kovesdi
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07K14/075 , C12N5/10 , C12N15/34 , C12N15/861 , C12P21/04 , C12R1/92
CPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/405 , C12N2810/60
摘要： The present invention provides a chimeric adenovirus fiber protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence in a conformationally-restrained manner. Such a chimeric adenovirus fiber protein according to the invention is able to direct entry into cells of a vector comprising the chimeric fiber protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus fiber protein rather than the chimeric adenovirus fiber protein. The nonnative amino acid sequences encodes a peptide motif that comprises an epitope for an antibody, or a ligand for a cell surface receptor, that can be employed in cell targeting. The present invention also pertains to vectors comprising such a chimeric adenovirus fiber protein, and to methods of using such vectors.

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