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1. 发明授权

US09052967B2 Detecting resource deadlocks in multi-threaded programs by controlling scheduling in replay 有权
标题翻译：通过控制重播中的调度来检测多线程程序中的资源死锁
公开(公告)号：US09052967B2
公开(公告)日：2015-06-09
申请号：US12848023
申请日：2010-07-30
申请人： Qi Gao , Min Xu
发明人： Qi Gao , Min Xu
IPC分类号： G06F9/52 , G06F11/36
CPC分类号： G06F9/524 , G06F11/3636
摘要： A method and system for determining potential deadlock conditions in a target multi-threaded software application. The target application is first run in a virtual machine and the events within the application are recorded. The recorded events are replayed and analyzed to identify potential lock acquisition conflicts occurring between threads of the application. The potential lock acquisition conflicts are identified by analyzing the order in which resource locks are obtained and pairs of resources that have respective locks obtained in different orders are analyzed. These analyzed pairs are used to define a different order of events in the target application that, when the target application is re-run with the second order of events, may trigger a deadlock condition. The target application is then re-run with the different order of events in an attempt to trigger and then identify potential deadlock situations.
摘要翻译：一种用于确定目标多线程软件应用程序中潜在的死锁状况的方法和系统。目标应用程序首先在虚拟机中运行，并记录应用程序中的事件。记录的事件被重放和分析，以识别在应用程序的线程之间发生的潜在锁定获取冲突。通过分析获得资源锁定的顺序来识别潜在锁获取冲突，并分析具有以不同顺序获得的相应锁的资源对。这些分析的对用于定义目标应用程序中不同的事件顺序，当目标应用程序以二次事件重新运行时，可能会触发死锁条件。然后，目标应用程序以不同的事件顺序重新运行，以尝试触发，然后识别潜在的死锁情况。

2. 发明授权

US07968718B2 Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein 有权
标题翻译：制备三唑取代的亚氮杂双氧乙酸哌嗪衍生物的方法及其中生成的新型盐形式
公开(公告)号：US07968718B2
公开(公告)日：2011-06-28
申请号：US12548809
申请日：2009-08-27
申请人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
发明人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译：提供制备三唑取代的氮杂糊精乙酸哌嗪衍生物的方法。还提供了在上述方法中制备的新型中间体和新的N-1和无定形形式的1,2,3-三唑取代的氮杂寡脱氧乙酸哌嗪衍生物及其制备方法。

3. 发明申请

US20100292246A1 FORMULATIONS OF 1-(4-BENZOYL-PIPERAZIN-1-YL)-2-[4-METHOXY-7-(3-METHYL-[1,2,4]TRIAZOL-1-YL)-1H-PYRROLO[2,3-C]PYRIDIN-3-YL]-ETHANE-1,2-DIONE 审中-公开
标题翻译： 1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）-1H-吡咯并[2,1- 3-C]吡啶-3-基] - 乙基-1,2-二酮
公开(公告)号：US20100292246A1
公开(公告)日：2010-11-18
申请号：US12847014
申请日：2010-07-30
申请人： Chong-Hui Gu , Qi Gao , Shan-Ming Kuang , Chiajen Lai , Jaquan Kalani Levons , Feng Qian
发明人： Chong-Hui Gu , Qi Gao , Shan-Ming Kuang , Chiajen Lai , Jaquan Kalani Levons , Feng Qian
IPC分类号： A61K31/496 , A61P31/18
CPC分类号： A61K31/53 , A61K9/14 , A61K9/146 , A61K9/1635 , A61K31/496 , A61K47/32
摘要： The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.
摘要翻译：本发明提供1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）吡咯并[2,3-c]吡啶-3-基] - 乙烷-1,2-二酮; 制备这种制剂的方法; 以及用这种结晶材料或这种制剂治疗HIV或AIDS的方法。

4. 发明授权

US07723338B2 Crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-yl]-1,2-dioxoethyl]-piperazine 有权
标题翻译： 1-苯甲酰基-4- [2- [4,7-二甲氧基-1 - [（膦酰氧基）甲基] -1H-吡咯并[2,3-C]吡啶-3-基] -1,2-二氧代乙基 ] - 哌嗪
公开(公告)号：US07723338B2
公开(公告)日：2010-05-25
申请号：US11340032
申请日：2006-01-26
申请人： Chung-Pin H. Chen , Qi Gao , David K. Leahy , Srividya Ramakrishnan , Venkatramana M. Rao , Anne I. Song
发明人： Chung-Pin H. Chen , Qi Gao , David K. Leahy , Srividya Ramakrishnan , Venkatramana M. Rao , Anne I. Song
IPC分类号： A61K31/497 , C07D241/04 , C07D295/00
CPC分类号： C07F9/6561
摘要： The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).
摘要翻译：本公开提供了1-苯甲酰基-4- [2- [4,7-二甲氧基-1 - [（膦酰氧基）甲基] -1H-吡咯并[2,3-c]吡啶-3-基] -1 ，2-二氧代乙基] - 哌嗪，其盐和溶剂化物。本公开还通常涉及包含结晶形式的药物组合物，以及在治疗HIV和/或AIDS中使用结晶形式的方法以及获得这种结晶形式的方法。

5. 发明申请

US20090227794A1 CRYSTALLINE MATERIALS OF 1-(4-BENZOYL-PIPERAZIN-1-YL)-2-[4-METHOXY-7-(3-METHYL-[1,2,4]TRIAZOL-1-YL)-1H-PYRROLO[2,3-C]PYRIDIN-3-YL]-ETHANE-1,2-DIONE 有权
标题翻译： 1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）-1H-吡咯并[2,3-b]吡啶的晶体物质，3-C]吡啶-3-基] - 乙基-1,2-二酮
公开(公告)号：US20090227794A1
公开(公告)日：2009-09-10
申请号：US12468105
申请日：2009-05-19
申请人： John D. Matiskella , Chenkou Wei , Qi Gao , Chong-Hui Gu , Shan-Ming Kuang
发明人： John D. Matiskella , Chenkou Wei , Qi Gao , Chong-Hui Gu , Shan-Ming Kuang
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical compositions comprising such crystalline materials; and methods of treating HIV or AIDS with such crystalline materials or such pharmaceutical compositions.
摘要翻译：本发明提供1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）-1H - 吡咯并[2,3-c]吡啶-3-基] - 乙烷-1,2-二酮; 生产这种结晶材料的方法; 包含这种结晶材料的药物组合物; 以及用这种结晶材料或这种药物组合物治疗HIV或AIDS的方法。

6. 发明申请

US20090041716A1 CRYSTALLINE FORM OF METHYL ((1S)-1-(((2S)-2-(5-(4'-(2-((2S)-1((2S)-2-((METHOXYCARBONYL)AMINO)-3-METHYLBUTANOYL)-2-PYRROLIDINYL)-1H-IMIDAZOL-5-YL)-4-BIPHENYLYL)-1H-IMIDAZOL-2-YL)-1-PYRROLIDINYL)CARBONYL)-2-METHYLPROPYL)CARBAMATE DIHYDROCHLORIDE SALT 有权
标题翻译：（（1S）-1 - （（（2S）-2-（5-（4' - （2 - （（2S）-1（（2S）-2 - （（甲氧基羰基）氨基） -2-甲基吡咯烷-1-基）咪唑并 - 5-YL）-4-二苯基）-1H-咪唑-2-基）-1-吡咯烷基）羰基）-2-甲基丙烯酸）二羧酸二盐酸盐
公开(公告)号：US20090041716A1
公开(公告)日：2009-02-12
申请号：US12175104
申请日：2008-07-17
申请人： Soojin Kim , Qi Gao , Fukang Yang
发明人： Soojin Kim , Qi Gao , Fukang Yang
IPC分类号： A61K38/20 , C07D403/14 , A61K31/4178 , A61K31/7105 , A61P31/12 , A61K38/21 , A61K31/708
CPC分类号： C07D403/04
摘要： The present disclosure generally relates to a crystalline form of methyl ((1S)-1-(((2S)-2-(5-(4′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1 H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to a pharmaceutical composition comprising a crystalline form, as well of methods of using a crystalline form in the treatment of Hepatitis C and methods for obtaining such crystalline form.
摘要翻译：本发明一般涉及（（1S）-1 - （（1S）-2-（5-（4' - （2 - （（2S）-1 - （（2S）（（甲氧基羰基）氨基）-3-甲基丁酰基）-2-吡咯烷基）-1H-咪唑-5-基）-4-联苯基）-1H-咪唑-2-基）-1-吡咯烷基）羰基）-2- 甲基丙基）氨基甲酸酯二盐酸盐。本公开还通常涉及包含结晶形式的药物组合物，以及在治疗丙型肝炎中使用结晶形式的方法以及获得这种结晶形式的方法。

7. 发明申请

US20060264406A1 Mono-lysine salts of azole compounds 审中-公开
标题翻译：唑化合物的单赖氨酸盐
公开(公告)号：US20060264406A1
公开(公告)日：2006-11-23
申请号：US11416322
申请日：2006-05-03
申请人： Qi Gao , Chung-Pin Chen , Michael Fakes , Yadagiri Pendri , Susanne Kiau , Blisse Vakkalagadda
发明人： Qi Gao , Chung-Pin Chen , Michael Fakes , Yadagiri Pendri , Susanne Kiau , Blisse Vakkalagadda
IPC分类号： A61K31/675 , C07F9/6509
CPC分类号： C07D405/14 , C07C229/26 , C07D417/06 , C07F9/65583 , C07F9/65586
摘要： Mono-lysine salts of triazole compounds having a secondary or tertiary hydroxy group are provided. More particularly, the new water-soluble triazole antifungal mono-lysine salt compounds, or solvates thereof, are provided having the general formula I: wherein A in formula I represents the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group. R and R1 in formula I can each be a hydrogen atom or an alkyl group having one to six carbon atoms. The novel water-soluble azole compounds are useful for the treatment of fungal infections and can be administered orally, topically and parenterally.
摘要翻译：提供具有仲羟基或叔羟基的三唑化合物的单赖氨酸盐。更具体地，提供了具有通式I的新的水溶性三唑抗真菌单赖氨酸盐化合物或其溶剂合物：其中式I中的A表示含有二级的三唑类抗真菌化合物的非羟基部分或叔羟基。式I中的R 1和R 2各自可以是氢原子或具有1-6个碳原子的烷基。新型水溶性唑类化合物可用于治疗真菌感染，可以口服，局部和肠胃外给药。

8. 发明申请

US20060172974A1 Crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-yl]-1,2-dioxoethyl]-piperazine 有权
标题翻译： 1-苯甲酰基-4- [2- [4,7-二甲氧基-1 - [（膦酰氧基）甲基] -1H-吡咯并[2,3-C]吡啶-3-基] -1,2-二氧代乙基 ] - 哌嗪
公开(公告)号：US20060172974A1
公开(公告)日：2006-08-03
申请号：US11340032
申请日：2006-01-26
申请人： Chung-Pin Chen , Qi Gao , David Leahy , Srividya Ramakrishnan , Venkatramana Rao , Anne Song
发明人： Chung-Pin Chen , Qi Gao , David Leahy , Srividya Ramakrishnan , Venkatramana Rao , Anne Song
IPC分类号： A61K31/675 , C07F9/6509
CPC分类号： C07F9/6561
摘要： The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).
摘要翻译：本公开提供了1-苯甲酰基-4- [2- [4,7-二甲氧基-1 - [（膦酰氧基）甲基] -1H-吡咯并[2,3-c]吡啶-3-基] -1 ，2-二氧代乙基] - 哌嗪，其盐和溶剂化物。本公开还通常涉及包含结晶形式的药物组合物，以及在治疗HIV和/或AIDS中使用结晶形式的方法以及获得这种结晶形式的方法。

9. 发明申请

US20120030657A1 METHOD AND SYSTEM FOR USING A VIRTUALIZATION SYSTEM TO IDENTIFY DEADLOCK CONDITIONS IN MULTI-THREADED PROGRAMS BY CONTROLLING SCHEDULING IN REPLAY 有权
标题翻译：使用虚拟化系统通过控制重排调度来识别多线程程序中的死锁条件的方法和系统
公开(公告)号：US20120030657A1
公开(公告)日：2012-02-02
申请号：US12848023
申请日：2010-07-30
申请人： Qi Gao , Min Xu
发明人： Qi Gao , Min Xu
IPC分类号： G06F9/44
CPC分类号： G06F9/524 , G06F11/3636
摘要： A method and system for determining potential deadlock conditions in a target multi-threaded software application. The target application is first run in a virtual machine and the events within the application are recorded. The recorded events are replayed and analyzed to identify potential lock acquisition conflicts occurring between threads of the application. The potential lock acquisition conflicts are identified by analyzing the order in which resource locks are obtained and pairs of resources that have respective locks obtained in different orders are analyzed. These analyzed pairs are used to define a different order of events in the target application that, when the target application is re-run with the second order of events, may trigger a deadlock condition. The target application is then re-run with the different order of events in an attempt to trigger and then identify potential deadlock situations.
摘要翻译：一种用于确定目标多线程软件应用程序中潜在的死锁状况的方法和系统。目标应用程序首先在虚拟机中运行，并记录应用程序中的事件。记录的事件被重放和分析，以识别在应用程序的线程之间发生的潜在锁定获取冲突。通过分析获得资源锁定的顺序来识别潜在锁获取冲突，并分析具有以不同顺序获得的相应锁的资源对。这些分析的对用于定义目标应用程序中不同的事件顺序，当目标应用程序以二次事件重新运行时，可能会触发死锁条件。然后，目标应用程序以不同的事件顺序重新运行，以尝试触发，然后识别潜在的死锁情况。

10. 发明申请

US20100292250A1 CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4- TETRAHYDROISOQUINOLINE AND USE THEREOF 有权
标题翻译：（S）-7 - （[1,2,4]三唑并[1,5-a]吡啶-6-基）-4-（3,4-二氯苯基）-1,2,3,4-四氢异喹啉的晶体形式四氢喹诺酮及其用途
公开(公告)号：US20100292250A1
公开(公告)日：2010-11-18
申请号：US12777840
申请日：2010-05-11
申请人： CHENKOU WEI , VICTOR W. ROSSO , QI GAO
发明人： CHENKOU WEI , VICTOR W. ROSSO , QI GAO
IPC分类号： A61K31/495 , C07D471/04 , A61K31/437 , A61K31/438 , A61P25/16 , A61P25/28 , A61P3/04 , A61P3/10
CPC分类号： A61K31/4725 , A61K31/437 , A61K31/438 , A61K31/495 , A61K45/06 , C07D471/04
摘要： Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making these compounds and crystalline forms SA-1 and N-2 are also described in the present invention.
摘要翻译：在本发明中描述了新的[1,2,4]三唑并[1,5-a]吡啶基-6-基取代的四氢异喹啉。这些化合物和结晶形式SA1和N-2用于治疗各种神经和生理疾病。制备这些化合物和结晶形式SA-1和N-2的方法也在本发明中描述。

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