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    • 8. 发明授权
    • Polymeric carriers linked to nucleotide analogues via a phosphoramide
bond
    • 通过磷酰胺键与核苷酸类似物连接的聚合载体
    • US5981507A
    • 1999-11-09
    • US766597
    • 1996-12-12
    • Lee JosephsonErnest V. GromanYong-Qian Wu
    • Lee JosephsonErnest V. GromanYong-Qian Wu
    • A61K47/48A01N43/04
    • A61K47/48038A61K47/4823A61K47/48315
    • Novel compositions of nucleotide analog prodrugs for the treatment of viral infections and cancer are herein disclosed. The prodrugs have a biocompatible polymeric carrier conjugated to the nucleotide analog via an amino-phosphate linkage. The amino group is provided by the carrier, which either inherently possesses a primary amine, or is modified with reactive groups that incorporate the primary amine onto the carrier. The carrier can be a polyamino acid, a polyvinylic polymer, a polysaccharide or combinations thereof, such as polylysine, HPMA, dextran, hydroxyethyl starch, or polyethylene glycol; the nucleotide analog can be ribavirin araA, AZT, acyclovir, 5-FUDR, araC or ddI. Methods of treating a viral infection of cancer using these prodrugs are also disclosed. The prodrugs endow the nucleotide analogs with substantially enhanced therapeutic efficacy and reduces toxicity in comparison to the nucleotide analog alone.
    • 本文公开了用于治疗病毒感染和癌症的核苷酸类似物前药的新型组合物。 前药具有通过氨基 - 磷酸键连接至核苷酸类似物的生物相容性聚合物载体。 氨基由载体提供,其本身具有伯胺,或者由将伯胺掺入到载体上的反应性基团进行改性。 载体可以是聚氨基酸,聚乙烯基聚合物,多糖或其组合,例如聚赖氨酸,HPMA,葡聚糖,羟乙基淀粉或聚乙二醇; 核苷酸类似物可以是利巴韦林araA,AZT,阿昔洛韦,5-FUDR,araC或ddI。 还公开了使用这些前药治疗癌症病毒感染的方法。 与单独的核苷酸类似物相比,前药使核苷酸类似物具有显着增强的治疗功效并降低毒性。
    • 10. 发明申请
    • DYNAMICALLY RECONFIGURABLE HYBRID CIRCUIT-SWITCHED AND PACKET-SWITCHED NETWORK ARCHITECTURE
    • 动态可重构混合电路开关和分组交换网络架构
    • US20130044634A1
    • 2013-02-21
    • US13588012
    • 2012-08-17
    • Xiaolin WangQian WuJie Sun
    • Xiaolin WangQian WuJie Sun
    • H04L12/66
    • H04L12/6418
    • A dynamically reconfigurable network architecture includes a plurality of switching modules arranged in an ordered, multi-level, switched-tree configuration. A network is formed by selecting one switching module as the root and assigning it and all directly or indirectly subsidiary modules to the network. The operating mode of each switching module can be dynamically selected as either circuit-switched or packet-switched. The modules can be grouped into a single network or into a plurality of separate networks operating in parallel, including both circuit-switched and packet-switched networks. When a network is no longer needed, its operation can be halted and its resources released for reassignment to other networks. In embodiments, a selector controlled by allocation registers selects either a circuit-switching sequencer or a packet connection arbitration circuit to control the switching circuits. Switching modules can include crossbar switches. Circuit-switched connections can use TDM to share allocated physical resources.
    • 动态可重新配置的网络架构包括以有序,多层次的交换树配置布置的多个交换模块。 通过选择一个交换模块作为根,并将其分配到所有直接或间接的辅助模块来形成网络。 每个切换模块的操作模式可以被动态地选择为电路交换或分组交换。 这些模块可以被分组成单个网络或者并行操作的多个独立网络,包括电路交换网络和分组交换网络。 当不再需要网络时,可以停止其操作并释放其资源以重新分配给其他网络。 在实施例中,由分配寄存器控制的选择器选择电路切换定序器或分组连接仲裁电路来控制开关电路。 交换模块可以包括交叉开关。 电路交换连接可以使用TDM来共享所分配的物理资源。