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1. 发明授权

US09199939B2 Quinoline amide M1 receptor positive allosteric modulators 有权
标题翻译：喹啉酰胺M1受体阳性变构调节剂
公开(公告)号：US09199939B2
公开(公告)日：2015-12-01
申请号：US13515724
申请日：2010-12-13
申请人： Scott D. Kuduk , Kelly-Ann S. Schlegel , Zhi-Qiang Yang
发明人： Scott D. Kuduk , Kelly-Ann S. Schlegel , Zhi-Qiang Yang
IPC分类号： C07D401/06 , C07D215/48 , C07D215/60 , C07D409/14 , C07D413/06 , C07D405/12 , C07D401/14 , C07D413/14 , C07D405/14 , C07D417/14
CPC分类号： C07D215/60 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
摘要翻译：本发明涉及作为M1受体阳性变构调节剂的式（I）的喹啉酰胺化合物，其可用于治疗涉及M1受体的疾病，例如阿尔茨海默氏病，精神分裂症，疼痛或睡眠障碍。本发明还涉及包含该化合物的药物组合物，以及该化合物和组合物在治疗由M1受体介导的疾病中的用途。

2. 发明授权

US09058509B1 Screen privacy filter using software 有权
标题翻译：屏幕隐私过滤器使用软件
公开(公告)号：US09058509B1
公开(公告)日：2015-06-16
申请号：US13331421
申请日：2011-12-20
申请人： Qiang Yang , Lei Zhang , Zhiguo Li
发明人： Qiang Yang , Lei Zhang , Zhiguo Li
IPC分类号： G06F7/64 , G06F17/30 , H04N7/16 , G06F21/84 , H04N1/44
CPC分类号： G06F21/84 , G06F2221/032 , H04N1/44
摘要： A software-based privacy filter is provided on a computing device. First, a content window is opened and displayed on a display of the computing device. Then a semi-transparent topmost window is created, wherein the semi-transparent topmost window includes a moving privacy pattern designed to obscure first portions of the content window at a first time and obscure second portions of the content window at a second time. The semi-transparent topmost window is then displayed on top of the first content window on the display of the computing device.
摘要翻译：在计算设备上提供基于软件的隐私过滤器。首先，将内容窗口打开并显示在计算装置的显示器上。然后，创建半透明的最上面的窗口，其中半透明顶部窗口包括设计成在第一时间遮蔽内容窗口的第一部分并且在第二时间遮蔽内容窗口的第二部分的移动隐私模式。然后，半透明顶部窗口显示在计算设备的显示器上的第一内容窗口的顶部。

3. 发明授权

US08697690B2 Isoindolone M1 receptor positive allosteric modulators 有权
标题翻译：异吲哚酮M1受体阳性变构调节剂
公开(公告)号：US08697690B2
公开(公告)日：2014-04-15
申请号：US13805346
申请日：2011-06-27
申请人： Douglas C. Beshore , Scott D. Kuduk , Youheng Shu , Zhi-Qiang Yang
发明人： Douglas C. Beshore , Scott D. Kuduk , Youheng Shu , Zhi-Qiang Yang
IPC分类号： C07D209/62 , C07D405/04 , C07D401/14 , C07D471/04 , C07D401/10 , C07D405/14
CPC分类号： C07D209/62 , C07D209/64 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/14 , C07D471/04
摘要： The present invention is directed to isoindolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
摘要翻译：本发明涉及式（I）的异吲哚酮化合物，其为M1受体阳性变构调节剂，可用于治疗涉及M1受体的疾病，例如阿尔茨海默氏病，精神分裂症，疼痛或睡眠障碍。本发明还涉及包含该化合物的药物组合物，以及该化合物和组合物在治疗由M1受体介导的疾病中的用途。

4. 发明申请

US20140001098A1 Method and Device for Enclosed Recycling of Oil-Water-Sludge in Oil Shale Dry Distillation System 审中-公开
标题翻译：油页岩干馏系统油水污泥封闭回收方法与装置
公开(公告)号：US20140001098A1
公开(公告)日：2014-01-02
申请号：US13884156
申请日：2011-12-13
申请人： Mingfu Bao , Hualin Wang , Dasong Xing , Jiangang Wang , Da Zhao , Xin Cui , Rongpu Zhang , Yuan Huang , Ling Shen , Qiang Yang , Yi Fan
发明人： Mingfu Bao , Hualin Wang , Dasong Xing , Jiangang Wang , Da Zhao , Xin Cui , Rongpu Zhang , Yuan Huang , Ling Shen , Qiang Yang , Yi Fan
IPC分类号： C10G33/04
CPC分类号： C10G33/04 , C02F11/12 , C10B53/06 , C10G1/00 , C10G1/002 , C10G1/02 , C10G5/04 , C10G33/02 , C10G2300/4081 , C10K1/02 , C10K1/04
摘要： The present invention relates to a method and a device for enclosed recycling of oil-water-sludge in an oil shale dry distillation system. According to the method, the technology is advanced, equipment investment costs are low, the occupied area is small, the failure rate is low, a highly pure shale oil product and a highly concentrated oil sludge product can be obtained efficiently, and the waste water generated in the purification and concentration processes can be recycled, thereby achieving full enclosure of the device system, greatly reducing the energy consumption, and improving the oil shale dry distillation process in the prior art.
摘要翻译：本发明涉及油页岩干馏系统中油 - 水污泥的封闭回收方法和装置。按照该方法，技术先进，设备投资成本低，占地面积小，故障率低，可以高效地获得高纯度页岩油产品和高浓缩油泥产品，废水在净化和浓缩过程中产生的可以再循环，从而实现装置系统的完全封闭，大大降低了能量消耗，并改进了现有技术中的油页岩干馏过程。

5. 发明授权

US08513289B2 P38 kinase inhibiting agents 有权
标题翻译： P38激酶抑制剂
公开(公告)号：US08513289B2
公开(公告)日：2013-08-20
申请号：US13266043
申请日：2010-04-26
申请人： Hiroo Koyama , Soumya P. Sahoo , Ginger Xu-Qiang Yang , Daniel J. Miller
发明人： Hiroo Koyama , Soumya P. Sahoo , Ginger Xu-Qiang Yang , Daniel J. Miller
IPC分类号： A61K31/4245 , A61K31/433 , C07D285/08 , C07D207/333
CPC分类号： C07D417/12 , C07D417/14
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: Formula (I); are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译：由化学式（I）或其药学上可接受的盐描述的化合物：式（I）; 是p38的抑制剂，可用于治疗炎症，例如治疗哮喘，COPD，ARDS，类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。

6. 发明申请

US20130012526A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH 有权
公开(公告)号：US20130012526A1
公开(公告)日：2013-01-10
申请号：US13635286
申请日：2011-04-18
申请人： Philippe G. Nantermet , Zhi-Qiang Yang , Constantine Kreatsoulas , Abbas M. Walji , Hong Zhu
发明人： Philippe G. Nantermet , Zhi-Qiang Yang , Constantine Kreatsoulas , Abbas M. Walji , Hong Zhu
IPC分类号： C07D413/12 , C07D413/14 , A61K31/4545 , A61K31/444 , A61K31/422 , C07D473/32 , A61K31/52 , C07D413/04 , A61P19/02 , A61P29/00 , A61P25/00 , A61P25/06 , A61P25/20 , A61P25/28 , A61P25/16 , A61K31/4439
CPC分类号： C07D263/46 , C07D413/12 , C07D413/14
摘要： The present invention is directed to certain Oxazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.

7. 发明授权

US08295012B1 Disk drive suspension assembly with rotary fine actuator at flexure tongue 有权
标题翻译：磁盘驱动器悬挂组件，带弯曲舌头的旋转精细执行器
公开(公告)号：US08295012B1
公开(公告)日：2012-10-23
申请号：US13159598
申请日：2011-06-14
申请人： Jifang Tian , Qiang Yang , Jian Yang
发明人： Jifang Tian , Qiang Yang , Jian Yang
IPC分类号： G11B21/16
CPC分类号： G11B5/483
摘要： A head gimbal assembly includes a rotary fine actuator attached to the head mounting tongue. The rotary fine actuator includes a fixed portion, a head mounting platform, first and second piezoelectric elements, and first and second curved compliant members. The first piezoelectric element is bonded to the fixed portion at a first bonding surface, and to the head mounting platform at a second bonding surface. The second piezoelectric element extends between the fixed portion and the head mounting platform. The first and second curved compliant members extend between the fixed portion and the head mounting platform. A read head is bonded to a mounting surface of the head mounting platform. The first and second bonding surfaces are parallel to the mounting surface. The read head is disposed between the first and second piezoelectric elements.
摘要翻译：头万向架组件包括附接到头部安装舌头的旋转精细致动器。旋转精细致动器包括固定部分，头部安装平台，第一和第二压电元件以及第一和第二弯曲柔顺构件。第一压电元件在第一接合表面处接合到固定部分，并且在第二接合表面处接合到头部安装平台。第二压电元件在固定部分和头部安装平台之间延伸。第一和第二弯曲柔性构件在固定部分和头部安装平台之间延伸。读头与头安装平台的安装面接合。第一和第二接合表面平行于安装表面。读头设置在第一和第二压电元件之间。

8. 发明申请

US20120252808A1 QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS 有权
标题翻译：喹啉胺M1受体阳性单独调节剂
公开(公告)号：US20120252808A1
公开(公告)日：2012-10-04
申请号：US13515724
申请日：2010-12-13
申请人： Scott D. Kuduk , Kelly-Ann S. Schlegel , Zhi-Qiang Yang
发明人： Scott D. Kuduk , Kelly-Ann S. Schlegel , Zhi-Qiang Yang
IPC分类号： A61K31/4709 , C07D405/12 , A61K31/506 , A61K31/47 , C07D413/04 , A61K31/5377 , C07D401/04 , A61K31/497 , A61K31/501 , C07D471/04 , A61K31/437 , A61P25/28 , A61P25/18 , A61P29/00 , A61P25/00 , C07D215/14
CPC分类号： C07D215/60 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
摘要翻译：本发明涉及作为M1受体阳性变构调节剂的式（I）的喹啉酰胺化合物，其可用于治疗涉及M1受体的疾病，例如阿尔茨海默氏病，精神分裂症，疼痛或睡眠障碍。本发明还涉及包含该化合物的药物组合物，以及该化合物和组合物在治疗由M1受体介导的疾病中的用途。

9. 发明授权

US08263627B2 Pyridyl amide T-type calcium channel antagonists 有权
标题翻译：吡啶酰胺T型钙通道拮抗剂
公开(公告)号：US08263627B2
公开(公告)日：2012-09-11
申请号：US13008161
申请日：2011-01-18
申请人： James C. Barrow , Thomas S. Reger , Zhi-Qiang Yang
发明人： James C. Barrow , Thomas S. Reger , Zhi-Qiang Yang
IPC分类号： A61K31/445 , A61K31/415 , C07D213/00 , C07D213/72
CPC分类号： C07D413/12 , C07D213/40 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D411/12
摘要： The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
摘要翻译：本发明涉及作为T型钙通道拮抗剂的吡啶酰胺化合物，其可用于治疗或预防其中涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。

10. 发明申请

US20120202852A1 HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS 有权
标题翻译：杂交酰胺T型钙通道拮抗剂
公开(公告)号：US20120202852A1
公开(公告)日：2012-08-09
申请号：US13500097
申请日：2010-10-25
申请人： James Barrow , Kelly-Ann Schlegel , Yoheng Shu , Zhi-Qiang Yang
发明人： James Barrow , Kelly-Ann Schlegel , Yoheng Shu , Zhi-Qiang Yang
IPC分类号： A61K31/4439 , C07D249/04 , A61K31/4192 , C07D277/30 , A61K31/426 , C07D263/34 , A61K31/421 , C07D257/04 , A61K31/41 , C07D413/04 , A61P25/08 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/30 , C07D401/06
CPC分类号： C07D401/06 , C07D233/64 , C07D249/04 , C07D257/04 , C07D263/32 , C07D271/10 , C07D271/113 , C07D277/28 , C07D413/04 , C07D413/06 , C07D417/14
摘要： The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
摘要翻译：本发明涉及作为T型钙通道拮抗剂的杂环酰胺化合物，其可用于治疗或预防涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。

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