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1. 发明授权

US08620414B2 Detection of T-wave alternans phase reversal for arrhythmia prediction and sudden cardiac death risk stratification 有权
标题翻译：检测心律失常预测和心源性猝死危险分层的T波交替相逆转
公开(公告)号：US08620414B2
公开(公告)日：2013-12-31
申请号：US12749753
申请日：2010-03-30
申请人： Raja N. Ghanem , Xiaohong Zhou
发明人： Raja N. Ghanem , Xiaohong Zhou
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7264 , A61B5/7275 , A61N1/36507 , G06F19/00
摘要： An implantable medical device and associated method for classifying a patient's risk for arrhythmias by sensing a cardiac electrogram (EGM) signal and selecting a first pair of T-wave signals and a second pair of T-wave signals. A first difference between the two T-wave signals of the first pair is compared to a second difference between the two T-wave signals of the second pair. A T-wave alternans phase reversal is detected in response to comparing the first difference and the second difference, and the patient's arrhythmia risk is classified in response to detecting the phase reversal.
摘要翻译：一种用于通过感测心电图（EGM）信号和选择第一对T波信号和第二对T波信号来分类患者心律失常风险的可植入医疗装置和相关方法。将第一对的两个T波信号之间的第一个差异与第二对的两个T波信号之间的第二个差值进行比较。响应于比较第一个差异和第二个差异，检测到T波交替相位逆转，并且响应于检测相位反转来分类患者的心律失常风险。

2. 发明授权

US07907993B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07907993B2
公开(公告)日：2011-03-15
申请号：US11380794
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Saul E. Greenhut , Karen J. Kleckner , Paul G. Krause , Veerdhaval Mahajan
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Saul E. Greenhut , Karen J. Kleckner , Paul G. Krause , Veerdhaval Mahajan
IPC分类号： A61B5/0402
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, and determining first heart rate estimates associated with cardiac signals sensed from the first sensing vector and cardiac signals sensed from the second sensing vector in response to a metric of heart rate associated with the sensed cardiac signals. Second heart rate estimates associated with the first sensing vector and with the second sensing vector are generated in response to the determined first heart rate estimates, and a determination is made as to whether both of the second heart rate estimates are greater than a predetermined heart rate threshold.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括从形成第一感测向量和第二感测向量的多个电极感测心脏信号，以及确定与从第一感测向量和心脏感测的心脏信号相关联的第一心率估计响应于与感测的心脏信号相关联的心率的度量，从第二感测向量感测的信号。响应于确定的第一心率估计而产生与第一感测向量和第二感测向量相关联的第二心率估计，并且确定第二心率估计是否大于预定心率阈。

3. 发明授权

US07761150B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07761150B2
公开(公告)日：2010-07-20
申请号：US11380846
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/368
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes determining a first characteristic in response to cardiac signals sensed along a first sensing vector over a predetermined sensing window and in response to cardiac signals sensed along a second sensing vector over the predetermined sensing window, determining a second characteristic in response to cardiac signals sensed along the first sensing vector over the predetermined sensing window and in response to cardiac signals sensed along the second sensing vector over the predetermined sensing window, and determining a third characteristic in response to cardiac signals sensed along the first sensing vector over the predetermined sensing window and in response to cardiac signals sensed along the second sensing vector over the predetermined sensing window.
摘要翻译：一种检测医疗设备中的心脏事件的方法，包括响应于沿着预定感测窗口沿着第一感测向量感测的心脏信号并且响应于沿着预定感测窗口沿着第二感测向量感测的心脏信号来确定第一特性，响应于沿着预定感测窗口沿着第一感测向量感测的心脏信号并且响应于沿着预定感测窗口沿着第二感测向量感测到的心脏信号，确定响应于感测到的心脏信号的第三特性的第二特性沿着预定感测窗口上的第一感测向量，并且响应于沿着预定感测窗口沿着第二感测向量感测的心脏信号。

4. 发明授权

US07496408B2 Electrodes array for a pacemaker 有权
标题翻译：用于起搏器的电极阵列
公开(公告)号：US07496408B2
公开(公告)日：2009-02-24
申请号：US11004498
申请日：2004-12-03
申请人： Raja N. Ghanem , Walter H. Olson
发明人： Raja N. Ghanem , Walter H. Olson
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/362
摘要： A cardiac pacemaker and method of its use. The pacemaker is provided with a pacing electrode array configured for location at a left anterior portion of a patient's thorax between the patients third and sixth ribs, outside the patient's thoracic cavity. The pacing electrode array includes multiple pacing electrodes and preferably includes one or more steering electrodes for configuring the electrical field produced by delivery of pacing pulses to avoid unwanted nerve and muscle stimulation while allowing cardiac stimulation. The electrode array may be located subcutaneously, submuscularly or on the patient's skin.
摘要翻译：心脏起搏器及其使用方法。起搏器设置有起搏电极阵列，其配置用于位于患者胸腔之间的患者胸部的左前部之间，患者第三肋和第六肋之间，位于患者胸腔外。起搏电极阵列包括多个起搏电极，并且优选地包括一个或多个转向电极，用于配置通过递送起搏脉冲产生的电场，以避免不必要的神经和肌肉刺激同时允许心脏刺激。电极阵列可以皮下，肌内或病人的皮肤上。

5. 发明授权

US08676289B2 Method and apparatus for discriminating cardiac signals in a medical device based on wavelet decomposition analysis 有权
标题翻译：基于小波分解分析来鉴别医疗装置中的心脏信号的方法和装置
公开(公告)号：US08676289B2
公开(公告)日：2014-03-18
申请号：US11744455
申请日：2007-05-04
申请人： Raja N. Ghanem , Troy E. Jackson
发明人： Raja N. Ghanem , Troy E. Jackson
IPC分类号： A61B5/0428
CPC分类号： A61B5/0464 , A61B5/0422 , A61B5/0424 , A61B5/046 , A61B5/726 , A61N1/362 , A61N1/3706 , G06K9/00536 , G06K9/527
摘要： A method of detecting cardiac signals in a medical device that includes decomposing a cardiac signal using a wavelet function at a plurality of scales to form a corresponding wavelet transform, determining approximation coefficients in response to the plurality of scales, reconstructing a first wavelet representation of the wavelet transform using predetermined approximation coefficients of the determined approximation coefficients, and evaluating the detected cardiac signals in response to the reconstructing.
摘要翻译：一种检测医疗装置中的心脏信号的方法，包括使用多个尺度的小波函数分解心脏信号以形成对应的小波变换，响应于所述多个标度确定近似系数，重建所述多个尺度的第一小波表示使用所确定的近似系数的预定近似系数的小波变换，以及响应于重建来评估检测到的心脏信号。

6. 发明授权

US08160684B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US08160684B2
公开(公告)日：2012-04-17
申请号：US11380837
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/0452 , A61N1/368
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, and determining whether the sensing of cardiac signals along the first sensing vector and along the second sensing vector is corrupted by noise. If the cardiac signals sensed along both the first sensing vector and the second sensing vector are not corrupted by noise, a determination is made as to whether the cardiac signals sensed along the first sensing vector and along the second sensing vector are one of a first cardiac event and a second cardiac event. The determination of whether the cardiac signals sensed along the first sensing vector and along the second sensing vector are one of a first cardiac event and a second cardiac event is then confirmed.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，以及确定沿着第一感测向量并沿着第二感测的心脏信号的感测矢量被噪音破坏了。如果沿着第一感测向量和第二感测矢量两者感测的心脏信号不被噪声破坏，则确定沿着第一感测向量和沿着第二感测向量感测的心脏信号是否是第一心脏事件和第二次心脏事件。然后确定沿着第一感测向量和沿着第二感测向量感测的心脏信号是否是第一心脏事件和第二心脏事件之一的确定。

7. 发明授权

US08068901B2 Method and apparatus for adjusting a sensing parameter 有权
标题翻译：用于调整感测参数的方法和装置
公开(公告)号：US08068901B2
公开(公告)日：2011-11-29
申请号：US11742625
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61B5/0402
CPC分类号： A61N1/3704 , A61B5/0456 , A61B5/046 , A61B5/7239 , A61N1/3925
摘要： A method and apparatus of updating a sensing parameter in a medical device that includes sensing cardiac signals, determining intervals in response to the sensed cardiac signals, determining interval patterns associated with the determined intervals, and updating the sensing parameter in response to the determined interval patterns.
摘要翻译：一种更新医疗设备中的感测参数的方法和装置，包括感测心脏信号，响应于感测的心脏信号确定间隔，确定与所确定的间隔相关联的间隔模式，以及响应于所确定的间隔模式来更新感测参数。

8. 发明申请

US20110245700A1 DETECTION OF T-WAVE ALTERNANS PHASE REVERSAL FOR ARRHYTHMIA PREDICTION AND SUDDEN CARDIAC DEATH RISK STRATIFICATION 有权
标题翻译： T-WAVE ALTERNANS相关检测ARRHYTHMIA预测和SUDDEN CARDIAC死亡风险分析
公开(公告)号：US20110245700A1
公开(公告)日：2011-10-06
申请号：US12749753
申请日：2010-03-30
申请人： Raja N. Ghanem , Xiaohong Zhou
发明人： Raja N. Ghanem , Xiaohong Zhou
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7264 , A61B5/7275 , A61N1/36507 , G06F19/00
摘要： An implantable medical device and associated method for classifying a patient's risk for arrhythmias by sensing a cardiac electrogram (EGM) signal and selecting a first pair of T-wave signals and a second pair of T-wave signals. A first difference between the two T-wave signals of the first pair is compared to a second difference between the two T-wave signals of the second pair. A T-wave alternans phase reversal is detected in response to comparing the first difference and the second difference, and the patient's arrhythmia risk is classified in response to detecting the phase reversal.
摘要翻译：一种用于通过感测心电图（EGM）信号和选择第一对T波信号和第二对T波信号来分类患者心律失常风险的可植入医疗装置和相关方法。将第一对的两个T波信号之间的第一个差异与第二对的两个T波信号之间的第二个差值进行比较。响应于比较第一个差异和第二个差异，检测到T波交替相位逆转，并且响应于检测相位反转来分类患者的心律失常风险。

9. 发明申请

US20110137193A1 CONTINUOUS MONITORING OF RISK BURDEN FOR SUDDEN CARDIAC DEATH RISK STRATIFICATION 有权
标题翻译：连续监测减少心脏死亡风险分析的危险因素
公开(公告)号：US20110137193A1
公开(公告)日：2011-06-09
申请号：US12793526
申请日：2010-06-03
申请人： Raja N. Ghanem , Paul J. DeGroot
发明人： Raja N. Ghanem , Paul J. DeGroot
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7275 , G06F19/00
摘要： System and method for assessing a likelihood of a patient to experience a cardiac arrhythmia. A biological sensor is configured to sense biological parameters of the patient. A processor is coupled to the biological sensor and is configured to determine the likelihood of the patient experiencing a cardiac arrhythmia based, at least in part, on a combination of the biological parameters, the combination dynamically weighting each of the plurality of biological parameters based on another one of the plurality of biological parameters.
摘要翻译：用于评估患者经历心律失常的可能性的系统和方法。生物传感器被配置为感测患者的生物学参数。处理器耦合到生物传感器并且被配置为至少部分地基于生物参数的组合来确定患者经历心律失常的可能性，所述组合基于动态加权多个生物参数中的每一个，基于多个生物参数中的另一个。

10. 发明授权

US07937135B2 Method and apparatus for adjusting a sensing parameter 有权
标题翻译：用于调整感测参数的方法和装置
公开(公告)号：US07937135B2
公开(公告)日：2011-05-03
申请号：US11742628
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61B5/0402
CPC分类号： A61N1/3925 , A61N1/3704
摘要： A method and apparatus for determining oversensing in a medical device that includes sensing cardiac signals, determining an oversensing characteristic associated with cardiac signals sensed during a predetermined sensing window, identifying oversensing in response to the oversensing characteristic, determining, in response to oversensing being identified, an adjusting characteristic associated with cardiac signals sensed during the predetermined sensing window, and updating a sensing parameter in response to the determined adjusting characteristic.
摘要翻译：一种用于确定医疗装置中的过度感测的方法和装置，包括感测心脏信号，确定与在预定感测窗口期间感测到的心脏信号相关联的过度感应特征，响应于过敏特性识别过敏，响应于被识别的过冷而确定，与在预定感测窗口期间感测到的心脏信号相关联的调整特性，以及响应于确定的调整特性来更新感测参数。

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