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1. 发明申请

US20130195915A1 Influenza C Virus and Vaccine 有权
标题翻译：流感C病毒和疫苗
公开(公告)号：US20130195915A1
公开(公告)日：2013-08-01
申请号：US13385004
申请日：2012-01-27
申请人： Randy R. Simonson , Benjamin M. Hause , Emily A. Collin
发明人： Randy R. Simonson , Benjamin M. Hause , Emily A. Collin
IPC分类号： A61K39/145 , C07H21/04 , C12Q1/70 , A61P31/16 , C12N7/00
CPC分类号： C07K14/005 , A61K2039/5252 , C12N7/00 , C12N2760/16321 , C12N2760/16322 , C12N2760/16334
摘要： A novel influenza C virus with only low homology to any influenza C virus previously characterized. Challenge studies show that the virus can infect pigs and be transmitted between pigs. Additionally, influenza C is commonly thought of as a human pathogen and serological studies have been performed, looking at the incidence of antibodies against this virus in both pigs and humans. Approximately 10% of pigs and 30% of humans have antibodies to this virus. Additional experimental data show that the virus can infect and transmit in ferrets (a surrogate for human infection studies). In a third aspect, the present invention is the partial genome of this novel influenza C virus. In another aspect, the present invention is a method of detection in animals of this novel influenza C virus.
摘要翻译：与以前特有的任何甲型流感病毒只有低同源性的新型甲型流感病毒。挑战研究表明，病毒可以感染猪，并在猪之间传播。此外，流感C通常被认为是人类病原体，并且已经进行血清学研究，研究在猪和人中针对该病毒的抗体的发生率。大约10％的猪和30％的人对这种病毒有抗体。额外的实验数据表明病毒可以感染和传播在雪貂（人类感染研究的替代品）。在第三方面，本发明是该新型甲型流感病毒的部分基因组。另一方面，本发明是这种新型甲型流感病毒的动物检测方法。

2. 发明申请

US20120225091A1 MODIFIED LIVE (JMSO STRAIN) HAEMOPHILUS PARASUIS VACCINE 有权
标题翻译：改良生物（JMSO菌株）HAEMOPHILUS PARASUIS VACCINE
公开(公告)号：US20120225091A1
公开(公告)日：2012-09-06
申请号：US13385303
申请日：2012-02-13
申请人： Kamesh R. Sirigireddy , Paulraj K. Lawrence , Russell F. Bey , Randy R. Simonson
发明人： Kamesh R. Sirigireddy , Paulraj K. Lawrence , Russell F. Bey , Randy R. Simonson
IPC分类号： A61K39/102 , A61P37/04 , A61P31/04 , C07H21/04
CPC分类号： A61K39/102 , A61K2039/522 , A61K2039/542 , A61K2039/552 , C07K14/285 , C12N9/1205 , C12N9/14 , C12R1/21 , C12Y207/01059 , C12Y306/03014
摘要： The present invention is a live vaccine from a culture of cells of Haemophilus parasuis exhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth. Several SNPs have been identified as associated with specific proteins that are associated with virulence as seen in the literature in H. parasuis or related bacterial species.
摘要翻译：本发明是来自展示减毒致病性的副嗜血杆菌细胞培养物的活疫苗，并且当施用于猪时能够引发保护性免疫应答。通过MNNG诱变从病原性亲本菌株修饰细胞培养物，并通过完全依赖链霉素进行选择来生长。已经鉴定了几种SNP与特异性蛋白质相关，与毒力相关，如在副作物或相关细菌物种中的文献中所见。

3. 发明申请

US20090110698A1 METHOD OF DETERMINING VACCINE COMPLIANCE 审中-公开
标题翻译：确定疫苗合规的方法
公开(公告)号：US20090110698A1
公开(公告)日：2009-04-30
申请号：US11931328
申请日：2007-10-31
申请人： Benjamin M. Hause , Randy R. Simonson , Russell F. Bey , Douglas L. Stine
发明人： Benjamin M. Hause , Randy R. Simonson , Russell F. Bey , Douglas L. Stine
IPC分类号： A61K39/00 , A61P43/00 , C12N9/24
CPC分类号： A61K38/47 , G01N33/5088
摘要： A protein (xylanase) has been identified that produces a strong immune response in pigs when added to a vaccine. The protein is added to vaccines at a particular concentration. The protein is delivered to the animal as part of the vaccine and elicits an immune reaction (antibodies are generated by the animal against the compliance marker protein). The antibodies are then detected in sera samples by a diagnostic test, enzyme-linked immunosorbent assay (ELISA). In the ELISA compliance marker assay, the marker protein (antigen) in coated onto polystyrene plates and is used to detect antibodies against the marker in sera samples. This combination of marker protein added to vaccines and the ELISA to detect antibodies raised against the marker protein can be used to determine whether a particular animal(s) has been vaccinated. The selected protein is commercially-available, identified as Generally Recognized as Safe by the FDA, and does not cause adverse reactions in animals.
摘要翻译：已经鉴定出蛋白质（木聚糖酶），当添加到疫苗中时，其在猪中产生强烈的免疫应答。将蛋白质以特定浓度加入疫苗中。蛋白质作为疫苗的一部分被递送到动物中并引发免疫反应（抗体由动物针对依从性标记蛋白产生）。然后通过诊断测试，酶联免疫吸附测定（ELISA）在血清样品中检测抗体。在ELISA顺应性标记测定中，将涂覆在聚苯乙烯板上的标记蛋白（抗原）用于检测针对血清样品中标记的抗体。加入疫苗的标记蛋白的这种组合和用于检测针对标记蛋白产生的抗体的ELISA可用于确定特定动物是否已接种疫苗。所选择的蛋白质是可商购的，被FDA认定为一般被认为是安全的，并且不会在动物中引起不良反应。

4. 发明授权

US09289484B2 Attenuated Streptococcus suis vaccines and methods of making and use thereof 有权
标题翻译：减毒链球菌疫苗及其制备和使用方法
公开(公告)号：US09289484B2
公开(公告)日：2016-03-22
申请号：US13924871
申请日：2013-06-24
申请人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson , Kamesh Reddy Sirigireddy , Danielle A McKeown
发明人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson , Kamesh Reddy Sirigireddy , Danielle A McKeown
IPC分类号： A61K39/09 , A61K39/02 , A61K45/00 , A61K39/00
CPC分类号： A61K39/092 , A61K39/09 , A61K2039/522 , A61K2039/542 , A61K2039/552
摘要： The present invention provides attenuated S. suis strains that elicit an immune response in animals against S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides novel, mutagenically-induced mutations in S. suis genes, which are useful in the production of novel attenuated S. suis bacterial strains.
摘要翻译：本发明提供减毒的猪链球菌菌株，其在动物中引起针对猪链球菌的免疫应答，包含所述菌株的组合物，针对猪链球菌疫苗接种的方法，以及用于此类方法和组合物的试剂盒。本发明还提供了在猪链球菌基因中的新型诱变突变，其可用于生产新的减毒的猪链球菌细菌菌株。

5. 发明授权

US09278999B2 Influenza C virus and vaccine 有权
标题翻译：流感C病毒和疫苗
公开(公告)号：US09278999B2
公开(公告)日：2016-03-08
申请号：US13385004
申请日：2012-01-27
申请人： Randy R. Simonson , Benjamin M. Hause , Emily A. Collin
发明人： Randy R. Simonson , Benjamin M. Hause , Emily A. Collin
IPC分类号： A61K39/145 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： C07K14/005 , A61K2039/5252 , C12N7/00 , C12N2760/16321 , C12N2760/16322 , C12N2760/16334
摘要： A novel influenza C virus with only low homology to any influenza C virus previously characterized. Challenge studies show that the virus can infect pigs and be transmitted between pigs. Additionally, influenza C is commonly thought of as a human pathogen and serological studies have been performed, looking at the incidence of antibodies against this virus in both pigs and humans. Approximately 10% of pigs and 30% of humans have antibodies to this virus. Additional experimental data show that the virus can infect and transmit in ferrets (a surrogate for human infection studies). In a third aspect, the present invention is the partial genome of this novel influenza C virus. In another aspect, the present invention is a method of detection in animals of this novel influenza C virus.
摘要翻译：与以前特有的任何甲型流感病毒只有低同源性的新型甲型流感病毒。挑战研究表明，病毒可以感染猪，并在猪之间传播。此外，流感C通常被认为是人类病原体，并且已经进行血清学研究，研究在猪和人中针对该病毒的抗体的发生率。大约10％的猪和30％的人对这种病毒有抗体。额外的实验数据表明病毒可以感染和传播在雪貂（人类感染研究的替代品）。在第三方面，本发明是该新型甲型流感病毒的部分基因组。另一方面，本发明是这种新型甲型流感病毒的动物检测方法。

6. 发明申请

US20140170190A1 Attenuated Mannheimia haemolytica Vaccines and Methods of Making and Use 有权
标题翻译：减毒的Mannheimia haemolytica疫苗和制造和使用方法
公开(公告)号：US20140170190A1
公开(公告)日：2014-06-19
申请号：US14075169
申请日：2013-11-08
申请人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson
发明人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson
IPC分类号： A61K39/102
CPC分类号： A61K39/102 , A61K2039/522 , A61K2039/543 , A61K2039/552 , A61K2039/70 , C07K14/285 , C12N1/36
摘要： The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
摘要翻译：本发明提供减毒的血液流行性感冒菌株，其在动物中引起血红蛋白溶血性免疫应答，包含所述菌株的组合物，针对血蓝单胞菌疫苗接种的方法，以及用于此类方法和组合物的试剂盒。本发明还提供了多价疫苗，当以有效量向易感“运送发热”或牛呼吸道疾病的动物施用时提供保护性免疫。

7. 发明申请

US20100255035A1 Modified live (JMSO strain) Haemophilus parasuis vaccine 有权
标题翻译：改良活（JMSO菌株）嗜血杆菌嗜血杆菌疫苗
公开(公告)号：US20100255035A1
公开(公告)日：2010-10-07
申请号：US11648390
申请日：2006-12-28
申请人： Simone R. Oliveira , Randy R. Simonson , Jonathan D. Mahlberg , Mark D. Titus , Tracy A. Oleson
发明人： Simone R. Oliveira , Randy R. Simonson , Jonathan D. Mahlberg , Mark D. Titus , Tracy A. Oleson
IPC分类号： A61K39/102 , C12N1/20 , A61P31/04
CPC分类号： C12N1/36 , A61K39/102 , A61K2039/522 , A61K2039/552 , C12N15/01 , C12R1/21
摘要： The present invention is a culture of cells of Haemophilus parasuis exhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs as a live vaccine. The present invention is also a method of preparing the cell culture, a method of preparing a vaccine from the cell culture, and a live vaccine based on the cell culture. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth.
摘要翻译：本发明是表现出减毒致病性的嗜血杆菌的细胞培养物，当作为活疫苗施用于猪时能够引发保护性免疫应答。本发明也是制备细胞培养物的方法，从细胞培养物制备疫苗的方法和基于细胞培养物的活疫苗。通过MNNG诱变从病原性亲本菌株修饰细胞培养物，并通过完全依赖链霉素进行选择来生长。

8. 发明申请

US20160158336A1 Attenuated Mannheimia haemolytica Vaccines and Methods of Making and Use 审中-公开
标题翻译：减毒的Mannheimia haemolytica疫苗和制造和使用方法
公开(公告)号：US20160158336A1
公开(公告)日：2016-06-09
申请号：US14934737
申请日：2015-11-06
申请人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson , Robert E Briggs , Fred M Tatum
发明人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson , Robert E Briggs , Fred M Tatum
IPC分类号： A61K39/102
CPC分类号： A61K39/102 , A61K2039/522 , A61K2039/543 , A61K2039/552 , A61K2039/70 , C07K14/285 , C12N1/36
摘要： The present invention provides attenuated M. haemolytica strains that elicit an immune response in animals against M. haemolytica, compositions comprising said strains, methods of vaccination against M. haemolytica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
摘要翻译：本发明提供减毒的解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军马氏解酒菌株，本发明还提供了多价疫苗，当以有效量向易感“运送发热”或牛呼吸道疾病的动物施用时提供保护性免疫。

9. 发明授权

US09132183B2 Modified live (JMSO strain) Haemophilus parasuis vaccine 有权
标题翻译：改良活（JMSO菌株）嗜血杆菌嗜血杆菌疫苗
公开(公告)号：US09132183B2
公开(公告)日：2015-09-15
申请号：US13385303
申请日：2012-02-13
申请人： Kamesh R. Sirigireddy , Paulraj K. Lawrence , Russell F. Bey , Randy R. Simonson
发明人： Kamesh R. Sirigireddy , Paulraj K. Lawrence , Russell F. Bey , Randy R. Simonson
IPC分类号： A61K39/102 , A61K39/00 , C12R1/21 , C07K14/285 , C12N9/12 , C12N9/14
CPC分类号： A61K39/102 , A61K2039/522 , A61K2039/542 , A61K2039/552 , C07K14/285 , C12N9/1205 , C12N9/14 , C12R1/21 , C12Y207/01059 , C12Y306/03014
摘要： The present invention is a live vaccine from a culture of cells of Haemophilus parasuis exhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth. Several SNPs have been identified as associated with specific proteins that are associated with virulence as seen in the literature in H. parasuis or related bacterial species.
摘要翻译：本发明是来自展示减毒致病性的副嗜血杆菌细胞培养物的活疫苗，并且当施用于猪时能够引发保护性免疫应答。通过MNNG诱变从病原性亲本菌株修饰细胞培养物，并通过完全依赖链霉素进行选择来生长。已经鉴定了几种SNP与特异性蛋白质相关，与毒力相关，如在副作物或相关细菌物种中的文献中所见。

10. 发明申请

US20140004144A1 Attenuated Streptococcus suis Vaccines and Methods of Making and Use Thereof 有权
标题翻译：减毒猪链球菌疫苗及其制备和使用方法
公开(公告)号：US20140004144A1
公开(公告)日：2014-01-02
申请号：US13924871
申请日：2013-06-24
申请人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson , Kamesh Reddy Sirigireddy , Danielle A McKeown
发明人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson , Kamesh Reddy Sirigireddy , Danielle A McKeown
IPC分类号： A61K39/09
CPC分类号： A61K39/092 , A61K39/09 , A61K2039/522 , A61K2039/542 , A61K2039/552
摘要： The present invention provides attenuated S. suis strains that elicit an immune response in animal S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides novel, mutagenically-induced mutations in S. suis genes, which are useful in the production of novel attenuated S. suis bacterial strains.
摘要翻译：本发明提供了在动物猪链球菌中引起免疫应答的减毒的猪链球菌菌株，包含所述菌株的组合物，针对猪链球菌的疫苗接种方法，以及用于此类方法和组合物的试剂盒。本发明还提供了在猪链球菌基因中的新的诱变诱变突变，其可用于生产新的减毒的猪链球菌细菌菌株。

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