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1. 发明授权

US09012162B2 Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers 有权
标题翻译：使用人血清蛋白生物标志物的新型小组对肝纤维化进行临床诊断
公开(公告)号：US09012162B2
公开(公告)日：2015-04-21
申请号：US11851619
申请日：2007-09-07
申请人： Bevin Gangadharan , Nicole Zitzmann , Raymond A. Dwek
发明人： Bevin Gangadharan , Nicole Zitzmann , Raymond A. Dwek
IPC分类号： G01N33/00 , G01N33/576
CPC分类号： G01N33/6893 , G01N33/576 , G01N33/5767 , G01N2333/775 , G01N2800/085 , Y10S436/811
摘要： The inventors have proposed a novel panel of human serum protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Serum from patients with varying degrees of hepatic scarring induced by infection with the hepatitis C virus (HCV) was analyzed. Several proteins associated with liver scarring and/or viral infection were identified. These proteins include the inter-α-trypsin inhibitor heavy chain H4 fragments, complement factor H-related protein 1, CD5L, Apo L1, and β2GPI. Increased and decreased thiolester cleavage of a2M and Complement C3, respectively, was also detected. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers.
摘要翻译：本发明人提出了用于诊断肝纤维化和肝硬化的人类血清蛋白生物标志物的新颖小组。目前尚无可靠的非侵入性肝纤维化评估方法。使用基于2D-PAGE的蛋白质组学研究来鉴定潜在的纤维化生物标志物。分析了丙型肝炎病毒（HCV）感染引起肝脏瘢痕形成程度不同的患者血清。鉴定了与肝脏瘢痕形成和/或病毒感染相关的几种蛋白质。这些蛋白质包括α-间胰蛋白酶抑制剂重链H4片段，补体因子H相关蛋白1，CD5L，Apo L1和＆bgr; 2GPI。还检测到了分别增加和减少的a2M和补体C3的硫醇裂解。这些新型生物标志物的浓度可以使用免疫测定来确定，其中浓度将反映纤维化程度。提出了每种新型生物标志物的纤维化评分量表。所有新生物标志物的得分的添加剂结果将给出更可靠的纤维化程度的指示，而不是检查个体生物标志物。

2. 发明授权

US08450345B2 Iminosugars and methods of treating viral diseases 有权
公开(公告)号：US08450345B2
公开(公告)日：2013-05-28
申请号：US12656992
申请日：2010-02-22
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/20
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.

3. 发明授权

US06809083B1 Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections 有权
标题翻译：使用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物治疗肝炎病毒感染
公开(公告)号：US06809083B1
公开(公告)日：2004-10-26
申请号：US09249220
申请日：1999-02-12
申请人： Richard A. Mueller , Martin L. Bryant , Richard A. Partis , Gary S. Jacob , Timothy M. Block , Raymond A. Dwek
发明人： Richard A. Mueller , Martin L. Bryant , Richard A. Partis , Gary S. Jacob , Timothy M. Block , Raymond A. Dwek
IPC分类号： A01N4304
CPC分类号： C07D211/46 , A61K31/445 , A61K45/06
摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
摘要翻译：提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。方法包括（1）单独或与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂单独或组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2）单独或与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

4. 发明授权

US5786369A Method of inhibiting the surface expression of glycolipid receptors for bacteria 失效
标题翻译：抑制细菌糖脂受体表面表达的方法
公开(公告)号：US5786369A
公开(公告)日：1998-07-28
申请号：US650558
申请日：1996-05-20
申请人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
发明人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the surface expression of glycolipid receptors for bacteria by subjecting bacteria cells to an inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译：公开了通过使细菌细胞抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物来抑制细菌的糖脂受体表面表达的方法，其中所述烷基含 2-8个碳原子。

5. 发明授权

US5043273A Phosphorylated glycosidase inhibitor prodrugs 失效
标题翻译：磷酸化糖苷酶抑制剂前药
公开(公告)号：US5043273A
公开(公告)日：1991-08-27
申请号：US394914
申请日：1989-08-17
申请人： Peter R. Scudder , Raymond A. Dwek , Thomas W. Rademacher , Gary S. Jacob
发明人： Peter R. Scudder , Raymond A. Dwek , Thomas W. Rademacher , Gary S. Jacob
IPC分类号： A61K31/445 , A61K31/675 , A61P3/06 , A61P3/08 , A61P31/12 , A61P43/00 , C07F9/09 , C07F9/59 , C12P9/00 , C12P17/12
CPC分类号： C07F9/592 , C12P17/12
摘要： A method is provided for converting therapeutic glycosidase inhibitors to novel prodrugs by phosphorylation of a free hydroxyl group on the molecule to substantially reduce the glycosidase inhibitory activity without thereby substantially reducing the therapeutic activity.

6. 发明授权

US4957926A Method of treating herpesviruses 失效
标题翻译：治疗疱疹病毒的方法
公开(公告)号：US4957926A
公开(公告)日：1990-09-18
申请号：US288528
申请日：1988-12-22
申请人： Gary S. Jacob , A. Stanley Tyms , Thomas W. Rademacher , Raymond A. Dwek
发明人： Gary S. Jacob , A. Stanley Tyms , Thomas W. Rademacher , Raymond A. Dwek
IPC分类号： C07H5/06 , A61K31/445 , A61K31/70 , A61K31/7008 , A61P31/12 , A61P31/22 , C07D211/46
CPC分类号： A61K31/445
摘要： A method is disclosed for the treatment of herpesvirus infections comprising treating the infected host with an effective amount of an N-alkyl derivative of deoxynojirimycin in which the alkyl group contains from one to about six carbon atoms, and preferably is butyl.

7. 发明授权

US4851517A Tissue plasminogen activator oligosaccharide from normal human colon cells 失效
标题翻译：来自正常人结肠细胞的组织纤溶酶原激活剂寡糖
公开(公告)号：US4851517A
公开(公告)日：1989-07-25
申请号：US159992
申请日：1988-02-24
申请人： Joseph Feder , William R. Tolbert , Thomas W. Rademacher , Raj B. Parekh , Raymond A. Dwek
发明人： Joseph Feder , William R. Tolbert , Thomas W. Rademacher , Raj B. Parekh , Raymond A. Dwek
IPC分类号： A61K38/00 , C08B37/00 , C12N9/72
CPC分类号： C12N9/6459 , C08B37/00 , C12Y304/21069 , A61K38/00
摘要： Glycosylated plasminogen activator (t-PA) having a glycosylation pattern significantly different than exhibited by t-PA from Bowes melanoma cells is obtained from cultured normal human colon fibroblast cells (CCD-18Co).
摘要翻译：从培养的正常人结肠成纤维细胞（CCD-18Co）获得具有与Bowes黑素瘤细胞的t-PA显示不同的糖基化模式的糖基化纤溶酶原激活剂（t-PA）。

8. 发明申请

US20110065752A1 METHODS OF TREATING ORTHOMYXOVIRAL INFECTIONS 审中-公开
标题翻译：治疗口腔感染的方法
公开(公告)号：US20110065752A1
公开(公告)日：2011-03-17
申请号：US12873704
申请日：2010-09-01
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/14 , C12N5/02
CPC分类号： A61K31/445 , A61K31/655 , C07D211/46
摘要： Provided are novel iminosugars and methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Orthomyxoviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：提供了新的亚氨基糖苷以及使用亚氨基二糖如DNJ衍生物治疗和/或预防由属于正粘病毒科的病毒引起或与之相关的疾病或病症的方法。

9. 发明申请

US20100222384A1 Iminosugars and methods of treating arenaviral infections 审中-公开
标题翻译：伊米诺糖和治疗异种病毒感染的方法
公开(公告)号：US20100222384A1
公开(公告)日：2010-09-02
申请号：US12656993
申请日：2010-02-22
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/12
CPC分类号： A61K31/445
摘要： Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Arenaviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：本发明提供了使用亚氨基二糖（例如DNJ衍生物）治疗由属于该病毒属（Arenaviridae）家族的病毒引起或与之相关的疾病或病症的方法。

10. 发明申请

US20100183669A1 Mannose immunogens for HIV-1 审中-公开
标题翻译：用于HIV-1的甘露糖免疫原
公开(公告)号：US20100183669A1
公开(公告)日：2010-07-22
申请号：US12656550
申请日：2010-02-03
申请人： Raymond A. Dwek , Pauline M. Rudd , Gayle E. Ritchie , Christopher Scanlan , M.D. Max Crispin
发明人： Raymond A. Dwek , Pauline M. Rudd , Gayle E. Ritchie , Christopher Scanlan , M.D. Max Crispin
IPC分类号： A61K39/21
CPC分类号： C12P21/005 , A61K39/00 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70596 , C07K16/1063 , C07K16/2803 , C12N9/16 , C12N9/48 , C12N2740/16122 , C12N2740/16134
摘要： Methods of producing a carbohydrate HIV vaccine or immunogenic composition are provided. One method comprises expressing a glycoprotein with a modified glycosylation, which facilitates binding of the glycoprotein to the 2G12 antibody. Another method comprises iteratively selecting cells with a high affinity for the 2G12 antibody.
摘要翻译：提供了生产碳水化合物HIV疫苗或免疫原性组合物的方法。一种方法包括表达具有修饰的糖基化的糖蛋白，其有助于糖蛋白与2G12抗体的结合。另一种方法包括迭代地选择对2G12抗体具有高亲和力的细胞。

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