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1. 发明申请

US20180178134A1 MULTIFUNCTIONAL SLIDE AND LADDER DEVICE 审中-公开
公开(公告)号：US20180178134A1
公开(公告)日：2018-06-28
申请号：US15855935
申请日：2017-12-27
申请人： TRENA NELSON , ANDREW RICHARD NELSON
发明人： TRENA NELSON , ANDREW RICHARD NELSON , DANIEL SNOW
IPC分类号： A63G21/04
CPC分类号： A63G21/04 , A63G21/00 , A63G31/00 , A63G31/14
摘要： The multifunctional device has slide and ladder portions easily connectable for use together as a self-supporting unit, and easily detachable for use separately on other equipment or for compact storage or transport. When set-up for use as a self-supporting unit, the ladder and slide portions are hooked together by a double-hook/double-axle connection system that does not allow the angle between the ladder and slide to change any significant amount during normal use of the set-up device. Yet, quick disconnection may be done when the weight of the user is removed, by purposely lifting and pivoting the portions, and then unhooking their top ends from each other. When disconnected from each other, the ladder and/or the slide portion (and preferably both) may be connected/hooked to another object(s), for example, a trampoline or a play equipment platform or other specially-adapted elevated structure, for climbing up to, and sliding down from, said trampoline/platform.

2. 发明授权

US09951379B2 Isothermal DNA amplification 有权
公开(公告)号：US09951379B2
公开(公告)日：2018-04-24
申请号：US13330745
申请日：2011-12-20
申请人： John Richard Nelson , Robert Scott Duthie , Carl Williams Fuller , Gregory Andrew Grossmann , Anuradha Sekher
发明人： John Richard Nelson , Robert Scott Duthie , Carl Williams Fuller , Gregory Andrew Grossmann , Anuradha Sekher
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6844 , C12Q2527/101 , C12Q2525/101 , C12Q2521/301
摘要： Provided herein are nucleic acid synthesis methods and agents that employ an endonuclease for example, endonuclease V, to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of the target DNA.

3. 发明授权

US09535314B2 Auto stereoscopic projector screen 有权
标题翻译：自动立体投影机屏幕
公开(公告)号：US09535314B2
公开(公告)日：2017-01-03
申请号：US14810483
申请日：2015-07-28
申请人： Jeremy Richard Nelson
发明人： Jeremy Richard Nelson
IPC分类号： G03B21/602 , G03B21/606 , G03B21/56 , G03B21/604 , G02B27/26 , H04N13/04 , H04N9/31 , G02B27/00 , G02B27/22
CPC分类号： G03B21/602 , G02B27/0093 , G02B27/2214 , G02B27/225 , G02B27/26 , G03B21/56 , G03B21/604 , G03B21/606 , H04N9/31 , H04N13/302 , H04N13/305 , H04N13/327 , H04N13/363
摘要： A projector system using a screen comprised of either a plurality of miniature, reflective, and concave or convex curved surfaces that are arranged in a pattern to create a screen surface for front projection, or a plurality of miniature, transparent, and curved convex or concave lenses that are arranged in a pattern to create a screen surface for rear projection, and a projector system with the pixel capacity to control the color and brightness focused onto many different subsections of each curved surface. Each curved lens or curved mirror surface is small enough so that when viewed from the viewing area, the lit and unlit areas seen within each individual curved surface blend together so that only the average brightness and color of each curved surface can be seen by a viewer. By controlling the subsections of each curved surface with focused light from a high resolution projector, the system can control the image the viewer sees in their left eye separately from their right eye and the viewer can see stereographic images without the need to wear filtering glasses. With inclusion of an external head tracking system, the left/right images for each subsection can be switched as needed when one or multiple viewers move their head or seating position within the viewing area.
摘要翻译：一种投影仪系统，其使用由多个微型的，反射的和凹的或凸起的曲面组成的屏幕，所述多个微型的，反射的和凹的或凸的曲面以图案排列以形成用于前投影的屏幕表面，或多个微型，透明和弯曲的凸或凹以图案布置以形成用于后投影的屏幕表面的透镜，以及具有像素能力的投影仪系统，其将颜色和亮度控制在每个曲面的许多不同部分上。每个弯曲的透镜或曲面镜面足够小，使得当从观察区域观察时，在每个单独的弯曲表面中看到的点亮和未点亮的区域混合在一起，使得只有观看者可以看到每个曲面的平均亮度和颜色。通过利用来自高分辨率投影仪的聚焦光控制每个弯曲表面的子部分，该系统可以控制观看者在其左眼中与其右眼分离的图像，并且观看者可以看到立体图像而不需要戴过滤眼镜。包括外部头跟踪系统时，当一个或多个观看者在观看区域内移动其头部或座席位置时，可以根据需要切换每个小节的左/右图像。

4. 发明授权

US09353393B2 Methods and kits for reducing non-specific nucleic acid amplification 有权
标题翻译：减少非特异性核酸扩增的方法和试剂盒
公开(公告)号：US09353393B2
公开(公告)日：2016-05-31
申请号：US13446474
申请日：2012-04-13
申请人： John Richard Nelson , Gregory Andrew Grossmann , Robert Scott Duthie , Sonali Jagdish Shah , Ryan Charles Heller
发明人： John Richard Nelson , Gregory Andrew Grossmann , Robert Scott Duthie , Sonali Jagdish Shah , Ryan Charles Heller
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12P19/34 , C12Q1/6848 , C12Q1/6853 , C12Q2525/113 , C12Q2525/179 , C12Q2525/204 , C12Q2527/107 , C12Q2527/101
摘要： Methods and kits for efficient amplification of nucleic acids are provided. The disclosure generally relates to methods and kits for nucleic acid amplification of target nucleic acids of interest. The methods described herein promote the synthesis of the target nucleic acid (i.e., template nucleic acid) by reducing the production of undesirable primer-dimer structures and chimeric nucleic acid products during the amplification process by using novel modified primers.
摘要翻译：提供了用于核酸有效扩增的方法和试剂盒。本公开内容通常涉及用于目标核酸的核酸扩增的方法和试剂盒。本文描述的方法通过使用新的修饰引物在扩增过程中减少不需要的引物二聚体结构和嵌合核酸产物的产生来促进靶核酸（即，模板核酸）的合成。

5. 发明申请

US20150331249A1 AUTO STEREOSCOPIC PROJECTOR SCREEN 审中-公开
标题翻译：自动STEREOSCOPIC投影仪屏幕
公开(公告)号：US20150331249A1
公开(公告)日：2015-11-19
申请号：US14810483
申请日：2015-07-28
申请人： Jeremy Richard Nelson
发明人： Jeremy Richard Nelson
IPC分类号： G02B27/26 , G02B27/00 , H04N9/31 , G03B21/604 , H04N13/04
CPC分类号： G03B21/602 , G02B27/0093 , G02B27/2214 , G02B27/225 , G02B27/26 , G03B21/56 , G03B21/604 , G03B21/606 , H04N9/31 , H04N13/302 , H04N13/305 , H04N13/327 , H04N13/363
摘要： A projector system using a screen comprised of either a plurality of miniature, reflective, and concave or convex curved surfaces that are arranged in a pattern to create a screen surface for front projection, or a plurality of miniature, transparent, and curved convex or concave lenses that are arranged in a pattern to create a screen surface for rear projection, and a projector system with the pixel capacity to control the color and brightness focused onto many different subsections of each curved surface. Each curved lens or curved mirror surface is small enough so that when viewed from the viewing area, the lit and unlit areas seen within each individual curved surface blend together so that only the average brightness and color of each curved surface can be seen by a viewer. By controlling the subsections of each curved surface with focused light from a high resolution projector, the system can control the image the viewer sees in their left eye separately from their right eye and the viewer can see stereographic images without the need to wear filtering glasses. With inclusion of an external head tracking system, the left/right images for each subsection can be switched as needed when one or multiple viewers move their head or seating position within the viewing area.
摘要翻译：一种投影仪系统，其使用由多个微型的，反射的和凹的或凸起的曲面组成的屏幕，所述多个微型的，反射的和凹的或凸的曲面以图案排列以形成用于前投影的屏幕表面，或多个微型，透明和弯曲的凸或凹以图案布置以形成用于后投影的屏幕表面的透镜，以及具有像素能力的投影仪系统，其将颜色和亮度控制在每个曲面的许多不同部分上。每个弯曲的透镜或曲面镜面足够小，使得当从观察区域观察时，在每个单独的弯曲表面中看到的点亮和未点亮的区域混合在一起，使得只有观看者可以看到每个曲面的平均亮度和颜色。通过利用来自高分辨率投影仪的聚焦光控制每个弯曲表面的子部分，该系统可以控制观看者在其左眼中与其右眼分离的图像，并且观看者可以看到立体图像而不需要戴过滤眼镜。包括外部头跟踪系统时，当一个或多个观看者在观看区域内移动其头部或座席位置时，可以根据需要切换每个小节的左/右图像。

6. 发明授权

US09125845B2 DNA vaccines, uses for unprocessed rolling circle amplification product and methods for making the same 有权
标题翻译： DNA疫苗，未加工的滚环扩增产物的用途及其制备方法
公开(公告)号：US09125845B2
公开(公告)日：2015-09-08
申请号：US13077231
申请日：2011-03-31
申请人： John Richard Nelson , Nichole Lea Wood , Brian Michael Davis , Andrew Soliz Torres
发明人： John Richard Nelson , Nichole Lea Wood , Brian Michael Davis , Andrew Soliz Torres
IPC分类号： A61K39/00 , A61K39/12 , A61K39/02 , A61K39/002 , A61K39/145
CPC分类号： A61K39/00 , A61K39/002 , A61K39/02 , A61K39/12 , A61K39/145 , A61K2039/53 , C12N2760/16134 , C12N2760/16234
摘要： A method of eliciting an immune response in an organism comprising: providing an unprocessed rolling circle amplification (RCA) product; and administering an effective amount of the unprocessed RCA product to the organism to elicit the immune response, wherein the unprocessed RCA product is prepared from a circular nucleic acid template comprising at least one promoter sequence, and at least one target sequence. A vaccine comprising unprocessed RCA product is also provided and methods for making the same.
摘要翻译：在生物体中引发免疫应答的方法，包括：提供未加工的滚环扩增（RCA）产物; 以及向生物体施用有效量的未加工的RCA产物以引发免疫应答，其中未加工的RCA产物由包含至少一个启动子序列和至少一个靶序列的环状核酸模板制备。还提供了包含未加工的RCA产品的疫苗及其制备方法。

7. 发明申请

US20150177608A1 AUTO STEREOSCOPIC PROJECTOR SCREEN 审中-公开
公开(公告)号：US20150177608A1
公开(公告)日：2015-06-25
申请号：US14133707
申请日：2013-12-19
申请人： Jeremy Richard Nelson
发明人： Jeremy Richard Nelson
IPC分类号： G03B21/56 , G03B21/60
CPC分类号： G03B21/602 , G02B27/0093 , G02B27/2214 , G02B27/225 , G02B27/26 , G03B21/56 , G03B21/604 , G03B21/606 , H04N9/31 , H04N13/302 , H04N13/305 , H04N13/327 , H04N13/363
摘要： A projector system using a screen comprised of either a plurality of miniature, reflective, and concave or convex curved surfaces that are arranged in a pattern to create a screen surface for front projection, or a plurality of miniature, transparent, and curved convex or concave lenses that are arranged in a pattern to create a screen surface for rear projection, and a projector system with the pixel capacity to control the color and brightness focused onto many different subsections of each curved surface. Each curved lens or curved mirror surface is small enough so that when viewed from the viewing area, the lit and unlit areas seen within each individual curved surface blend together so that only the average brightness and color of each curved surface can be seen by a viewer. By controlling the subsections of each curved surface with focused light from a high resolution projector, the system can control the image the viewer sees in their left eye separately from their right eye and the viewer can see stereographic images without the need to wear filtering glasses. With inclusion of an external head tracking system, the left/right images for each subsection can be switched as needed when one or multiple viewers move their head or seating position within the viewing area.

8. 发明申请

US20140039172A1 DEVICES AND SYSTEMS FOR ISOLATING BIOMOLECULES AND ASSOCIATED METHODS THEREOF 有权
标题翻译：用于分离生物分子的装置和系统及其相关方法
公开(公告)号：US20140039172A1
公开(公告)日：2014-02-06
申请号：US13599131
申请日：2012-08-30
申请人： John Richard Nelson , Li Zhu , Xiaohui Chen , Christopher Michael Puleo , Patrick McCoy Spooner
发明人： John Richard Nelson , Li Zhu , Xiaohui Chen , Christopher Michael Puleo , Patrick McCoy Spooner
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , B01D11/02
CPC分类号： F04B19/006 , F04B19/04 , F04B19/20
摘要： A device, a system, and a method for isolating biomolecules from biological materials are provided. The device comprises a quartz-based solid phase extraction matrix comprising one or more reagents impregnated therein; and an electroosmotic pump (EOP) operationally coupled to the quartz-based solid phase extraction matrix to elute the nucleic acids, wherein the EOP comprises a plurality of electroosmotic membranes comprising one or more positive electroosmotic membranes and one or more negative electroosmotic membranes disposed alternatively and a plurality of electrodes comprising one or more cathodes and one or more anodes, wherein at least one cathode is disposed on one side of one of the membranes and at least one anode is disposed on another side of that membrane and at least one cathode or anode is disposed between a positive electroosmotic membrane and a negative electroosmotic membrane.
摘要翻译：提供了一种从生物材料中分离生物分子的装置，系统和方法。该装置包括石英基固相萃取基质，其包含一种或多种浸渍在其中的试剂; 和电渗泵（EOP），其可操作地耦合到所述基于石英的固相萃取基质以洗脱所述核酸，其中所述EOP包括多个电渗膜，所述电渗膜包含一个或多个正电渗透膜和一个或多个负电渗渗膜，包括一个或多个阴极和一个或多个阳极的多个电极，其中至少一个阴极设置在一个膜的一侧上，并且至少一个阳极设置在该膜的另一侧上，并且至少一个阴极或阳极设置在正电渗透膜和负电渗膜之间。

9. 发明授权

US08507662B2 Methods and kits for reducing non-specific nucleic acid amplification 有权
标题翻译：减少非特异性核酸扩增的方法和试剂盒
公开(公告)号：US08507662B2
公开(公告)日：2013-08-13
申请号：US13183480
申请日：2011-07-15
申请人： John Richard Nelson , Robert Scott Duthie , Sonali Jagdish Shah , Clifford Leslie Smith
发明人： John Richard Nelson , Robert Scott Duthie , Sonali Jagdish Shah , Clifford Leslie Smith
IPC分类号： C07H21/04 , C12N9/00
CPC分类号： C12Q1/6848 , C12Q2525/185 , C12Q2525/179
摘要： Methods and kits for efficient amplification of nucleic acids are provided. The methods comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having terminal mismatch primer-dimer structure. The methods also comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having nucleotide analogues. The methods enhance efficiency of nucleic acid amplification reaction by reducing non-specific amplification reactions.
摘要翻译：提供了用于核酸有效扩增的方法和试剂盒。所述方法包括使用具有末端错配引物 - 二聚体结构的部分约束引物的核酸模板的体外扩增。所述方法还包括使用具有核苷酸类似物的部分约束引物的核酸模板的体外扩增。该方法通过减少非特异性扩增反应来提高核酸扩增反应的效率。

10. 发明申请

US20130136204A1 TURBINE METER PRE-SCALING TERMINAL BLOCK ELECTRONICS 有权
标题翻译：涡轮机预放电终端电子元件
公开(公告)号：US20130136204A1
公开(公告)日：2013-05-30
申请号：US13307125
申请日：2011-11-30
申请人： James A. Johnson , Richard Nelson
发明人： James A. Johnson , Richard Nelson
IPC分类号： H04L27/00
CPC分类号： G01F1/075 , G01F1/115 , G01F1/60 , G01F15/063
摘要： An electronic circuit for converting higher-frequency output signals from a sensor into lower-frequency input signals for a discrete input wireless transmitter. The circuit includes a differential amplifier, a digital comparator, a digital frequency divider, and a transistor switch. The differential amplifier amplifies the sensor signals as a function of a frequency of the sensor signals. The digital comparator generates a square wave signal by comparing the amplified sensor signals to a fixed reference voltage. The digital frequency divider generates a lower-frequency signal by dividing the square wave signal. The transistor switch generates the lower-frequency input signals for the discrete input wireless transmitter by switching as a function of the lower-frequency signal from the digital frequency divider.
摘要翻译：一种用于将来自传感器的较高频率输出信号转换为用于离散输入无线发射机的较低频率输入信号的电子电路。该电路包括差分放大器，数字比较器，数字分频器和晶体管开关。差分放大器将传感器信号放大为传感器信号频率的函数。数字比较器通过将放大的传感器信号与固定参考电压进行比较来产生方波信号。数字分频器通过划分方波信号来产生低频信号。晶体管开关根据来自数字分频器的低频信号的切换产生离散输入无线发射机的低频输入信号。

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