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1. 发明申请

US20210347805A1 AZITHROMYCIN DERIVATIVES CONTAINING A PHOSPHONIUM ION AS ANTICANCER AGENTS 有权
公开(公告)号：US20210347805A1
公开(公告)日：2021-11-11
申请号：US17286174
申请日：2019-10-18
申请人： RISING TIDE FOUNDATION
发明人： Tim SPAREY , Andrew RATCLIFFE , Brett STEVENSON , Franz LAGASSE
IPC分类号： C07H17/08
摘要： This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

2. 发明授权

US10350436B2 Radiosurgical planning and treatment 有权
公开(公告)号：US10350436B2
公开(公告)日：2019-07-16
申请号：US15813036
申请日：2017-11-14
申请人： Rising Tide Foundation
发明人： Douglas A. Kelly
IPC分类号： A61N5/10
摘要： Multiple tumors are grouped into multiple treatment groups. Tumors in different treatment groups are treated by a radiosurgery in different treatment sessions than the tumors in the same treatment groups. The tumors can be grouped so as to decrease the biologically effective dose received by normal tissue in the treatment area. The radiosurgical planning system can divide the tumors into groups based on their location relative to each other and the radiation the tumors will be treated with and create a plan for treating the tumors according to the treatment groups.

3. 发明申请

US20160213923A1 VENOUS ELECTRICAL STIMULATION APPARATUS AND METHODS AND USES THEREOF 审中-公开
标题翻译： VENOUS电刺激装置及其方法及用途
公开(公告)号：US20160213923A1
公开(公告)日：2016-07-28
申请号：US14917745
申请日：2014-09-15
申请人： RISING TIDE FOUNDATION
发明人： David Bruce PHILLIPS
IPC分类号： A61N1/36 , A61M5/42 , A61N1/04
CPC分类号： A61N1/36014 , A61M5/422 , A61N1/0456 , A61N1/0472 , A61N1/0476 , A61N1/0492
摘要： An electrical venous stimulation apparatus comprising an electrical signal generator, the signal generator configured to generate a specified electrical output signal. The apparatus also includes a plurality of electrodes in electrical communication with the signal generator and configured to be placed in electrical communication with a subject. The electrical output signal sent to the subject includes an output voltage, electrical current, and waveform that changes with time in a preprogrammed repeating cycle. The output voltage, electrical current, and waveform are configured to elicit a physiological response that stimulates a plurality of peripheral nerves in the subject, activates a venous muscle pump mechanism in one or more limbs of the subject, and non-invasively alter the physiology of target vein(s), wherein the target vein(s) is caused to distend from under the surface of the subject's skin.
摘要翻译：一种电静脉刺激装置，包括电信号发生器，所述信号发生器被配置为产生指定的电输出信号。该装置还包括多个与信号发生器电连通的电极，并被配置为与受试者电连通。发送到被摄体的电输出信号包括在预编程的重复周期中随时间变化的输出电压，电流和波形。输出电压，电流和波形被配置为引发刺激受试者中的多个外周神经的生理反应，激活受试者的一个或多个肢体中的静脉肌肉泵机制，并且非侵入性地改变目标静脉，其中使目标静脉从受试者皮肤表面下方膨胀。

4. 发明授权

US11427606B2 Azithromycin derivatives containing a phosphonium ion as anticancer agents 有权
公开(公告)号：US11427606B2
公开(公告)日：2022-08-30
申请号：US16606340
申请日：2018-04-20
申请人： Rising Tide Foundation
发明人： Tim Sparey , Andrew Ratcliffe , Brett Stevenson , Franz Lagasse , Edward Cochrane
IPC分类号： C07F9/6568 , C07F9/54
摘要： This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

5. 发明申请

US20210253616A1 AZITHROMYCIN DERIVATIVES CONTAINING A PHOSPHONIUM ION AS ANTICANCER AGENTS 有权
公开(公告)号：US20210253616A1
公开(公告)日：2021-08-19
申请号：US16606340
申请日：2018-04-20
申请人： Rising Tide Foundation
发明人： Tim Sparey , Andrew Ratcliffe , Brett Stevenson , Franz Lagasse , Edward Cochrane
IPC分类号： C07F9/6568 , C07F9/54
摘要： This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

6. 发明授权

US09956428B2 Radiosurgical planning and treatment 有权
公开(公告)号：US09956428B2
公开(公告)日：2018-05-01
申请号：US14334685
申请日：2014-07-18
申请人： Rising Tide Foundation
发明人： Douglas A. Kelly
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/103 , A61N5/1083 , A61N5/1084
摘要： Multiple tumors are grouped into multiple treatment groups. Tumors in different treatment groups are treated by a radiosurgery in different treatment sessions than the tumors in the same treatment groups. The tumors can be grouped so as to decrease the biologically effective dose received by normal tissue in the treatment area. The radiosurgical planning system can divide the tumors into groups based on their location relative to each other and the radiation the tumors will be treated with and create a plan for treating the tumors according to the treatment groups.

7. 发明授权

US11560395B2 Azithromycin derivatives containing a phosphonium ion as anticancer agents 有权
公开(公告)号：US11560395B2
公开(公告)日：2023-01-24
申请号：US16606336
申请日：2018-04-20
申请人： Rising Tide Foundation
发明人： Tim Sparey , Andrew Ratcliffe , David Hallett , Brett Stevenson , Edward Cochrane , Alexandre Froidbise
IPC分类号： C07F9/54
摘要： This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

8. 发明申请

US20210261582A1 AZITHROMYCIN DERIVATIVES CONTAINING A PHOSPHONIUM ION AS ANTICANCER AGENTS 有权
公开(公告)号：US20210261582A1
公开(公告)日：2021-08-26
申请号：US16606336
申请日：2018-04-20
申请人： Rising Tide Foundation
发明人： Tim Sparey , Andrew Ratcliffe , David Hallett , Brett Stevenson , Edward Cochrane , Alexandre Froidbise
IPC分类号： C07F9/54
摘要： This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

9. 发明申请

US20180078788A1 RADIOSURGICAL PLANNING AND TREATMENT 审中-公开
公开(公告)号：US20180078788A1
公开(公告)日：2018-03-22
申请号：US15813036
申请日：2017-11-14
申请人： Rising Tide Foundation
发明人： Douglas A. KELLY
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/103 , A61N5/1083 , A61N5/1084
摘要： Multiple tumors are grouped into multiple treatment groups. Tumors in different treatment groups are treated by a radiosurgery in different treatment sessions than the tumors in the same treatment groups. The tumors can be grouped so as to decrease the biologically effective dose received by normal tissue in the treatment area. The radiosurgical planning system can divide the tumors into groups based on their location relative to each other and the radiation the tumors will be treated with and create a plan for treating the tumors according to the treatment groups.

10. 发明申请

US20160016008A1 Radiosurgical Planning and Treatment 有权
标题翻译：放射外科规划与治疗
公开(公告)号：US20160016008A1
公开(公告)日：2016-01-21
申请号：US14334685
申请日：2014-07-18
申请人： RISING TIDE FOUNDATION
发明人： Douglas A. Kelly
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/103 , A61N5/1083 , A61N5/1084
摘要： Multiple tumors are grouped into multiple treatment groups. Tumors in different treatment groups are treated by a radiosurgery in different treatment sessions than the tumors in the same treatment groups. The tumors can be grouped so as to decrease the biologically effective dose received by normal tissue in the treatment area. The radiosurgical planning system can divide the tumors into groups based on their location relative to each other and the radiation the tumors will be treated with and create a plan for treating the tumors according to the treatment groups.
摘要翻译：多发肿瘤分为多个治疗组。不同治疗组的肿瘤在不同治疗阶段通过放射外科手术治疗，而不是在相同治疗组中的肿瘤。可以将肿瘤分组以减少治疗区域中正常组织接受的生物有效剂量。放射外科计划系统可以根据肿瘤的位置相对分开肿瘤，并根据治疗组制定治疗肿瘤的方案，并制定治疗肿瘤的方案。

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