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    • 7. 发明申请
    • Prosthetic hearing implant electrode assembly having optimal length for atraumatic implantation
    • 假体听力植入电极组件具有用于无创植入的最佳长度
    • US20070162098A1
    • 2007-07-12
    • US11605952
    • 2006-11-30
    • Frank RisiRobert BriggsMartin SvehlaThomas Lenarz
    • Frank RisiRobert BriggsMartin SvehlaThomas Lenarz
    • A61N1/05
    • A61N1/0541
    • An elongate carrier member configured for implantation into a cochlea, the carrier member having a proximal end adapted to be positioned in a basal region of the cochlea, and a distal end adapted to be positioned in an apical region of the cochlea; and a plurality of electrodes disposed at the distal end of the carrier member; wherein the carrier member has a length such that the carrier member cannot be implanted in the cochlea beyond a maximum insertion depth at which residual hearing of the apical region of the cochlea is substantially preserved and at which said carrier member provides electrical-only stimulation to a depth in the cochlea of approximately 270° to 320°. In one embodiment, the carrier member has a length such that the carrier member has a maximum insertion depth into the cochlea of between approximately 14 mm and 18 mm.
    • 构造成用于植入耳蜗的细长载体构件,所述载体构件具有适于定位在所述耳蜗的基底区域中的近端,以及适于定位在所述耳蜗的顶端区域中的远端; 以及设置在所述承载构件的远端的多个电极; 其中所述载体构件具有这样的长度,使得所述载体构件不能被植入到耳蜗的最大插入深度之外的最大插入深度处,所述最大插入深度基本上保留了所述耳蜗的顶端区域的残留听觉,并且所述载体构件向所述载体构件提供电刺激 耳蜗深度约270°至320°。 在一个实施例中,载体构件具有使得载体构件具有进入耳蜗的最大插入深度在大约14mm和18mm之间的长度。
    • 10. 发明授权
    • Processes for producing alkenals and alkenols
    • 生产烯烃和链烯醇的方法
    • US5886237A
    • 1999-03-23
    • US843389
    • 1997-04-15
    • Diane Lee PackettJohn Robert BriggsDavid Robert BryantAilene Gardner Phillips
    • Diane Lee PackettJohn Robert BriggsDavid Robert BryantAilene Gardner Phillips
    • C07C29/141C07C45/49C07C45/50C07C47/21
    • C07C29/141C07C45/49C07C45/50C07C47/21Y02P20/582
    • This invention relates in part to processes for selectively producing one or more substituted or unsubstituted alkenals. The process hydroformylates at least one substituted or unsubstituted alkadienes, e.g., butadiene, or a mixture of one or more substituted or unsubstituted alkadienes in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and at an alkadiene and/or carbon monoxide partial pressure sufficient to selectively produce at least one substituted or unsubstituted alkenals, e.g., pentenals. The substituted and unsubstituted alkenals produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., hydrogenation to alkenols, particularly pentenols. This invention also relates to reaction mixtures containing one or more substituted or unsubstituted alkenals or alkenols as principal product(s) of those reactions.
    • 本发明部分地涉及选择性地制备一种或多种取代或未取代的烯烃的方法。 该方法在加氢甲酰化催化剂(例如金属 - 有机磷配体配合物催化剂)存在下,在链烯二烯和/或二烷基化合物催化剂的存在下,将至少一种取代或未取代的烷二烯,例如丁二烯,或一种或多种取代或未取代的链烷二烯的混合物, 或一氧化碳分压足以选择性地产生至少一种取代或未取代的烯烃,例如戊烯醛。 通过本发明方法制备的取代和未取代的烯烃可以进一步反应以提供其所需的衍生物,例如氢化成烯醇,特别是戊烯醇。 本发明还涉及含有一种或多种取代或未取代的烯烃或链烯醇作为那些反应的主要产物的反应混合物。