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1. 发明授权

US08586501B2 Catalyst and method of manufacture 有权
标题翻译：催化剂及其制造方法
公开(公告)号：US08586501B2
公开(公告)日：2013-11-19
申请号：US12897650
申请日：2010-10-04
申请人： Larry Neil Lewis , Robert Edgar Colborn , Ashish Balkrishna Mhadeshwar , Dan Hancu
发明人： Larry Neil Lewis , Robert Edgar Colborn , Ashish Balkrishna Mhadeshwar , Dan Hancu
IPC分类号： B01J23/00 , B01J21/00 , B01J20/00 , B01J29/00
CPC分类号： B01J23/50 , B01D53/8628 , B01D53/9418 , B01D2251/208 , B01D2255/1021 , B01D2255/1023 , B01D2255/1025 , B01D2255/104 , B01D2255/106 , B01D2255/207 , B01D2255/20715 , B01D2255/20723 , B01D2255/20738 , B01D2255/20746 , B01D2255/20753 , B01D2255/20769 , B01D2255/20776 , B01D2255/20792 , B01D2255/2094 , B01D2255/9205 , B01D2255/9207 , B01D2258/012 , B01J35/10 , B01J37/03
摘要： According to various embodiments, a catalyst composition includes a catalytic metal secured to a porous substrate. The substrate has pores that are templated. The substrate is a product of adding a substrate precursor to a water-in-oil microemulsion including a catalytic metal salt, a solvent, a templating agent, and water.
摘要翻译：根据各种实施方案，催化剂组合物包括固定到多孔基材上的催化金属。底物具有模板的孔。基材是向包含催化金属盐，溶剂，模板剂和水的油包水微乳液中添加底物前体的产物。

2. 发明授权

US06670487B1 Method for removing impurities from oxidation products 有权
标题翻译：从氧化产物中除去杂质的方法
公开(公告)号：US06670487B1
公开(公告)日：2003-12-30
申请号：US10354402
申请日：2003-01-30
申请人： Robert Edgar Colborn , Farid Fouad Khouri
发明人： Robert Edgar Colborn , Farid Fouad Khouri
IPC分类号： C07D30789
CPC分类号： C07C51/48 , C07C51/573 , C07C63/16 , C07C63/72 , C07C63/68
摘要： Disclosed is a method for removing impurities from products derived from oxidation of an ortho-dialkylaromatic compound which comprises at least one step selected from the group consisting of extraction of an aqueous solution comprising aromatic dicarboxylic acid product with an organic solvent and extraction of an organic solution comprising aromatic anhydride product with an aqueous bicarbonate solution for a time period insufficient to allow hydrolysis of anhydride to acid.
摘要翻译：公开了一种从邻二烃基芳族化合物的氧化衍生的产物中除去杂质的方法，该方法包括至少一种选自以下的步骤：将芳族二羧酸产物与有机溶剂的水溶液萃取和萃取有机溶液包括芳族酸酐产物与碳酸氢盐水溶液一段时间不足以使酸酐水解成酸。

3. 发明授权

US06407276B1 Method for improving selectivity for dialkyldichlorosilane 失效
标题翻译：提高二烷基二氯硅烷选择性的方法
公开(公告)号：US06407276B1
公开(公告)日：2002-06-18
申请号：US09820025
申请日：2001-03-29
申请人： Larry Neil Lewis , Robert Edgar Colborn , John Matthew Bablin
发明人： Larry Neil Lewis , Robert Edgar Colborn , John Matthew Bablin
IPC分类号： C07F716
CPC分类号： C07F7/16
摘要： A method for forming a dialkyldichlorosilane, comprising reacting elemental silicon with an alkyl chloride using copper as a catalyst together with promoters zinc, tin, and a special promoter. The special promoter is silver, a silver compound, gold, a gold compound, or combinations thereof. The alkyl may be methyl such that the dialkyldichlorosilane is dimethyldichlorosilane and the alkyl chloride is methyl chloride. The reacting generates the dialkyldichlorosilane in accordance with a first selectivity for the dialkyldichlorosilane that exceeds a second selectivity for the dialkyldichlorosilane. The second selectivity is a selectivity for the dialkyldichlorosilane that would have existed had the special promoter been absent.
摘要翻译：一种形成二烷基二氯硅烷的方法，包括使用铜作为催化剂与促进剂锌，锡和特殊的促进剂一起使元素硅与烷基氯反应。特殊促进剂是银，银化合物，金，金化合物或其组合。烷基可以是甲基，使得二烷基二氯硅烷是二甲基二氯硅烷，并且烷基氯是甲基氯。该反应根据对二烷基二氯硅烷的第二选择性的二烷基二氯硅烷的第一选择性产生二烷基二氯硅烷。第二选择性是对于二烷基二氯硅烷的选择性，如果没有特殊促进剂，那么它将存在。

4. 发明授权

US09149545B2 Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same 有权
标题翻译：用于X射线/计算机断层扫描的基于纳米颗粒的成像剂及其制备方法
公开(公告)号：US09149545B2
公开(公告)日：2015-10-06
申请号：US12276817
申请日：2008-11-24
申请人： Peter John Bonitatibus, Jr. , David Cheney deMoulpied , Andrew Soliz Torres , Amit Mohan Kulkarni , Robert Edgar Colborn , Paul William Buckley
发明人： Peter John Bonitatibus, Jr. , David Cheney deMoulpied , Andrew Soliz Torres , Amit Mohan Kulkarni , Robert Edgar Colborn , Paul William Buckley
IPC分类号： A61K49/04 , B82Y30/00 , C01G27/02 , C01G35/00 , C01G3/12 , B82Y5/00 , C09C3/12
CPC分类号： A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01G35/00 , C01P2004/04 , C01P2004/64 , C09C3/12
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.
摘要翻译：本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。本文包括形成这种试剂的方法，包括形成核/壳纳米颗粒的组合，其中核/壳纳米颗粒的整体的平均直径被选择为使得组合体中的纳米颗粒可以被哺乳动物肾基本上清除。

5. 发明申请

US20140056821A1 NANOPARTICULATE COMPOSITIONS FOR DIAGNOSTIC IMAGING 有权
标题翻译：用于诊断成像的纳米颗粒组合物
公开(公告)号：US20140056821A1
公开(公告)日：2014-02-27
申请号：US13592897
申请日：2012-08-23
申请人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Andrew Soliz Torres
发明人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Andrew Soliz Torres
IPC分类号： A61K49/04 , C07F5/00 , C07F7/18 , B82Y5/00
CPC分类号： A61K49/0428 , B82Y5/00 , C07F7/1804 , Y10T428/2982
摘要： The present invention provides a trialkoxysilane having structure I wherein R1 is independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and X− represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.
摘要翻译：本发明提供具有结构I的三烷氧基硅烷，其中R 1在每次出现时独立地为C 1 -C 3烷基; R 3在每次出现时独立地为氢或C 1 -C 3烷基; R4是C1-C5脂族基团，C7-C12芳族基团或C5-C10脂环族基团; n为0,1,2或3; q为1,2或3; t为0,1或2; X-表示电荷平衡抗衡离子。三烷氧基硅烷可用于制备纳米颗粒诊断成像剂组合物。

6. 发明申请

US20130128713A1 REVERSE SATURABLE ABSORBTION SENSITIZERS FOR OPTICAL DATA STORAGE MEDIA AND METHODS FOR USE 失效
标题翻译：用于光数据存储介质的反向可吸收吸收敏感元件及其使用方法
公开(公告)号：US20130128713A1
公开(公告)日：2013-05-23
申请号：US13299029
申请日：2011-11-17
申请人： Arunkumar Natarajan , Patrick Joseph McCloskey , Kwok Pong Chan , Evgenia Mikhailovna Kim , Robert Edgar Colborn , Eugene Pauling Boden
发明人： Arunkumar Natarajan , Patrick Joseph McCloskey , Kwok Pong Chan , Evgenia Mikhailovna Kim , Robert Edgar Colborn , Eugene Pauling Boden
IPC分类号： G11B7/241 , G11B7/0065 , C07F5/02 , G03F7/027 , C07F19/00
CPC分类号： G11B7/245 , G11B7/246
摘要： The invention relates generally to optical data storage media, and more specifically, to holographic storage media. In one embodiment, an optical storage medium composition includes a polymer matrix. Disposed within the polymer matrix is a reactant capable of undergoing a modification that alters the refractive index of the composition upon receiving an energy transfer from an excited sensitizer. A non-linear sensitizer is also disposed within the polymer matrix, and the sensitizer includes a metal-substituted subphthalocyanine (M-sub-PC) reverse saturable absorber configured to become excited upon exposure to light beyond an intensity threshold at approximately 405 nm and configured to transfer energy to the reactant.
摘要翻译：本发明一般涉及光学数据存储介质，更具体地说涉及全息存储介质。在一个实施方案中，光学存储介质组合物包括聚合物基质。在聚合物基质内设置的是能够经受改变的反应物，其在接受来自激发的敏化剂的能量转移时改变组合物的折射率。非线性敏化剂也设置在聚合物基质内，敏化剂包括金属取代的亚酞菁（M-sub-PC）反向可饱和吸收体，其被配置成在暴露于大约405nm处的强度阈值以上的光时被激发并配置以将能量转移到反应物。

7. 发明申请

US20120093703A1 CATALYST AND METHOD OF MANUFACTURE 审中-公开
标题翻译：催化剂及其制造方法
公开(公告)号：US20120093703A1
公开(公告)日：2012-04-19
申请号：US12903908
申请日：2010-10-13
申请人： Larry Neil Lewis , Robert Edgar Colborn , Ashish Balkrishna Mhadeshwar , Dan Hancu
发明人： Larry Neil Lewis , Robert Edgar Colborn , Ashish Balkrishna Mhadeshwar , Dan Hancu
IPC分类号： B01D53/56 , B01J23/50 , B01J23/52 , B01J23/44 , B01J23/75 , B01J23/755 , B01J23/745 , B01J23/08 , B01J23/22 , B01J21/06 , B01J23/06 , B01J23/14 , B01J23/28 , B01J23/30 , B01J23/42 , B01D53/94 , B01J35/02
CPC分类号： B01J23/50 , B01D53/9418 , B01D2251/208 , B01D2255/104 , B01J35/10 , B01J37/03
摘要： A catalyst composition includes a catalytic metal secured to a porous substrate. The substrate has pores that are templated. The catalyst composition is prepared by a process that includes the steps of mixing a catalytic metal salt, a templating agent, and water to form a mixture, adding a substrate precursor to the mixture to form a slurry, and calcining the slurry to form a substrate having a porous template that is capable of supporting the catalyst composition.
摘要翻译：催化剂组合物包括固定到多孔基材上的催化金属。底物具有模板的孔。催化剂组合物通过包括以下步骤的方法制备，所述方法包括将催化金属盐，模板剂和水混合以形成混合物，向混合物中加入底物前体以形成浆料，并煅烧该浆料以形成底物具有能够支撑催化剂组合物的多孔模板。

8. 发明申请

US20100278748A1 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
公开(公告)号：US20100278748A1
公开(公告)日：2010-11-04
申请号：US12431892
申请日：2009-04-29
申请人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
IPC分类号： A61K49/18 , A61K49/06
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.

9. 发明授权

US07790292B2 Polysiloxane copolymers, thermoplastic composition, and articles formed therefrom 有权
标题翻译：聚硅氧烷共聚物，热塑性组合物和由其形成的制品
公开(公告)号：US07790292B2
公开(公告)日：2010-09-07
申请号：US11537154
申请日：2006-09-29
申请人： Robert Edgar Colborn , Gary C. Davis , Jianbo Di , Constantin Donea , Irene Dris , Katherine Lee Jackson , Brian D. Mullen , Laura G. Schultz , Moitreyee Sinha , Paul D. Sybert
发明人： Robert Edgar Colborn , Gary C. Davis , Jianbo Di , Constantin Donea , Irene Dris , Katherine Lee Jackson , Brian D. Mullen , Laura G. Schultz , Moitreyee Sinha , Paul D. Sybert
IPC分类号： C08G77/14
CPC分类号： C08G63/64 , B64C1/1492 , C08G63/19 , C08G63/605 , C08G63/6956 , C08L83/10 , Y10T428/31663
摘要： A polysiloxane copolymer composition comprises: a polysiloxane unit comprising 4 to 50 siloxane units, and a polyester-polycarbonate unit consisting of 50 to 100 mole percent of arylate ester units, less than 50 mole percent aromatic carbonate units, less than 30 mole percent resorcinol carbonate units, and less than 35 mole percent bisphenol carbonate units, wherein the siloxane units are present in the polysiloxane unit in an amount of 0.2 to 10 wt % of the total weight of the polysiloxane copolymer composition, and wherein the polysiloxane copolymer composition has a 2 minute integrated heat release rate of less than or equal to 65 kilowatt-minutes per square meter (kW-min/m2) and a peak heat release rate of less than 65 kilowatts per square meter (kW/m2) as measured using the method of FAR F25.4, in accordance with Federal Aviation Regulation FAR 25.853 (d). A window article for an aircraft, comprising the polysiloxane copolymer composition, is also disclosed.
摘要翻译：聚硅氧烷共聚物组合物包括：包含4至50个硅氧烷单元的聚硅氧烷单元和由50至100摩尔％的芳基酯单元，小于50摩尔％的芳族碳酸酯单元，小于30摩尔％的间苯二酚碳酸酯组成的聚酯 - 聚碳酸酯单元单体和小于35摩尔％的双酚碳酸酯单元，其中硅氧烷单元以聚硅氧烷共聚物组合物总重量的0.2-10重量％的量存在于聚硅氧烷单元中，并且其中聚硅氧烷共聚物组合物具有2 小于或等于65千瓦分/平方米（kW-min / m2）的小时集成放热速率和小于65千瓦/平方米（kW / m 2）的峰值放热率，使用 FAR F25.4，根据联邦航空条例FAR 25.853（d）。还公开了一种包含聚硅氧烷共聚物组合物的飞机用窗构件。

10. 发明申请

US20100166664A1 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
公开(公告)号：US20100166664A1
公开(公告)日：2010-07-01
申请号：US12344604
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
IPC分类号： A61K49/18 , A61K49/04 , B82B1/00 , B82B3/00
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.

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