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1. 发明授权

US09549974B2 Method for selecting and producing vaccine components and vaccines based thereon 有权
标题翻译：基于此选择和制备疫苗组分和疫苗的方法
公开(公告)号：US09549974B2
公开(公告)日：2017-01-24
申请号：US13397354
申请日：2012-02-15
申请人： Cornelis Johannes Leenhouts , Ronald de Groot , Peter Wilhelmus Maria Hermans
发明人： Cornelis Johannes Leenhouts , Ronald de Groot , Peter Wilhelmus Maria Hermans
IPC分类号： A61K51/00 , A61K39/09 , C07K16/12 , G01N33/569 , A61K39/00
CPC分类号： A61K39/092 , A61K2039/505 , C07K16/1275 , G01N33/56911 , Y02A50/47
摘要： The invention relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccines. More in particular, the invention relates to means and methods to identify, select and isolate a vaccine component for passive and/or active immunization against a microorganism that can be killed by opsonophagocytic cells. The invention relates to a method to identify an opsonophagocytosis inducing antigen as a vaccine component for immunization against a microorganism. The invention describes three pneumococcal proteins SlrA, IgA1 proteinase, and PsaA, and their use as a vaccine component with or without PpmA. The invention also discloses the use of antibodies against said proteins for passive immunization and diagnosis.
摘要翻译：本发明涉及针对微生物感染的疫苗领域，特别是涉及肺炎球菌疫苗的疫苗领域。更具体地，本发明涉及鉴定，选择和分离针对可被调理吞噬细胞杀死的微生物的被动和/或主动免疫的疫苗组分的方法和方法。本发明涉及一种鉴定诱导免疫细胞因子的抗原作为免疫微生物的疫苗组分的方法。本发明描述了三种肺炎球菌蛋白质SlrA，IgA1蛋白酶和PsaA，以及它们作为具有或不具有PpmA的疫苗组分的用途。本发明还公开了使用针对所述蛋白质的抗体进行被动免疫和诊断。

2. 发明申请

US20070082003A1 Method for selecting and producing vaccine components and vaccines based thereon 有权
标题翻译：基于此选择和制备疫苗组分和疫苗的方法
公开(公告)号：US20070082003A1
公开(公告)日：2007-04-12
申请号：US10556733
申请日：2004-05-17
申请人： Cornelis Leenhouts , Ronald de Groot , Peter Hermans
发明人： Cornelis Leenhouts , Ronald de Groot , Peter Hermans
IPC分类号： A61K39/40 , A61K39/02 , G06F19/00 , C07K16/12
CPC分类号： A61K39/092 , A61K2039/505 , C07K16/1275 , G01N33/56911 , Y02A50/47
摘要： The invention relates to the field of biology, more specifically to the field of immunology and microbiology. The invention further relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccines. More in particular, the invention relates to means and methods to identify, select and isolate a vaccine component for passive and/or active immunisation against a microorganism that can be killed by opsonophagocytic cells. The invention relates to a method to identify an opsonophagocytosis inducing antigen as a vaccine component for immunisation against a microorganism. The invention describes three pneumococcal proteins SlrA, IgAl proteinase, and PsaA, and their use as a vaccine component with or without PpmA. The invention also discloses the use of antibodies against said proteins for passive immunization and diagnosis.
摘要翻译：本发明涉及生物学领域，更具体涉及免疫学和微生物学领域。本发明还涉及针对微生物感染的疫苗领域，特别是细菌疫苗领域，特别是肺炎球菌疫苗领域。更具体地，本发明涉及鉴定，选择和分离针对可被调理吞噬细胞杀死的微生物的被动和/或主动免疫的疫苗组分的方法和方法。本发明涉及一种鉴定诱导免疫细胞因子的抗原作为免疫微生物的疫苗组分的方法。本发明描述了三种肺炎球菌蛋白SlrA，IgA1蛋白酶和PsaA，以及它们作为具有或不具有PpmA的疫苗组分的用途。本发明还公开了使用针对所述蛋白质的抗体进行被动免疫和诊断。

3. 发明授权

US08142789B2 Method for selecting and producing vaccine components and vaccines based thereon 有权
标题翻译：基于此选择和制备疫苗组分和疫苗的方法
公开(公告)号：US08142789B2
公开(公告)日：2012-03-27
申请号：US10556733
申请日：2004-05-17
申请人： Cornelis Johannes Leenhouts , Ronald de Groot , Peter Wilhelmus Maria Hermans
发明人： Cornelis Johannes Leenhouts , Ronald de Groot , Peter Wilhelmus Maria Hermans
IPC分类号： A61K39/02
CPC分类号： A61K39/092 , A61K2039/505 , C07K16/1275 , G01N33/56911 , Y02A50/47
摘要： The invention relates to the field of biology, more specifically to the field of immunology and microbiology. The invention further relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccines. More in particular, the invention relates to means and methods to identify, select and isolate a vaccine component for passive and/or active immunisation against a microorganism that can be killed by opsonophagocytic cells. The invention relates to a method to identify an opsonophagocytosis inducing antigen as a vaccine component for immunisation against a microorganism. The invention describes three pneumococcal proteins SlrA, IgAl proteinase, and PsaA, and their use as a vaccine component with or without PpmA. The invention also discloses the use of antibodies against said proteins for passive immunization and diagnosis.
摘要翻译：本发明涉及生物学领域，更具体涉及免疫学和微生物学领域。本发明还涉及针对微生物感染的疫苗领域，特别是细菌疫苗领域，特别是肺炎球菌疫苗领域。更具体地，本发明涉及鉴定，选择和分离针对可被调理吞噬细胞杀死的微生物的被动和/或主动免疫的疫苗组分的方法和方法。本发明涉及一种鉴定诱导免疫细胞因子的抗原作为免疫微生物的疫苗组分的方法。本发明描述了三种肺炎球菌蛋白SlrA，IgA1蛋白酶和PsaA，以及它们作为具有或不具有PpmA的疫苗组分的用途。本发明还公开了使用针对所述蛋白质的抗体进行被动免疫和诊断。

4. 发明申请

US20120301501A1 METHOD FOR SELECTING AND PRODUCING VACCINE COMPONENTS AND VACCINES BASED THEREON 有权
标题翻译：选择和生产疫苗组分和疫苗的方法
公开(公告)号：US20120301501A1
公开(公告)日：2012-11-29
申请号：US13397354
申请日：2012-02-15
申请人： Cornelis Johannes Leenhouts , Ronald de Groot , Peter Wilhelmus Maria Hermans
发明人： Cornelis Johannes Leenhouts , Ronald de Groot , Peter Wilhelmus Maria Hermans
IPC分类号： A61K39/09 , A61P37/04 , A61P31/04 , A61K39/385
CPC分类号： A61K39/092 , A61K2039/505 , C07K16/1275 , G01N33/56911 , Y02A50/47
摘要： The invention relates to the field of biology, more specifically to the field of immunology and microbiology. The invention further relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccines. More in particular, the invention relates to means and methods to identify, select and isolate a vaccine component for passive and/or active immunisation against a microorganism that can be killed by opsonophagocytic cells. The invention relates to a method to identify an opsonophagocytosis inducing antigen as a vaccine component for immunisation against a microorganism. The invention describes three pneumococcal proteins SlrA, IgA1 proteinase, and PsaA, and their use as a vaccine component with or without PpmA. The invention also discloses the use of antibodies against said proteins for passive immunization and diagnosis.
摘要翻译：本发明涉及生物学领域，更具体涉及免疫学和微生物学领域。本发明还涉及针对微生物感染的疫苗领域，特别是细菌疫苗领域，特别是肺炎球菌疫苗领域。更具体地，本发明涉及鉴定，选择和分离针对可被调理吞噬细胞杀死的微生物的被动和/或主动免疫的疫苗组分的方法和方法。本发明涉及一种鉴定诱导免疫细胞因子的抗原作为免疫微生物的疫苗组分的方法。本发明描述了三种肺炎球菌蛋白质SlrA，IgA1蛋白酶和PsaA，以及它们作为具有或不具有PpmA的疫苗组分的用途。本发明还公开了使用针对所述蛋白质的抗体进行被动免疫和诊断。

5. 发明授权

US07337657B2 Pressure glow plug for a diesel engine 有权
标题翻译：用于柴油发动机的压力电热塞
公开(公告)号：US07337657B2
公开(公告)日：2008-03-04
申请号：US10944403
申请日：2004-09-20
申请人： Michael Haussner , Ulf Wyrwich , Hans Houben , Frank Pechhold , Heinz-Georg Schmitz , Dirk Von Hacht , Marc Gerard Johan Borgers , Albert Ferdinand Zwijze , Paulus Thomas Johannes Gennissen , Ronald De Groot , Arie-Jan Koelling
发明人： Michael Haussner , Ulf Wyrwich , Hans Houben , Frank Pechhold , Heinz-Georg Schmitz , Dirk Von Hacht , Marc Gerard Johan Borgers , Albert Ferdinand Zwijze , Paulus Thomas Johannes Gennissen , Ronald De Groot , Arie-Jan Koelling
IPC分类号： G01M15/00
CPC分类号： F23Q7/001 , F02P19/028 , F23Q2007/002
摘要： A pressure glow plug for a diesel engine has a glow plug body 2 for being inserted into a cylinder of the diesel engine, a heating rod 1 that is arranged in the glow plug body 2 and a pressure sensor 9 that is arranged between the heating rod 1 and the glow plug body 2 in such a way that the pressure in the combustion chamber of the cylinder that is transmitted by the heating rod 1 influences the pressure sensor 9. The heating rod 1 is arranged in the glow plug body 2 such that it can be displaced in an axially sliding fashion, namely by a corresponding sliding element, for example, a membrane 7 or seals 3.
摘要翻译：用于柴油发动机的压力预热塞具有用于插入柴油发动机的气缸中的电热塞主体2，布置在电热塞主体2中的加热棒1和布置在加热棒之间的压力传感器9 1和电热塞主体2，使得由加热棒1传递的气缸的燃烧室中的压力影响压力传感器9。加热棒1布置在电热塞主体2中，使得其可以以轴向滑动的方式移动，即通过相应的滑动元件，例如膜7或密封件3。

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