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1. 发明申请

US20130073571A1 Method And System For Extraction And Normalization Of Relationships Via Ontology Induction 有权
标题翻译：通过本体感应的关系提取和归一化的方法和系统
公开(公告)号：US20130073571A1
公开(公告)日：2013-03-21
申请号：US13481808
申请日：2012-05-26
申请人： Adrien Coulet , Nigam H. Shah , Yael Garten , Mark Musen , Russ B. Altman
发明人： Adrien Coulet , Nigam H. Shah , Yael Garten , Mark Musen , Russ B. Altman
IPC分类号： G06F17/30
CPC分类号： G06F17/2785 , G06F19/28
摘要： Methods for developing an ontology of pharmacogenomics (PGx) relationships starting from a lexicon of key pharmacogenomic entities and a syntactic parse is described. The syntactic structure of PGx statements is used to systematically extract commonly occurring relationships and to map them to a common schema. In an embodiment, extracted relationships have a 70-87.7% precision and involve not only key PGx entities such as genes, drugs, and phenotypes (e.g., VKORCl, warfarin, clotting disorder), but also critical entities that are frequently modified by these key entities (e.g., VKORCl polymorphism, warfarin response, clotting disorder treatment).
摘要翻译：描述从关键药物基因组实体和语法分析的词典开始开发药物基因组学（PGx）关系本体的方法。 PGx语句的句法结构用于系统地提取常见的关系，并将其映射到共同的模式。在一个实施方案中，提取的关系具有70-87.7％的精度，并且不仅涉及诸如基因，药物和表型（例如，VKORCl，华法林，凝血障碍）的关键PGx实体，而且还涉及经由这些密钥经常修饰的关键实体实体（例如，VKORC1多态性，华法林反应，凝血障碍治疗）。

2. 发明授权

US06178416B1 Method and apparatus for knowledgebase searching 失效
公开(公告)号：US06178416B1
公开(公告)日：2001-01-23
申请号：US09097849
申请日：1998-06-15
申请人： Kathleen A. Thompson , Russ B. Altman , Oliver M. Duschka
发明人： Kathleen A. Thompson , Russ B. Altman , Oliver M. Duschka
IPC分类号： G06F1730
CPC分类号： G06F17/30398 , G06F17/30395 , Y10S707/99933 , Y10S707/99934 , Y10S707/99935
摘要： A library of query templates and a dictionary that relates keywords to more abstract concepts are first prepared on a computer system. Each template contains one or more typed variables. A query is then generated by entering into the system one or more keywords. Each keyword is abstracted to a concept. Advantageously, each concept may be further refined, for example, by additional abstraction, or by picking one concept from several candidates, or by successive abstraction and rejection of different keywords until an acceptable concept is found. Next, for the concepts that are obtained, the system finds all query templates are then instantiated with those concepts or with the keywords used to form the concepts. The user then selects the most appropriate query from among the instantiated query templates. The invention may be practiced in formulating queries to access any set of information sources. It is particularly useful to use the invention to access distributed, heterogeneous databases which do not have a single standardized vocabulary or structure.

3. 发明授权

US10025774B2 Method and system for extraction and normalization of relationships via ontology induction 有权
公开(公告)号：US10025774B2
公开(公告)日：2018-07-17
申请号：US13481808
申请日：2012-05-26
申请人： Adrien Coulet , Nigam H. Shah , Yael Garten , Mark Musen , Russ B. Altman
发明人： Adrien Coulet , Nigam H. Shah , Yael Garten , Mark Musen , Russ B. Altman
IPC分类号： G06F7/00 , G06F17/27 , G06F19/28
摘要： Methods for developing an ontology of pharmacogenomics (PGx) relationships starting from a lexicon of key pharmacogenomic entities and a syntactic parse is described. The syntactic structure of PGx statements is used to systematically extract commonly occurring relationships and to map them to a common schema. In an embodiment, extracted relationships have a 70-87.7% precision and involve not only key PGx entities such as genes, drugs, and phenotypes (e.g., VKORC1, warfarin, clotting disorder), but also critical entities that are frequently modified by these key entities (e.g., VKORC1 polymorphism, warfarin response, clotting disorder treatment).

4. 发明授权

US6052730A Method for monitoring and/or modifying web browsing sessions 失效
标题翻译：用于监视和/或修改网络浏览会话的方法
公开(公告)号：US6052730A
公开(公告)日：2000-04-18
申请号：US4584
申请日：1998-01-09
申请人： Ramon M. Felciano , Russ B. Altman
发明人： Ramon M. Felciano , Russ B. Altman
IPC分类号： G06F11/34 , H04L29/06 , H04L29/08 , G06F15/173
CPC分类号： G06F11/3476 , G06F11/3495 , H04L29/06 , H04L67/02 , H04L67/20 , H04L67/22 , H04L67/2804 , H04L67/2814 , G06F11/3438 , G06F2201/875 , H04L69/329
摘要： A method for transparently monitoring and/or modifying web browsing activities over an entire computer network does not require modification of client software and can be implemented on a single server. By rerouting HTTP requests through a centralized gateway server, the sequence and timing of URLs accessed by individual clients are recorded, providing the full information required to recreate a user session. The client HTTP requests are rerouted through the gateway server by modifying URLs within HTML documents. For each document sent to the client, any original URL which points to another server is modified so that it points to a CGI script program on the gateway. The gateway server then fetches the requested document from the other server, modifies the URLs within the document, and passes it on to the client. Thus, subsequent requests from the client will automatically be directed through the gateway server. The method permits tracking individual web sessions and provides valuable information about user behavior. This information can be used for general purpose evaluation of web-based user interfaces to information systems. The technique can also be used to modify a browsing experience by layering or stripping hypertext content or functionality.
摘要翻译：通过整个计算机网络透明地监控和/或修改网络浏览活动的方法不需要修改客户端软件，并且可以在单个服务器上实现。通过通过集中式网关服务器重新路由HTTP请求，记录各个客户端访问的URL的顺序和时间，提供重新创建用户会话所需的完整信息。通过修改HTML文档中的URL，通过网关服务器重新路由客户端HTTP请求。对于发送到客户端的每个文档，指向另一个服务器的任何原始URL被修改，以便它指向网关上的CGI脚本程序。然后，网关服务器从其他服务器获取所请求的文档，修改文档中的URL，并将其传递给客户端。因此，客户端的后续请求将自动通过网关服务器。该方法允许跟踪单个Web会话并提供有关用户行为的有价值的信息。该信息可用于对信息系统的基于Web的用户界面的通用评估。该技术还可以用于通过分层或剥离超文本内容或功能来修改浏览体验。

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