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1. 发明申请

US20110022108A1 SYSTEM AND METHOD OF AV INTERVAL SELECTION IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：可移植医疗设备中AV间隔选择的系统和方法
公开(公告)号：US20110022108A1
公开(公告)日：2011-01-27
申请号：US12848769
申请日：2010-08-02
申请人： Raul Chirife , William J. Combs , Russell L. Lundstrom
发明人： Raul Chirife , William J. Combs , Russell L. Lundstrom
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/365
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.
摘要翻译：可植入医疗装置提供心室起搏功能并优化AV间隔用于多种目的。通常，通过确定何时机电收缩（EMS）结束并相应地设置AV间隔来促进固有传导。使用包括QT间隔，传感器输入和算法计算的各种数据来确定EMS。

2. 发明申请

US20100222840A1 SYSTEM AND METHOD OF AV INTERVAL SELECTION IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：可移植医疗设备中AV间隔选择的系统和方法
公开(公告)号：US20100222840A1
公开(公告)日：2010-09-02
申请号：US12716038
申请日：2010-03-02
申请人： Raul Chirife , William J. Combs , Russell L. Lundstrom
发明人： Raul Chirife , William J. Combs , Russell L. Lundstrom
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/365
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.
摘要翻译：可植入医疗装置提供心室起搏功能并优化AV间隔用于多种目的。通常，通过确定何时机电收缩（EMS）结束并相应地设置AV间隔来促进固有传导。使用包括QT间隔，传感器输入和算法计算的各种数据来确定EMS。

3. 发明授权

US08332031B2 System and method of AV interval selection in an implantable medical device 有权
公开(公告)号：US08332031B2
公开(公告)日：2012-12-11
申请号：US12848769
申请日：2010-08-02
申请人： Raul Chirife , William J Combs , Russell L. Lundstrom
发明人： Raul Chirife , William J Combs , Russell L. Lundstrom
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/365
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.

4. 发明授权

US08200333B2 System and method of AV interval selection in an implantable medical device 有权
标题翻译：植入式医疗设备中AV间隔选择的系统和方法
公开(公告)号：US08200333B2
公开(公告)日：2012-06-12
申请号：US12716038
申请日：2010-03-02
申请人： Raul Chirife , William J. Combs , Russell L. Lundstrom
发明人： Raul Chirife , William J. Combs , Russell L. Lundstrom
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/365
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.
摘要翻译：可植入医疗装置提供心室起搏功能并优化AV间隔用于多种目的。通常，通过确定何时机电收缩（EMS）结束并相应地设置AV间隔来促进固有传导。使用包括QT间隔，传感器输入和算法计算的各种数据来确定EMS。

5. 发明授权

US5213098A Post-extrasystolic potentiation stimulation with physiologic sensor feedback 失效
标题翻译：用生理传感器反馈进行后外切电位刺激
公开(公告)号：US5213098A
公开(公告)日：1993-05-25
申请号：US736198
申请日：1991-07-26
申请人： Tom D. Bennett , Russell L. Lundstrom, Jr. , Paul M. Stein
发明人： Tom D. Bennett , Russell L. Lundstrom, Jr. , Paul M. Stein
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/3622 , A61N1/3627
摘要： A post-extrasystolic potentiation (PESP) cardiac pacing energy stimulator for applying paired and/or triggered pacing stimulation pulses to the right atrium and/or ventricle incorporating one or more sensors, such as a venous oxygen saturation, ventricular, atrial, or arterial blood pressure, or intracardiac or systemic blood flow sensor, and signal processing circuitry for controlling the frequency of or number of heart cycles between periodic delivery of triggered or paired pacing to induce PESP for the treatment of congestive heart failure or other cardiac dysfunctions. Preferably, a first sensor, e.g., a ventricular or arterial blood pressure or flow sensor, is employed to monitor the performance of the heart, and develop a cardiac performance index (CPI) and a second sensor, e.g., an oxygen saturation sensor positioned in the coronary sinus, is employed to monitor cardiac muscle stress and develop a cardiac stress index (CSI) to balance performance and stress. The PESP stimulator may be incorporated into a dual chamber (DDD) pacing system with or without physiologic rate control and with or without backup cardioversion/defibrillation therapy capabilities or in a separate, single purpose device. The PESP stimulator has particular application in atrial stimulation for augmenting filling of the ventricles.
摘要翻译：一种收缩后增生（PESP）心脏起搏能量刺激器，用于将配对和/或触发的起搏刺激脉冲施加到合并一个或多个传感器的右心房和/或心室，例如静脉血氧饱和度，心室，心房或动脉血压力或心脏内或全身血流传感器，以及信号处理电路，用于控制周期性递送触发或配对起搏以诱导PESP治疗充血性心力衰竭或其他心脏功能障碍的心脏周期的频率或数量。优选地，使用第一传感器，例如心室或动脉血压或流量传感器来监测心脏的性能，并且开发心脏性能指数（CPI）和第二传感器，例如位于冠状动脉窦，用于监测心肌应力，并开发心脏应激指数（CSI）以平衡性能和压力。 PESP刺激器可以并入具有或不具有生理速率控制的双室（DDD）起搏系统，并且具有或不具有备用心脏复律/除颤治疗能力或在单独的单用途装置中。 PESP刺激器在心房刺激中具有特别的应用，用于增加心室的填充。

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