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1. 发明申请

US20230138844A1 SYSTEMS FOR SUPPRESSION OF BALLISTOCARDIOGRAM ARTIFACTS IN ELECTROENCEPHALOGRAPHY SIGNALS VIA DYNAMIC HEARTBEAT MODELING 有权
公开(公告)号：US20230138844A1
公开(公告)日：2023-05-04
申请号：US17700694
申请日：2022-03-22
申请人： SUNNYBROOK RESEARCH INSTITUTE
发明人： FA-HSUAN LIN
IPC分类号： A61B5/00 , A61B5/369 , A61B5/291 , A61B5/346
摘要： Systems are provided that employ dynamic modeling of heartbeats to process electroencephalography (EEG) signals for the suppression of BCG artifacts. The system may be configured to generate an instantaneous EEG correction for ballistocardiogram (BCG) artifact subtraction, the correction being modeled for a selected latency within a selected cardiac cycle. Cardiac cycles with similar EKG signals at the selected latency to that of the selected cardiac cycle are identified and the EEG signals from these similar cardiac cycles, at the selected latency, are employed to generate a modeled EEG signal that represents the instantaneous contribution from the BCG artifact. Accordingly, the system models BCG artifacts by pooling EEG signals at time instants with similar cardiac dynamics. The resulting modeled EEG signal is taken as the estimated BCG artifact and subtracted from the measured EEG signals to generate artifact-suppressed EEG signals.

2. 发明授权

US11589997B2 Systems and methods for surgical implant guidance and positioning with optical surface imaging 有权
公开(公告)号：US11589997B2
公开(公告)日：2023-02-28
申请号：US16562679
申请日：2019-09-06
申请人： Sunnybrook Research Institute
发明人： David M. Burns , Cari M. Whyne , Normand Robert
IPC分类号： A61B34/20 , A61F2/40 , A61B34/10 , A61F2/46 , A61B17/17 , A61B90/00
摘要： Described here are systems and methods for positioning a surgical implant, such as a glenoid component, or other medical device intra-operatively. In general, the systems and methods described in the present disclosure implement a computer vision system, which may be a structured light computer vision system, together with a suitable optical tracker as an accurate intra-operative tool for predicting post-operative implant position in surgical procedures.

3. 发明申请

US20220347432A1 MAGNETICALLY-TRACKED CATHETER AND METHOD FOR TRACKING A CATHETER 有权
公开(公告)号：US20220347432A1
公开(公告)日：2022-11-03
申请号：US17621197
申请日：2020-06-19
申请人： Sunnybrook Research Institute
发明人： Ananth RAVI , Mark SEMPLE , Alexandru NICOLAE , John DILLON
IPC分类号： A61M25/01 , A61B17/12 , A61B34/20
摘要： A magnetically-tracked catheter system having a catheter and a magnetic beacon. The catheter has a proximal end and a distal end. The catheter includes a first magnetic sensor disposed at (i.e., near) the distal end. The magnetic beacon is configured to be disposed external to an individual and in a target zone. An operator interface is in electronic communication with the first magnetic sensor. The catheter may further include a guide lumen (and/or other lumen or lumens) extending between the proximal end and the distal end and the configured for use with a guidewire. The catheter may include an occlusion member configured to occlude a vessel or other passage of an individual (e.g, respiratory tract, gastrointestinal tract, etc.).

4. 发明申请

US20220296382A1 Systems and Methods for Surgical Implant Guidance and Positioning with Optical Surface Imaging 有权
公开(公告)号：US20220296382A1
公开(公告)日：2022-09-22
申请号：US17832134
申请日：2022-06-03
申请人： Sunnybrook Research Institute
发明人： David M. Burns , Cari M. Whyne , Normand Robert
IPC分类号： A61F2/40 , A61B34/20 , A61B34/10 , A61F2/46 , A61B17/17
摘要： Described here are systems and methods for positioning a surgical implant, such as a glenoid component, or other medical device intra-operatively. In general, the systems and methods described in the present disclosure implement a computer vision system, which may be a structured light computer vision system, together with a suitable optical tracker as an accurate intra-operative tool for predicting post-operative implant position in surgical procedures.

5. 发明申请

US20220233890A1 SYSTEMS AND METHODS FOR REDUCING THERMAL SKULL-INDUCED ABERRATIONS DURING TRANSCRANIAL ULTRASOUND THERAPEUTIC PROCEDURES 有权
公开(公告)号：US20220233890A1
公开(公告)日：2022-07-28
申请号：US17613654
申请日：2020-05-28
申请人： SUNNYBROOK RESEARCH INSTITUTE
发明人： KULLERVO HYNYNEN , ALEC HUGHES , LULU DENG
IPC分类号： A61N7/02 , A61B6/03 , A61B6/00 , A61B8/08 , A61B8/00
摘要： Various example embodiments of the present disclosure provide systems and methods for the dynamic correction and reduction of thermal variations in skull-induced aberrations during a focused ultrasound therapy procedure. Unlike conventional approaches involving static corrections for skull-induced aberrations, various example embodiments of the present disclosure employ ultrasound detection and a skull thickness estimate from volumetric image data to intermittently and dynamically determine corrections for skull-induced aberrations, such that aberration correction reduction is updated intraoperatively and maintained despite local thermally-induced changes in the speed of sound of the local skull region due to intraoperative intracranial heating. Furthermore, in some example embodiments, a measure dependent on the speed of sound with the skull is intraoperatively determined and compared to a previously determined value of the measure to determine a change in the skull temperature, based on a pre-determined relationship between changes in the measure and changes in skull temperature.

6. 发明授权

US11361436B2 Systems and methods for metabolite topography of the brain with magnetic resonance imaging 有权
公开(公告)号：US11361436B2
公开(公告)日：2022-06-14
申请号：US16871699
申请日：2020-05-11
申请人： Sunnybrook Research Institute
发明人： Charles Cunningham
IPC分类号： G06K9/00 , G06T7/00 , G01R33/56 , G01R33/48 , G06T7/11 , A61B5/055 , A61B5/00 , A61B5/145
摘要： Metabolite profiles are generated from magnetic resonance images. These metabolite profiles indicate a topography of the metabolites in one or more anatomical regions. The magnetic resonance images can be metabolite images, such as those obtained using hyperpolarized 13C-MRI. The metabolite profiles can be generated by parcellating the magnetic resonance images into different regions, computing z-scores for those regions, and generating the metabolite profile based on the computed z-scores.

7. 发明申请

US20220133294A1 DEEP ORBITAL ACCESS RETRACTOR 有权
公开(公告)号：US20220133294A1
公开(公告)日：2022-05-05
申请号：US17429857
申请日：2020-02-11
申请人： SUNNYBROOK RESEARCH INSTITUTE
发明人： JEFFREY ALLAN FIALKOV , GLENN PATRICK EDWARDS
IPC分类号： A61B17/02
摘要： The present disclosure provides a deep orbital access retractor (DOAR) device which includes a manipulable body section including a compressible handle having a size and shape to be manipulated by at least two (2) digits of a clinician. A flexible head section having two (2) arms with each arm having a distal end and a proximal end, with the distal ends of the arms spaced apart forming a gap there-between at a distal tip section. A flexible flange material envelops and encloses the two arms and the gap and extends around a periphery of the flexible head section. A flexible diaphragm is attached to and extends between the two arms to provide a generally spoon-shaped flexible head section. The flexible head section is linked to the compressible handle section with the linkage being configured such that upon compression of the handle section the arms articulate with respect to each other thereby causing narrowing of the flexible head section to allow for insertion into the orbit and positioning between soft tissue and bone while the flexible diaphragm remains in sufficient tension to not obstruct the view of the operator into the orbit. When compression is released the flexible diaphragm develops sufficient tension and rigidity for applying sufficient force to retract the orbital contents of a patient to allow access to orbital walls.

8. 发明申请

US20220104709A1 SYSTEMS AND METHODS FOR PERFORMING FREQUENCY-DOMAIN PHOTOACOUSTIC IMAGING 有权
公开(公告)号：US20220104709A1
公开(公告)日：2022-04-07
申请号：US17418983
申请日：2019-12-20
申请人： SUNNYBROOK RESEARCH INSTITUTE , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人： ANDREAS MANDELIS , SUNG SOO CHOI , BAHMAN LASHKARI , BRIAN COURTNEY , STUART FOSTER
IPC分类号： A61B5/00
摘要： Systems and methods are disclosed that facilitate the reduction of both radio frequency (RF) noise and photoacoustic artefacts in differential photoacoustic radar imaging through a multi-step electrical and optical domain calibration method. An example two-step calibration method involves reducing RF image noise via an initial calibration step that involves the control of the relative amplitudes and phases of electrical driving modulation waveforms, while a second calibration step involves the differential suppression of photoacoustic artefact signals via tuning, in the optical domain, of the relative intensity the optical beams that are delivered to the sample. Another example embodiment involves the use of the standard deviation of the unwrapped phase that is obtained, after performing frequency-domain cross-correlation and an inverse transform to the time domain, to improve the amplitude signal that is employed to generate a differential photoacoustic radar image.

9. 发明授权

US11253727B2 Magnetic resonance visible markers for magnetic resonance imaging guided brachytherapy 有权
公开(公告)号：US11253727B2
公开(公告)日：2022-02-22
申请号：US16755973
申请日：2018-10-18
申请人： Sunnybrook Research Institute
发明人： Ananth Ravi , Moti Raj Paudel , Amir Owrangi , Harry Easton
IPC分类号： A61N5/10
摘要： Magnetic resonance (“MR”) visible markers for use in MR-guided placement of brachytherapy seeds, and for use in other MR-guided interventional procedures, are described. The MR-visible markers generally include a tube in which an absorbent thread assembly is disposed. The tube is made fluid-tight by sealing it at both ends with suitable end plugs. The absorbent thread assembly is soaked in a suitable MR-visible fluid.

10. 发明授权

US11049238B2 Systems and methods for prediction of tumor response to chemotherapy using pre-treatment quantitative ultrasound parameters 有权
公开(公告)号：US11049238B2
公开(公告)日：2021-06-29
申请号：US15739003
申请日：2016-06-21
申请人： Sunnybrook Research Institute
发明人： Hadi Tadayyon , Gregory J. Czarnota , Ali Sadeghi-Naini , Mehrdad Gangeh , Lakshmanan Sannachi , William Tyler Tran
IPC分类号： G06T7/00 , A61B8/08 , G16H50/20 , G16H20/10 , A61B8/14 , A61B8/00 , G06K9/62 , A61B5/00
摘要： Systems and methods for using quantitative ultrasound (“QUS”) techniques to generate imaging biomarkers that can be used to assess a prediction of tumor response to different chemotherapy treatment regimens are provided. For instance, the imaging biomarkers can be used to subtype tumors that have resistance to certain chemotherapy regimens prior to drug exposure. These imaging biomarkers can therefore be useful for predicting tumor response and for assessing the prognostic value of particular treatment regimens.

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