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1. 发明授权

US11280803B2 Slide management system 有权
公开(公告)号：US11280803B2
公开(公告)日：2022-03-22
申请号：US15359484
申请日：2016-11-22
申请人： Sakura Finetek U.S.A., Inc.
发明人： Erico Von Bueren , Ralf Van Den Berg
IPC分类号： G02B21/34 , H04N5/247 , G01N35/00 , G02B21/00 , G02B21/36 , G06T7/00
摘要： An apparatus including a first and a second imaging module; a storage module; an automated transport module operable to transport at least one slide; and a controller operable to direct transport of the at least one slide by the transport module into the first imaging module and into the second imaging module. A method and a machine-readable medium including program instructions to cause a controller to perform a method including transporting at least one slide to a first imaging module using an automated transport module; capturing by the first imaging module of an image of a specimen on the at least one slide; transporting the at least one slide to a storage module using the automated transport module; and transporting the at least one slide to a second imaging module in response to a request for capturing an image in addition to the image captured by the first imaging module.

2. 发明申请

US20200309800A1 SLIDE IDENTIFICATION SENSOR 审中-公开
公开(公告)号：US20200309800A1
公开(公告)日：2020-10-01
申请号：US16370879
申请日：2019-03-29
申请人： SAKURA FINETEK U.S.A., INC.
发明人： Erico von Bueren , Niccolo von Bueren , Xuan S. Bui
IPC分类号： G01N35/00 , G01N35/04
摘要： An apparatus including a receptacle including a slot for receiving a basket; a push bar disposed in the receptacle, the push bar having an end to contact an edge of a single slide of a plurality of slides in a basket, the push bar including a first position below a bottom surface of a base of a basket that is received in the slot and a second position in the slot; and a sensor focused in a direction of the slot operable to acquire information from a slide in a received basket. A method including placing a slide basket into a slot of a receptacle; individually raising one or more slides from a respective position in the basket; using a sensor, acquiring information from the raised slide in the basket; and after acquiring information, lowering the raised slide.

3. 发明授权

US10495867B2 Autofocus method and autofocus device 有权
公开(公告)号：US10495867B2
公开(公告)日：2019-12-03
申请号：US15092285
申请日：2016-04-06
申请人： Sakura Finetek U.S.A., Inc.
发明人： Paul Hing , Sven Hensler
IPC分类号： G02B21/36 , G02B21/08 , G02B21/18 , G02B7/09 , G02B21/24
CPC分类号： G02B21/365 , G02B7/09 , G02B21/08 , G02B21/18 , G02B21/247
摘要： The invention is based on an autofocus method in which light from a light source is focused at a measurement light focus in a sample and is reflected from there and the reflected light is guided through an optical system in two light paths onto at least two detector elements. In order to achieve fast and accurate automatic focusing on the sample, it is proposed that the measurement light focus is moved in layers of the sample which reflect light to different extents, and the detector elements are arranged in such a way that, in this case, profiles of a radiation property registered by the detector elements are different and a focus position is set in a manner dependent on the profiles.

4. 发明申请

US20180143214A1 SLIDE MANAGEMENT SYSTEM 审中-公开
公开(公告)号：US20180143214A1
公开(公告)日：2018-05-24
申请号：US15359484
申请日：2016-11-22
申请人： Sakura Finetek U.S.A., Inc.
发明人： Erico VON BUEREN , Ralf VAN DEN BERG
IPC分类号： G01N35/00 , H04N5/247 , G06T7/00 , G02B21/34 , G02B21/36 , G02B21/00
CPC分类号： G01N35/00029 , G01N35/00603 , G01N2035/00039 , G02B21/002 , G02B21/34 , G02B21/365 , G02B21/368 , G06T7/0012 , G06T2207/10056 , G06T2207/30024 , H04N5/247
摘要： An apparatus including a first and a second imaging module; a storage module; an automated transport module operable to transport at least one slide; and a controller operable to direct transport of the at least one slide by the transport module into the first imaging module and into the second imaging module. A method and a machine-readable medium including program instructions to cause a controller to perform a method including transporting at least one slide to a first imaging module using an automated transport module; capturing by the first imaging module of an image of a specimen on the at least one slide; transporting the at least one slide to a storage module using the automated transport module; and transporting the at least one slide to a second imaging module in response to a request for capturing an image in addition to the image captured by the first imaging module.

5. 发明申请

US20180136088A1 MICROTOME STORAGE ASSEMBLY 审中-公开
公开(公告)号：US20180136088A1
公开(公告)日：2018-05-17
申请号：US15811464
申请日：2017-11-13
申请人： Sakura Finetek U.S.A., Inc.
发明人： Xuan S. Bui , Alyicia Marie Rios , Erico Von Bueren
IPC分类号： G01N1/06
摘要： A microtome including a microtome housing having a base portion, a front portion and a top portion, a microtome storage member associated with the top portion of the microtome housing, and a sample sectioning assembly associated with the front portion of the microtome housing, the sample sectioning assembly operable to cut sections from a sample.

6. 发明授权

US09835529B2 Biological specimen handling apparatus and method 有权
公开(公告)号：US09835529B2
公开(公告)日：2017-12-05
申请号：US14189894
申请日：2014-02-25
申请人： SAKURA FINETEK U.S.A., INC.
发明人： James B. McCormick
IPC分类号： G01N1/36
CPC分类号： G01N1/36
摘要： In accordance with one aspect of the invention, a mold is provided for receiving a tissue specimen and molten embedding material that improves the ease of withdrawing the embedded tissue specimen. The mold has a barrier coating intimately bonded to one or more surfaces of the mold that repels the attraction of the embedding material to the one or more mold surfaces and produces a positive meniscus of the embedding material in the mold. The barrier coating permits the mold to be re-used without needing to manually re-apply a release agent to the mold before using the mold. Further, the barrier coating permits the use of more aggressive draft angles than conventional molds by reducing the frictional engagement between the embedding material and the mold cavity surfaces.

7. 发明申请

US20170191909A1 TISSUE PROCESSING REAGENT 审中-公开
公开(公告)号：US20170191909A1
公开(公告)日：2017-07-06
申请号：US15371588
申请日：2016-12-07
申请人： Sakura Finetek U.S.A., Inc.
发明人： Amit D. SHAH
IPC分类号： G01N1/36 , G01N1/30
CPC分类号： G01N1/36 , G01N1/30 , G01N2001/305 , G01N2001/364
摘要： A method including placing a biological sample taken from a body into a chamber; adding a composition including an acetal solvent to the chamber; and fixating the biological sample. A method including placing a tissue from a body into a chamber; and contacting the tissue with a composition including an acetal solvent as a fixating process.

8. 发明授权

US09573278B2 Integrated tissue processing and embedding systems, and methods thereof 有权
标题翻译：综合组织处理和嵌入系统及其方法
公开(公告)号：US09573278B2
公开(公告)日：2017-02-21
申请号：US14479990
申请日：2014-09-08
申请人： SAKURA FINETEK U.S.A., INC.
发明人： Gilles Lefebvre , Robert E. Evans
IPC分类号： B08B7/00 , B08B7/04 , B25J11/00 , G01N1/36 , G05B15/00 , G05B15/02
CPC分类号： B25J11/00 , B08B3/022 , B08B7/00 , B08B7/04 , G01N1/36 , G05B15/02 , Y10S901/02
摘要： Apparatus and methods for integrating tissue processors and embedding systems. An apparatus, of one aspect, includes a robot. The robot has a work envelope that encompasses a location having a tissue holder and an input of an embedding system. The tissue holder has at least one processed tissue. The robot is configured to transfer the tissue holder from the location to the input of the embedding system. A method, of one aspect, may include moving a robot to a location having a tissue holder. The tissue holder may have at least one processed tissue. The robot may engage with the tissue holder at the location. The robot may move the tissue holder from the location to an input to an embedding system. The robot may disengage from the tissue holder at the input to the embedding system. Other methods, apparatus, and systems are also disclosed.
摘要翻译：用于整合组织处理器和嵌入系统的装置和方法。一方面，一种装置包括机器人。机器人具有包括具有组织保持器和嵌入系统的输入的位置的工作信封。组织保持器具有至少一个处理过的组织。机器人被配置为将组织保持器从位置传送到嵌入系统的输入。一个方面的方法可以包括将机器人移动到具有纸巾支架的位置。组织保持器可以具有至少一个处理过的组织。机器人可以在位置处与组织保持器接合。机器人可以将组织保持器从位置移动到输入到嵌入系统。机器人可以在嵌入系统的输入处从组织保持器脱离。还公开了其它方法，装置和系统。

9. 发明申请

US20160109337A1 METHOD AND SYSTEM FOR INDICATING TIME ON A REAGENT CONTAINER 审中-公开
标题翻译：用于在试剂容器上显示时间的方法和系统
公开(公告)号：US20160109337A1
公开(公告)日：2016-04-21
申请号：US14518793
申请日：2014-10-20
申请人： Sakura Finetek U.S.A., Inc.
发明人： Wouter Valkenier , Robert Heijmen , Ralf van den Berg
IPC分类号： G01N1/30 , G01N1/31
CPC分类号： G01N1/31 , G01N31/22 , G01N35/00732 , G01N2035/00811
摘要： An apparatus, system and method for monitoring fixation of a biological sample within a container. The apparatus system or method including a container having a fixation medium for fixation of a biological sample placed within the container and a label attached to the container, the label having a time indicator operable to automatically indicate a processing time of a biological sample placed within the fixation medium.
摘要翻译：用于监测生物样品在容器内的固定的装置，系统和方法。所述装置系统或方法包括具有用于固定放置在所述容器内的生物样品的固定介质的容器和附接到所述容器的标签，所述标签具有可自动指示放置在所述容器内的生物样品的处理时间的时间指示器固定介质。

10. 发明申请

US20150111202A1 AUTOMATED STAINING SYSTEM AND REACTION CHAMBER 审中-公开
标题翻译：自动染色系统和反应室
公开(公告)号：US20150111202A1
公开(公告)日：2015-04-23
申请号：US14579858
申请日：2014-12-22
申请人： Sakura Finetek U.S.A., Inc.
发明人： Xuan S. Bui , Anthony L. Hartman , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
IPC分类号： G01N1/31 , G01N35/00 , G01N35/02
CPC分类号： G01N1/31 , B01L3/502715 , B01L9/52 , B01L2300/0822 , B01L2300/0877 , B01L2400/0409 , B01L2400/0478 , G01N35/00732 , G01N35/02 , G01N2035/00752 , G01N2035/00831 , G01N2035/00851 , Y10T436/11 , Y10T436/112499
摘要： An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations. A method including determining an inventory of an automated sample processing system, downloading a processing protocol from a central controller to the automated sample processing system, operating the automated sample processing system based on the processing protocol and independently of the central controller and dispensing a reagent from the automated sample processing system.
摘要翻译：一种包括试剂盒和反应室的装置，所述试剂盒具有可移除地定位在其中的试剂盒，用于将试剂分配到反应室上。一种包括线性平移安装组件的系统，其具有多个安装台，其尺寸被设计成容纳至少一个流体分配筒，线性可平移体积试剂分配组件，其具有耦合到其上的多个散装试剂分配喷嘴和位于安装组件下方的接收组件和批量试剂分配组件，所述接收组件包括多个反应站。一种方法，包括确定自动化样品处理系统的清单，将处理协议从中央控制器下载到自动化样品处理系统，基于处理协议操作自动化样品处理系统，并且独立于中央控制器并将试剂从自动化样品处理系统。

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