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1. 发明授权

US09111179B2 High-throughput biomarker segmentation utilizing hierarchical normalized cuts 有权
标题翻译：高通量生物标志物分割利用分级归一化切割
公开(公告)号：US09111179B2
公开(公告)日：2015-08-18
申请号：US13496627
申请日：2010-09-17
申请人： Andrew Janowczyk , Sharat Chandran , Anant Madabhushi
发明人： Andrew Janowczyk , Sharat Chandran , Anant Madabhushi
IPC分类号： G06K9/00 , G06K9/62 , G06T7/00
CPC分类号： G06K9/6224 , G06K9/0014 , G06T7/12 , G06T7/162 , G06T2207/10056 , G06T2207/20016 , G06T2207/30024 , G06T2207/30072
摘要： A method and apparatus for obtaining segmented images of the stained regions may comprise quantifying the extent of the presence of staining of a biomarker in an original image of a sample, which may comprise selecting a domain swatch of data based upon a user specified domain knowledge; clustering the data within the original image by conducting a frequency weighted mean shift of the data within the original image to convergence, forming a hierarchical plurality of layers each having a different data resolution to form a hierarchical data pyramid; segmenting the plurality of mean shifted data images to determine in each mean shifted data image within the hierarchical data pyramid data not excluded as outside of the swatch; mapping the data not excluded as outside the swatch spatially back to the original image to create a final image; and, storing the final image on a storage medium for further analysis.
摘要翻译：用于获得染色区域的分割图像的方法和装置可以包括量化样品原始图像中生物标志物染色存在的程度，其可以包括基于用户指定的领域知识来选择数据域域样本; 通过对原始图像内的数据进行频率加权平均偏移来收敛，从而对原始图像内的数据进行聚类，形成分层数层，每层具有不同的数据分辨率，形成分层数据金字塔; 分割多个平均偏移数据图像，以确定不被排除在样本外的分层数据金字塔数据内的每个平均偏移数据图像; 将没有排除的数据映射到样板外部空间回到原始图像以创建最终图像; 并将最终图像存储在存储介质上用于进一步分析。

2. 发明申请

US20100152594A1 NON-INVASIVE DEVICE NADI TARANGINI USEFUL FOR QUANTITAVE DETECTION OF ARTERIAL NADI PULSE WAVEFORM 审中-公开
标题翻译：非侵入性装置NADI TARANGINI有用于定量检测阿片样NADA脉冲波形
公开(公告)号：US20100152594A1
公开(公告)日：2010-06-17
申请号：US12733153
申请日：2008-08-07
申请人： Ashok Bhat , Aniruddha Joshi , Anand Kulkarni , Bhaskar Kulkarni , Valadi Jayaraman , Sharat Chandran
发明人： Ashok Bhat , Aniruddha Joshi , Anand Kulkarni , Bhaskar Kulkarni , Valadi Jayaraman , Sharat Chandran
IPC分类号： A61B5/0245
CPC分类号： A61B5/021 , A61B5/02116 , A61B5/4854 , A61B5/6824 , A61B5/6844 , A61B5/6886 , A61B5/7203 , A61B5/726 , A61B2560/045 , A61B2562/0247 , A61B2562/043 , A61B2562/046 , A61B2562/164
摘要： The present invention discloses the procedure for obtaining complete spectrum of the Nadi pulses, as a time series and capable of detecting the major types and the subtypes of the Nadi pulses. The device of this invention involves three diaphragm elements equipped with strain gauge, three transmitters cum amplifiers, and a digitizer for quantifying analog signal. The system acquires the data with 12-bit accuracy with practically no electronic and/or external interfering noise. The pertaining proofs are given which clearly shows the capability of delivering the accurate spectrums, with repeatability of the pulses from the invented system. ‘Nadi-Nidan’ is a prominent method in Ayurveda (Ayurveda is a Sanskrit word derived from ‘Ayus’ and ‘vid’, meaning life and knowledge respectively. It is a holistic science encompassing mental, physical and spiritual health), which is known to dictate all the salient features of a human body. Nadi-Nidan is a specialty of ‘Vaidyas’ (Ayurvedic physicians) and hence the present system would enable the diagnosis accurately, quantitatively and independent of any human errors.
摘要翻译：本发明公开了用于获得Nadi脉冲的完整光谱作为时间序列并且能够检测Nadi脉冲的主要类型和亚型的过程。本发明的装置包括配有应变计的三个隔膜元件，三个发射器和放大器以及用于量化模拟信号的数字化仪。系统以12位精度获取数据，几乎没有电子和/或外部干扰噪声。给出了相关证明，其清楚地显示了传递精确谱的能力，并且具有来自本发明系统的脉冲的可重复性。 “N adi an an an an known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known known 规定人体的所有显着特征。 Nadi-Nidan是“Vaidyas”（阿育吠陀医师）的专长，因此本系统能使诊断准确，定量和独立于任何人为错误。

3. 发明申请

US20120219206A1 High-Throughput Biomarker Segmentation Utilizing Hierarchical Normalized Cuts 有权
标题翻译：利用分层规范化切割的高通量生物标记分割
公开(公告)号：US20120219206A1
公开(公告)日：2012-08-30
申请号：US13496627
申请日：2010-09-17
申请人： Andrew Janowczyk , Sharat Chandran , Anant Madabhushi
发明人： Andrew Janowczyk , Sharat Chandran , Anant Madabhushi
IPC分类号： G06K9/62
CPC分类号： G06K9/6224 , G06K9/0014 , G06T7/12 , G06T7/162 , G06T2207/10056 , G06T2207/20016 , G06T2207/30024 , G06T2207/30072
摘要： A method and apparatus for obtaining segmented images of the stained regions may comprise quantifying the extent of the presence of staining of a biomarker in an original image of a sample, which may comprise selecting a domain swatch of data based upon a user specified domain knowledge; clustering the data within the original image by conducting a frequency weighted mean shift of the data within the original image to convergence, forming a hierarchical plurality of layers each having a different data resolution to form a hierarchical data pyramid; segmenting the plurality of mean shifted data images to determine in each mean shifted data image within the hierarchical data pyramid data not excluded as outside of the swatch; mapping the data not excluded as outside the swatch spatially back to the original image to create a final image; and, storing the final image on a storage medium for further analysis.
摘要翻译：用于获得染色区域的分割图像的方法和装置可以包括量化样品原始图像中生物标志物染色存在的程度，其可以包括基于用户指定的领域知识来选择数据域域样本; 通过对原始图像内的数据进行频率加权平均偏移来收敛，从而对原始图像内的数据进行聚类，形成分层数层，每层具有不同的数据分辨率，形成分层数据金字塔; 分割多个平均偏移数据图像，以确定不被排除在样本外的分层数据金字塔数据内的每个平均偏移数据图像; 将没有排除的数据映射到样板外部空间回到原始图像以创建最终图像; 并将最终图像存储在存储介质上用于进一步分析。

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