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1. 发明申请

US20110054185A1 PROCESS FOR PRODUCING THIAZOLE COMPOUND 有权
标题翻译：生产噻唑化合物的方法
公开(公告)号：US20110054185A1
公开(公告)日：2011-03-03
申请号：US11918004
申请日：2006-04-05
申请人： Kazuyuki Tanaka , Naoyuki Takano , Shinzo Seko
发明人： Kazuyuki Tanaka , Naoyuki Takano , Shinzo Seko
IPC分类号： C07D277/28
CPC分类号： C07D277/32 , C07D277/28 , C07D417/14
摘要： A process for producing a thiazole compound of the formula (3): wherein X1 is a hydrogen atom or a halogen atom, which comprises reacting a compound of the formula (1): wherein X1 is as defined above, and X2 represents a halogen atom, with ammonia and formaldehyde to obtain a hexahydrotriazine compound of the formula (2): wherein X1 is as defined above, and reacting the resulting hexahydrotriazine compound with hydroxylamine under acidic conditions. According to this process, the thiazole compound of the formula (3) can be industrially advantageously produced using inexpensive ammonia with suppressing the formation of a byproduct of the formula (4): wherein X1 is as defined above.
摘要翻译：一种制备式（3）的噻唑化合物的方法：其中X 1是氢原子或卤素原子，其包括使式（1）的化合物：其中X 1如上所定义，X 2表示卤素原子与氨和甲醛反应，得到式（2）的六氢三嗪化合物：其中X1如上定义，并在酸性条件下使所得六氢三嗪化合物与羟胺反应。根据该方法，式（3）的噻唑化合物可以在工业上有利地使用廉价的氨制备，抑制式（4）的副产物的形成：其中X1如上所定义。

2. 发明授权

US07745669B2 Process for production of alcohol compound 有权
标题翻译：醇化合物生产工艺
公开(公告)号：US07745669B2
公开(公告)日：2010-06-29
申请号：US12307223
申请日：2007-07-03
申请人： Toru Sakamoto , Shinzo Seko
发明人： Toru Sakamoto , Shinzo Seko
IPC分类号： C07C33/46 , C07C33/28
CPC分类号： C07C41/16 , C07C319/20 , C07C323/20 , C07C43/23
摘要： A process for the production of an alcohol compound represented by the formula (3): wherein X1, X2, X3, X4, Z, R and n are as defined below, comprising reacting a phenol represented by the formula (1): wherein X1, X2, X3 and X4 independently represent a hydrogen atom, a halogen atom or an alkyl group having 1 to 3 carbon atoms; Z represents an oxygen atom or a sulfur atom; and R represents an alkyl group, an alkenyl group, an alkynyl group, or an aralkyl group which may be substituted by a halogen atom, with a haloalcohol represented by the formula (2): wherein Y represents a chlorine atom or a bromine atom; and n represents an integer of 2 or 3, in a biphase system composed of a water-immiscible organic solvent and an aqueous alkali metal hydroxide solution in the presence of a phase-transfer catalyst.
摘要翻译：一种制备由式（3）表示的醇化合物的方法：其中X1，X2，X3，X4，Z，R和n如下所定义，包括使由式（1）表示的苯酚：其中X1 ，X 2，X 3和X 4独立地表示氢原子，卤素原子或碳原子数1〜3的烷基。 Z表示氧原子或硫原子; 和R表示可以被卤素原子取代的烷基，烯基，炔基或芳烷基与式（2）表示的卤代醇：其中Y表示氯原子或溴原子; 在相转移催化剂存在下，在由水不混溶的有机溶剂和碱金属氢氧化物水溶液组成的双相体系中，n表示2或3的整数。

3. 发明授权

US07439357B2 Process for preparing thiazole by aminomethylation 有权
标题翻译：通过氨基甲基化制备噻唑的方法
公开(公告)号：US07439357B2
公开(公告)日：2008-10-21
申请号：US11629754
申请日：2005-06-10
申请人： Naoyuki Takano , Shinzo Seko , Kazuyuki Tanaka
发明人： Naoyuki Takano , Shinzo Seko , Kazuyuki Tanaka
IPC分类号： C07D251/04 , C07D277/28
CPC分类号： C07D277/28
摘要： A process for preparing a thiazole compound of formula (3): wherein X1 represents a hydrogen atom or a halogen atom comprising reacting a compound of formula (1): wherein X1 is as defined above, and X2 represents a halogen atom, with ammonia and formaldehyde to obtain a hexahydrotriazine compound of formula (2): wherein X1 is as defined above, and hydrolyzing the compound of formula (2).
摘要翻译：制备式（3）的噻唑化合物的方法：其中X 1表示氢原子或卤素原子，包括使式（1）化合物：其中X 1〜 >如上所定义，X 2表示卤素原子，与氨和甲醛反应，得到式（2）的六氢三嗪化合物：其中X 1如上定义，并水解式（2）的化合物。

4. 发明授权

US5597940A Process for producing .beta.-nitroenamine 失效
公开(公告)号：US5597940A
公开(公告)日：1997-01-28
申请号：US401928
申请日：1995-03-09
申请人： Shinzo Seko
发明人： Shinzo Seko
IPC分类号： C07C209/00 , C07C211/24 , C07C211/29 , C07C215/52 , C07C217/60 , C07C239/20 , C07C209/60 , C07C253/30
CPC分类号： C07C217/60 , C07C209/00 , C07C211/24 , C07C211/29 , C07C215/52 , C07C239/20 , C07C2101/16
摘要： Disclosed is a process for producing .beta.-nitroenamine represented by the formula I: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and independently indicate a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group which may be optionally substituted with at least one group selected from the group consisting of a halogen atom, a lower alkoxy group, an aryloxy group, a hydroxyl group or an aryl group, or an aryl group which may be optionally substituted with a halogen atom, a lower alkyl group, a lower alkoxy group, an aryl group, an aryloxy group, a nitro group, a cyano group, an acylamino group, a di-lower alkylamino group, an arylamino group, a hydroxyl group, an arylsulfonyl group, a mercapto group, a lower alkylthio group or an arylthio group, R.sub.1 and R.sub.2 may bond together to form a cycloalkyl or bicycloalkyl and R.sub.3 is a hydrogen atom, a lower alkyl group, a cycloalkyl group or an aralkyl group; and an intermediate for producing the .beta.-nitroenamine.

5. 发明授权

US08269044B2 Method for selectively producing primary amine compound 失效
标题翻译：选择性生产伯胺化合物的方法
公开(公告)号：US08269044B2
公开(公告)日：2012-09-18
申请号：US12097234
申请日：2006-12-14
申请人： Naoyuki Takano , Kazuyuki Tanaka , Shinzo Seko
发明人： Naoyuki Takano , Kazuyuki Tanaka , Shinzo Seko
IPC分类号： C07D213/38 , C07D251/04 , C07C209/08
CPC分类号： C07C209/62 , C07C213/02 , C07D213/26 , C07D213/38 , C07D251/04 , C07C211/27 , C07C211/29 , C07C217/58
摘要： Disclosed is a method for producing a primary amine compound represented by the formula (3): wherein, Ar is as defined below, which is characterized in that a halogen compound represented by the formula (1): wherein, Ar represents an unsubstituted aromatic group such as a phenyl group, a naphthyl group, a pyridyl group, a furyl group, a thienyl group, a pyrrolyl group, an oxazolyl group, an isoxazolyl group or a pyrimidinyl group, or an aromatic group obtained by substituting such an unsubstituted aromatic group with 1-3 substituents; and X represents a halogen atom, ammonia and formaldehyde are reacted with each other, thereby obtaining a hexahydrotriazine compound represented by the formula (2): wherein, Ar is as defined above, and then the thus-obtained hexahydrotriazine compound is decomposed. By this method, a primary amine compound can be commercially advantageously produced by using a low-cost ammonia while suppressing production of a secondary amine as a by-product.
摘要翻译：公开了一种由式（3）表示的伯胺化合物的制备方法：其中Ar如下所定义，其特征在于由式（1）表示的卤素化合物：其中Ar表示未取代的芳族基团苯基，萘基，吡啶基，呋喃基，噻吩基，吡咯基，恶唑基，异恶唑基或嘧啶基，或通过取代这些未取代的芳基取代的芳基具有1-3个取代基; X表示卤素原子，氨和甲醛彼此反应，得到式（2）表示的六氢三嗪化合物：其中，Ar如上定义，然后将由此得到的六氢三嗪化合物分解。通过这种方法，可以通过使用低成本氨同时抑制作为副产物的仲胺的生产，商业上有利地生产伯胺化合物。

6. 发明授权

US07652177B2 Process for production of alcohol compound 有权
标题翻译：醇化合物生产工艺
公开(公告)号：US07652177B2
公开(公告)日：2010-01-26
申请号：US12307240
申请日：2007-07-03
申请人： Toru Sakamoto , Shinzo Seko
发明人： Toru Sakamoto , Shinzo Seko
IPC分类号： C07C33/18 , C07C33/46 , C07C33/28
CPC分类号： C07C41/16 , C07C319/20 , C07C323/20 , C07C43/23
摘要： A process for the production of an alcohol compound represented by the formula (3): wherein X1, X2, X3, X4, Z, R and n are as defined below, comprising reacting a phenol represented by the formula (1): wherein X1, X2, X3 and X4 independently represent a hydrogen atom, a halogen atom or an alkyl group having 1 to 3 carbon atoms; Z represents an oxygen atom or a sulfur atom; and R represents a halogen-substituted alkenyl group, with a haloalcohol represented by the formula (2): wherein Y represents a chlorine atom or a bromine atom; and n represents an integer of 2 or 3, in a biphase system composed of a water-immiscible organic solvent and an aqueous alkali metal hydroxide solution in the presence of a phase-transfer catalyst.
摘要翻译：一种制备由式（3）表示的醇化合物的方法：其中X1，X2，X3，X4，Z，R和n如下所定义，包括使由式（1）表示的苯酚：其中X1 ，X 2，X 3和X 4独立地表示氢原子，卤素原子或碳原子数1〜3的烷基。 Z表示氧原子或硫原子; 和R表示卤素取代的烯基，与式（2）表示的卤代醇：其中Y表示氯原子或溴原子; 在相转移催化剂存在下，由与水不混溶的有机溶剂和碱金属氢氧化物水溶液组成的双相体系中，n表示2或3的整数。

7. 发明申请

US20090287023A1 METHOD FOR PRODUCING PRIMARY AMINE COMPOUND 有权
标题翻译：生产主要胺化合物的方法
公开(公告)号：US20090287023A1
公开(公告)日：2009-11-19
申请号：US12097974
申请日：2006-12-25
申请人： Hiroshi Souda , Naoyuki Takano , Shinzo Seko
发明人： Hiroshi Souda , Naoyuki Takano , Shinzo Seko
IPC分类号： C07C209/24
CPC分类号： C07C209/62 , C07C209/08 , C07C211/21 , C07C211/28
摘要： Disclosed is a method for producing a primary amine compound represented by the formula (2) below, which is characterized in that a halogen compound represented by the formula (1) below, ammonia and formaldehyde are reacted with each other, and then the thus-obtained reaction product is [1] brought into contact with an aqueous solution of an acid or [2] reacted with a hydroxylamine under acidic conditions. By this method, a primary amine compound can be commercially advantageously produced by using a low-cost ammonia while suppressing production of a secondary amine as a by-product. (1) (In the formula, R1 and R2 independently represent a hydrogen atom, a C1-C5 alkyl group which may be substituted by a halogen atom or the like, a C1-C5 alkoxy group which may be substituted by a halogen atom, a cyano group, a C2-C11 alkenyl group or a phenyl group or the like; R3 represents a hydrogen atom, a linear or branched C1-C5 alkyl group or a cyano group; and X represents a halogen atom.) (2) (In the formula, R1, R2 and R3 are as defined above.)
摘要翻译：公开了下述式（2）表示的伯胺化合物的制造方法，其特征在于，将下式（1）表示的卤素化合物与氨和甲醛反应，得到的反应产物[1]在酸性条件下与酸的水溶液或[2]与羟胺反应。通过这种方法，可以通过使用低成本氨同时抑制作为副产物的仲胺的生产，商业上有利地生产伯胺化合物。（1）（式中，R 1和R 2各自独立地表示氢原子，可被卤素原子等取代的C1〜C5烷基，可被卤素原子取代的C1〜C5烷氧基，氰基，C 2 -C 11烯基或苯基等; R 3表示氢原子，直链或支链C 1 -C 5烷基或氰基; X表示卤素原子）（2）（在式中，R 1，R 2和R 3如上所定义。）

8. 发明申请

US20090192336A1 PROCESS FOR PRODUCTION OF ALCOHOL COMPOUND 有权
标题翻译：生产醇溶液的方法
公开(公告)号：US20090192336A1
公开(公告)日：2009-07-30
申请号：US12307240
申请日：2007-07-03
申请人： Toru Sakamoto , Shinzo Seko
发明人： Toru Sakamoto , Shinzo Seko
IPC分类号： C07C39/10
CPC分类号： C07C41/16 , C07C319/20 , C07C323/20 , C07C43/23
摘要： A process for the production of an alcohol compound represented by the formula (3): wherein X1, X2, X3, X4, Z, R and n are as defined below, comprising reacting a phenol represented by the formula (1): wherein X1, X2, X3 and X4 independently represent a hydrogen atom, a halogen atom or an alkyl group having 1 to 3 carbon atoms; Z represents an oxygen atom or a sulfur atom; and R represents a halogen-substituted alkenyl group, with a haloalcohol represented by the formula (2): wherein Y represents a chlorine atom or a bromine atom; and n represents an integer of 2 or 3, in a biphase system composed of a water-immiscible organic solvent and an aqueous alkali metal hydroxide solution in the presence of a phase-transfer catalyst.
摘要翻译：一种制备由式（3）表示的醇化合物的方法：其中X1，X2，X3，X4，Z，R和n如下所定义，包括使由式（1）表示的苯酚：其中X1 ，X 2，X 3和X 4独立地表示氢原子，卤素原子或碳原子数1〜3的烷基。 Z表示氧原子或硫原子; 和R表示卤素取代的烯基，与式（2）表示的卤代醇：其中Y表示氯原子或溴原子; 在相转移催化剂存在下，在由水不混溶的有机溶剂和碱金属氢氧化物水溶液组成的双相体系中，n表示2或3的整数。

9. 发明授权

US06784321B2 Process for producing retinol and intermediate compounds for producing the same 失效
标题翻译：制备视黄醇和中间体化合物的方法
公开(公告)号：US06784321B2
公开(公告)日：2004-08-31
申请号：US10687880
申请日：2003-10-20
申请人： Toshiya Takahashi , Shinzo Seko , Kazutaka Kimura , Noriyuki Doi , Naoto Konya
发明人： Toshiya Takahashi , Shinzo Seko , Kazutaka Kimura , Noriyuki Doi , Naoto Konya
IPC分类号： C07C31700
CPC分类号： C07C403/08 , C07B2200/09 , C07C403/12 , C07C403/22 , C07C2601/16 , Y02P20/55
摘要： There are disclosed a disulfone compound of formula (1): wherein Ar denotes an aryl group that may have a substituent, R1 denotes a hydrogen atom or a protective group of a hydroxyl group and the wavy line means that the disulfone compound is an E or Z geometrical isomer or a mixture thereof, a method for producing the same, intermediate compounds therefore and a process for producing retinol through the disulfone compound.
摘要翻译：公开了式（1）的二砜化合物：其中Ar表示可以具有取代基的芳基，R 1表示氢原子或羟基保护基，波浪线表示二砜化合物为E或 Z几何异构体或其混合物，其制备方法，中间体化合物和通过二砜化合物生产视黄醇的方法。

10. 发明授权

US06444857B1 Process for producing vitamin A aldehyde and intermediate for producing the same 失效
标题翻译：生产维生素A醛的方法及其制备方法
公开(公告)号：US06444857B1
公开(公告)日：2002-09-03
申请号：US09684922
申请日：2000-10-10
申请人： Shinzo Seko , Naoto Konya , Toshiya Takahashi
发明人： Shinzo Seko , Naoto Konya , Toshiya Takahashi
IPC分类号： C07C4500
CPC分类号： C07C403/14 , C07B2200/09 , C07C403/22 , C07C2601/16
摘要： There are disclosed an alcohol derivative of formula (1): wherein Ar is an optionally substituted aryl group and R is a straight or branched C1-C3 lower alkyl group, and the wavy line depicted by indicates a single bond and stereochemistry relating to a double bond bound therewith is E or Z or a mixture thereof, and a process for producing the same and a process for producing Vitamin A aldehyde using the same.
摘要翻译：公开了式（1）的醇衍生物：其中Ar是任选取代的芳基，R是直链或支链C 1 -C 3低级烷基，并且所描绘的波浪线表示单键和与双键相关的立体化学与其结合的是E或Z或其混合物，及其制备方法和使用其制备维生素A醛的方法。

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