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1. 发明申请

US20130101629A1 HOMOGENOUS SUSPENSION OF IMMUNOPOTENTIATING COMPOUNDS AND USES THEREOF 有权
标题翻译：免疫抑制化合物的均质悬浮液及其用途
公开(公告)号：US20130101629A1
公开(公告)日：2013-04-25
申请号：US13516227
申请日：2010-12-15
申请人： David Skibinski , Siddhartha Jain , Manmohan Singh , Derek O'Hagan
发明人： David Skibinski , Siddhartha Jain , Manmohan Singh , Derek O'Hagan
IPC分类号： A61K39/39 , A61K31/496 , A61K31/683 , A61K31/675 , A61K31/4745 , A61K31/5377
CPC分类号： A61K39/39 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K31/683 , A61K31/7004 , A61K31/717 , A61K39/095 , A61K39/12 , A61K39/155 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/14134 , C12N2760/18534 , Y02A50/41 , A61K2300/00
摘要： The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
摘要翻译：本发明一般涉及能够刺激或调节有需要的受试者的免疫应答的小分子免疫增强剂（SMIP）的均匀悬浮液。均匀悬浮液可以与各种抗原或佐剂组合用于疫苗疗法。

2. 发明申请

US20100231256A1 SPARE CELL LIBRARY DESIGN FOR INTEGRATED CIRCUIT 审中-公开
标题翻译：集成电路的备用电池库设计
公开(公告)号：US20100231256A1
公开(公告)日：2010-09-16
申请号：US12400849
申请日：2009-03-10
申请人： Siddhartha Jain , Gaurav Agarwal , Ankit Desai , Anurag Sharma
发明人： Siddhartha Jain , Gaurav Agarwal , Ankit Desai , Anurag Sharma
IPC分类号： H03K19/177 , H01L21/82
CPC分类号： H03K19/173 , H03K19/1735
摘要： A cell based design layout of an application specific integrated circuit (ASIC) having a function has reduceddecreased power leakage because functionally unconnected additional cells or spare cells of the integrated design layout are unconnected to the power supplies Vdd and Vss.
摘要翻译：具有功能的专用集成电路（ASIC）的基于单元的设计布局已经降低了功率泄漏的降低，因为集成设计布局的功能未连接的附加单元或备用单元未与电源Vdd和Vss连接。

3. 发明授权

US09408907B2 Homogenous suspension of immunopotentiating compounds and uses thereof 有权
标题翻译：免疫增强化合物的均匀悬浮液及其用途
公开(公告)号：US09408907B2
公开(公告)日：2016-08-09
申请号：US13516227
申请日：2010-12-15
申请人： David Skibinski , Siddhartha Jain , Manmohan Singh , Derek O'Hagan
发明人： David Skibinski , Siddhartha Jain , Manmohan Singh , Derek O'Hagan
IPC分类号： A61K39/39 , A61K31/4745 , A61K31/7004 , A61K31/717 , A61K39/095 , A61K39/155 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K31/683 , A61K39/12 , A61K39/00
CPC分类号： A61K39/39 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K31/683 , A61K31/7004 , A61K31/717 , A61K39/095 , A61K39/12 , A61K39/155 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/14134 , C12N2760/18534 , Y02A50/41 , A61K2300/00
摘要： The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
摘要翻译：本发明一般涉及能够刺激或调节有需要的受试者的免疫应答的小分子免疫增强剂（SMIP）的均匀悬浮液。均匀悬浮液可以与各种抗原或佐剂组合用于疫苗疗法。

4. 发明申请

US20130101609A1 IRRADIATED BIODEGRADABLE POLYMER MICROPARTICLES 审中-公开
标题翻译：辐射可生物降解聚合物微生物
公开(公告)号：US20130101609A1
公开(公告)日：2013-04-25
申请号：US13574958
申请日：2011-01-24
申请人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Padma Malyala
发明人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Padma Malyala
IPC分类号： A61K9/14 , A61J1/00
CPC分类号： A61K9/14 , A61J1/00 , A61K39/00 , A61K39/095 , A61K2039/55555
摘要： In one aspect, the present invention provides sterile microparticle compositions comprising biodegradable microparticles, which comprise at least one biodegradable polymer. In other aspects, the present invention provides methods of making and using such compositions as well as articles of manufacture and kits containing the same.
摘要翻译：一方面，本发明提供了包含可生物降解的微粒的无菌微粒组合物，其包含至少一种可生物降解的聚合物。在其它方面，本发明提供了制备和使用这些组合物以及制备制品的方法以及含有该组合物的试剂盒。

5. 发明授权

US09950062B2 Compounds and compositions as TLR activity modulators 有权
公开(公告)号：US09950062B2
公开(公告)日：2018-04-24
申请号：US13394036
申请日：2010-09-01
申请人： Manmohan Singh , David Skibinski , Simona Cianetti , Francesco Doro , Siddhartha Jain
发明人： Manmohan Singh , David Skibinski , Simona Cianetti , Francesco Doro , Siddhartha Jain
IPC分类号： A61K39/39 , A61K31/66 , A61K33/08 , A61K45/06 , A61K31/4375 , A61K33/42 , A61K39/095 , A61K39/00
CPC分类号： A61K39/39 , A61K31/4375 , A61K31/66 , A61K33/08 , A61K33/42 , A61K39/095 , A61K45/06 , A61K2039/55505 , A61K2039/55511 , Y02A50/386 , Y02A50/41 , A61K2300/00
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.

6. 发明授权

US09517263B2 Benzonaphthyridine-containing vaccines 有权
标题翻译：含有苯并萘啶的疫苗
公开(公告)号：US09517263B2
公开(公告)日：2016-12-13
申请号：US13377511
申请日：2010-06-10
申请人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
发明人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
IPC分类号： A61K39/02 , C07D471/00 , A61K39/39 , A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译：本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。

7. 发明申请

US20120263753A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES 有权
标题翻译：含有苯并噻嗪的疫苗
公开(公告)号：US20120263753A1
公开(公告)日：2012-10-18
申请号：US13377511
申请日：2010-06-10
申请人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
发明人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
IPC分类号： A61K39/39 , A61P37/04 , A61K39/02 , A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译：本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。

8. 发明申请

US20050053667A1 Programmed immune responses using a vaccination node 审中-公开
标题翻译：使用疫苗接种节点的程序化免疫反应
公开(公告)号：US20050053667A1
公开(公告)日：2005-03-10
申请号：US10886707
申请日：2004-07-09
申请人： Darrell Irvine , Siddhartha Jain , Nir Hacohen , William Warren
发明人： Darrell Irvine , Siddhartha Jain , Nir Hacohen , William Warren
IPC分类号： A61K20060101 , A61K9/16 , A61K9/50 , A61K9/51 , A61K9/64 , A61K39/12 , A61K39/38 , A61K39/39 , A61K47/48
CPC分类号： A61K39/39 , A61K47/60 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/484 , Y02A50/487
摘要： The present invention provides compositions and methods for modulating immune responses to antigens. One aspect of the present invention relates to a particle-based antigen delivery system (vaccination node) that comprises a hydrogel particle capable of both antigen presentation and DC activation. The VN may further comprise a chemoattractant-loaded microsphere capable of attracting DCs to the site of administration. Another aspect of the present invention relates to the use of the VN to modulate antigen presenting cells activation for the prevention and/treatment of various diseases, such as infectious diseases, cancers and autoimmune diseases.
摘要翻译：本发明提供了调节对抗原的免疫应答的组合物和方法。本发明的一个方面涉及一种基于颗粒的抗原递送系统（疫苗接种节点），其包括能够同时进行抗原呈递和DC激活的水凝胶颗粒。 VN还可以包含能够将DC吸引到给药部位的化学吸引剂负载微球。本发明的另一方面涉及VN调节抗原呈递细胞活化以预防和/或治疗各种疾病如感染性疾病，癌症和自身免疫性疾病的用途。

9. 发明授权

US08689068B2 Low leakage current operation of integrated circuit using scan chain 有权
标题翻译：使用扫描链的集成电路的低漏电流操作
公开(公告)号：US08689068B2
公开(公告)日：2014-04-01
申请号：US13305702
申请日：2011-11-28
申请人： Siddhartha Jain , Himanshu Goel , Himanshu Kukreja
发明人： Siddhartha Jain , Himanshu Goel , Himanshu Kukreja
IPC分类号： G01R31/28
CPC分类号： G01R31/318555 , G01R31/318575
摘要： An integrated circuit (IC) having a low leakage current mode of operation has a number of modules for running respective applications. The modules have respective cells and respective test scan chain elements. The IC also has a controller for configuring an active module to operate in a functional mode and a selected inactive module to operate in a low leakage current mode. Configuring the selected inactive module to operate in low leakage current mode includes enabling scan mode of the selected inactive module, and applying a low leakage vector of input signals from the controller to the cells of the inactive module using the scan chain. Functional data outputs of the inactive module are disabled during low leakage current mode. In the meantime, the active modules continue to operate in the functional mode.
摘要翻译：具有低泄漏电流操作模式的集成电路（IC）具有用于运行各种应用的多个模块。模块具有各自的单元和相应的测试扫描链元件。该IC还具有用于配置有源模块以在功能模式下操作的控制器和所选择的非活动模块以低泄漏电流模式操作。将所选择的非活动模块配置为以低泄漏电流模式工作，包括启用所选非活动模块的扫描模式，以及使用扫描链将来自控制器的输入信号的低泄漏矢量应用于非活动模块的单元。低电流模式下禁用模块的功能数据输出。同时，主动模块继续在功能模式下运行。

10. 发明申请

US20130183355A1 DELIVERY OF SELF-REPLICATING RNA USING BIODEGRADABLE POLYMER PARTICLES 有权
标题翻译：使用生物可降解聚合物颗粒递送自我替代RNA
公开(公告)号：US20130183355A1
公开(公告)日：2013-07-18
申请号：US13808245
申请日：2011-06-07
申请人： Siddhartha Jain , Derek O'Hagan , Manmohan Singh
发明人： Siddhartha Jain , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/385
CPC分类号： A61K39/385 , A61K9/1617 , A61K9/1647 , A61K9/5123 , A61K9/5153 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/622 , A61P31/14 , C12N15/86 , C12N15/88 , C12N2760/18534 , C12N2770/36143
摘要： Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.
摘要翻译：描述包含吸附的RNA复制子的颗粒组合物以及其制备和使用方法。

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