专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08969362B2 9-substituted 8-oxoadenine compound 有权
标题翻译： 9-取代的8-氧代腺嘌呤化合物
公开(公告)号：US08969362B2
公开(公告)日：2015-03-03
申请号：US14058064
申请日：2013-10-21
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/522 , C07D473/18 , A61K31/5377
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译：本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。

2. 发明申请

US20120214822A1 N-CYCLOPROPYL-3-FLUORO-5-[3-[[1-[2-[2- [(2-HYDROXETHYL)AMINO] ETHOXY]PHENYL] CYCLOPROPYL] AMINO]-2-OXO- 1 (2H)-PYRAZINYL]-4-METHYL-BENZAMIDE, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND THEIR USES 有权
标题翻译： N-环丙基-3-氟-5- [3 - [[1- [2- [2- [（2-羟基乙基）氨基]乙氧基]苯基]环丙基]氨基] -2-氧代-1-（2H） - 吡嗪 ] -4-甲基苯甲酰胺或其药学上可接受的盐及其用途
公开(公告)号：US20120214822A1
公开(公告)日：2012-08-23
申请号：US13412907
申请日：2012-03-06
申请人： Stephen Brough , Richard Evans , Timothy Jon Luker , Piotr Raubo
发明人： Stephen Brough , Richard Evans , Timothy Jon Luker , Piotr Raubo
IPC分类号： A61K31/4965 , A61P11/00 , A61P11/06 , C07D241/20
CPC分类号： C07D491/113 , C07D241/08 , C07D241/20 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D471/10
摘要： The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明涉及式（I）的吡嗪酮衍生物：其中R1，R2，R3，R4，R5，R6和R7如本文所定义; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

3. 发明授权

US08158820B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US08158820B2
公开(公告)日：2012-04-17
申请号：US10551783
申请日：2004-04-06
申请人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukhsana Rasul , Stephen Thom
发明人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukhsana Rasul , Stephen Thom
IPC分类号： C07C63/33 , A61K31/19
CPC分类号： C07C59/68 , C07C59/70 , C07C65/24 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/80 , C07C235/42 , C07C255/55 , C07C271/28 , C07C275/32 , C07C311/29 , C07C317/22 , C07C323/18 , C07C2601/02 , C07D205/04 , C07D207/02 , C07D213/61 , C07D213/72 , C07D215/12 , C07D233/52 , C07D239/26 , C07D239/34 , C07D239/42 , C07D277/52 , C07D285/10 , C07D295/192 , C07D295/26 , C07D307/80 , C07D317/54 , C07D333/56 , C07D403/04 , C07D417/04
摘要： The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
摘要翻译：本发明涉及取代的苯氧基乙酸（I）作为治疗呼吸系统疾病的有用的药物化合物，含有它们的药物组合物及其制备方法。

4. 发明申请

US20090181962A1 Substituted thiophene compounds 审中-公开
标题翻译：取代噻吩化合物
公开(公告)号：US20090181962A1
公开(公告)日：2009-07-16
申请号：US11949273
申请日：2007-12-03
申请人： Andrew Baxter , Stephen Brough , Alan Faull , Craig Johnstone , Thomas Mcinally
发明人： Andrew Baxter , Stephen Brough , Alan Faull , Craig Johnstone , Thomas Mcinally
IPC分类号： A61K31/5377 , C07D333/38 , A61K31/381 , C07D413/04 , A61P11/06
CPC分类号： C07D409/04 , C07D333/38 , C07D413/04 , C07D417/04
摘要： The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2, and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明涉及式（I）的杂芳族羧酰胺，其中A，R 1，R 2和X如说明书中所定义，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途。

5. 发明申请

US20070190071A1 9-Substituted 8-oxoadenine compound 有权
标题翻译： 9-取代的8-氧代腺嘌呤化合物
公开(公告)号：US20070190071A1
公开(公告)日：2007-08-16
申请号：US10593691
申请日：2005-03-24
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/52 , A61K31/522 , C07D473/10
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.
摘要翻译：本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元芳香族碳环等，R表示卤素原子，烷基等，n表示0〜2的整数，Z 1表示亚烷基，X 2，表示氧原子，硫原子，SO 2，NR 5，CO，CONR 5，NR 5 CO和 Y 1，Y 2和Y 3独立地表示单键或亚烷基，X 1，O 2， >表示氧原子，硫原子，NR 4（R 4）是氢原子或烷基或单键，R 2表示取代或未取代的烷基，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或芳烷基]或其药学上可接受的盐。

6. 发明授权

US06946478B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US06946478B2
公开(公告)日：2005-09-20
申请号：US10339261
申请日：2003-01-09
申请人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
发明人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
IPC分类号： C07D295/18 , A61K31/427 , A61K31/4375 , A61K31/445 , A61K31/4468 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/541 , A61P1/00 , A61P3/10 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P31/18 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/14 , C07D211/22 , C07D211/32 , C07D211/36 , C07D211/40 , C07D211/46 , C07D211/58 , C07D217/14 , C07D241/04 , C07D295/192 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/02 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
CPC分类号： C07D401/12 , C07D211/32 , C07D211/46 , C07D211/58 , C07D217/14 , C07D295/192 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds of general formula wherein R1, m, Q, T, n, R2, R3, V, W, X and R4 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供通式的化合物其中R 1，m，Q，T，n，R 2，R 3，V，W， X和R 4如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

7. 发明授权

US08889692B2 Pyrazinone derivatives, pharmaceutically acceptance salts thereof and their uses 有权
标题翻译：吡嗪酮衍生物，其药学上可接受的盐及其用途
公开(公告)号：US08889692B2
公开(公告)日：2014-11-18
申请号：US13616179
申请日：2012-09-14
申请人： Stephen Brough , Richard Evans , Timothy Jon Luker , Piotr Raubo
发明人： Stephen Brough , Richard Evans , Timothy Jon Luker , Piotr Raubo
IPC分类号： A61K31/4965 , C07D403/04 , C07D241/20 , C07D403/12 , C07D401/12 , C07D413/12
CPC分类号： C07D491/113 , C07D241/08 , C07D241/20 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D471/10
摘要： The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明涉及式（I）的吡嗪酮衍生物：其中R1，R2，R3，R4，R5，R6和R7如本文所定义; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

8. 发明申请

US20110306610A1 9-SUBSTITUTED 8-OXOADENINE COMPOUND 有权
标题翻译： 9-取代的8-氧杂环丁烯化合物
公开(公告)号：US20110306610A1
公开(公告)日：2011-12-15
申请号：US13187260
申请日：2011-07-20
申请人： Ayumu KURIMOTO , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu KURIMOTO , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/522 , C07D413/14 , A61P37/08 , A61P37/00 , A61P31/12 , A61P35/00 , C07D473/18 , A61K31/5377
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译：本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。

9. 发明授权

US06518286B1 Compounds 失效
标题翻译：化合物
公开(公告)号：US06518286B1
公开(公告)日：2003-02-11
申请号：US09555565
申请日：2000-06-01
申请人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
发明人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
IPC分类号： C07D40112
CPC分类号： C07D401/12 , C07D211/32 , C07D211/46 , C07D211/58 , C07D217/14 , C07D295/192 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds of general formula (I) wherein: R1 represents optionally substituted, C1-C12 alkyl or optionally substituted 3- to 10-membered saturated or unsaturated ring system comprising up to two ring carbon atoms that form carbonyl groups and comprising up to 4 ring heteroatoms independently selected from nitrogen, oxygen and sulfur; m is 0-1; Q represents OCH2, C1-C4 alkylene or C2-C4 alkenylene; T represents C(O)NH, or when m is 0, T may additionally represent a bond or NH, or when m is 1 and Q represents C1-C4 alkylene, T may additionally represent NH; n is 1-4; each R2 and R3 independently represents H or C1-C4 alkyl; V represents N, and W represents N or CH; X represents O, C(O), CH(OH), SO2, NH or N(C1-C6 alkyl), provided that when W represents N, then X represents either C(O) or SO2 and when W represents CH, then X is other than SO2; R4 represents optionally substituted phenyl; R5 and R6 each independently represent H, C1-C6 alkyl or hydroxyC1-C6 alkyl, or R5 and R6 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring; R7 and R8 each independently represent H or C1-C6 alkyl; and R9 represents OH or —NR7R8; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供了通式（I）的化合物，其中：R 1表示任选取代的C 1 -C 12烷基或任选取代的3至10元饱和或不饱和环体系，其包含至多两个形成羰基的环碳原子，独立地选自氮，氧和硫的4个环杂原子; m为0-1; Q表示OCH 2，C 1 -C 4亚烷基或C 2 -C 4亚烯基; T表示C（O）NH，或当m为0时，T可另外表示键或NH，或当m为1且Q表示C1-C4亚烷基时，T可另外表示NH; n为1-4; 每个R 2和R 3独立地表示H或C 1 -C 4烷基; V表示N，W表示N或CH; X表示O，C（O），CH（OH），SO 2，NH或N（C 1 -C 6烷基），条件是当W表示N时，X表示C（O）或SO 2，当W表示CH时， X不是SO2; R 4表示任选取代的苯基; R 5和R 6各自独立地表示H，C 1 -C 6烷基或羟基C 1 -C 6烷基，或者R 5和R 6与它们所连接的氮原子一起形成4-至7-元饱和杂环; R 7和R 8各自独立地表示H或C 1 -C 6烷基; 并且R 9表示OH或-NR 7 R 8; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

10. 发明申请

US20130012523A1 PYRAZINONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND THEIR USES 有权
标题翻译：吡嗪酮衍生物，药用药物及其用途
公开(公告)号：US20130012523A1
公开(公告)日：2013-01-10
申请号：US13616179
申请日：2012-09-14
申请人： Stephen Brough , Richard Evans , Timothy Jon Luker , Piotr Raubo
发明人： Stephen Brough , Richard Evans , Timothy Jon Luker , Piotr Raubo
IPC分类号： A61K31/4965 , A61P11/00 , C07D241/20
CPC分类号： C07D491/113 , C07D241/08 , C07D241/20 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D471/10
摘要： The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明涉及式（I）的吡嗪酮衍生物：其中R1，R2，R3，R4，R5，R6和R7如本文所定义; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式