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1. 发明授权

US11524048B2 HMGB1 antagonist treatment of severe sepsis 有权
公开(公告)号：US11524048B2
公开(公告)日：2022-12-13
申请号：US16869905
申请日：2020-05-08
申请人： THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
发明人： Yousef Al-Abed
IPC分类号： A61K38/07 , C07K5/107 , A61K38/17 , A61K9/00 , C07K1/113 , A61P25/02 , A61K47/65 , C07K14/47 , A61K31/197 , A61K47/10 , A61K47/26 , A61K38/00 , A61K9/08
摘要： The present invention is related to the use of HMGB1 antagonists such as K883 in the treatment and/or prevention and/or inhibition of severe sepsis in mammals, e.g., humans, and pharmaceutical compositions for the same comprising HMGB1 antagonists in an effective amount to treat and/or prevent and/or inhibit this condition.

2. 发明授权

US11266716B2 Use of dermcidin in sterile inflammatory conditions 有权
公开(公告)号：US11266716B2
公开(公告)日：2022-03-08
申请号：US15769880
申请日：2016-10-21
申请人： THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
发明人： Ping Wang , Haichao Wang
IPC分类号： A61K38/17 , A61K38/16 , A61K47/54 , A61K47/60 , A61P29/00 , A01N1/02 , A61K9/00
摘要： A method of treating a sterile inflammatory condition in a subject using an isolated dermcidin peptide or an active fragment thereof of or an active analog thereof is provided. Also provided is a method of inhibiting organ transplantation-associated is chemia/reperfusion and/or organ transplantation-associated inflammation.

3. 发明授权

US11083777B2 Hemichannel extracellular-domain specific agents for treating ischemia-reperfusion injury 有权
公开(公告)号：US11083777B2
公开(公告)日：2021-08-10
申请号：US16744326
申请日：2020-01-16
申请人： The Feinstein Institutes for Medical Research
发明人： Haichao Wang , Wei Li , Kevin J. Tracey , Ping Wang
IPC分类号： A61K38/17 , A61K31/19 , A61K31/22 , A61K31/704 , C07K16/18 , A61P37/02 , A61K38/08 , A61K38/04 , C07K14/00 , A61K39/395 , A61P31/02
摘要： Methods of treating sepsis or endotoxemia in a subject comprising administering to the subject an amount of an antagonist of a Panx1 hemichannel protein or an amount of an antagonist of a Cx43 hemichannel protein.

4. 发明授权

US10933240B2 Treatment of inflammation by selective DMV cholinergic neuron stimulation 有权
公开(公告)号：US10933240B2
公开(公告)日：2021-03-02
申请号：US16272295
申请日：2019-02-11
申请人： THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
发明人： Adam M. Kressel , Valentin A. Pavlov , Sangeeta S. Chavan , Kevin J. Tracey
IPC分类号： A61N1/36 , A61N1/05 , A61N1/04
摘要： Methods for electrical modulation of inflammation or serum TNF levels in a subject.

5. 发明申请

US20230131980A1 NERVE STIMULATION FOR TREATMENT OF DISEASES AND DISORDERS 有权
公开(公告)号：US20230131980A1
公开(公告)日：2023-04-27
申请号：US18083629
申请日：2022-12-19
申请人： THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
发明人： Kevin J. Tracey , Sangeeta S. Chavan
IPC分类号： A61N1/36
摘要： Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.

6. 发明授权

US11541239B2 Nerve stimulation for treatment of diseases and disorders 有权
公开(公告)号：US11541239B2
公开(公告)日：2023-01-03
申请号：US16695557
申请日：2019-11-26
申请人： THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
发明人： Kevin J. Tracey , Sangeeta S. Chavan
IPC分类号： A61N1/36
摘要： Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.

7. 发明申请

US20220346961A1 CONSTRAINED ACETABULAR LINER 有权
公开(公告)号：US20220346961A1
公开(公告)日：2022-11-03
申请号：US17867828
申请日：2022-07-19
申请人： The Feinstein Institutes for Medical Research
发明人： Stanley Asnis , Todd Goldstein
IPC分类号： A61F2/34 , A61F2/46 , A61F2/36
摘要： There is provided an acetabular cup liner for a total hip replacement (THR) prosthesis comprising an inner surface with a hemispherical portion having a radius of curvature. The hemispherical portion is disposed about a centerline and it intersects a hemisphere plane perpendicular to the centerline so that the intersection of the hemispherical portion and the plane define a circle having a radius equal to the radius of curvature. The liner further comprises a capture portion continuous with the hemispherical portion that has the same radius of curvature as the hemispherical portion and connects with the hemispherical portion at the hemispherical plane along a first arc of the circle on the plane, and extends a first distance out of the plane. The liner further comprises an insertion portion continuous with the hemispherical portion. The insertion region is connected with the hemispherical portion along a second arc of the circle on the plane. The distance from the centerline to the insertion portion is greater than the radius. The cup liner constrains the femoral ball portion of the THR prosthesis. The femoral ball portion is engaged with the liner by orienting the ball at an angle so that the shoulder portion of the ball aligns with the insertion portion, pressing the ball into the liner, and orienting the ball away from the angle.

8. 发明授权

US11433235B2 Systems and methods for delivering non-invasive neuromodulation to reduce the effects of shock and traumatic brain injury in animals and humans and to prolong life 有权
公开(公告)号：US11433235B2
公开(公告)日：2022-09-06
申请号：US17045429
申请日：2018-04-20
申请人： The Feinstein Institutes for Medical Research
发明人： Raj Kumar Narayan , Chunyan Li
IPC分类号： A61N1/36 , A61N1/05
摘要： Systems and methods of mitigating one or more bodily effects of a shock condition experienced by an animal (including a human, e.g., a patient) are described. One exemplary method includes providing a device for applying non-invasive neurostimulation to the animal's trigeminal nerve. The method also includes applying the non-invasive neurostimulation to the animal's trigeminal nerve, thereby increasing oxygen flow to the animal's brain and/or reducing brain inflammation.

9. 发明授权

US11278469B2 Bioelectronic pharmaceuticals 有权
公开(公告)号：US11278469B2
公开(公告)日：2022-03-22
申请号：US15677062
申请日：2017-08-15
申请人： THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
发明人： Kevin J. Tracey , Sangeeta S. Chavan
IPC分类号： A61H23/00 , A61H23/02 , A61N1/05 , A61B5/145 , A61B5/24
摘要： Methods are disclosed for treating a subject having a disease or disorder comprising providing the subject with an acoustic energy stimulus derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.

10. 发明申请

US20220054599A1 CHOLINE ACETYLTRANSFERASE AS A THERAPY FOR HYPERTENSION 有权
公开(公告)号：US20220054599A1
公开(公告)日：2022-02-24
申请号：US17299392
申请日：2019-12-11
申请人： THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
发明人： Kevin J. Tracey , Sangeeta S. Chavan , Andrew Stiegler , Jian Hua Li
IPC分类号： A61K38/45 , A61P9/12 , A61K47/60
摘要： Compositions and methods are provided comprising choline acetyltransferase (ChAT) and PEGylated ChAT for treating hypertension.

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