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1. 发明授权

US08226980B2 Orally disintegrating solid dosage forms comprising progestin and methods of making and using thereof 失效
标题翻译：口服崩解包含孕激素的固体剂型及其制备和使用方法
公开(公告)号：US08226980B2
公开(公告)日：2012-07-24
申请号：US12958975
申请日：2010-12-02
申请人： Salah U. Ahmed , Sundeep Sethia , Tahseen A. Chowdhury
发明人： Salah U. Ahmed , Sundeep Sethia , Tahseen A. Chowdhury
IPC分类号： A61K9/20
CPC分类号： A61K31/56 , A61K9/0056 , A61K9/2018 , A61K9/2054
摘要： The present invention is directed to non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising progestin and methods of making and using the dosage forms to treat conditions in females in need thereof.
摘要翻译：本发明涉及包含孕激素的非泡腾口腔崩解固体药物剂型，以及制备和使用该剂型以治疗有需要的女性中的病症的方法。

2. 发明授权

US07390503B1 Ondansetron orally disintegrating tablets 失效
标题翻译：昂丹司琼口服崩解片
公开(公告)号：US07390503B1
公开(公告)日：2008-06-24
申请号：US10923021
申请日：2004-08-23
申请人： Salah U. Ahmed , Sudhir R. Gorukanti , Tahseen A. Chowdhury
发明人： Salah U. Ahmed , Sudhir R. Gorukanti , Tahseen A. Chowdhury
IPC分类号： A61K9/20 , A61K9/14 , A61K9/50
CPC分类号： A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： An ondansetron solid orally disintegrating dosage form for oral administration having at least one first water-dispersible component or water-insoluble cellulose derivative, a component having a —CHOH functional group, a disintegrating agent and at least one lubricant is provided. The dosage form can comprise ondansetron, a hydrophilic polymer such as microcrystalline cellulose, a component having a —CHOH functional group such as mannitol or xylitol and a disintegrating agent such as crospovidone. The lubricant may be a mixture of magnesium stearate, sodium stearyl fumarate and colloidal silicon dioxide. The present invention provides a non-effervescent tablet comprising the ondansetron dosage form. Another aspect of the invention is the treatment of emesis such as nausea and vomiting caused by cancer chemotherapy and radiation by the administration of the ondansetron formulation of the present composition. Finally, a process of forming an ondansetron disintegrating tablet using the ondansetron dosage form is disclosed.
摘要翻译：提供了具有至少一种第一水分散性成分或水不溶性纤维素衍生物，具有-CHOH官能团的成分，崩解剂和至少一种润滑剂的口服的昂丹司琼固体口腔崩解剂型。剂型可以包含昂丹司琼，亲水性聚合物如微晶纤维素，具有-CHOH官能团的组分如甘露醇或木糖醇和崩解剂如交聚维酮。润滑剂可以是硬脂酸镁，硬脂酰富马酸钠和胶体二氧化硅的混合物。本发明提供了包含昂丹司琼剂型的非泡腾片剂。本发明的另一方面是通过施用本发明组合物的昂丹司琼制剂来治疗呕吐，例如由癌症化疗和放射引起的恶心和呕吐。最后，公开了使用昂丹司琼剂型形成昂丹司琼崩解片的方法。

3. 发明申请

US20110046115A1 Mirtazapine Solid Dosage Forms 审中-公开
标题翻译：米氮平固体剂型
公开(公告)号：US20110046115A1
公开(公告)日：2011-02-24
申请号：US12914478
申请日：2010-10-28
申请人： Salah U. Ahmed , Gandha V. Naringrekar , Tahseen A. Chowdhury , Sudhir R. Gorukanti
发明人： Salah U. Ahmed , Gandha V. Naringrekar , Tahseen A. Chowdhury , Sudhir R. Gorukanti
IPC分类号： A61K31/55 , A61P25/00
CPC分类号： A61K9/0056 , A61K9/2054 , C07D223/00
摘要： A non-effervescent, solid dosage form containing mirtazapine, which is used to form mirtazapine pharmaceutical tablets. The dosage form contains mirtazapine, a hydrophilic component, and at least one lubricant. In some embodiments, the dosage forms contain a salivating agent. Processes for producing mirtazapine orally disintegrating tablets are also provided.
摘要翻译：含有米氮平的非泡腾固体剂型，用于形成米氮平药物片剂。剂型含有米氮平，亲水组分和至少一种润滑剂。在一些实施方案中，剂型含有唾液酸化剂。还提供了生产米氮平口腔崩解片的方法。

4. 发明授权

US07838029B1 Mirtazapine solid dosage forms 失效
标题翻译：米氮平固体剂型
公开(公告)号：US07838029B1
公开(公告)日：2010-11-23
申请号：US10902836
申请日：2004-08-02
申请人： Salah U. Ahmed , Gandha V. Naringrekar , Tahseen A. Chowdhury , Sudhir R. Gorukanti
发明人： Salah U. Ahmed , Gandha V. Naringrekar , Tahseen A. Chowdhury , Sudhir R. Gorukanti
IPC分类号： A61K9/20 , C07D223/00
CPC分类号： A61K9/0056 , A61K9/2054 , C07D223/00
摘要： A non-effervescent, solid dosage form containing mirtazapine, which is used to form mirtazapine pharmaceutical tablets. The dosage form contains mirtazapine, a hydrophilic component, and at least one lubricant. In some embodiments, the dosage forms contain a salivating agent. Processes for producing mirtazapine orally disintegrating tablets are also provided.
摘要翻译：含有米氮平的非泡腾固体剂型，用于形成米氮平药物片剂。剂型含有米氮平，亲水组分和至少一种润滑剂。在一些实施方案中，剂型含有唾液酸化剂。还提供了生产米氮平口腔崩解片的方法。

5. 发明授权

US08202534B2 Attachment of a handle to a solid oral dosage form 有权
标题翻译：把手固定在固体口服剂型上
公开(公告)号：US08202534B2
公开(公告)日：2012-06-19
申请号：US11446510
申请日：2006-06-05
申请人： Tahseen A. Chowdhury , Edward J. Gabrielski , Christopher H. Baker
发明人： Tahseen A. Chowdhury , Edward J. Gabrielski , Christopher H. Baker
IPC分类号： A61K9/00
CPC分类号： A61K9/2027 , A61J3/00 , A61J7/003 , A61K9/0056 , A61K9/2009 , A61K9/2013 , B29C65/645 , B29C66/71 , B29C66/7392 , B29C66/7394 , B29L2031/753 , B29K2025/08 , B29K2023/00 , B29K2021/003 , B29K2005/00 , B29K2003/00
摘要： The present invention relates to a method of attaching a handle to a solid oral dosage form by use of high frequency mechanical vibrations. The present invention also relates to a method of attaching a handle to a solid oral dosage form, the method comprising: (a) placing a handle in contact with a solid oral dosage form, wherein an area of contact between the handle and the solid oral dosage form forms a joint interface; (b) applying high frequency mechanical vibrations to the joint interface until the solid oral dosage form at the joint interface reaches a molten state; and (c) cooling the joint interface in a molten state to allow solidification, thereby attaching the handle to the solid oral dosage form.
摘要翻译：本发明涉及通过使用高频机械振动将手柄附接到固体口服剂型的方法。本发明还涉及一种将手柄附接到固体口服剂型的方法，所述方法包括：（a）将手柄放置成与固体口服剂型接触，其中手柄与固体口服之间的接触面积剂型形成联合界面; （b）将高频机械振动施加到接合界面，直到接合界面处的固体口服剂型达到熔融状态; 和（c）在熔融状态下冷却接合界面以允许固化，从而将手柄附接到固体口服剂型。

6. 发明授权

US07811604B1 Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same 有权
标题翻译：不含泡腾，口服崩解的包含氯氮平的固体药物剂型及其制备和使用方法
公开(公告)号：US07811604B1
公开(公告)日：2010-10-12
申请号：US11598833
申请日：2006-11-14
申请人： Salah U. Ahmed , Lianli Li , Tahseen A. Chowdhury
发明人： Salah U. Ahmed , Lianli Li , Tahseen A. Chowdhury
IPC分类号： A61K9/20 , A61K9/14 , A01N43/62
CPC分类号： A61K9/2054 , A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K31/5513
摘要： The present invention is directed to non-effervescent, orally disintegrating dosage forms comprising free base clozapine that are substantially free of acids, water-soluble polymers, taste-masking polymers, and coatings, and methods of making and using the same.
摘要翻译：本发明涉及非泡腾口腔崩解剂型，其包含基本上不含酸的游离碱氯氮平，水溶性聚合物，掩味聚合物和涂层，以及制备和使用它们的方法。

7. 发明申请

US20120207798A1 Solid Oral Dosage Form Attached to a Handle 审中-公开
标题翻译：实心的口服剂型附在手柄上
公开(公告)号：US20120207798A1
公开(公告)日：2012-08-16
申请号：US13456724
申请日：2012-04-26
申请人： Tahseen A. CHOWDHURY , Edward J. GABRIELSKI , Christopher H. BAKER
发明人： Tahseen A. CHOWDHURY , Edward J. GABRIELSKI , Christopher H. BAKER
IPC分类号： A61K9/00 , A61K31/4468
CPC分类号： A61K9/2027 , A61J3/00 , A61J7/003 , A61K9/0056 , A61K9/2009 , A61K9/2013 , B29C65/645 , B29C66/71 , B29C66/7392 , B29C66/7394 , B29L2031/753 , B29K2025/08 , B29K2023/00 , B29K2021/003 , B29K2005/00 , B29K2003/00
摘要： The present invention relates to a method of attaching a handle to a solid oral dosage form by use of high frequency mechanical vibrations. The present invention also relates to a method of attaching a handle to a solid oral dosage form, the method comprising: (a) placing a handle in contact with a solid oral dosage form, wherein an area of contact between the handle and the solid oral dosage form forms a joint interface; (b) applying high frequency mechanical vibrations to the joint interface until the solid oral dosage form at the joint interface reaches a molten state; and (c) cooling the joint interface in a molten state to allow solidification, thereby attaching the handle to the solid oral dosage form.
摘要翻译：本发明涉及通过使用高频机械振动将手柄附接到固体口服剂型的方法。本发明还涉及一种将手柄附接到固体口服剂型的方法，所述方法包括：（a）将手柄放置成与固体口服剂型接触，其中手柄与固体口服之间的接触面积剂型形成联合界面; （b）将高频机械振动施加到接合界面，直到接合界面处的固体口服剂型达到熔融状态; 和（c）在熔融状态下冷却接合界面以允许固化，从而将手柄附接到固体口服剂型。

8. 发明授权

US07867515B2 Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof 有权
标题翻译：口服崩解包含孕激素的固体剂型及其制备和使用方法
公开(公告)号：US07867515B2
公开(公告)日：2011-01-11
申请号：US12003234
申请日：2007-12-20
申请人： Salah U. Ahmed , Sundeep Sethia , Tahseen A. Chowdhury
发明人： Salah U. Ahmed , Sundeep Sethia , Tahseen A. Chowdhury
IPC分类号： A61K9/20
CPC分类号： A61K31/56 , A61K9/0056 , A61K9/2018 , A61K9/2054
摘要： The present invention is directed to non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising progestin and methods of making and using the dosage forms to treat conditions in females in need thereof.
摘要翻译：本发明涉及包含孕激素的非泡腾口腔崩解固体药物剂型，以及制备和使用该剂型以治疗有需要的女性中的病症的方法。

9. 发明申请

US20080175906A1 Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof 有权
标题翻译：口服崩解包含孕激素的固体剂型及其制备和使用方法
公开(公告)号：US20080175906A1
公开(公告)日：2008-07-24
申请号：US12003234
申请日：2007-12-20
申请人： Salah U. Ahmed , Sundeep Sethia , Tahseen A. Chowdhury
发明人： Salah U. Ahmed , Sundeep Sethia , Tahseen A. Chowdhury
IPC分类号： A61K9/20 , A61K31/56
CPC分类号： A61K31/56 , A61K9/0056 , A61K9/2018 , A61K9/2054
摘要： The present invention is directed to non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising progestin and methods of making and using the dosage forms to treat conditions in females in need thereof.
摘要翻译：本发明涉及包含孕激素的非泡腾口腔崩解固体药物剂型，以及制备和使用该剂型以治疗有需要的女性中的病症的方法。

10. 发明授权

US08323679B2 Flexible, compressed intravaginal rings, methods of making and using the same, and apparatus for making the same 有权
标题翻译：柔性，压缩的阴道内环，制造和使用它们的方法及其制造方法
公开(公告)号：US08323679B2
公开(公告)日：2012-12-04
申请号：US12984729
申请日：2011-01-05
申请人： Salah U. Ahmed , Tahseen A. Chowdhury , Yi Luo
发明人： Salah U. Ahmed , Tahseen A. Chowdhury , Yi Luo
IPC分类号： A61F6/14 , A61K38/43 , A61P15/02 , A61P29/00 , A61P31/00 , A61P23/02 , A61P19/10 , B29C3/52
CPC分类号： A61K9/0036 , A61K31/00 , A61K31/20 , A61K38/00
摘要： The present invention is directed to flexible, compressed intravaginal rings comprising a substantially homogeneous compressed mixture comprising a polymethacrylate, a plasticizer, and an active agent, and methods of making and using the same, and apparatus for making the same.
摘要翻译：本发明涉及柔性压缩阴道内环，其包含基本均匀的压缩混合物，其包含聚甲基丙烯酸酯，增塑剂和活性剂，以及制备和使用它们的方法及其制备方法。

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