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1. 发明授权

US09474567B2 Method for coating surgical instruments 有权
标题翻译：手术器械涂层方法
公开(公告)号：US09474567B2
公开(公告)日：2016-10-25
申请号：US14516782
申请日：2014-10-17
申请人： Team Medical, LLC
发明人： Warren P. Heim , James Brassell
IPC分类号： A61B18/14 , C04B24/42 , C04B28/26 , A61B18/00 , C09D1/00 , H01B3/44 , A61L31/08 , A61L31/14 , B05D1/36 , B05D3/00 , B05D5/00 , C04B111/00 , A61B17/00
CPC分类号： A61B18/14 , A61B18/00 , A61B2017/00526 , A61B2018/00601 , A61L31/088 , A61L31/14 , A61L2420/02 , A61L2420/06 , A61L2420/08 , B05D1/36 , B05D3/007 , B05D5/00 , C04B24/42 , C04B28/26 , C04B2111/00482 , C04B2111/00525 , C04B2111/00836 , C09D1/00 , H01B3/445 , Y02W30/94 , Y10T428/259 , C04B14/06 , C04B14/30 , C04B14/303 , C04B14/305 , C04B14/322 , C04B14/325 , C04B14/366 , C04B18/146 , C04B40/0263 , C04B2103/40 , C04B14/323 , C04B14/324 , C04B14/328 , C04B24/2682
摘要： A coating and devices using the coating are provided. The coating is applied in liquid form and dried or otherwise cured to form a durable adherent coating resistant to high temperatures and having optional hydrophobic properties. The coating formulation contains an aqueous formulation of silica, one or more fillers, and sufficient base, (e.g., potassium hydroxide), to have a pH exceeding about 10.5 during at least part of the formulation process. The formulation may contain a compound(s) that affects surface free energy, energy to make the cured coating hydrophobic. Such compounds include silanes containing halogens (e.g., fluorine or chlorine) and in particular silanes containing one or more hydrolyzable groups attached to at least one silicon atom and a group containing one or more halogens (e.g., chlorine or fluorine). A medical instrument (e.g., electrosurgical instrument) may be at least partially covered by a coating using the formulation.
摘要翻译：提供涂层和使用该涂层的装置。将涂层以液体形式施加并干燥或以其它方式固化以形成耐高温且具有任选疏水性质的耐久粘合涂层。涂料制剂含有二氧化硅的水性制剂，一种或多种填料和足够的碱（例如氢氧化钾），在制剂过程的至少一部分期间具有超过约10.5的pH。制剂可以含有影响表面自由能的化合物，使固化的涂层具有疏水性的能量。这样的化合物包括含有卤素（例如氟或氯）的硅烷，特别是含有连接至少一个硅原子的一个或多个可水解基团和含有一个或多个卤素（例如氯或氟）的基团的硅烷。医疗器械（例如，电外科器械）可以至少部分地由使用该制剂的涂层覆盖。

2. 发明申请

US20230101362A1 RNA STABILIZATION 有权
公开(公告)号：US20230101362A1
公开(公告)日：2023-03-30
申请号：US17932978
申请日：2022-09-16
申请人： Team Medical LLC
发明人： Kyle P. HEIM , Warren P. HEIM
IPC分类号： C12N15/10 , C12N15/113
摘要： Formulations of substances comprising at least one RNA stabilizing substance and at least one substance comprising RNA or based on RNA and methods of using the formulations to improve the storage and use stability of substances comprising RNA or based on RNA.

3. 发明申请

US20170027631A1 METHOD FOR COATING SURGICAL INTRUMENTS 审中-公开
标题翻译：涂敷手术治疗方法
公开(公告)号：US20170027631A1
公开(公告)日：2017-02-02
申请号：US15293395
申请日：2016-10-14
申请人： Team Medical, LLC
发明人： Warren P. Heim , James Brassell
IPC分类号： A61B18/14 , A61L31/14 , A61L31/08
CPC分类号： A61B18/14 , A61B18/00 , A61B2017/00526 , A61B2018/00601 , A61L31/088 , A61L31/14 , A61L2420/02 , A61L2420/06 , A61L2420/08 , B05D1/36 , B05D3/007 , B05D5/00 , C04B24/42 , C04B28/26 , C04B2111/00482 , C04B2111/00525 , C04B2111/00836 , C09D1/00 , H01B3/445 , Y02W30/94 , Y10T428/259 , C04B14/06 , C04B14/30 , C04B14/303 , C04B14/305 , C04B14/322 , C04B14/325 , C04B14/366 , C04B18/146 , C04B40/0263 , C04B2103/40 , C04B14/323 , C04B14/324 , C04B14/328 , C04B24/2682
摘要： A coating and devices using the coating are provided. The coating is applied in liquid form and dried or otherwise cured to form a durable adherent coating resistant to high temperatures and having optional hydrophobic properties. The coating formulation contains an aqueous formulation of silica, one or more fillers, and sufficient base, (e.g., potassium hydroxide), to have a pH exceeding about 10.5 during at least part of the formulation process. The formulation may contain a compound(s) that affects surface free energy, energy to make the cured coating hydrophobic. Such compounds include silanes containing halogens (e.g., fluorine or chlorine) and in particular silanes containing one or more hydrolyzable groups attached to at least one silicon atom and a group containing one or more halogens (e.g., chlorine or fluorine). A medical instrument (e.g., electrosurgical instrument) may be at least partially covered by a coating using the formulation.
摘要翻译：提供涂层和使用该涂层的装置。将涂层以液体形式施加并干燥或以其它方式固化以形成耐高温且具有任选疏水性质的耐久粘合涂层。涂料制剂含有二氧化硅的水性制剂，一种或多种填料和足够的碱（例如氢氧化钾），在制剂过程的至少一部分期间具有超过约10.5的pH。制剂可以含有影响表面自由能的化合物，使固化的涂层具有疏水性的能量。这样的化合物包括含有卤素（例如氟或氯）的硅烷，特别是含有连接至少一个硅原子的一个或多个可水解基团和含有一个或多个卤素（例如氯或氟）的基团的硅烷。医疗器械（例如，电外科器械）可以至少部分地由使用该制剂的涂层覆盖。

4. 发明申请

US20150141989A1 METHOD FOR COATING SURGICAL INSTRUMENTS 有权
标题翻译：涂敷手术器械的方法
公开(公告)号：US20150141989A1
公开(公告)日：2015-05-21
申请号：US14516782
申请日：2014-10-17
申请人： Team Medical, LLC
发明人： Warren P. Heim , James Brassell
IPC分类号： A61B18/14 , B05D5/00 , B05D1/36 , B05D3/00 , A61L31/08 , A61L31/14
CPC分类号： A61B18/14 , A61B18/00 , A61B2017/00526 , A61B2018/00601 , A61L31/088 , A61L31/14 , A61L2420/02 , A61L2420/06 , A61L2420/08 , B05D1/36 , B05D3/007 , B05D5/00 , C04B24/42 , C04B28/26 , C04B2111/00482 , C04B2111/00525 , C04B2111/00836 , C09D1/00 , H01B3/445 , Y02W30/94 , Y10T428/259 , C04B14/06 , C04B14/30 , C04B14/303 , C04B14/305 , C04B14/322 , C04B14/325 , C04B14/366 , C04B18/146 , C04B40/0263 , C04B2103/40 , C04B14/323 , C04B14/324 , C04B14/328 , C04B24/2682
摘要： A coating and devices using the coating are provided. The coating is applied in liquid form and dried or otherwise cured to form a durable adherent coating resistant to high temperatures and having optional hydrophobic properties. The coating formulation contains an aqueous formulation of silica, one or more fillers, and sufficient base, (e.g., potassium hydroxide), to have a pH exceeding about 10.5 during at least part of the formulation process. The formulation may contain a compound(s) that affects surface free energy, energy to make the cured coating hydrophobic. Such compounds include silanes containing halogens (e.g., fluorine or chlorine) and in particular silanes containing one or more hydrolyzable groups attached to at least one silicon atom and a group containing one or more halogens (e.g., chlorine or fluorine). A medical instrument (e.g., electrosurgical instrument) may be at least partially covered by a coating using the formulation.
摘要翻译：提供涂层和使用该涂层的装置。将涂层以液体形式施加并干燥或以其它方式固化以形成耐高温且具有任选疏水性质的耐久粘合涂层。涂料制剂含有二氧化硅的水性制剂，一种或多种填料和足够的碱（例如氢氧化钾），在制剂过程的至少一部分期间具有超过约10.5的pH。制剂可以含有影响表面自由能的化合物，使固化的涂层具有疏水性的能量。这样的化合物包括含有卤素（例如氟或氯）的硅烷，特别是含有连接至少一个硅原子的一个或多个可水解基团和含有一个或多个卤素（例如氯或氟）的基团的硅烷。医疗器械（例如，电外科器械）可以至少部分地由使用该制剂的涂层覆盖。

5. 发明授权

US10405916B2 Method for coating surgical instruments 有权
公开(公告)号：US10405916B2
公开(公告)日：2019-09-10
申请号：US15293395
申请日：2016-10-14
申请人： Team Medical, LLC
发明人： Warren P. Heim , James Brassell
IPC分类号： A61B18/14 , C04B24/42 , C04B28/26 , A61B18/00 , C09D1/00 , H01B3/44 , A61L31/08 , A61L31/14 , B05D1/36 , B05D3/00 , B05D5/00 , C04B111/00 , A61B17/00
摘要： A coating and devices using the coating are provided. The coating is applied in liquid form and dried or otherwise cured to form a durable adherent coating resistant to high temperatures and having optional hydrophobic properties. The coating formulation contains an aqueous formulation of silica, one or more fillers, and sufficient base, (e.g., potassium hydroxide), to have a pH exceeding about 10.5 during at least part of the formulation process. The formulation may contain a compound(s) that affects surface free energy, energy to make the cured coating hydrophobic. Such compounds include silanes containing halogens (e.g., fluorine or chlorine) and in particular silanes containing one or more hydrolyzable groups attached to at least one silicon atom and a group containing one or more halogens (e.g., chlorine or fluorine). A medical instrument (e.g., electrosurgical instrument) may be at least partially covered by a coating using the formulation.

6. 发明公开

US20240115595A1 MATERIAL COMPOSITIONS AND METHODS OF USE IMPROVING RNA STABILITY 审中-公开
公开(公告)号：US20240115595A1
公开(公告)日：2024-04-11
申请号：US18464129
申请日：2023-09-08
申请人： Team Medical, LLC
发明人： Kyle P. HEIM , Warren P. HEIM
IPC分类号： A61K31/7105 , A61K47/18 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/36
CPC分类号： A61K31/7105 , A61K47/186 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/36
摘要： Formulations of substances comprising at least one RNA stabilizing substance and at least one substance comprising extracellular RNA or based on RNA and methods of using the formulations to improve the storage and use stability of substances comprising extracellular RNA or based on RNA at temperatures of 4° C. and above in solution without lyophilization.

7. 发明申请

US20220162587A1 RNA STABILIZATION 有权
公开(公告)号：US20220162587A1
公开(公告)日：2022-05-26
申请号：US17531297
申请日：2021-11-19
申请人： Team Medical LLC
发明人： Kyle P. Heim , Warren P. Heim
IPC分类号： C12N15/10 , C12N15/113
摘要： Formulations of substances comprising at least one RNA stabilizing substance and at least one substance comprising RNA or based on RNA and methods of using the formulations to improve the storage and use stability of substances comprising RNA or based on RNA.

8. 发明申请

US20130226175A1 COATING SUITABLE FOR SURGICAL INSTRUMENTS 审中-公开
标题翻译：适用于外科手术的涂层
公开(公告)号：US20130226175A1
公开(公告)日：2013-08-29
申请号：US13776411
申请日：2013-02-25
申请人： Team Medical, LLC
发明人： Warren P. Heim , James Brassell
IPC分类号： A61B18/00 , C09D1/00 , H01B3/44
CPC分类号： A61B18/14 , A61B18/00 , A61B2017/00526 , A61B2018/00601 , A61L31/088 , A61L31/14 , A61L2420/02 , A61L2420/06 , A61L2420/08 , B05D1/36 , B05D3/007 , B05D5/00 , C04B24/42 , C04B28/26 , C04B2111/00482 , C04B2111/00525 , C04B2111/00836 , C09D1/00 , H01B3/445 , Y02W30/94 , Y10T428/259 , C04B14/06 , C04B14/30 , C04B14/303 , C04B14/305 , C04B14/322 , C04B14/325 , C04B14/366 , C04B18/146 , C04B40/0263 , C04B2103/40 , C04B14/323 , C04B14/324 , C04B14/328 , C04B24/2682
摘要： A coating and devices using the coating are provided. The coating is applied in liquid form and dried or otherwise cured to form a durable adherent coating resistant to high temperatures and having optional hydrophobic properties. The coating formulation contains an aqueous formulation of silica, one or more fillers, and sufficient base, (e.g., potassium hydroxide), to have a pH exceeding about 10.5 during at least part of the formulation process. The formulation may contain a compound(s) that affects surface free energy, energy to make the cured coating hydrophobic. Such compounds include silanes containing halogens (e.g., fluorine or chlorine) and in particular silanes containing one or more hydrolyzable groups attached to at least one silicon atom and a group containing one or more halogens (e.g., chlorine or fluorine). A medical instrument (e.g., electrosurgical instrument) may be at least partially covered by a coating using the formulation.
摘要翻译：提供涂层和使用该涂层的装置。将涂层以液体形式施加并干燥或以其它方式固化以形成耐高温且具有任选疏水性质的耐久粘合涂层。涂料制剂含有二氧化硅的水性制剂，一种或多种填料和足够的碱（例如氢氧化钾），在制剂过程的至少一部分期间具有超过约10.5的pH。制剂可以含有影响表面自由能的化合物，使固化的涂层具有疏水性的能量。这样的化合物包括含有卤素（例如氟或氯）的硅烷，特别是含有连接至少一个硅原子的一个或多个可水解基团和含有一个或多个卤素（例如氯或氟）的基团的硅烷。医疗器械（例如，电外科器械）可以至少部分地由使用该制剂的涂层覆盖。

9. 发明申请

US20150164341A1 METHOD AND SYSTEM FOR OBTAINING DIMENSION RELATED INFORMATION FOR A FLOW CHANNEL 审中-公开
标题翻译：用于获取流量信道尺寸相关信息的方法和系统
公开(公告)号：US20150164341A1
公开(公告)日：2015-06-18
申请号：US14334367
申请日：2014-07-17
申请人： TEAM MEDICAL, LLC
发明人： WARREN P. HEIM
IPC分类号： A61B5/026 , A61B5/00 , A61B5/02
CPC分类号： A61B5/026 , A61B5/02007 , A61B5/72 , A61B8/06
摘要： A method and system for determination of dimension related information such as volumetric flow rate(s) of a fluid flowing through a channel. In one implementation, the method and system analyzes temporal changes in a moving fluid's velocity profile to calculate the fluid channel dimensions. In turn, the fluid channel dimensions and the fluid velocity profile data may be combined to calculate the volumetric flow rate of the fluid flowing through the channel. In this regard, the geometry of the channel can be characterized using dimensionless variables that relate dimensions, such as the radius across a circular cross-section, to the largest extent of a dimension. For example, in the case where the channel is a cylindrical tube and a pressure gradient is applied long enough for the fluid to have reached a steady state, the dimensionless radius will be the radius at any point divided by the overall radius of the tube. One or more dimensionless variables can be used to characterize geometries: for instance, one dimensionless radius characterizes a circular tube and two dimensionless teams characterize an elliptical tube (one for the major axis and one for the minor axis). The time required for velocity profiles to change from one shape to another may be characterized by dimensionless time. Dimensionless time, in turn, uses the fluid's viscosity and density along with time and overall channel dimensions and may be used in combination with at least one velocity profile to calculate the volumetric flow rate of the fluid flowing through the channel.
摘要翻译：用于确定尺寸相关信息的方法和系统，例如流过通道的流体的体积流量。在一个实施方案中，该方法和系统分析移动流体的速度分布的时间变化以计算流体通道尺寸。反过来，流体通道尺寸和流体速度分布数据可以被组合以计算流过通道的流体的体积流量。在这方面，可以使用无量纲变量来表征通道的几何形状，其将尺寸（例如圆形横截面上的半径）与尺寸的最大程度相关联。例如，在通道是圆柱形管并且施加足够长的压力梯度以使流体达到稳定状态的情况下，无量纲半径将是在任何点除以管的总半径的半径。一个或多个无量纲变量可用于表征几何形状：例如，一个无量纲半径表征圆形管，两个无量纲的组合表征椭圆管（一个用于长轴，一个用于短轴）。速度分布从一个形状变为另一个形状所需的时间可以是无量纲时间的特征。无尺寸时间反过来又使用流体的粘度和密度以及时间和总体通道尺寸，并且可以与至少一个速度分布组合使用，以计算流过通道的流体的体积流量。

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