专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09125939B2 Carbostyril derivatives and mood stabilizers for treating mood disorders 有权
标题翻译：卡波他汀衍生物和情绪稳定剂用于治疗情绪障碍
公开(公告)号：US09125939B2
公开(公告)日：2015-09-08
申请号：US10556600
申请日：2004-05-19
申请人： Tetsuro Kikuchi , Taro Iwamoto , Tsuyoshi Hirose
发明人： Tetsuro Kikuchi , Taro Iwamoto , Tsuyoshi Hirose
IPC分类号： A61K31/47 , A61K31/44 , A61K33/14 , A01N59/08 , A61K45/06 , A61K31/19 , A61K31/195 , A61K31/425 , A61K31/4704 , A61K31/496 , A61K31/497 , A61K31/55 , A61K31/7008 , A61K33/00
CPC分类号： A61K31/496 , A61K31/19 , A61K31/195 , A61K31/357 , A61K31/4015 , A61K31/423 , A61K31/425 , A61K31/4704 , A61K31/497 , A61K31/53 , A61K31/55 , A61K31/5513 , A61K31/7008 , A61K33/00 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-sero-tonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbamaza-pine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, mania or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.
摘要翻译：本发明的药物组合物包含喹诺酮衍生物，其是药学上可接受的载体中的多巴胺 - 血清素系统稳定剂和情绪稳定剂。喹诺酮类衍生物可以是阿立哌唑或其代谢物。情绪稳定剂可以包括但不限于锂，丙戊酸，二丙酸钠，氨基马扎松，奥卡马沙平，唑尼沙胺，拉莫拉膦，托吡酯，加巴喷丁，左乙拉西坦或氯硝西泮。这些组合物用于治疗情绪障碍的患者，特别是伴有或没有精神病特征，躁狂或混合发作的双相情感障碍。提供了用于将单独施用喹诺酮衍生物和情绪稳定剂给患有情绪障碍的患者的方法。

2. 发明申请

US20140120185A1 COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER 审中-公开
标题翻译：包含吡喹酮或其盐的组合和用于治疗CNS疾病的第二种药物
公开(公告)号：US20140120185A1
公开(公告)日：2014-05-01
申请号：US14009436
申请日：2012-04-04
申请人： Tsuyoshi Hirose , Kenji Maeda , Tetsuro Kikuchi , Masafumi Toda
发明人： Tsuyoshi Hirose , Kenji Maeda , Tetsuro Kikuchi , Masafumi Toda
IPC分类号： A61K31/496 , A61K45/06
CPC分类号： A61K31/496 , A61K9/20 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/15 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/4525 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The present invention provides a medicament having a wider treatment spectrum, causing a fewer side effects and superior in tolerability and safety, as compared to known typical antipsychotic agents and atypical antipsychotic agents. The present invention related to a medicament containing (I) a compound which is 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof, and (II) at least one drug selected from the group consisting of a mood stabilizer, a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a serotonin and norepinephrine reuptake inhibitor, a noradrenergic and specific serotonergic antidepressant, an antianxiety drug, a tricyclic antidepressant, a tetracyclic antidepressant, an antipsychotic drug and an anti-ADHD drug, in combination.
摘要翻译：与已知的典型抗精神病药和非典型抗精神病药相比，本发明提供了具有更宽治疗谱的药物，其副作用较小，耐受性和安全性优异。本发明涉及含有（I）7- [4-（4-苯并[b]噻吩-4-基 - 哌嗪-1-基）丁氧基] -1H-喹啉-2-酮的化合物或其盐，和（II）选自情绪稳定剂，5-羟色胺再摄取抑制剂，去甲肾上腺素再摄取抑制剂，5-羟色胺和去甲肾上腺素再摄取抑制剂，去甲肾上腺素能和特异性5-羟色胺能抗抑郁药，抗焦虑药物，三环抗抑郁药，四环抗抑郁药，抗精神病药和抗ADHD药。

3. 发明授权

US08426423B2 Method of treating Attention Deficit Hyper-Activity Disorder 有权
标题翻译：治疗注意力缺陷超活动障碍的方法
公开(公告)号：US08426423B2
公开(公告)日：2013-04-23
申请号：US11932795
申请日：2007-10-31
申请人： Shaun Jordan , Tetsuro Kikuchi , Katsura Tottori , Tsuyoshi Hirose , Yasufumi Uwahodo
发明人： Shaun Jordan , Tetsuro Kikuchi , Katsura Tottori , Tsuyoshi Hirose , Yasufumi Uwahodo
IPC分类号： A61K31/496
CPC分类号： A61K31/496 , A61K31/4704 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1) wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
摘要翻译：本发明涉及一种治疗患有与5-HT 1A受体亚型相关的中枢神经系统病症的患者的方法，其包含由式（1）表示的喹诺酮衍生物或其盐作为活性成分，其中碳喹诺酮骨架中3-和4-位之间的碳键是单键或双键。

4. 发明申请

US20120238584A1 5-HT1A receptor subtype agonist 审中-公开
标题翻译： 5-HT1A受体亚型激动剂
公开(公告)号：US20120238584A1
公开(公告)日：2012-09-20
申请号：US13426886
申请日：2012-03-22
申请人： Shaun Jordan , Tetsuro Kikuchi , Katsura Tottori , Tsuyoshi Hirose , Yasufumi Uwahodo
发明人： Shaun Jordan , Tetsuro Kikuchi , Katsura Tottori , Tsuyoshi Hirose , Yasufumi Uwahodo
IPC分类号： A61K31/496 , A61P25/24 , A61P25/18 , A61P25/00
CPC分类号： A61K31/496 , A61K31/4704 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1) wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
摘要翻译：本发明涉及一种治疗患有与5-HT 1A受体亚型相关的中枢神经系统病症的患者的方法，其包含由式（1）表示的喹诺酮衍生物或其盐作为活性成分，其中碳喹诺酮骨架中3-和4-位之间的碳键是单键或双键。

5. 发明申请

US20120165402A1 USE OF ONE OR A COMBINATION OF PHYTO-CANNABINOIDS IN THE TREATMENT OF EPILEPSY 有权
标题翻译：使用一种或将PHYTO-CANNABINOIDS组合在治疗EPILEPSY
公开(公告)号：US20120165402A1
公开(公告)日：2012-06-28
申请号：US13380305
申请日：2010-06-29
申请人： Ben Whalley , Gary Stephens , Claire Willaims , Geoffrey Guy , Stephen Wright , Tetsuro Kikuchi
发明人： Ben Whalley , Gary Stephens , Claire Willaims , Geoffrey Guy , Stephen Wright , Tetsuro Kikuchi
IPC分类号： A61K31/352 , A61P25/08 , A61K31/05
CPC分类号： A61K31/05 , A61K31/352
摘要： This invention relates to the use of one or more cannabinoids in the treatment of epilepsy and more particularly to the use of one or a combination of cannabinoids in the treatment of generalized or partial seizure. In one embodiment it relates to the use of the cannabinoid THCV, as a pure or isolated compound, or as a plant extract in which significant amounts of any THC naturally present has been selectively removed. In another embodiment the phytocannabinoid is CBD.
摘要翻译：本发明涉及一种或多种大麻素用于治疗癫痫的用途，更具体地说涉及使用一种或大麻素的组合来治疗广泛性或部分性发作。在一个实施方案中，其涉及大麻素THCV作为纯的或分离的化合物或作为其中显着量的任何THC天然存在的植物提取物的使用已被选择性地除去。在另一个实施方案中，植物大麻素是CBD。

6. 发明申请

US20090114404A1 Sprinkler head 有权
标题翻译：喷头
公开(公告)号：US20090114404A1
公开(公告)日：2009-05-07
申请号：US11989696
申请日：2005-08-02
申请人： Tetsuro Kikuchi , Rikiya Kato
发明人： Tetsuro Kikuchi , Rikiya Kato
IPC分类号： A62C37/11
CPC分类号： C22C28/00 , A62C35/68 , A62C37/11 , C22C12/00
摘要： The present invention is directed to overcome such a problem associated with a sprinkler head made of In-based alloy with no use of Pb or Cd that in contradiction with the fact that a testing temperature in a strength test of a sprinkler head is proximal to a melting temperature of a solder alloy used in a heat-sensitive decomposition structure of the sprinkler head, and therefore a good creeping property over a higher temperature zone in which a sprinkler is activated is required, typically, the sprinkler head made of the In-based alloy with no use of Pb or Cd could not achieve the creeping property over the higher temperature zone in which the sprinkler is activated as favorably as any conventional sprinkler head using Pb or Cd could do, and could occasionally end in failure in a durability test.To solve the above problem, the present invention provides an alloy usable for a heat-sensitive material in a sprinkler head, which is composed of Sn in an amount of 0.1-2.0% by mass, Bi in an amount of 31-37% by mass and In for balance for a temperature range around 70-75° C. or which is composed of Zn in an amount of 0.05-0.4% by mass, Bi in an amount of 43-55% by mass and In for balance for a temperature range around 90-95° C.
摘要翻译：本发明旨在克服与不使用Pb或Cd的In基合金制成的喷头相关的问题，这与喷洒头的强度试验中的试验温度接近于在喷洒头的热敏分解结构中使用的焊料合金的熔融温度，因此需要在喷洒器启动的较高温度区域具有良好的蠕变性能，通常，由In-based 没有使用Pb或Cd的合金在喷淋头被激活的较高温度区域不能达到蠕变性能，因为任何使用Pb或Cd的常规喷淋头可以做到，并且偶尔在耐久性测试中可能会失败。为了解决上述问题，本发明提供了一种可用于喷洒头中的热敏材料的合金，其由0.1-2.0质量％的Sn组成，Bi为31-37％，Bi为质量和In，在70-75℃左右的温度范围内进行平衡，或者由0.05-0.4质量％的Zn组成，Bi为43-55质量％，In为温度范围在90-95°C左右

7. 发明申请

US20080131309A1 Alloy For A Fusible Plug And A Fusible Plug 有权
标题翻译：可熔插头和可熔插头的合金
公开(公告)号：US20080131309A1
公开(公告)日：2008-06-05
申请号：US11667959
申请日：2004-11-24
申请人： Rikiya Kato , Tetsuro Kikuchi , Mutsumi Deguchi
发明人： Rikiya Kato , Tetsuro Kikuchi , Mutsumi Deguchi
IPC分类号： C22C28/00 , C22C12/00
CPC分类号： F16K17/383
摘要： Problem A conventional alloy for a fusible plug contained harmful elements such as Cd or Pb, so there was a concern of pollution by these harmful elements. The present invention provides a fusible plug which does not contain the harmful components Cd or Pb, with which the alloy is not forced out of the fusible plug even when used for long periods as a safety device for refrigeration equipment, and which has a high mechanical strength such as creep strength.Means for Solving the Problem A fusible plug is used which employs a fusible alloy consisting essentially of 0.1-2.0 mass percent of Sn, 31-37 mass percent of Bi, and a remainder of In, the alloy melting at approximately at 70-75° C. A fusible plug is used which employs an alloy consisting essentially of 0.05-0.4 mass percent of Zn, 47-55 mass percent of Bi, and a remainder of In, the alloy melting at approximately 90-95° C.
摘要翻译：问题用于易熔塞的常规合金包含有害元素如Cd或Pb，因此受到这些有害元素污染的担忧。本发明提供一种不含有害成分Cd或Pb的可熔插塞，即使长时间作为制冷装置的安全装置，合金也不会被迫从易熔丝塞出来，并且具有高机械性强度如蠕变强度。解决问题的手段使用易熔合金，其熔融金属基本上由0.1-2.0质量％的Sn，31-37质量％的Bi和余量的In组成，熔融约为70-75℃ C.使用可熔插塞，其使用基本上由Zn的0.05-0.4质量％，Bi的47-55质量％和In的剩余部分组成的合金，在约90-95℃熔化。

8. 发明申请

US20070031513A1 Carbostyril derivatives and mood stabilizers for treating mood disorders 有权
标题翻译：卡波他汀衍生物和情绪稳定剂用于治疗情绪障碍
公开(公告)号：US20070031513A1
公开(公告)日：2007-02-08
申请号：US10556600
申请日：2004-05-19
申请人： Tetsuro Kikuchi , Taro Iwamoto , Tsuyoshi Hirose
发明人： Tetsuro Kikuchi , Taro Iwamoto , Tsuyoshi Hirose
IPC分类号： A61K31/7008 , A61K31/55 , A61K31/496 , A61K33/00 , A61K31/4704 , A61K31/425 , A61K31/19 , A61K31/195
CPC分类号： A61K31/496 , A61K31/19 , A61K31/195 , A61K31/357 , A61K31/4015 , A61K31/423 , A61K31/425 , A61K31/4704 , A61K31/497 , A61K31/53 , A61K31/55 , A61K31/5513 , A61K31/7008 , A61K33/00 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-sero-tonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbamaza-pine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, mania or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.
摘要翻译：本发明的药物组合物包含喹诺酮衍生物，其是药学上可接受的载体中的多巴胺 - 血清素系统稳定剂和情绪稳定剂。喹诺酮类衍生物可以是阿立哌唑或其代谢物。情绪稳定剂可以包括但不限于锂，丙戊酸，二丙酸钠，氨基马扎松，奥卡马沙平，唑尼沙胺，拉莫拉膦，托吡酯，加巴喷丁，左乙拉西坦或氯硝西泮。这些组合物用于治疗情绪障碍的患者，特别是伴有或没有精神病特征，躁狂或混合发作的双相情感障碍。提供了用于将单独施用喹诺酮衍生物和情绪稳定剂给患有情绪障碍的患者的方法。

9. 发明授权

US06840329B2 Cover assembly for a concealed sprinkler head 失效
标题翻译：隐形喷头头盖组件
公开(公告)号：US06840329B2
公开(公告)日：2005-01-11
申请号：US10379546
申请日：2003-03-06
申请人： Tetsuro Kikuchi , Hiroki Ishikawa , Yasuaki Koiwa
发明人： Tetsuro Kikuchi , Hiroki Ishikawa , Yasuaki Koiwa
IPC分类号： A62C37/11 , A62C37/09 , A62C37/08 , A62C37/12
CPC分类号： A62C37/09
摘要： A concealed sprinkler head is mounted above the ceiling of a fire protected zone. The sprinkler head includes a housing within which a valve and other operative parts are contained. A decorative cover plate is secured to the housing to conceal the sprinkler head within the ceiling so that none of the operative parts is visible. The cover assembly includes a thin metallic cover plate made of a heat conductive material such as copper, and a metallic skirt including a cylindrical wall threaded on the housing, an annular flange extending outwardly from one end of the cylindrical wall, and a plurality of tabs extending downwardly from the flange. A plurality of heat insulative elements are disposed between the tabs and the cover plate. A metallic layer is attached to the lower surface of each of the insulative elements. A layer of fusible material is disposed between the metallic layer and the cover plate to secure each of the insulative elements to the cover plate through the metallic layer.
摘要翻译：一个隐蔽的洒水头安装在防火区的天花板上方。喷洒头包括壳体，其中容纳有阀和其它操作部件。将装饰盖板固定到壳体上以将喷洒头隐藏在天花板内，使得所有操作部分都不可见。盖组件包括由诸如铜的导热材料制成的薄金属盖板和包括螺纹连接在壳体上的圆柱形壁的金属裙部，从圆柱形壁的一端向外延伸的环形凸缘，以及多个凸片从法兰向下延伸。多个绝热元件设置在突片和盖板之间。金属层附着在每个绝缘元件的下表面。在金属层和盖板之间设置一层可熔材料，以将每个绝缘元件通过金属层固定到盖板上。

10. 发明授权

US5924492A Sprinkler head assembly 失效
标题翻译：喷头组件
公开(公告)号：US5924492A
公开(公告)日：1999-07-20
申请号：US886971
申请日：1997-07-02
申请人： Tetsuro Kikuchi , Fukuji Obara , Takatoshi Chiba
发明人： Tetsuro Kikuchi , Fukuji Obara , Takatoshi Chiba
IPC分类号： A62C35/68 , A62C37/11 , A62C37/12 , A62C37/08
CPC分类号： A62C37/12 , Y10T137/1797
摘要： A sprinkler head includes a nozzle through which water is discharged to extinguish fire. The nozzle is normally held in a closed position. The nozzle is opened in the event of fire. A leaf spring is provided to hold the nozzle in its closed position and permit the nozzle to open. The leaf spring is deformed both in the axial direction of the sprinkler head and in a direction at right angles to the axial direction when an axial force is applied. Furthermore, the leaf spring and is resiliently returned to its original shape when the axial force is released.
摘要翻译：喷头包括一个喷嘴，通过该喷嘴排出水以扑灭火。喷嘴通常保持在关闭位置。喷枪在发生火灾时打开。提供一个板簧以将喷嘴保持在其关闭位置并允许喷嘴打开。当施加轴向力时，板簧在喷头的轴向方向和与轴向成直角的方向上变形。此外，当释放轴向力时，板簧弹性地恢复到其原始形状。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式