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1. 发明申请

US20230133022A1 BRAIN COMPUTER INTERFACE (BCI) SYSTEM THAT CAN BE IMPLEMENTED ON MULTIPLE DEVICES 有权
公开(公告)号：US20230133022A1
公开(公告)日：2023-05-04
申请号：US17978271
申请日：2022-11-01
申请人： BROWN UNIVERSITY , THE GENERAL HOSPITAL CORPORATION , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Leigh Hochberg , John D. Simeral , Tyler Singer-Clark , Ronnie Gross , Thomas Hosman , Anastasia Kapitonava
IPC分类号： G06F3/01
摘要： Instances of a single brain computer interface (BCI) system can be implemented on multiple devices. An active instance can control the associated device. The instances can each communicate with a neural decoding system that can receive neural signals from a user, process the neural signals, and output a command based on the processed neural signals. A device running the active instance of can be in communication with the neural decoding system to receive a command. The device can include a display, a non-transitory memory storing instructions, and a processor to execute the instructions to: run an instance of a control program; and execute the task based on the command.

2. 发明授权

US11639325B2 Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders 有权
公开(公告)号：US11639325B2
公开(公告)日：2023-05-02
申请号：US17116427
申请日：2020-12-09
申请人： Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Li-Huei Tsai , Stephen J. Haggarty , Debasis Patnaik , Ping-Chieh Pao
IPC分类号： C07C49/83 , A61K9/00 , A61K45/06 , A61K31/12 , C07C49/84 , C07C215/20 , C07C69/017 , A61P25/28 , C07C65/34
摘要： The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.

3. 发明授权

US11637527B2 Broadband wireless system for multi-modal imaging 有权
公开(公告)号：US11637527B2
公开(公告)日：2023-04-25
申请号：US17618064
申请日：2019-06-12
申请人： The General Hospital Corporation , Board of Trustees Michigan State University
发明人： Xin Yu , Chunqi Qian
IPC分类号： H03B5/12 , H03J3/18 , H03L7/099 , G01R33/36 , G01R33/48
摘要： The multi-modal imaging system, in particular for brain imaging, comprising a pump signal generator which emits at least one pump signal in the radio frequency (RF)-range with a first power P1 and a second power P2, a wireless detection unit, which comprises at least one parametric resonator circuit with multiple resonance modes, wherein the at least one parametric resonator circuit comprises at least two varactors, at least one capacitor and at least one inductance, wherein, in a first detection mode, the pump signal, having a first power P1, induces a first pump current in the at least one parametric resonator circuit, wherein the at least one parametric resonator circuit is operated below its oscillation threshold and generates a first output signal by amplifying a first input signal, which is provided due to a magnetic-resonance (MR) measurement, wherein an external receiving device receives the first output signal, wherein, in a second detection mode, the pump signal, having a second power P2, induces a second pump current in the at least one parametric resonator circuit, wherein the at least one parametric resonator circuit is operated above its oscillation threshold and generates a second output signal, wherein the second output signal is modulated with a second input signal, wherein the second input signal is provided by at least one neuronal probe device, connected to the at least one parametric resonator circuit, wherein the external receiving device receives the second output signal.

4. 发明授权

US11634448B2 Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions 有权
公开(公告)号：US11634448B2
公开(公告)日：2023-04-25
申请号：US15624399
申请日：2017-06-15
申请人： The General Hospital Corporation
发明人： Harald C. Ott , Xi Ren , Jordan P. Bloom , Taufiek Konrad Rajab
IPC分类号： A61K31/655 , C12N5/06 , C07H13/04 , A61L27/38 , A61L27/54 , C12N5/07 , A61K35/22 , A61K35/34 , A61K35/36 , A61K35/407 , A61K35/42 , A61K35/44 , A61L27/36
摘要： The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix (ECM) of an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal. In some aspects, the present application provides a decellularized scaffold of a mammalian organ or tissue comprising an extracellular matrix, wherein the extracellular matrix of the decellularized scaffold is functionalized with a chemical group that is reactive in a bioorthogonal chemical reaction, such as an azide chemical group. The present application also provides biological prosthetic mesh and mammalian organs and tissues for transplantation prepared according to the methods of the application.

5. 发明申请

US20230117240A1 SYSTEMS, METHODS, AND MEDIA FOR CAPSULE-BASED MULTIMODE ENDOSCOPY 有权
公开(公告)号：US20230117240A1
公开(公告)日：2023-04-20
申请号：US18067566
申请日：2022-12-16
申请人： The General Hospital Corporation
发明人： Guillermo J. Tearney , Kanwarpal Singh
IPC分类号： A61B1/00 , A61B1/01 , A61B1/04 , A61B1/07
摘要： In some embodiments, systems, methods, and media for capsule-based multimode endoscopy are provided. In some embodiments, a probe for capsule-based multimode endoscopy is provided, the probe comprising: a rigid capsule; a flexible tether coupled to a proximal end of the capsule; a rotatable reflective surface disposed within the capsule; a static ball lens disposed within the capsule; a first optical fiber optically coupled to the ball lens, the first optical fiber passing through the flexible tether; a second optical fiber optically coupled to the ball lens, the second optical fiber passing through the flexible tether; a graded index fiber disposed between a distal end of the second optical fiber and the ball lens, the graded index fiber optically coupled to the second optical fiber and the ball lens.

6. 发明授权

US11630177B2 Coil mixing error matrix and deep learning for prospective motion assessment 有权
公开(公告)号：US11630177B2
公开(公告)日：2023-04-18
申请号：US17719916
申请日：2022-04-13
申请人： Siemens Healthcare GmbH , The General Hospital Corporation
发明人： Daniel Nicolas Splitthoff , Julian Hossbach , Daniel Polak , Stephen Farman Cauley , Bryan Clifford , Wei-Ching Lo
IPC分类号： G01R33/54 , G01R33/56
摘要： Systems and Methods that identify the effect of motion during a medical imaging procedure. A neural network is trained to translate motion induced deviations of a coil-mixing matrix relative to a reference acquisition into a motion score. This score can be used for the prospective detection of the most corrupted echo trains for removal or triggering a replacement by reacquisition.

7. 发明授权

US11630103B2 Product and methods useful for modulating and evaluating immune responses 有权
公开(公告)号：US11630103B2
公开(公告)日：2023-04-18
申请号：US16325807
申请日：2017-08-17
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Alexandra-Chloé Villani , Rahul Satija , Aviv Regev , Nir Hacohen
IPC分类号： G01N33/50 , G01N33/68 , C12N5/078
摘要： The present invention provides isolated immune cells, immune cell populations and compositions, as well as markers, marker signatures and molecular targets characterising the immune cells. The cell products, substances, compositions, markers, marker signatures, molecular targets, kits of parts and methods of the present invention provide for new ways to characterise, evaluate and modulate the immune system and immune responses.

8. 发明授权

US11623103B2 Systems and methods for enhancing platelet biogenesis and extending platelet lifespan with low level light 有权
公开(公告)号：US11623103B2
公开(公告)日：2023-04-11
申请号：US16875111
申请日：2020-05-15
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Meixiong Wu , Qi Zhang
IPC分类号： A61B5/06 , A61N5/06 , A61N5/067
摘要： The present disclosure is directed to systems and methods that can apply low level light (LLL) to facilitate platelet biogenesis or extend platelet lifespan. While not wishing to be bound by theory, it is believed that LLL can enhance the ATP synthesis by the mitochondria within platelets and/or platelet precursor cells, which, thereby, helps to enhance platelet biogenesis and extend the platelet lifespan. In some instances, LLL can facilitate in vitro and/or in vivo platelet biogenesis. In other instances, LLL can extend platelet lifespan in circulation. In still other instances, LLL can be employed to prolong the shelf-life of stored platelets.

9. 发明申请

US20230082466A1 SYSTEMS AND METHODS FOR A HAIR TRANSPLANT SYSTEM WITH EXTRACTION AND IMPLANTATION NEEDLES 有权
公开(公告)号：US20230082466A1
公开(公告)日：2023-03-16
申请号：US17800925
申请日：2021-02-22
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Walfre FRANCO , Esmeralda IBARRA-SILVA , William A. FARINELLI , Joshua TAM , Richard Rox Anderson , Lynn Drake , Sandeep Korupolu
IPC分类号： A61B17/3205 , A61F2/10
摘要： Systems and methods are provided for performing a hair transplant using a hair transplant device. The hair transplant device comprises an extraction unit including a coring needle configured to extract at least one hair follicle from a donor site, an implanting unit removably coupled to the extraction unit, the implanting unit including a splitting needle configured to create an opening in a recipient site, a housing coupled to the extraction unit, and a user interface extending from the housing and moveable relative to the housing. The user interface includes a pin movable within the coring needle relative to the housing.

10. 发明授权

US11590176B2 Compositions of microbiota and methods related thereto 有权
公开(公告)号：US11590176B2
公开(公告)日：2023-02-28
申请号：US16670695
申请日：2019-10-31
申请人： Johnson & Johnson Consumer Inc. , The General Hospital Corporation , President and Fellows of Harvard College
发明人： Lee M. Kaplan , Alice P. Liou , Peter J. Turnbaugh , Jason L. Harris
IPC分类号： A61K35/74 , A61K35/741 , A61K45/06 , C12Q1/689 , A61K9/00 , A61K35/00
摘要： Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.

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