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1. 发明授权

US11325967B2 Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light a version in subjects in need thereof, especially migraine sufferers 有权
公开(公告)号：US11325967B2
公开(公告)日：2022-05-10
申请号：US16388184
申请日：2019-04-18
申请人： H. LUNDBECK A/S , THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
发明人： Andrew F. Russo , Eric A. Kaiser , Ana Recober , Adisa Kuburas , Ann C. Raddant , Brian R. Kovacevich , John Latham , Jeffrey T. L. Smith , Leon F. Garcia-Martinez
IPC分类号： C07K16/18 , A61K39/00
摘要： The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.
The present invention also provides assays using transgenic Nestin/Ramp1 rodents, utilizing a CGRP model light aversive behavior model for identifying therapeutically effective anti-CGRP antibodies and fragments thereof having binding specificity for CGRP which inhibit or prevent photophobia in subjects in need thereof. The present invention is specifically directed to methods for identifying therapeutically effective antibodies and fragments thereof having binding specificity for CGRP that may be used to treat CGRP associated disorders such as migraine. Specifically, this invention relates to assays and therapies using the antibodies described herein to inhibit or prevent photophobia, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them.

2. 发明申请

US20200170813A1 Vascular Prosthetic Assemblies 审中-公开
公开(公告)号：US20200170813A1
公开(公告)日：2020-06-04
申请号：US16787291
申请日：2020-02-11
申请人： The University of Iowa Research Foundation
发明人： Benjamin Dickerhoff , Robert S. Farivar , Madhavan L. Raghavan , Vijay Kumar
IPC分类号： A61F2/86 , C22F1/10 , C21D1/18 , B29C39/10 , B29C39/02 , A61F2/95 , A61L27/50 , A61L27/20 , A61F2/24
摘要： Vascular prosthetic assemblies (e.g., heart valves), such as those, for example, configured to be deployed percutaneously.

3. 发明授权

US10426528B2 Percutaneous transverse connector system 有权
公开(公告)号：US10426528B2
公开(公告)日：2019-10-01
申请号：US15141745
申请日：2016-04-28
申请人： The University of Iowa Research Foundation
发明人： Stephanus V. Viljoen , Andrew Grossbach
IPC分类号： A61B17/70
摘要： A system and method for stabilizing a spine of an animal subject involving a transverse rod installation instrument assembly for inserting a transverse rod on the spine of a subject percutaneously comprising: a first rod clamp extender mounted on a ipsilateral rod clamp and a second rod clamp extender mounted on a contralateral rod clamp wherein the ipsilateral rod clamp and the contralateral rod clamp are secured to a vertebra at the ipsilateral and contralateral pedicle; and a pivoting installation instrument pivotably mounted to the first rod clamp extender and the second rod clamp extender to pass a transverse rod percutaneously through a head portion of the ipsilateral side rod clamp and to the head portion of the contralateral rod clamp after passing through a spinous process of the vertebra through pivot axis “A” such that the transverse rod is secured at the head portion of the ipsilateral rod clamp and the head portion of the contralateral rod clamp.

4. 发明申请

US20190270807A1 USE OF ANTI-PACAP ANTIBODIES AND ANTIGEN BINDING FRAGMENTS THEREOF FOR TREATMENT, PREVENTION, OR INHIBITION OF PHOTOPHOBIA 审中-公开
公开(公告)号：US20190270807A1
公开(公告)日：2019-09-05
申请号：US16217567
申请日：2018-12-12
申请人： ALDER BIOPHARMACEUTICALS, INC. , The University of Iowa Research Foundation
发明人： Adisa KUBURAS , Bianca MASON , Levi P. SOWERS , Andrew F. RUSSO , Maria-Cristina LOOMIS , Leon F. GARCIA-MARTINEZ , Benjamin H. DUTZAR , Daniel S. ALLISON , Katherine Lee HENDRICKS , Ethan W. OJALA , Pei FAN , Jeffrey T.L. SMITH , John A. LATHAM , Charlie KARASEK , Jenny MULLIGAN , Michelle SCALLEY-KIM , Erica STEWART , Vanessa Lisbeth RUBIN , Jens J. BILLGREN
IPC分类号： C07K16/26 , A61K49/00 , A61K45/06 , G01N33/50 , G01N33/74
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof

5. 发明申请

US20190169639A1 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS 审中-公开
公开(公告)号：US20190169639A1
公开(公告)日：2019-06-06
申请号：US16256615
申请日：2019-01-24
申请人： EDITAS MEDICINE, INC. , THE BROAD INSTITUTE, INC. , THE UNIVERSITY OF IOWA RESEARCH FOUNDATION , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Feng Zhang , Deborah Palestrant , Beverly Davidson , Jordi Mata-Fink , Edgardo Rodriguez , Alexis Borisy
IPC分类号： C12N15/90 , C12N15/11 , C12N15/113 , C12N9/22 , C12N15/63
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.

6. 发明授权

US10266587B2 Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers 有权
公开(公告)号：US10266587B2
公开(公告)日：2019-04-23
申请号：US15621105
申请日：2017-06-13
申请人： ALDERBIO HOLDINGS LLC , THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
发明人： Andrew F. Russo , Eric A. Kaiser , Ana Recober , Adisa Kuburas , Ann C. Raddant , Brian R. Kovacevich , John Latham , Jeffrey T. L. Smith , Leon F. Garcia-Martinez
IPC分类号： C07K16/18 , A61K39/00
摘要： The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.The present invention also provides assays using transgenic Nestin/Ramp1 rodents, utilizing a CGRP model light aversive behavior model for identifying therapeutically effective anti-CGRP antibodies and fragments thereof having binding specificity for CGRP which inhibit or prevent photophobia in subjects in need thereof. The present invention is specifically directed to methods for identifying therapeutically effective antibodies and fragments thereof having binding specificity for CGRP that may be used to treat CGRP associated disorders such as migraine. Specifically, this invention relates to assays and therapies using the antibodies described herein to inhibit or prevent photophobia, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them.

7. 发明授权

US10190137B2 CRISPR-related methods and compositions with governing gRNAS 有权
公开(公告)号：US10190137B2
公开(公告)日：2019-01-29
申请号：US15825616
申请日：2017-11-29
申请人： EDITAS MEDICINE, INC. , THE BROAD INSTITUTE, INC. , THE UNIVERSITY OF IOWA RESEARCH FOUNDATION , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Feng Zhang , Deborah Palestrant , Beverly Davidson , Jordi Mata-Fink , Edgardo Rodriguez , Alexis Borisy
IPC分类号： C07H21/04 , C12N15/90 , C12N15/63 , C12N15/11 , C12N15/113 , C12N9/22
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.

8. 发明申请

US20180296559A1 TREATMENT OF AIRWAY SMOOTH MUSCLE DYSFUNCTION 审中-公开
公开(公告)号：US20180296559A1
公开(公告)日：2018-10-18
申请号：US15724361
申请日：2017-10-04
申请人： THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
发明人： David A. STOLTZ , Daniel COOK
IPC分类号： A61K31/506 , A61K9/00 , A61K45/06 , A61P11/00
摘要： The present disclosure is directed to compositions and methods for treating airway smooth muscle dysfunction in a subject. The compounds target the tyrosine protein kinase 2 beta. A particular dysfunction is asthma, including cystic fibrosis-induced asthma.

9. 发明申请

US20160242827A1 Percutaneous Transverse Connector System 审中-公开
标题翻译：经皮横向连接器系统
公开(公告)号：US20160242827A1
公开(公告)日：2016-08-25
申请号：US15141745
申请日：2016-04-28
申请人： The University of Iowa Research Foundation
发明人： Stephanus V. Viljoen , Andrew Grossbach
IPC分类号： A61B17/70
CPC分类号： A61B17/7089 , A61B17/7043 , A61B17/7049 , A61B17/7052 , A61B17/7076 , A61B17/7083 , A61B17/7085
摘要： A system and method for stabilizing a spine of an animal subject involving a transverse rod installation instrument assembly for inserting a transverse rod on the spine of a subject percutaneously comprising: a first rod clamp extender mounted on a ipsilateral rod clamp and a second rod clamp extender mounted on a contralateral rod clamp wherein the ipsilateral rod clamp and the contralateral rod clamp are secured to a vertebra at the ipsilateral and contralateral pedicle; and a pivoting installation instrument pivotably mounted to the first rod clamp extender and the second rod clamp extender to pass a transverse rod percutaneously through a head portion of the ipsilateral side rod clamp and to the head portion of the contralateral rod clamp after passing through a spinous process of the vertebra through pivot axis “A” such that the transverse rod is secured at the head portion of the ipsilateral rod clamp and the head portion of the contralateral rod clamp.
摘要翻译：一种用于稳定涉及横杆安装仪器组件的动物对象的脊柱的系统和方法，用于将横向杆经皮经皮插入到脊柱上，包括：安装在同侧杆夹上的第一杆夹持器和第二杆夹持器安装在对侧杆夹上，其中同侧杆夹和对侧杆夹固定在同侧和对侧椎弓根的椎骨上; 以及可枢转地安装到第一杆夹具延伸器和第二杆夹具延伸器上的枢转安装仪器，其通过横向杆经由同侧侧杆夹的头部部分穿过横向杆，并穿过棘突后的对侧杆夹的头部椎骨通过枢转轴线“A”的过程，使得横杆固定在同侧杆夹的头部和对侧杆夹的头部。

10. 发明申请

US20040265798A1 Methods and compositions related to high-titer pseudotyped retroviruses 有权
标题翻译：与高滴度假型逆转录病毒相关的方法和组合物
公开(公告)号：US20040265798A1
公开(公告)日：2004-12-30
申请号：US10845253
申请日：2004-05-13
申请人： The University of Iowa Research Foundation , The Regents of the University of California, a California Corporation
发明人： Paul McCray , Hung Fan , Patrick Sinn
IPC分类号： C12Q001/70 , C12N007/00 , C07H021/04
CPC分类号： C12N15/86 , A61K48/00 , C12N7/00 , C12N2740/12043 , C12N2740/15021 , C12N2740/15043 , C12N2740/15045 , C12N2830/003 , C12N2840/44
摘要： The present invention concerns the methods and compositions related to pseudotyped viral vectors. Embodiments of the invention include pseudotyping expression cassettes that include nucleic acid elements for enhancing the titer of pseudotyped viral particles. Embodiments of the invention include novel methods and compositions related to making high titer pseudotyped retroviral vector compositions. A heterologous envelope glycoprotein is typically incorporated into the virus during the budding or virus production process. Certain embodiments of the invention include pseudotyped retroviral vectors comprising a heterologous envelope glycoprotein derived from a Jaagsiekte sheep retrovirus (JSRV env). Pseudotyped viruses or viral particles may have a modified host range that is influenced by the properties of the heterologous envelope glycoprotein. Thus, embodiments of the invention include improved methods and compositions related to pseudotyped viruses suitable for ex vivo and in vivo methods including gene transfer and other therapeutic and experimental methods.
摘要翻译：本发明涉及与假型病毒载体相关的方法和组合物。本发明的实施方案包括假型分型表达盒，其包括用于增强假型病毒颗粒滴度的核酸元件。本发明的实施方案包括与制备高滴度假型逆转录病毒载体组合物有关的新方法和组合物。在发芽或病毒生产过程中，异源包膜糖蛋白通常并入病毒。本发明的某些实施方案包括包含衍生自Jaagsiekte绵羊逆转录病毒（JSRV env）的异源包膜糖蛋白的假型逆转录病毒载体。伪型病毒或病毒颗粒可能具有受异源包膜糖蛋白特性影响的修饰的宿主范围。因此，本发明的实施方案包括与适用于离体和体内方法（包括基因转移和其他治疗和实验方法）的假型病毒相关的改进的方法和组合物。

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