专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20220411447A1 Methods of Preparing Primary Phosphine Products Using Lewis Acid Catalysts 有权
公开(公告)号：US20220411447A1
公开(公告)日：2022-12-29
申请号：US17787650
申请日：2021-01-07
申请人： The University of Vermont and State Agricultural College
发明人： Rory Waterman , Brandon Ackley
IPC分类号： C07F9/50
摘要： Methods of preparing primary phosphine products using one or more precursor cyclophosphanes, hydrogen, and one or more Lewis acid catalysts. In some embodiments, a cyclophosphane precursor and at least one Lewis acid are dissolved in a solvent to provide a solution. The solution is treated with hydrogen, and optionally heated, to cause a reaction that produces a primary phosphine © product. The primary phosphine product may be isolated from the Lewis acid(s) and optionally purified. In some embodiments, a method may include synthesizing the cyclophosphane precursor prior to mixing the cyclophosphane precursor and the Lewis acid(s).

2. 发明申请

US20220169746A1 ANTIBODIES TO NEOANTIGENS AND USES THEREOF 有权
公开(公告)号：US20220169746A1
公开(公告)日：2022-06-02
申请号：US17433982
申请日：2020-02-26
申请人： The University of Vermont and State Agricultural College
发明人： David N. Krag , Girja S. Shukla , Stephanie C. Fournier , Sunny Yujing Sun
IPC分类号： C07K16/30 , A61P35/00 , C07K16/28 , A61K35/17 , A61K39/395 , A61K31/437
摘要： Compositions and methods involving anti-neoantigen antibodies and/or effector cells armed with anti-neoantigen antibodies are disclosed herein. Such compositions may also include immune checkpoint inhibitors and may be used, for example, in the treatment of cancers.

3. 发明申请

US20190324415A1 Packetized Energy Management Control Systems and Methods of Using the Same 审中-公开
公开(公告)号：US20190324415A1
公开(公告)日：2019-10-24
申请号：US16421171
申请日：2019-05-23
申请人： The University of Vermont and State Agricultural College
发明人： Jeffrey Frolik , Paul Hines , Mads Almassalkhi
IPC分类号： G05B19/042 , H02J13/00 , H03H17/02
摘要： Aspects of the present disclosure include anonymous, asynchronous, and randomized control schemes for distributed energy resources (DERs). Such control schemes may include packetized energy management (PEM) control schemes for managing DERs that may provide near-optimal tracking performance under imperfect information and consumer quality of service (QoS) constraints.

4. 发明申请

US20190120842A1 METHODS AND COMPOUNDS FOR DIAGNOSING THREONYL-tRNA SYNTHETASE-ASSOCIATED DISEASES AND CONDITIONS 审中-公开
公开(公告)号：US20190120842A1
公开(公告)日：2019-04-25
申请号：US16202884
申请日：2018-11-28
申请人： The University of Vermont and State Agricultural College
发明人： Christopher Francklyn , Karen M. Lounsbury , Tamara Williams
IPC分类号： G01N33/573 , C12Q1/6883 , C12Q1/6886 , C12Q1/25 , G01N33/574
摘要： The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.

5. 发明授权

US10143718B2 Covalent inhibitors of dual oxidase 1 (DUOX 1) 有权
公开(公告)号：US10143718B2
公开(公告)日：2018-12-04
申请号：US15299848
申请日：2016-10-21
申请人： The University of Vermont and State Agricultural College
发明人： Albert van der Vliet , David Earl Heppner , Karamatullah Danyal
IPC分类号： A61K38/03 , A61K9/00
摘要： The present invention generally relates to inhibitors of DUOX1. In some aspects, an inhibitor may be applied to a subject having or being at risk for asthma or other conditions. The inhibitor may be applied by various techniques, such as pulmonary or topical delivery. In some embodiments, the inhibitor may include a peptide or other moiety having a reactive electrophile. The reactive electrophile can target cysteine or other residues within DUOX1 to inhibit its activity, e.g., by covalently binding to the residue. Other non-limiting examples of suitable inhibitors include hydroxynonenal, curcumin, sulforaphane, cinnamaldehyde, dimethyl fumarate, or phenyl vinyl sulfonate. Other aspects of the invention are generally directed to methods of making or using such inhibitors, kits involving such inhibitors, devices or formulations containing such inhibitors, or the like.

6. 发明申请

US20180224452A1 DETECTION OF GLUTATHIONYLATED PROTEINS 审中-公开
公开(公告)号：US20180224452A1
公开(公告)日：2018-08-09
申请号：US15886084
申请日：2018-02-01
申请人： The University of Vermont and State Agricultural College , Universiteit Maastricht
发明人： Yvonne M. Janssen-Heininger , Niki Reynaert
IPC分类号： G01N33/573 , G01N33/68 , G01N33/58
CPC分类号： G01N33/573 , G01N33/58 , G01N33/6815 , G01N33/6842 , G01N33/6893 , G01N2333/902 , G01N2800/122 , G01N2800/24
摘要： The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc. As a specific example, a glutathionylated moiety on a glutathionylated protein may be reacted with an alkylating agent to form an alkylthio moiety; the alkylthio moiety may include a detection entity or otherwise be able to interact with a signaling entity. In some embodiments, other moieties on the protein may be altered or blocked before reaction of the protein with the detection entity. Such moieties on the protein may be, for instance, non-oxidized or non-glutathionylated moieties able to react with the detection entity. As a particular example, in a protein containing a glutathionylated moiety and non-glutathionylated thiol moieties, the thiol moieties may first be altered or blocked prior to reaction of the protein with the detection entity. Also provided in certain aspects of the present invention are kits for determining oxidized proteins, which may include components such as detection entities, alkylating agents, blocking agents, reducing agents, signaling entities, binding partners, antibodies, instructions, and the like.

7. 发明申请

US20150157686A1 TREATMENTS OF OXIDATIVE STRESS CONDITIONS 有权
标题翻译：氧化应激条件的处理
公开(公告)号：US20150157686A1
公开(公告)日：2015-06-11
申请号：US14407265
申请日：2013-06-20
申请人： The University of Vermont and State Agricultural College
发明人： Yvonne M. Janssen-Heininger , Vikas Anathy
IPC分类号： A61K38/12 , A61K31/437 , C12N15/113 , A61K45/06 , A61K31/713 , A61K31/425 , A61K31/197
CPC分类号： A61K38/12 , A61K31/197 , A61K31/425 , A61K31/437 , A61K31/713 , A61K38/06 , A61K38/164 , A61K38/45 , A61K45/06 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12Y205/01018 , C12Y503/04001 , A61K2300/00
摘要： The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.
摘要翻译：本发明一般涉及用于治疗某些氧化应激状况的系统和方法。一方面，本发明的组合物和方法可用于治疗具有氧化应激状况的受试者，例如具有肺纤维化的受试者。在一些实施方案中，可以使用ERP57抑制剂（例如硫假皮霉素）和/或GSTP抑制剂（例如，TLK-199）来治疗受试者。在本发明的某些方面也提供了用于这种疗法的试剂盒，用于促进这些疗法的方法等。

8. 发明申请

US20150051660A1 CARDIAC PACEMAKER AND USES THEREOF 有权
标题翻译： CARDIAC PACEMAKER及其用途
公开(公告)号：US20150051660A1
公开(公告)日：2015-02-19
申请号：US14387971
申请日：2013-03-13
申请人： The University of Vermont and State Agricultural College
发明人： Markus Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36507 , A61N1/36514 , A61N1/36535 , A61N1/36542
摘要： The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output.
摘要翻译：本发明涉及改进的心脏起搏器及其使用方法。特别地，心脏起搏器可用于使心率超过静息心率的归一化，以便调节心脏以改善整体心输出量。

9. 发明授权

US11340227B2 Methods and compounds for diagnosing threonyl-tRNA synthetase-associated diseases and conditions 有权
公开(公告)号：US11340227B2
公开(公告)日：2022-05-24
申请号：US16202884
申请日：2018-11-28
申请人： The University of Vermont and State Agricultural College
发明人： Christopher Francklyn , Karen M. Lounsbury , Tamara Williams
IPC分类号： G01N33/573 , C12Q1/25 , C12Q1/6883 , C12Q1/6886 , G01N33/574
摘要： The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.

10. 发明授权

US10794332B2 Microfluidic homogeneous catalyzation systems and methods, and apparatuses incorporating same 有权
公开(公告)号：US10794332B2
公开(公告)日：2020-10-06
申请号：US15354508
申请日：2016-11-17
申请人： The University of Vermont and State Agricultural College
发明人： Kevin R. Gagne , Darren L. Hitt , Michael Ryan McDevitt
IPC分类号： F02K9/56 , F02K9/42 , F02K9/94 , B64G1/40 , F02K9/88 , B64G1/26
摘要： Systems, apparatuses, and methods for generating hot gases based on catalyzation involving flowing catalyst. Catalysis occurs in a flow-type mixing catalyzation channel in which a liquid catalyst mixes with a liquid reactant flowing in a desired flow regime, such as a striated (laminar) flow regime or a slug flow regime. Devices such as micro-thrusters for satellite and other applications and hot gas generators for powering another device, such as an electrical generator, can be made using one or more flow-type mixing catalyzation channels.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式