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1. 发明授权

US07657379B2 Methods and systems for determining the biological function of cell constituents using response profiles 有权
标题翻译：使用反应曲线确定细胞成分的生物学功能的方法和系统
公开(公告)号：US07657379B2
公开(公告)日：2010-02-02
申请号：US10332305
申请日：2001-07-02
申请人： Roland Stoughton , Timothy R. Hughes
发明人： Roland Stoughton , Timothy R. Hughes
IPC分类号： G06F19/00 , C12Q1/68 , C12N15/09 , G06G7/58
CPC分类号： G06F19/18 , C12Q1/6809 , C12Q1/6837 , C40B30/04 , G01N33/5005 , G01N2500/00 , G06F19/20 , G06F19/24 , C12Q2545/114 , C12Q2521/107 , C12Q2539/113
摘要： The invention relates to methods and systems (e.g., computer systems and computer program products) for determining the biological function of uncharacterized cellular constituents, particularly genes and gene products, by using “response profiles,” i.e., measurements of pluralities of cellular constituents in cells having a modified gene or gene product, as phenotypic markers for the gene or gene product. Methods are provided for clustering such response profiles so that similar or correlated response profiles are organized into the same cluster. The invention also provides databases or “compendiums” of response profiles to which the response profile of an uncharacterized gene or gene product can be compared. In one embodiment, steps of the methods comprise comparing the measured response profiles to response profiles stored in the databases or compendiums, and determining the biological function of the response profiles in the databases that are most similar to the measured response profiles.
摘要翻译：本发明涉及通过使用“响应曲线”来确定未表征的细胞成分，特别是基因和基因产物的生物学功能的方法和系统（例如，计算机系统和计算机程序产品），即细胞中多种细胞成分的测量具有修饰的基因或基因产物，作为基因或基因产物的表型标记。提供了用于聚类这种响应简档的方法，使得相似或相关的响应简档被组织到相同的集群中。本发明还提供可以比较非特异性基因或基因产物的反应谱的响应谱的数据库或“汇编”。在一个实施例中，方法的步骤包括将测量的响应简档与存储在数据库或汇编中的响应简档进行比较，以及确定与测量的响应简档最相似的数据库中的响应简档的生物学功能。

2. 发明授权

US4962719A Protective boat hull device 失效
标题翻译：保护船体装置
公开(公告)号：US4962719A
公开(公告)日：1990-10-16
申请号：US333533
申请日：1989-04-05
申请人： Timothy R. Hughes , Theodore A. Siebert, Jr.
发明人： Timothy R. Hughes , Theodore A. Siebert, Jr.
IPC分类号： B63B59/02
CPC分类号： B63B59/02
摘要： A protective boat hull device is disclosed to prevent damage to a boat hull during beaching. An elongated flexible and waterproof sheet is provided having a length substantially greater than the width thereof, and capable of being wound into a roll along the elongated length thereof for storage purposes. The sheet includes a centering notch extending across the width of one end of the sheet for engaging the front hull of the boat above the water line, in order to center the sheet underneath the hull of the boat below the water line and prevent hull damage during beaching of the boat. The sheet further includes fastening means to facilitate attachment and detachment of the sheet relative to the boat.
摘要翻译：公开了一种保护船体装置，以防止在海滩期间损坏船体。提供细长的柔性和防水片材，其长度基本上大于其宽度，并且能够沿着其长度长度卷绕成卷以用于存储目的。该片材包括延伸穿过片材一端的宽度的定心切口，用于接合船上方的水线上方的前船体，以便将船体船体的下方的中心位于水线下方，并防止船体损坏海边的船。片材还包括紧固装置，以便于片材相对于舟皿的附接和分离。

3. 发明申请

US20110251081A1 METHODS AND COMPOSITIONS FOR DETERMINING GENE FUNCTION 有权
标题翻译：用于确定基因功能的方法和组合物
公开(公告)号：US20110251081A1
公开(公告)日：2011-10-13
申请号：US12686311
申请日：2010-01-12
申请人： Roland Stoughton , Timothy R. Hughes
发明人： Roland Stoughton , Timothy R. Hughes
IPC分类号： C40B30/04 , G06F19/00 , C12Q1/68
CPC分类号： G06F19/18 , C12Q1/6809 , C12Q1/6837 , C40B30/04 , G01N33/5005 , G01N2500/00 , G06F19/20 , G06F19/24 , C12Q2545/114 , C12Q2521/107 , C12Q2539/113
摘要： The invention relates to methods and systems (e.g., computer systems and computer program products) for characterizing cellular constituents, particularly genes and gene products. In particular, the invention provides methods for assigning or determining the biological function of uncharacterized genes and gene products by using “response profiles,” i.e., measurements of pluralities of cellular constituents in cells having a modified gene or gene product, as phenotypic markers for the gene or gene product. Methods are provided for clustering such response profiles so that similar or correlated response profiles are organized into the same cluster. The invention also provides databases or “compendiums” of response profiles to which the response profile of an uncharacterized gene or gene product can compared.
摘要翻译：本发明涉及用于表征细胞组分，特别是基因和基因产物的方法和系统（例如，计算机系统和计算机程序产品）。特别地，本发明提供了通过使用“响应曲线”来分配或确定未表征的基因和基因产物的生物学功能的方法，即，具有修饰的基因或基因产物的细胞中多种细胞成分的测量作为表型标记物基因或基因产物。提供了用于聚类这种响应简档的方法，使得相似或相关的响应简档被组织到相同的集群中。本发明还提供了可以比较非特异性基因或基因产物的响应特征的响应概况的数据库或“纲要”。

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