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1. 发明授权

US11492370B2 Method of making a cross metathesis product 有权
公开(公告)号：US11492370B2
公开(公告)日：2022-11-08
申请号：US16626234
申请日：2018-07-20
申请人： Trustees of Boston College
发明人： Amir H. Hoveyda , Chaofan Xu , Xiao Shen
IPC分类号： B01J31/00 , C07K1/107 , B01J31/22 , C07C51/353 , C07D313/00
摘要： Method of making a cross metathesis product, the method comprising at least step (X) or step (Y): (X) reacting in a cross metathesis reaction a first compound comprising a terminal olefinic group with a second compound comprising a terminal olefinic group, wherein the first and the second compound may be identical or may be different from one another; or (Y) reacting in a ring-closing metathesis reaction two terminal olefinic groups which are comprised in a third compound; wherein the reacting in step (X) or step (Y) is performed in the presence of a ruthenium carbene complex comprising a [Ru═C]-moiety and an internal olefin.

2. 发明申请

US20220119793A1 Genetically Encoded Tyrosine Sulfation of Proteins in Eukaryotes 有权
公开(公告)号：US20220119793A1
公开(公告)日：2022-04-21
申请号：US17594570
申请日：2020-04-23
申请人： Trustees of Boston College
发明人： Abhishek Chatterjee , James S. Italia
IPC分类号： C12N9/00 , C12P21/00
摘要： An engineered tyrosyl-tRNA synthetase/tRNA pair that co-translationally incorporates O-sulfotyrosine in response to UAG codons in E. coli and mammalian cells is described herein. This platform enables recombinant expression of eukaryotic proteins homogeneously sulfated at chosen sites.

3. 发明申请

US20220056200A1 RADICAL CASCADE-ENABLED SYNTHESIS OF PRECISION POLYMERS WITH COMPLEX MAIN-CHAIN STRUCTURES 有权
公开(公告)号：US20220056200A1
公开(公告)日：2022-02-24
申请号：US17512055
申请日：2021-10-27
申请人： The Trustees of Boston College
发明人： Jia Niu , Hanchu Huang , Wenqi Wang
IPC分类号： C08G61/12
摘要： Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

4. 发明申请

US20210198657A1 METHODS AND COMPOSITIONS OF CHEMICALLY MODIFIED PHAGE LIBRARIES 有权
公开(公告)号：US20210198657A1
公开(公告)日：2021-07-01
申请号：US17156908
申请日：2021-01-25
申请人： The Trustees of Boston College
发明人： Jianmin Gao
IPC分类号： C12N15/10 , C12N7/00 , A61K45/06 , G01N33/50
摘要： Provided is a chemically modified phage display platform and method of use thereof. More specifically, the present disclosure provides a chemically modified phage display library that incorporates 2-acetylphenylboronic acid (APBA) moieties to elicit dynamic covalent binding to the bacterial cell surface. The APBA-modified phage display libraries described herein are applicable to a wide array of bacterial strains and/or mammalian cells, paving the way to facile diagnosis and development of strain-specific antibiotics, and/or peptide-antibiotic conjugates for effective and targeted treatment. Also provided are therapeutic peptides, and pharmaceutical compositions thereof, that are identified by screening the phage display library of the present disclosure, and method of use of such therapeutic peptides for effective and targeted treatment.

5. 发明申请

US20200316096A1 COMBINATION OF DIET AND DRUG THERAPY FOR TREATING CANCER 审中-公开
公开(公告)号：US20200316096A1
公开(公告)日：2020-10-08
申请号：US16839369
申请日：2020-04-03
申请人： Trustees of Boston College
发明人： Thomas N. Seyfried , Purna Mukherjee
IPC分类号： A61K31/655 , A23L33/00 , A61P35/04
摘要： The present disclosure provides a unique novel diet-drug combination, and method thereof, for cancer management, with synergistic and non-toxic effects.

6. 发明申请

US20200216610A1 RADICAL CASCADE-ENABLED SYNTHESIS OF PRECISION POLYMERS WITH COMPLEX MAIN-CHAIN STRUCTURES 审中-公开
公开(公告)号：US20200216610A1
公开(公告)日：2020-07-09
申请号：US16701031
申请日：2019-12-02
申请人： Trustees of Boston College
发明人： Jia Niu , Hanchu Huang , Wenqi Wang
IPC分类号： C08G63/688 , C08G63/78 , C08G61/12 , C08K5/38
摘要： Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

7. 发明申请

US20170081347A1 FUNCTIONALIZED AZABORINE COMPOUNDS AND AZABORINE-CONTAINING BIARYLCARBOXAMIDES, AND COMPOSITIONS AND METHODS THEREOF 审中-公开
公开(公告)号：US20170081347A1
公开(公告)日：2017-03-23
申请号：US15126233
申请日：2015-04-13
申请人： The Trustees of Boston College
发明人： Shih-Yuan Liu , Peng Zhao , Alec Nathaniel Brown
IPC分类号： C07F7/08 , C07F5/02
CPC分类号： C07F7/0803 , C07D207/14 , C07D209/16 , C07D213/40 , C07D213/71 , C07D231/40 , C07D249/14 , C07F5/02
摘要： The invention provides novel azaborine compounds, methods for their syntheses and functionalization, and various applications thereof. For example, novel azaborine-containing biarylcarboxylic acids and biarylcarboxamides are disclosed herein, which provide the opportunity to be used as therapeutic agents in different diseases. The novel azaborine-containing compounds show unique physical and biological properties when compared to their corresponding all-carbon compounds. Also, disclosed herein are substituted 1,2-dihydro-1,2-azaborine compounds and methods for making the same including methods for the preparation of various substituted azaborines including alkyl, alkenyl, aryl, nitrile, heteroaryl, and fused ring substituents in the presence of B—H, B—Cl, B—O and N—H bonds from Br-substituted azaborines as well as the synthesis of new fused BN-heterocycles.

8. 发明授权

US09173884B2 Inhibitors of phosphodiesterase 11 (PDE11) 有权
标题翻译：磷酸二酯酶11抑制剂（PDE11）
公开(公告)号：US09173884B2
公开(公告)日：2015-11-03
申请号：US14361979
申请日：2012-11-29
申请人： TRUSTEES OF BOSTON COLLEGE
发明人： Charles Stuart Hoffman , Ozge Ceyhan
IPC分类号： C07D495/04 , A61K31/519 , C07D513/04 , A61K45/06 , A61K31/416 , A61K31/437 , A61K31/53 , A61K31/573
CPC分类号： A61K31/519 , A61K31/416 , A61K31/437 , A61K31/53 , A61K31/573 , A61K45/06 , C07D513/04 , A61K2300/00
摘要： The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency. Another aspect relates to kits comprising PDE11 inhibitors for administration to a subject, pharmaceutical compositions comprising compounds of formula (I)-(VI) for use in methods to increase cortisol levels and/or treat adrenal insufficiency, and their use as an adjuvant for treatment of cancer or other disorders such as psychiatric diseases where elevating cortisol levels would be beneficial to the subject.
摘要翻译：本发明通常涉及包含用于增加受试者中的皮质醇水平的PDE11抑制剂或用于从受试者的腺皮质细胞中增加皮质醇的产生的组合物。本发明的方面涉及在治疗受试者的低皮质醇水平和/或肾上腺功能不全的方法中使用PDE11抑制剂或治疗与肾上腺功能不全相关的疾病或病症的方法。本发明的方面涉及属于式（I） - （VI）化合物的PDE11抑制剂及其单独使用或与长期皮质类固醇治疗组合以提高受试者的皮质醇水平和/或治疗肾上腺功能不全的用途。另一方面涉及包含用于给予受试者的PDE11抑制剂的试剂盒，包含用于增加皮质醇水平和/或治疗肾上腺功能不全的方法的式（I） - （VI）化合物的药物组合物及其作为治疗佐剂的用途的癌症或其他疾病，例如提高皮质醇水平对受试者有益的精神疾病。

9. 发明申请

US20150265661A1 PREBIOTIC EFFECT OF SIALYLLACTOSE 审中-公开
标题翻译： SIALYLLACTOSE的预处理效果
公开(公告)号：US20150265661A1
公开(公告)日：2015-09-24
申请号：US14391739
申请日：2013-03-13
申请人： Trustees of Boston College
发明人： David S. Newburg , Zhuoteng Yu
IPC分类号： A61K35/745 , A23L1/29 , A23L1/30 , A61K31/717 , A61K31/702
CPC分类号： A61K35/745 , A23L33/10 , A23L33/135 , A23L33/30 , A23V2002/00 , A23Y2300/45 , A23Y2300/55 , A61K31/702 , A61K31/717 , Y02A50/473 , A61K2300/00
摘要： Provided herein are prebiotic compositions comprising a combination of oligosaccharides such as sialyated oligosaccharides and fusocylated oligosaccharides, and uses thereof in stimulating the proliferation of beneficial intestinal micro biota, for example, of bifidobacteria, and/or in decreasing the abundance of enteric pathogens. The prebiotic compositions can further contain a probiotic, which can be a population of bifidobacteria, lactobacilli, Bacteriodes fragilis, Bacteriodes thetaiotaomicron, Enterococcus faecalis (pro biotic strains thereof), Staphylococcus epidermides, Enterobacter aerogenes, Enterobacter cloacae, or related bacteria having similar functions.
摘要翻译：本文提供的益生元组合物包含低聚糖如唾液酸化低聚糖和融合寡糖的组合，以及其在刺激有益肠微生物群（例如双歧杆菌）和/或减少肠道病原体丰度方面的用途。益生元组合物可以进一步含有益生菌，其可以是双歧杆菌，乳杆菌，脆弱细菌，大肠杆菌，粪肠球菌（其生物菌株），表皮葡萄球菌，产气肠杆菌，阴沟肠杆菌或具有相似功能的相关细菌的群体。

10. 发明授权

US09119874B2 Cell-penetrating markers of apoptosis 有权
标题翻译：凋亡细胞穿透标记物
公开(公告)号：US09119874B2
公开(公告)日：2015-09-01
申请号：US13886549
申请日：2013-05-03
申请人： TRUSTEES OF BOSTON COLLEGE
发明人： Jianmin Gao , Hong Zheng
IPC分类号： A61K49/00 , G01N21/64 , G01N33/58 , G01N33/50 , G01N33/52
CPC分类号： A61K49/0041 , G01N21/6486 , G01N33/5005 , G01N33/52 , G01N33/582 , G01N2800/52 , G01N2800/7028
摘要： Provided herein are compounds useful for selectively labeling an apoptotic cell, and methods and assays using such compounds for the detection of an apoptotic cell in vivo or in a biological sample obtained from a subject.
摘要翻译：本文提供了可用于选择性标记凋亡细胞的化合物，以及使用这种化合物在体内或从受试者获得的生物样品中检测凋亡细胞的方法和测定法。

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