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1. 发明授权

US11701414B2 Periodontitis vaccine and related compositions and methods of use 有权
公开(公告)号：US11701414B2
公开(公告)日：2023-07-18
申请号：US17308872
申请日：2021-05-05
申请人： Vaxcyte, Inc.
发明人： Jeffery Fairman
IPC分类号： A61K39/00 , A61K39/02
CPC分类号： A61K39/0216 , A61K2039/54 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/70
摘要： An immunogenic composition, a periodontal vaccine formulation containing the immunogenic composition, and methods for treating or preventing periodontal disease are provided, where the methods involves administering an immunologically effective amount of the composition or vaccine formulation to a subject. The immunogenic composition contains at least one polypeptide that comprises: an Mfa1 antigen sequence that is substantially homologous to an immunogenic amino acid sequence from an Mfa1 fimbrilin protein of a Porphyromonas bacterium; and an HA1 antigen sequence, an HA2 antigen sequence, or both an HA1 antigen sequence and an HA2 antigen sequence, wherein the HA1 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 1 contained within an RgpA Gingipain protein of a Porphyromonas bacterium, and the HA2 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 2 contained within an RgpA Gingipain protein of a Porphyromonas bacterium.

2. 发明公开

US20240226259A9 PERIODONTITIS VACCINE AND RELATED COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：US20240226259A9
公开(公告)日：2024-07-11
申请号：US18325563
申请日：2023-05-30
申请人： Vaxcyte, Inc.
发明人： Jeffery FAIRMAN
IPC分类号： A61K39/02
CPC分类号： A61K39/0216 , A61K2039/70
摘要： An immunogenic composition, a periodontal vaccine formulation containing the immunogenic composition, and methods for treating or preventing periodontal disease are provided, where the methods involves administering an immunologically effective amount of the composition or vaccine formulation to a subject. The immunogenic composition contains at least one polypeptide that comprises: an Mfa1 antigen sequence that is substantially homologous to an immunogenic amino acid sequence from an Mfa1 fimbrilin protein of a Porphyromonas bacterium; and an HA1 antigen sequence, an HA2 antigen sequence, or both an HA1 antigen sequence and an HA2 antigen sequence, wherein the HA1 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 1 contained within an RgpA Gingipain protein of a Porphyromonas bacterium, and the HA2 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 2 contained within an RgpA Gingipain protein of a Porphyromonas bacterium.

3. 发明公开

US20230293658A1 GROUP A STREP IMMUNOGENIC COMPOSITIONS WITH POLYSACCHARIDE-PROTEIN CONJUGATES 审中-公开
公开(公告)号：US20230293658A1
公开(公告)日：2023-09-21
申请号：US17820554
申请日：2022-08-17
申请人： Vaxcyte, Inc.
发明人： Jeffery C. FAIRMAN , Neeraj KAPOOR , Peter T. DAVEY , Angie A. SEDRA
IPC分类号： A61K39/09 , A61K38/48 , A61K39/112 , A61K39/116 , A61P31/04
CPC分类号： A61K39/092 , A61K38/482 , A61K39/0283 , A61K39/116 , A61P31/04 , C12Y304/2111 , A61K2039/6087
摘要： The present disclosure provides immunogenic compositions comprising Group A Streptococcus (GAS) polypeptide antigens and at least one polypeptide-polysaccharide conjugate. The present disclosure further provides methods of using such compositions to induce immune responses against GAS infections in subjects.

4. 发明申请

US20220389476A1 ANIMAL PRODUCT-FREE CULTURE OF STREPTOCOCCUS BACTERIA 有权
公开(公告)号：US20220389476A1
公开(公告)日：2022-12-08
申请号：US17747534
申请日：2022-05-18
申请人： Vaxcyte, Inc.
发明人： Peter DAVEY
IPC分类号： C12Q1/04 , C12N1/20 , C12N9/08 , C12P19/04
摘要： The present disclosure provides methods, compositions, and kits for in vitro cultivation of catalase-negative bacteria. The present disclosure further provides catalase-negative bacteria cultivated according to the methods described herein and bacterial stocks thereof.

5. 发明申请

US20210361756A1 PERIODONTITIS VACCINE AND RELATED COMPOSITIONS AND METHODS OF USE 有权
公开(公告)号：US20210361756A1
公开(公告)日：2021-11-25
申请号：US17308872
申请日：2021-05-05
申请人： Vaxcyte, Inc.
发明人： Jeffery FAIRMAN
IPC分类号： A61K39/02
摘要： An immunogenic composition, a periodontal vaccine formulation containing the immunogenic composition, and methods for treating or preventing periodontal disease are provided, where the methods involves administering an immunologically effective amount of the composition or vaccine formulation to a subject. The immunogenic composition contains at least one polypeptide that comprises: an Mfa1 antigen sequence that is substantially homologous to an immunogenic amino acid sequence from an Mfa1 fimbrilin protein of a Porphyromonas bacterium; and an HA1 antigen sequence, an HA2 antigen sequence, or both an HA1 antigen sequence and an HA2 antigen sequence, wherein the HA1 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 1 contained within an RgpA Gingipain protein of a Porphyromonas bacterium, and the HA2 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 2 contained within an RgpA Gingipain protein of a Porphyromonas bacterium.

6. 发明公开

US20240131134A1 PERIODONTITIS VACCINE AND RELATED COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：US20240131134A1
公开(公告)日：2024-04-25
申请号：US18325563
申请日：2023-05-29
申请人： Vaxcyte, Inc.
发明人： Jeffery FAIRMAN
IPC分类号： A61K39/02
CPC分类号： A61K39/0216 , A61K2039/70
摘要： An immunogenic composition, a periodontal vaccine formulation containing the immunogenic composition, and methods for treating or preventing periodontal disease are provided, where the methods involves administering an immunologically effective amount of the composition or vaccine formulation to a subject. The immunogenic composition contains at least one polypeptide that comprises: an Mfa1 antigen sequence that is substantially homologous to an immunogenic amino acid sequence from an Mfa1 fimbrilin protein of a Porphyromonas bacterium; and an HA1 antigen sequence, an HA2 antigen sequence, or both an HA1 antigen sequence and an HA2 antigen sequence, wherein the HA1 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 1 contained within an RgpA Gingipain protein of a Porphyromonas bacterium, and the HA2 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 2 contained within an RgpA Gingipain protein of a Porphyromonas bacterium.

7. 发明公开

US20230183147A1 CARRIER-PROTEIN POLYSACCHARIDE CONJUGATION METHODS 审中-公开
公开(公告)号：US20230183147A1
公开(公告)日：2023-06-15
申请号：US18171055
申请日：2023-02-17
申请人： Vaxcyte, Inc.
发明人： Jeffery C. FAIRMAN , Neeraj KAPOOR , Lucy Estella PILL , Scott SNYDER
IPC分类号： C07B37/10 , C07K1/107 , C07K19/00 , A61K47/54 , A61K47/62
CPC分类号： C07B37/10 , C07K1/1077 , C07K19/00 , A61K47/545 , A61K47/62
摘要： The present disclosure provides methods of preparing heteroaryl-containing compounds, wherein an azide-alkyne cycloaddition is accelerated in the presence of lauryldimethylamine oxide (LDAO). The present disclosure further provides conjugates of polypeptides and antigens prepared using such methods.

8. 发明授权

US10835590B2 Periodontitis vaccine and related compositions and methods of use 有权
公开(公告)号：US10835590B2
公开(公告)日：2020-11-17
申请号：US16158155
申请日：2018-10-11
申请人： Vaxcyte, Inc.
发明人： Jeffery Fairman
IPC分类号： C07K1/00 , A61K39/02 , A61K39/00
CPC分类号： A61K39/0216 , A61K2039/54 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/70
摘要： An immunogenic composition, a periodontal vaccine formulation containing the immunogenic composition, and methods for treating or preventing periodontal disease are provided, where the methods involves administering an immunologically effective amount of the composition or vaccine formulation to a subject. The immunogenic composition contains at least one polypeptide that comprises: an Mfa1 antigen sequence that is substantially homologous to an immunogenic amino acid sequence from an Mfa1 fimbrilin protein of a Porphyromonas bacterium; and an HA1 antigen sequence, an HA2 antigen sequence, or both an HA1 antigen sequence and an HA2 antigen sequence, wherein the HA1 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 1 contained within an RgpA Gingipain protein of a Porphyromonas bacterium, and the HA2 antigen sequence is substantially homologous to an immunogenic amino acid sequence from an RgpA Gingipain hemagglutinin domain 2 contained within an RgpA Gingipain protein of a Porphyromonas bacterium.

9. 发明授权

US11998599B2 Polypeptide-antigen conjugates with non-natural amino acids 有权
公开(公告)号：US11998599B2
公开(公告)日：2024-06-04
申请号：US15859251
申请日：2017-12-29
申请人： Vaxcyte, Inc.
发明人： Jeffery Fairman , Jon H. Heinrichs , Wei Chan
IPC分类号： A61K39/385 , A61K39/09 , A61K47/64 , A61P29/00 , A61P31/04 , A61P37/00 , A61K39/00
CPC分类号： A61K39/385 , A61K39/092 , A61K47/6415 , A61K47/646 , A61P29/00 , A61P31/04 , A61P37/00 , A61K2039/575 , A61K2039/6037 , A61K2039/627
摘要： Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.

10. 发明授权

US11951165B2 Conjugated vaccine carrier proteins 有权
公开(公告)号：US11951165B2
公开(公告)日：2024-04-09
申请号：US16459303
申请日：2019-07-01
申请人： Vaxcyte, Inc.
发明人： Jeffery C. Fairman , Jon H. Heinrichs , Wei Chan
IPC分类号： A61K39/385 , A61K39/09 , A61P31/04 , C07K14/00 , C07K14/285 , C07K14/33 , C07K14/34 , A61K38/00 , A61K39/00
CPC分类号： A61K39/385 , A61K39/092 , A61P31/04 , C07K14/001 , C07K14/285 , C07K14/33 , C07K14/34 , A61K38/00 , A61K2039/6037 , A61K2039/627 , A61K2039/70
摘要： Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.

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