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1. 发明申请

US20070248949A1 Sensitive and Specific Test to Detect Sars Coronavirus 审中-公开
标题翻译：检测Sars冠状病毒的敏感和特异性检测
公开(公告)号：US20070248949A1
公开(公告)日：2007-10-25
申请号：US10582969
申请日：2004-12-17
申请人： Masafumi Inoue , Wanjin Hong
发明人： Masafumi Inoue , Wanjin Hong
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/70 , C12Q1/701
摘要： The invention provides a simple, specific and sensitive test for the presence of SARS coronavirus. Kits comprising primers useful in the test are also provided.
摘要翻译：本发明提供了对SARS冠状病毒存在的简单，特异和灵敏的测试。还提供了包含在试验中有用的引物的试剂盒。

2. 发明申请

US20060292178A1 Proteins encoded by the severe acute respiratory syndrome (SARS) coronavirus and a role in apoptosis 审中-公开
标题翻译：由严重急性呼吸综合征（SARS）冠状病毒编码的蛋白质和凋亡的作用
公开(公告)号：US20060292178A1
公开(公告)日：2006-12-28
申请号：US11197722
申请日：2005-08-04
申请人： Wanjin Hong , Seng Lim , Yee Tan , Burtram Fielding , Shuo Shen , Hoe Peng Tan
发明人： Wanjin Hong , Seng Lim , Yee Tan , Burtram Fielding , Shuo Shen , Hoe Peng Tan
IPC分类号： A61K39/215 , C12Q1/70 , C07H21/04 , C12N15/86 , C07K14/165
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C12N2770/20022 , G01N33/5008 , G01N33/502 , G01N33/5023 , G01N33/5088 , G01N33/56966 , G01N33/6893 , G01N2333/165
摘要： Compositions related to expressed severe acute respiratory syndrome (SARS) coronavirus group-specific polypeptides are provided. Further provided are methods and compositions related to the use of these polypeptides, in particular use for inducing apoptosis in cells, diagnosing SARS infection and screening for modulator and inhibitor compounds of such polypeptides and in turn the virus itself, and in the treatment and/or prophylaxis of disease caused by SARS infection.
摘要翻译：提供与表达的严重急性呼吸综合征（SARS）冠状病毒组特异性多肽相关的组合物。进一步提供了与这些多肽的使用有关的方法和组合物，特别是用于诱导细胞凋亡，诊断SARS感染和筛选这些多肽的调节剂和抑制剂化合物，进而病毒本身以及治疗和/或预防SARS感染引起的疾病。

3. 发明申请

US20110027186A1 TAZ/WWTR1 FOR DIAGNOSIS AND TREATMENT OF CANCER 有权
标题翻译： TAZ / WWTR1用于诊断和治疗癌症
公开(公告)号：US20110027186A1
公开(公告)日：2011-02-03
申请号：US12680982
申请日：2008-10-06
申请人： Wanjin Hong , Siew Wee Chan
发明人： Wanjin Hong , Siew Wee Chan
IPC分类号： A61K49/00 , C12Q1/68 , A61K31/7105 , A61K39/395 , C12N5/071 , A61P35/00
CPC分类号： G01N33/6893 , C07K16/18 , C12N5/0693 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2503/02 , G01N33/57415
摘要： We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of TAZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of TAZ in the cell.
摘要翻译：我们提供抗TAZ药物治疗，预防或减轻癌症。我们进一步提供用于检测个体对乳腺癌或个体对乳腺癌的易感性的试剂盒，其包括用于检测个体中TAZ表达的手段或者取自他或她的样品以及检测癌细胞的方法方法包括检测细胞中TAZ的表达，量或活性的调节。

4. 发明申请

US20070116716A1 Sars coronavirus s proteins and uses thereof 审中-公开
标题翻译： Sars冠状病毒的蛋白质及其用途
公开(公告)号：US20070116716A1
公开(公告)日：2007-05-24
申请号：US10582301
申请日：2004-12-10
申请人： Shuo Shen , Wanjin Hong , Seng Lim , Yee Tan , Burtram Fielding , Phuay Goh , Timothy Tan , Jian Fu
发明人： Shuo Shen , Wanjin Hong , Seng Lim , Yee Tan , Burtram Fielding , Phuay Goh , Timothy Tan , Jian Fu
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/215 , A61K2039/57 , C07K16/10 , C07K2317/76 , C07K2319/23 , C12N2710/14143 , C12N2770/20022 , C12N2770/20034
摘要： The present invention relates to the use of a matured, glycosylated Spike (S) protein of SARS Coronavirus, fragments of the S protein, methods for producing the same, their use in detecting SARS infection, and their use or the use of their corresponding antibodies to treat patients suffering from SARS.
摘要翻译：本发明涉及SARS冠状病毒的成熟的糖基化峰（S）蛋白，S蛋白的片段，其制备方法，其用于检测SARS感染的用途及其使用或使用其相应的抗体治疗患有SARS的患者。

5. 发明授权

US08486903B2 TAZ/WWTR1 for diagnosis and treatment of cancer 有权
标题翻译： TAZ / WWTR1用于诊断和治疗癌症
公开(公告)号：US08486903B2
公开(公告)日：2013-07-16
申请号：US12680982
申请日：2008-10-06
申请人： Wanjin Hong , Siew Wee Chan
发明人： Wanjin Hong , Siew Wee Chan
IPC分类号： C12N15/113
CPC分类号： G01N33/6893 , C07K16/18 , C12N5/0693 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2503/02 , G01N33/57415
摘要： We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of TAZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of TAZ in the cell.
摘要翻译：我们提供抗TAZ药物治疗，预防或减轻癌症。我们进一步提供用于检测个体对乳腺癌或个体对乳腺癌的易感性的试剂盒，其包括用于检测个体中TAZ表达的手段或者取自他或她的样品以及检测癌细胞的方法方法包括检测细胞中TAZ的表达，量或活性的调节。

6. 发明授权

US06207146B1 Gene expression in mammalian cells 失效
标题翻译：哺乳动物细胞中的基因表达
公开(公告)号：US06207146B1
公开(公告)日：2001-03-27
申请号：US08913778
申请日：1997-10-24
申请人： Yin Hwee Tan , Wanjin Hong
发明人： Yin Hwee Tan , Wanjin Hong
IPC分类号： A61K3821
CPC分类号： C07K14/565 , A61K38/00 , C07K14/505 , C12N15/85 , C12N2800/108 , C12N2830/002 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： Proteins such as human &bgr;-interferon or human erythropoietin are prepared by culturing mammalian cells which harbour a nucleic acid sequence comprising: (i) a coding sequence which encodes the desired protein and which is operably linked to a promoter capable of directing expression of the coding sequence in a mammalian cell in the presence of a heavy metal ion; and (ii) a first selectable marker sequence comprises a metallothionein gene and which is operably linked to a promoter capable of directing expression of the metallothionein gene in a mammalian cell in the presence of a heavy metal ion; and optionally (iii) a second selectable marker sequence which comprises a neo gene and which is operably linked to a promoter capable of directing expression of the neo gene in a mammalian cell.
摘要翻译：蛋白质如人β-干扰素或人促红细胞生成素通过培养携带核酸序列的哺乳动物细胞来制备，所述核酸序列包含：（i）编码所需蛋白质的编码序列，其可操作地连接于能够引导编码在重金属离子存在下的哺乳动物细胞中的序列; 和（ii）第一选择性标记序列包含金属硫蛋白基因，并且在重金属离子存在下，其可操作地连接于能够引导金属硫蛋白基因在哺乳动物细胞中表达的启动子; 和任选地（iii）第二选择性标记序列，其包含neo基因并且可操作地连接到能够引导neo基因在哺乳动物细胞中的表达的启动子。

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