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1. 发明授权

US10395757B2 Parental genome assembly method 有权
公开(公告)号：US10395757B2
公开(公告)日：2019-08-27
申请号：US14361865
申请日：2011-12-02
申请人： Weiming He , Shancen Zhao , Xuemei Zhang , Yingrui Li , Jun Wang , Jian Wang , Huanming Yang
发明人： Weiming He , Shancen Zhao , Xuemei Zhang , Yingrui Li , Jun Wang , Jian Wang , Huanming Yang
IPC分类号： G16B20/00 , C12Q1/6869 , C12Q1/6895 , G16C99/00
摘要： Provided is a parental genome assembly method, comprising: using the sequencing data of parental selfing line progeny population to assemble and perfect the parental genome data. Also provided is a device for implementing the method.

2. 发明申请

US20150205913A1 PARENTAL GENOME ASSEMBLY METHOD 审中-公开
标题翻译：亲本基因组装方法
公开(公告)号：US20150205913A1
公开(公告)日：2015-07-23
申请号：US14361865
申请日：2011-12-02
申请人： Weiming He , Shancen Zhao , Xuemei Zhang , Yingrui Li , Jun Wang , Jian Wang , Huanming Yang
发明人： Weiming He , Shancen Zhao , Xuemei Zhang , Yingrui Li , Jun Wang , Jian Wang , Huanming Yang
IPC分类号： G06F19/18 , C12Q1/68
CPC分类号： G16B20/00 , C12Q1/6869 , C12Q1/6895 , C12Q2535/122 , G16C99/00
摘要： Provided is a parental genome assembly method, comprising: using the sequencing data of parental selfing line progeny population to assemble and perfect the parental genome data. Also provided is a device for implementing the method.
摘要翻译：提供了一种亲本基因组装配方法，其包括：使用亲本自交系后代群体的测序数据来组合和完善亲本基因组数据。还提供了一种用于实现该方法的装置。

3. 发明申请

US20110268153A1 ELECTRICITY GENERATING BASED ON THE DIFFERENCE IN TEMPERATURE ELECTRONIC PAN WITH A SEMICONDUCTOR REFRIGERATION SLICE 审中-公开
标题翻译：基于具有半导体制冷液温度电子PAN的差异的电力产生
公开(公告)号：US20110268153A1
公开(公告)日：2011-11-03
申请号：US13141629
申请日：2008-11-03
申请人： Weiming He , Ming Li
发明人： Weiming He , Ming Li
IPC分类号： G01K7/02
CPC分类号： A47J45/068 , A47J37/108 , A47J2202/00
摘要： An electricity generating based on the difference in temperature electronic pan with a semiconductor refrigeration slice is provided. The electronic pan comprises a pan body, a handle, an electricity generating based on the difference in temperature unit and a temperature measuring unit. The electricity generating based on the difference in temperature unit is composed of a semiconductor refrigeration slice, a voltage increased and regulated electronic module and an energy storage unit. The temperature measuring unit is composed of a temperature sensor, a microprocessor, a circuit board and a liquid crystal display for displaying temperature. The temperature sensor is provided under the pan body directly. The circuit board is provided inside the chamber of the handle. The semiconductor refrigeration slice connected to the pan body is provided inside the chamber at the connection of the handle and the pan body. The other surface of the semiconductor refrigeration slice is contacted with metal heat exchange slices firmly. The electricity generating based on the difference in temperature unit, the temperature measuring unit and the liquid crystal display are connected to the circuit board, respectively.
摘要翻译：提供了一种基于温度差电子盘与半导体制冷片的发电。电子盘包括锅体，把手，基于温差单位的发电和温度测量单元。基于温差单位的发电由半导体制冷片，增压调节电子模块和能量存储单元构成。温度测量单元由温度传感器，微处理器，电路板和用于显示温度的液晶显示器组成。温度传感器直接设置在锅体下方。电路板设置在手柄的腔室内。连接到锅体的半导体制冷片在手柄和锅体的连接处设置在腔室的内部。半导体制冷片的另一表面牢固地与金属热交换片接触。基于温差单位的发电量，温度测量单元和液晶显示器分别连接到电路板。

4. 发明申请

US20140206006A1 SINGLE CELL CLASSIFICATION METHOD, GENE SCREENING METHOD AND DEVICE THEREOF 审中-公开
标题翻译：单细胞分类方法，基因筛选方法及其装置
公开(公告)号：US20140206006A1
公开(公告)日：2014-07-24
申请号：US14239650
申请日：2012-08-24
申请人： Xun Xu , Li Bao , Weiming He , Yong Hou , Ye Tao
发明人： Xun Xu , Li Bao , Weiming He , Yong Hou , Ye Tao
IPC分类号： G06F19/22
CPC分类号： G16B30/00 , C12Q1/6827 , C12Q1/6869 , G16B20/00
摘要： Provided are a single cell classification method, a gene screening method and a device for implementing the method. In that, the single cell classification method includes the following steps: sequencing the whole genomes of a plurality of single cell samples from the same group, respectively, so as to obtain reads from each single cell sample; aligning the reads from each single cell sample to the sequence of a reference genome, respectively, and performing data filtering on said reads; on the basis of the filtered reads, determining a consistent genotype of each single cell sample, in which consistent genotypes of all the single cell samples constitute an SNP dataset of said group; aimed at said each single cell, on the basis of the SNP dataset of said group, determining a corresponding genotype for each cell at a site corresponding to a position in an SNP dataset of the reference genome; and selecting an SNP site associated with cell mutation, and on the basis of the genotype of said single cell at the site, classifying said single cell.
摘要翻译：提供单细胞分类方法，基因筛选方法和实施该方法的装置。其中，单细胞分类方法包括以下步骤：从同一组分别测序多个单细胞样品的全基因组，从而获得每个单细胞样品的读数; 将每个单个细胞样本的读数分别对准参考基因组的序列，并对所述读取执行数据过滤; 基于经过滤的读数，确定每个单细胞样品的一致的基因型，其中所有单细胞样品的一致基因型构成所述组的SNP数据集; 针对所述每个单细胞，基于所述组的SNP数据集，在对应于参照基因组的SNP数据集中的位置的位点处确定每个细胞的相应基因型; 并选择与细胞突变相关的SNP位点，并且基于所述单细胞在所述位点处的基因型，对所述单细胞进行分类。

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