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1. 发明授权

US09007061B2 Method for magnetic resonance imaging using inversion recovery with on-resonant water suppression including MRI systems and software embodying same 有权
标题翻译：使用包括MRI系统在内的具有共振水分抑制的反演恢复的磁共振成像方法和体现其的软件
公开(公告)号：US09007061B2
公开(公告)日：2015-04-14
申请号：US13279686
申请日：2011-10-24
申请人： Matthias Stuber , Wesley D. Gilson , Dara L. Kraitchman
发明人： Matthias Stuber , Wesley D. Gilson , Dara L. Kraitchman
IPC分类号： G01V3/00 , G01R33/48
CPC分类号： G01R33/4828
摘要： Featured are methods for magnetic resonance imaging of a volume, such a volume having susceptibility-generating objects or interfaces having susceptibility mismatches therein. Such a method includes selectively visualizing one of susceptibility-generating objects or interfaces having susceptibility mismatches as hyperintense signals, where such visualizing includes controlling variable imaging parameters so as to control a geometric extent of a signal enhancing effect, m more particular aspects of the present invention, such selectively visualizing includes attenuating or essentially suppressing signals from fat and/or water, namely on-resonant water protons, so as to thereby enhance a signal(s) associated with magnetic susceptibility gradient(s). Also featured are MRI systems, apparatuses and/or applications programs for execution on a computer system controlling the MRI data acquisition process embodying such methods.
摘要翻译：特征是用于体积的磁共振成像的方法，例如具有易感性产生对象的体积或其中具有敏感性失配的界面。这样的方法包括选择性地将敏感性产生对象或具有敏感度失配的接口中的一个选择性地视觉为高信号信号，其中这种可视化包括控制可变成像参数，以便控制信号增强效果的几何程度，本发明更具体的方面，这种选择性可视化包括衰减或基本上抑制来自脂肪和/或水的信号，即谐振水质子，从而增强与磁化率梯度相关联的信号。还特征在于用于在控制实施这种方法的MRI数据采集过程的计算机系统上执行的MRI系统，装置和/或应用程序。

2. 发明申请

US20120089008A1 SYSTEM AND METHOD FOR PASSIVE MEDICAL DEVICE NAVIGATION UNDER REAL-TIME MRI GUIDANCE 有权
标题翻译：实时MRI指导下被动式医疗器械导航的系统与方法
公开(公告)号：US20120089008A1
公开(公告)日：2012-04-12
申请号：US13150384
申请日：2011-06-01
申请人： Wilhelm Strehl , Wesley D. Gilson , Eva Rothgang
发明人： Wilhelm Strehl , Wesley D. Gilson , Eva Rothgang
IPC分类号： A61B5/055
CPC分类号： A61B34/20 , A61B2034/2065 , A61B2090/374 , G01R33/286
摘要： A method for tracking a needle along a path under real-time magnetic resonance imaging (MRI) guidance includes extracting a candidate needle artifact region from a plurality of incoming MR images of a needle inside biological tissue, determining an initial needle direction vector from the candidate needle artifact region in each of the plurality of incoming needle images, determining an initial needle base point from an intersection of the needle direction vector with a first incoming needle image, and an initial needle tip point from an intersection of the needle direction vector with a last incoming needle image, and tracking said needle by minimizing a cost function of the initial base point and initial direction vector to calculate an updated base point and updated direction vector. The updated base point and direction vector are used to visualize the advance of the needle along the path through the biological tissue.
摘要翻译：用于在实时磁共振成像（MRI）指导下沿着路径跟踪针的方法包括从生物组织内的针的多个入射MR图像中提取候选针刺伪影区域，从候选者确定初始针向量矢量在多个进针图像中的每一个中的针刺伪影区域，从针方向矢量与第一入射针图像的交点确定初始针基点，以及从针方向矢量与并且通过最小化初始基点和初始方向向量的成本函数来计算更新的基点和更新的方向向量来跟踪所述针。更新的基点和方向向量用于沿着穿过生物组织的路径可视化针的前进。

3. 发明申请

US20110096974A1 METHOD FOR FAT FRACTION QUANTIFICATION IN MAGNETIC RESONANCE IMAGING 有权
标题翻译：磁共振成像中脂肪分数量化的方法
公开(公告)号：US20110096974A1
公开(公告)日：2011-04-28
申请号：US12910909
申请日：2010-10-25
申请人： Wesley D. Gilson
发明人： Wesley D. Gilson
IPC分类号： G06K9/00
CPC分类号： G01R33/4828 , G01R33/50
摘要： A method for determining a concentration of fat within a region of a subject includes acquiring at least three gradient echo images from at least two different flip angles. The first and third images occur at an in-phase time when resonance signals of fat and water are in-phase with one another. The second images occur at an opposed-phase time when the resonance signals of fat and water are 180° out of phase with one another. T2* and T1 relaxation time maps are approximated based on the acquired images. Fat and water signals are distinguished based on observed relative signal phase. The amplitude of the fat and water signals are modulated using the T2* and T1 relaxation time maps. A ratio between fat and water signals for one or more voxels of the images is calculated based on the amplitude modulated fat and water signal images.
摘要翻译：用于确定受试者的区域内的脂肪浓度的方法包括从至少两个不同的翻转角度获取至少三个梯度回波图像。第一和第三图像在脂肪和水的共振信号彼此同相的同时发生。当脂肪和水的共振信号彼此相位相差180°时，第二个图像出现在相对相位时间。 T2 *和T1弛豫时间图基于所获取的图像近似。脂肪和水信号根据观察到的相对信号相区分。使用T2 *和T1弛豫时间图调制脂肪和水信号的幅度。基于幅度调制的脂肪和水信号图像计算图像的一个或多个体素的脂肪和水信号之间的比率。

4. 发明授权

US08526691B2 System and method for passive medical device navigation under real-time MRI guidance 有权
标题翻译：实时MRI指导下被动医疗器械导航的系统和方法
公开(公告)号：US08526691B2
公开(公告)日：2013-09-03
申请号：US13150384
申请日：2011-06-01
申请人： Wilhelm Strehl , Wesley D. Gilson , Eva Rothgang
发明人： Wilhelm Strehl , Wesley D. Gilson , Eva Rothgang
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： A61B34/20 , A61B2034/2065 , A61B2090/374 , G01R33/286
摘要： A method for tracking a needle along a path under real-time magnetic resonance imaging (MRI) guidance includes extracting a candidate needle artifact region from a plurality of incoming MR images of a needle inside biological tissue, determining an initial needle direction vector from the candidate needle artifact region in each of the plurality of incoming needle images, determining an initial needle base point from an intersection of the needle direction vector with a first incoming needle image, and an initial needle tip point from an intersection of the needle direction vector with a last incoming needle image, and tracking said needle by minimizing a cost function of the initial base point and initial direction vector to calculate an updated base point and updated direction vector. The updated base point and direction vector are used to visualize the advance of the needle along the path through the biological tissue.
摘要翻译：用于在实时磁共振成像（MRI）指导下沿着路径跟踪针的方法包括从生物组织内的针的多个入射MR图像中提取候选针刺伪影区域，从候选者确定初始针向量矢量在多个进针图像中的每一个中的针刺伪影区域，从针方向矢量与第一入射针图像的交点确定初始针基点，以及从针方向矢量与并且通过最小化初始基点和初始方向向量的成本函数来计算更新的基点和更新的方向向量来跟踪所述针。更新的基点和方向向量用于沿着穿过生物组织的路径可视化针的前进。

5. 发明授权

US08488859B2 Method for fat fraction quantification in magnetic resonance imaging 有权
$Method for fat fraction quantification in magnetic resonance imaging$
标题翻译：磁共振成像中脂肪分数定量的方法
公开(公告)号：US08488859B2
公开(公告)日：2013-07-16
申请号：US12910909
申请日：2010-10-25
申请人： Wesley D. Gilson
发明人： Wesley D. Gilson
IPC分类号： G06K9/00
CPC分类号： G01R33/4828 , G01R33/50
摘要： A method for determining a concentration of fat within a region of a subject includes acquiring at least three gradient echo images from at least two different flip angles. The first and third images occur at an in-phase time when resonance signals of fat and water are in-phase with one another. The second images occur at an opposed-phase time when the resonance signals of fat and water are 180° out of phase with one another. T2* and T1 relaxation time maps are approximated based on the acquired images. Fat and water signals are distinguished based on observed relative signal phase. The amplitude of the fat and water signals are modulated using the T2* and T1 relaxation time maps. A ratio between fat and water signals for one or more voxels of the images is calculated based on the amplitude modulated fat and water signal images.
摘要翻译：用于确定受试者的区域内的脂肪浓度的方法包括从至少两个不同的翻转角度获取至少三个梯度回波图像。第一和第三图像在脂肪和水的共振信号彼此同相的同时发生。当脂肪和水的共振信号彼此相位相差180°时，第二个图像出现在相对相位时间。 T2 *和T1弛豫时间图基于所获取的图像近似。脂肪和水信号根据观察到的相对信号相区分。使用T2 *和T1弛豫时间图调制脂肪和水信号的幅度。基于幅度调制的脂肪和水信号图像计算图像的一个或多个体素的脂肪和水信号之间的比率。

6. 发明申请

US20090027051A1 Method for magnetic resonance imaging using inversion recovery with on-resonant water suppression including mri systems and software embodying same 有权
标题翻译：使用包含mri系统的非谐振抑水反转恢复和体现其的软件的磁共振成像方法
公开(公告)号：US20090027051A1
公开(公告)日：2009-01-29
申请号：US11883534
申请日：2006-02-03
申请人： Matthias Stuber , Wesley D. Gilson , Dara L. Kraitchman
发明人： Matthias Stuber , Wesley D. Gilson , Dara L. Kraitchman
IPC分类号： G01R33/483
CPC分类号： G01R33/4828
摘要： Featured are methods for magnetic resonance imaging of a volume, such a volume having susceptibility-generating objects or interfaces having susceptibility mismatches therein. Such a method includes selectively visualizing one of susceptibility-generating objects or interfaces having susceptibility mismatches as hyperintense signals, where such visualizing includes controlling variable imaging parameters so as to control a geometric extent of a signal enhancing effect, m more particular aspects of the present invention, such selectively visualizing includes attenuating or essentially suppressing signals from fat and/or water, namely on-resonant water protons, so as to thereby enhance a signal(s) associated with magnetic susceptibility gradient(s). Also featured are MRI systems, apparatuses and/or applications programs for execution on a computer system controlling the MRI data acquisition process embodying such methods.
摘要翻译：特征是用于体积的磁共振成像的方法，例如具有易感性产生对象的体积或其中具有敏感性失配的界面。这样的方法包括选择性地将敏感性产生对象或具有敏感度失配的接口中的一个选择性地视觉为高信号信号，其中这种可视化包括控制可变成像参数，以便控制信号增强效果的几何程度，本发明更具体的方面，这种选择性可视化包括衰减或基本上抑制来自脂肪和/或水的信号，即谐振水质子，从而增强与磁化率梯度相关联的信号。还特征在于用于在控制实施这种方法的MRI数据采集过程的计算机系统上执行的MRI系统，装置和/或应用程序。

7. 发明申请

US20120062227A1 METHOD FOR MAGNETIC RESONANCE IMAGING USING INVERSION RECOVERY WITH ON-RESONANT WATER SUPPRESSION INCLUDING MRI SYSTEMS AND SOFTWARE EMBODYING SAME 有权
标题翻译：使用具有包含MRI系统和软件实现的共振水抑制的反相恢复的磁共振成像方法
公开(公告)号：US20120062227A1
公开(公告)日：2012-03-15
申请号：US13279686
申请日：2011-10-24
申请人： Matthias Stuber , Wesley D. Gilson , Dara L. Kraitchman
发明人： Matthias Stuber , Wesley D. Gilson , Dara L. Kraitchman
IPC分类号： G01R33/44
CPC分类号： G01R33/4828
摘要： Featured are methods for magnetic resonance imaging of a volume, such a volume having susceptibility-generating objects or interfaces having susceptibility mismatches therein. Such a method includes selectively visualizing one of susceptibility-generating objects or interfaces having susceptibility mismatches as hyperintense signals, where such visualizing includes controlling variable imaging parameters so as to control a geometric extent of a signal enhancing effect, m more particular aspects of the present invention, such selectively visualizing includes attenuating or essentially suppressing signals from fat and/or water, namely on-resonant water protons, so as to thereby enhance a signal(s) associated with magnetic susceptibility gradient(s). Also featured are MRI systems, apparatuses and/or applications programs for execution on a computer system controlling the MRI data acquisition process embodying such methods.
摘要翻译：特征是用于体积的磁共振成像的方法，例如具有易感性产生对象的体积或其中具有敏感性失配的界面。这样的方法包括选择性地将敏感性产生对象或具有敏感度失配的接口中的一个选择性地视觉为高信号信号，其中这种可视化包括控制可变成像参数，以便控制信号增强效果的几何程度，本发明更具体的方面，这种选择性可视化包括衰减或基本上抑制来自脂肪和/或水的信号，即谐振水质子，从而增强与磁化率梯度相关联的信号。还特征在于用于在控制实施这种方法的MRI数据采集过程的计算机系统上执行的MRI系统，装置和/或应用程序。

8. 发明授权

US08054075B2 Method for magnetic resonance imaging using inversion recovery with on-resonant water suppression including MRI systems and software embodying same 有权
标题翻译：使用包括MRI系统在内的具有共振水分抑制的反演恢复的磁共振成像方法和体现其的软件
公开(公告)号：US08054075B2
公开(公告)日：2011-11-08
申请号：US11883534
申请日：2006-02-03
申请人： Matthias Stuber , Wesley D. Gilson , Dara L. Kraitchman
发明人： Matthias Stuber , Wesley D. Gilson , Dara L. Kraitchman
IPC分类号： G01V3/00
CPC分类号： G01R33/4828
摘要： Featured are methods for magnetic resonance imaging of a volume, such a volume having susceptibility-generating objects or interfaces having susceptibility mismatches therein. Such a method includes selectively visualizing one of susceptibility-generating objects or interfaces having susceptibility mismatches as hyperintense signals, where such visualizing includes controlling variable imaging parameters so as to control a geometric extent of a signal enhancing effect, m more particular aspects of the present invention, such selectively visualizing includes attenuating or essentially suppressing signals from fat and/or water, namely on-resonant water protons, so as to thereby enhance a signal(s) associated with magnetic susceptibility gradient(s). Also featured are MRI systems, apparatuses and/or applications programs for execution on a computer system controlling the MRI data acquisition process embodying such methods.
摘要翻译：特征是用于体积的磁共振成像的方法，例如具有易感性产生对象的体积或其中具有敏感性失配的界面。这样的方法包括选择性地将敏感性产生对象或具有敏感度失配的接口中的一个选择性地视觉为高信号信号，其中这种可视化包括控制可变成像参数，以便控制信号增强效果的几何程度，本发明更具体的方面，这种选择性可视化包括衰减或基本上抑制来自脂肪和/或水的信号，即谐振水质子，从而增强与磁化率梯度相关联的信号。还特征在于用于在控制实施这种方法的MRI数据采集过程的计算机系统上执行的MRI系统，装置和/或应用程序。

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