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1. 发明授权

US10668012B2 Chewable sustained release formulations 审中-公开
公开(公告)号：US10668012B2
公开(公告)日：2020-06-02
申请号：US12554361
申请日：2009-09-04
申请人： Andrew Xian Chen , Patricia D Kigin , Hai Liang Chen , Jun Fan
发明人： Andrew Xian Chen , Patricia D Kigin , Hai Liang Chen , Jun Fan
IPC分类号： A61K31/16 , A61K9/00 , A61K9/16 , A61K9/20
摘要： Sustained release compositions in tablet or multiparticulate forms comprising (a) an active ingredient, (b) a primary sustain release agent, (c) a wax-like agent, and (d) a bulking or spheronizing agent are provided. The compositions are chewable and/or taste masked. Oral dosage forms comprising such compositions and methods for preparing and using such compositions and dosage forms are also provided.

2. 发明授权

US09248098B2 Treating or preventing pain using spicamycin derivatives 有权
标题翻译：使用spicamycin衍生物治疗或预防疼痛
公开(公告)号：US09248098B2
公开(公告)日：2016-02-02
申请号：US13122771
申请日：2009-10-09
申请人： John R. Didsbury , Kenneth J. Ingold , Linda Goff Jet , Andrew Xian Chen , Hailiang Chen
发明人： John R. Didsbury , Kenneth J. Ingold , Linda Goff Jet , Andrew Xian Chen , Hailiang Chen
IPC分类号： A01N43/04 , A61K31/70 , C07H19/04 , C07H19/20 , A61K9/107 , A61K31/7076
CPC分类号： A61K9/1075 , A61K31/7076
摘要： The present invention relates to a pharmaceutical composition comprising spicamycin derivatives that vary in their fatty acid side chain moieties and are useful in the treatment of pain. The invention further provides a method of using the pharmaceutical composition to treat pain, including neuropathic pain.
摘要翻译：本发明涉及包含其脂肪酸侧链部分变化且可用于治疗疼痛的spicamycin衍生物的药物组合物。本发明还提供使用该药物组合物治疗疼痛的方法，包括神经性疼痛。

3. 发明授权

US09132144B2 Phospholipid depot 有权
标题翻译：磷脂仓库
公开(公告)号：US09132144B2
公开(公告)日：2015-09-15
申请号：US13242778
申请日：2011-09-23
申请人： Hailiang Chen , Andrew Xian Chen , Dushyanth Surakanti , Franklin Okumu
发明人： Hailiang Chen , Andrew Xian Chen , Dushyanth Surakanti , Franklin Okumu
IPC分类号： A61K31/7036 , A61P31/00 , A61K38/14 , A61K9/00 , A61K9/107 , A61K9/14 , A61K9/16
CPC分类号： A61K9/107 , A61K9/0019 , A61K9/0024 , A61K9/1075 , A61K9/145 , A61K9/16 , A61K9/1617 , A61K9/1682 , A61K31/7036 , A61K38/14 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.
摘要翻译：本发明提供了一种清洁剂，其包含至少一种选自万古霉素，庆大霉素，其药学上可接受的盐及其混合物的亲水性水溶性药物活性剂，水，磷脂，油，任选的pH调节试剂和选自乙醇，异丙醇及其混合物的粘度调节剂，其中存在于贮存库中的水相对于贮存库的总重量不超过约4重量％，并且贮存库具有约3至约6的pH值，其制备和施用方法。

4. 发明申请

US20140155320A1 USE OF STORAGE STABLE VISCOUS PHOSPHOLIPID DEPOT TO TREAT WOUNDS 审中-公开
标题翻译：使用储存稳定的粘稠磷酸盐沉积物进行处理
公开(公告)号：US20140155320A1
公开(公告)日：2014-06-05
申请号：US13824119
申请日：2011-10-18
申请人： Hailiang Chen , Andrew Xian Chen , Dushyanth Surakanti , Franklin Omuku
发明人： Hailiang Chen , Andrew Xian Chen , Dushyanth Surakanti , Franklin Omuku
IPC分类号： A61K38/14 , A61K31/7036
CPC分类号： A61K38/14 , A61K9/0024 , A61K9/06 , A61K31/7036 , A61K31/7052 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method of preventing and/or treating a wound infection by introducing to a wound a clear depot comprising a hydrophilic water-soluble pharmaceutically active agent(s) selected from the group consisting of vancomycin, gentamicin, and a mixture thereof, water, a phospholipid, an oil, a pH adjusting agent, and a viscosity modifying agent, wherein the water present in the viscous depot is no more than about 4 wt %, no more than about 2 wt %, or no more than about 0.5 wt % of water relative to the total weight of the depot.
摘要翻译：本发明提供了一种通过向伤口引入包含选自万古霉素，庆大霉素及其混合物的亲水性水溶性药物活性剂的透明贮库来预防和/或治疗伤口感染的方法，水，磷脂，油，pH调节剂和粘度调节剂，其中存在于粘性贮库中的水不超过约4重量％，不超过约2重量％或不超过约0.5重量％ wt％的水相对于贮库的总重量。

5. 发明授权

US08667086B2 Method, device, and system for downloading games 有权
标题翻译：用于下载游戏的方法，设备和系统
公开(公告)号：US08667086B2
公开(公告)日：2014-03-04
申请号：US13990051
申请日：2011-11-28
申请人： Guangcheng Sun , Min Zhao , Xian Chen
发明人： Guangcheng Sun , Min Zhao , Xian Chen
IPC分类号： G06F15/16 , G06F12/00
CPC分类号： H04L67/42 , H04L67/125 , H04L67/34
摘要： The present disclosure applies to the field of software, and provides a method, a device and a system for downloading games. The method includes that: after a user logs in, a client device sends a version number of a local game hall and personal information of the user to a server, which generates and returns a silent configuration file for downloading according to the version number of the local game hall and personal information of the user, wherein the silent configuration file for downloading includes a list of games that needs to be updated and/or downloaded and a silent download speed-limiting mode; the client device receives the silent configuration file for downloading returned by the server, and silently downloads and/or updates corresponding games of the local game hall according to the silent configuration file for downloading. An embodiment of the present disclosure can set the most appropriate silent download mode according to network conditions and user requirements.
摘要翻译：本公开适用于软件领域，并且提供用于下载游戏的方法，设备和系统。该方法包括：在用户登录之后，客户端设备将本地游戏厅的版本号和用户的个人信息发送到服务器，服务器生成并根据版本号发送用于下载的静默配置文件本地游戏厅和用户的个人信息，其中用于下载的静音配置文件包括需要更新和/或下载的游戏列表以及无声下载速度限制模式; 客户端装置接收服务器返回的下载的静音配置文件，并根据用于下载的静音配置文件静音地下载和/或更新本地游戏厅的对应游戏。本公开的实施例可以根据网络条件和用户需求设置最合适的无声下载模式。

6. 发明申请

US20120245761A1 Three-way airplane model control system with 2.4G communication mode 失效
标题翻译：具有2.4G通信模式的三通飞机模型控制系统
公开(公告)号：US20120245761A1
公开(公告)日：2012-09-27
申请号：US13052133
申请日：2011-03-21
申请人： Dong Xian CHEN
发明人： Dong Xian CHEN
IPC分类号： A63H30/04 , A63H27/00
CPC分类号： A63H27/02 , A63H30/04
摘要： The utility model provides an airplane model control system capable of conducting omnidirectional and long-distance transmission of signals without being interfered by the sunlight and other visible lights. The airplane model control system can transverse obstacles for data communication, and comprises a remote control transmitting control device and an airplane receiving control device which all work in the frequency band of 2.4 GHz and 83 communication channels are included; and each remote control transmitting control device has unique ID number, which will not be controlled and interfered due to the reason of same frequency, realizes a share port of multiple functions simultaneously on one main controller and can realize reduction of cost.
摘要翻译：本实用新型提供一种能够进行全方向和长距离传输信号而不受太阳光和其他可见光干扰的飞机模型控制系统。飞机模型控制系统可以横向进行数据通信的障碍物，包括遥控发射控制装置和飞行员接收控制装置，其全部工作在2.4GHz的频带和83个通信信道; 并且每个遥控发送控制装置具有唯一的ID号，由于相同频率的原因而不被控制和干扰，在一个主控制器上同时实现多个功能的共享端口并且可以实现成本的降低。

7. 发明授权

US08035944B2 Power supply system with adaptive blown fuse detection using negative sequence component 有权
标题翻译：使用负序分量的自适应熔断器熔断器检测电源系统
公开(公告)号：US08035944B2
公开(公告)日：2011-10-11
申请号：US12371644
申请日：2009-02-16
申请人： Xian Chen , Brian P. Heber
发明人： Xian Chen , Brian P. Heber
IPC分类号： H02H5/00
CPC分类号： H02M7/219 , G01R19/2513
摘要： Existing measurements of an input component (such as voltage or current) in a three phase power supply system are decomposed into a negative sequence component. The negative sequence component, which is significantly higher when a rectifier fuse is blown, is compared to a threshold and a determination made that a rectifier fuse is blown when the negative component exceeds the threshold. In an aspect, an adaptive algorithm is used to make the detection work better in the range of the nominal frequency of the input voltage. In an aspect, the negative sequence is determined indirectly from the existing measurements.
摘要翻译：在三相电源系统中的输入部件（例如电压或电流）的现有测量被分解为负序分量。将整流器熔断器熔断时显着较高的负序分量与阈值进行比较，并确定当负极成分超过阈值时整流熔断器被熔断。在一方面，使用自适应算法使得检测在输入电压的额定频率的范围内更好地工作。在一方面，从现有测量值间接确定负序。

8. 发明申请

US20100067269A1 INTELLIGENT SENSORLESS CONTROL OF A PHASE CONTROLLED RECTIFIER 有权
标题翻译：相控制整流器的智能传感器控制
公开(公告)号：US20100067269A1
公开(公告)日：2010-03-18
申请号：US12209572
申请日：2008-09-12
申请人： Brian P. Heber , Xian Chen , Paul Taylor
发明人： Brian P. Heber , Xian Chen , Paul Taylor
IPC分类号： H02M7/04
CPC分类号： H02M7/219 , H02J9/062
摘要： An uninterruptible power supply (“UPS”) has a phase-controlled rectifier coupled to a source of AC power and having an output providing a DC bus, the output of the phase-controlled rectifier coupled to an inverter. A first controller generates a firing angle for the rectifier and a fuzzy logic controller generates a firing angle for the rectifier. In an aspect, the rectifier is controlled by the firing angle generated by the first controller during normal operating conditions of the UPS and the rectifier is controlled by the firing angle generated by the fuzzy logic controller during abnormal operating conditions of the UPS. The abnormal operating conditions can include loss of a direct DC bus voltage measurement and or a period of time after the UPS experiences a large load change. In an aspect, the firing angle generated by the first controller is compared to the firing angle generated by the fuzzy logic controller and a rectifier fault condition determined to exist when the two firing angles differ by at least a threshold amount. In an aspect, the first controller is a PI controller.
摘要翻译：不间断电源（“UPS”）具有耦合到AC电源的相控整流器，并且具有提供DC总线的输出，该相控整流器的输出耦合到逆变器。第一控制器产生用于整流器的触发角，并且模糊逻辑控制器产生用于整流器的触发角。在一方面，在UPS的正常操作状态期间，由第一控制器产生的触发角度控制整流器，并且整流器由在UPS的异常工作状态期间由模糊逻辑控制器产生的触发角度控制。异常工作条件可能包括直流总线电压测量的损失，以及UPS遇到大负载变化后的一段时间。在一方面，将由第一控制器产生的触发角与由模糊逻辑控制器产生的触发角和当两个触发角相差至少阈值时确定存在的整流器故障条件进行比较。在一方面，第一控制器是PI控制器。

9. 发明授权

US07636470B2 Red-eye detection based on red region detection with eye confirmation 有权
公开(公告)号：US07636470B2
公开(公告)日：2009-12-22
申请号：US10958136
申请日：2004-10-04
申请人： Tong-Xian Chen , Xiangrong Chen , John C. Platt , Jie Yan , Hong-Jiang Zhang
发明人： Tong-Xian Chen , Xiangrong Chen , John C. Platt , Jie Yan , Hong-Jiang Zhang
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G06K9/0061 , G06T7/0002 , G06T7/70 , G06T7/90 , G06T2207/30216 , H04N1/624
摘要： Red-eye detection based on red region detection with eye confirmation initially identifies pixels that correspond to the color of red-eye within an image. A determination is then made as to whether these identified pixels and surrounding areas are part of an eye or not part of an eye. Those identified pixels that are determined to be part of an eye are the detected red-eye regions.

10. 发明申请

US20050124014A1 Stable isotope, site-specific mass tagging for protein identification 失效
标题翻译：用于蛋白质鉴定的稳定同位素，位点特异性质量标签
公开(公告)号：US20050124014A1
公开(公告)日：2005-06-09
申请号：US10985268
申请日：2004-11-10
申请人： Xian Chen
发明人： Xian Chen
IPC分类号： G01N33/68 , H01J49/04 , G01N33/554 , C07K14/245 , C12N1/21 , C12P21/06 , G01N33/569
CPC分类号： G01N33/6803 , G01N2458/15 , H01J49/04
摘要： Proteolytic peptide mass mapping as measured by mass spectrometry provides an important method for the identification of proteins, which are usually identified by matching the measured and calculated m/z values of the proteolytic peptides. A unique identification is, however, heavily dependent upon the mass accuracy and sequence coverage of the fragment ions generated by peptide ionization. The present invention describes a method for increasing the specificity, accuracy and efficiency of the assignments of particular proteolytic peptides and consequent protein identification, by the incorporation of selected amino acid residue(s) enriched with stable isotope(s) into the protein sequence without the need for ultrahigh instrumental accuracy. Selected amino acid(s) are labeled with 13C/15N/2H and incorporated into proteins in a sequence-specific manner during cell culturing. Each of these labeled amino acids carries a defined mass change encoded in its monoisotopic distribution pattern. Through their characteristic patterns, the peptides with mass tag(s) can then be readily distinguished from other peptides in mass spectra. The present method of identifying unique proteins can also be extended to protein complexes and will significantly increase data search specificity, efficiency and accuracy for protein identifications.
摘要翻译：通过质谱法测定的蛋白水解肽质谱图提供了鉴定蛋白质的重要方法，其通常通过匹配测量和计算的蛋白水解肽的m / z值来鉴定。然而，独特的鉴定依赖于通过肽电离产生的片段离子的质量精度和序列覆盖度。本发明描述了通过将富含稳定同位素的所选择的氨基酸残基并入蛋白质序列中而不增加特定蛋白水解肽的分配的特异性，准确性和效率以及随后的蛋白质鉴定的方法，需要超高仪器准确度。所选择的氨基酸用细胞标记为具有序列特异性方式的蛋白质，并在细胞中以序列特异性方式掺入蛋白质培养这些标记的氨基酸中的每一个携带以单同位素分布模式编码的定义的质量变化。通过其特征模式，可以容易地将具有质量标签的肽与其他肽在质谱中区分开。识别独特蛋白质的本方法也可以扩展到蛋白质复合物，并且将显着增加蛋白质鉴定的数据搜索特异性，效率和准确性。

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