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1. 发明授权

US09371305B2 Deuterated benzopyran compounds and application thereof 有权
标题翻译：氘化苯并吡喃化合物及其应用
公开(公告)号：US09371305B2
公开(公告)日：2016-06-21
申请号：US14401600
申请日：2012-08-10
申请人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
发明人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
IPC分类号： C07D311/58
CPC分类号： A61K31/353 , A61K31/382 , A61K31/47 , C07D311/58
摘要： The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
摘要翻译：本发明公开了具有式（I）所示结构特征的氘代苯并吡喃化合物或其药学上可接受的盐或立体异构体或其前药分子。具有优异的抗炎和镇痛作用和抑制肿瘤细胞生长的能力，这些化合物是新型的COX-2选择性抑制剂。本申请公开的化合物及其药学上可接受的盐可用于制备用于治疗或预防肿瘤的抗炎和镇痛药物和药物。

2. 发明授权

US06930300B1 Method and apparatus for monitoring a photo-detector in an optical transceiver 有权
标题翻译：用于监视光收发器中的光检测器的方法和装置
公开(公告)号：US06930300B1
公开(公告)日：2005-08-16
申请号：US10209452
申请日：2002-07-30
申请人： Darin James Douma , Philip D. Shapiro , Linda Xiaorong Liu
发明人： Darin James Douma , Philip D. Shapiro , Linda Xiaorong Liu
IPC分类号： H01J40/14 , H04B10/158
CPC分类号： H04B10/69
摘要： The method and apparatus for monitoring a photo-detector generates a highly compliant mirror current across a broad range of photo-detector current levels. The apparatus for monitoring includes: a pair of bipolar transistors and a first non-linear isolation element. The pair of transistors are connected in a mirror configuration with a sense transistor one of the pair of transistors sensing a photo-detector current and with a mirror transistor one of the pair of transistors mirroring the photo-detector current with a mirror current. The first non-linear isolation element has at least two terminals a first of which couples to the collector of the mirror transistor. The first non-linear isolation element exhibits a non-linear voltage drop between the at least two terminals in response to varying levels of the mirror current to improve compliance between the mirror current and the detector current. Methods and means for monitoring a photo-detector are also disclosed.
摘要翻译：用于监测光电检测器的方法和装置在宽范围的光电检测器电流水平上产生高度兼容的镜像电流。用于监视的装置包括：一对双极晶体管和第一非线性隔离元件。该对晶体管以反射镜配置与感测晶体管连接，该对晶体管中的一个感测光电检测器电流，并且与反射镜晶体管中的一对晶体管中的一个以镜像电流反射光检测器电流。第一非线性隔离元件具有至少两个端子，其中第一端子耦合到反射镜晶体管的集电极。第一非线性隔离元件响应于反射镜电流的变化水平而在至少两个端子之间呈现非线性电压降，以提高镜电流和检测器电流之间的一致性。还公开了用于监测光检测器的方法和装置。

3. 发明申请

US20140293507A1 COMPOSITE ELECTRODE FOR LITHIUM ION CAPACITOR 有权
标题翻译：用于锂离子电容器的复合电极
公开(公告)号：US20140293507A1
公开(公告)日：2014-10-02
申请号：US13852053
申请日：2013-03-28
申请人： Kishor Purushottam Gadkaree , Xiaorong Liu
发明人： Kishor Purushottam Gadkaree , Xiaorong Liu
IPC分类号： H01G11/46 , H01G9/00
CPC分类号： H01G11/46 , H01G9/0029 , H01G11/06 , H01G11/50 , Y02E60/13 , Y10T29/417
摘要： A lithium-ion capacitor includes a cathode, an anode, and a porous separator positioned between the cathode and the anode. The cathode is formed using activated carbon, and the anode is formed from a composite material that includes lithium titanium oxide and a carbon material such as hard carbon or graphite.
摘要翻译：锂离子电容器包括阴极，阳极和位于阴极和阳极之间的多孔隔离物。阴极使用活性炭形成，阳极由包含锂二氧化钛和碳材料如硬碳或石墨的复合材料形成。

4. 发明申请

US20140128384A1 TUMOR TARGETED DRUG COMBRETASTATIN A4 DERIVATIVE 有权
标题翻译：肿瘤靶向药物组合A4衍生物
公开(公告)号：US20140128384A1
公开(公告)日：2014-05-08
申请号：US14127847
申请日：2012-07-04
申请人： Yong Wang , Cang Zhang , Xiaorong Liu , Yan Zhang , Yunyun Wang , Wenping Zhang
发明人： Yong Wang , Cang Zhang , Xiaorong Liu , Yan Zhang , Yunyun Wang , Wenping Zhang
IPC分类号： C07D413/04 , C07D277/24 , C07D263/32 , C07D233/64 , C07C251/24
CPC分类号： C07D413/04 , C07C251/24 , C07D233/64 , C07D263/32 , C07D277/22 , C07D277/24
摘要： The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.
摘要翻译：本发明涉及肿瘤靶向药物考布他汀A4的咪唑，恶唑和噻唑衍生物，以及磷酸酯，磺酸酯或其药学上可接受的盐，糖苷衍生物，溶剂合物，其中A环包含3,5-二甲氧基苯基， 4位的取代基。药理活性试验表明本发明化合物具有良好的体外抗肿瘤活性和优异的微管蛋白抑制作用。

5. 外观设计

USD914952S1 LED star projector light 有权
公开(公告)号：USD914952S1
公开(公告)日：2021-03-30
申请号：US29749119
申请日：2020-09-03
申请人： Xiaorong Liu
设计人： Xiaorong Liu

6. 发明授权

US09183994B2 Lithium ion capacitors and methods of production 有权
标题翻译：锂离子电容器及其生产方法
公开(公告)号：US09183994B2
公开(公告)日：2015-11-10
申请号：US13687161
申请日：2012-11-28
申请人： Kishor Purushottam Gadkaree , Xiaorong Liu
发明人： Kishor Purushottam Gadkaree , Xiaorong Liu
IPC分类号： H01G11/62 , H01G11/32 , H01G11/06 , H01G11/50 , H01M4/38 , H01M10/0566 , H01M10/0568 , H01M12/00 , H01M4/04 , H01M4/1395 , H01M4/36 , H01M10/052
CPC分类号： H01G11/06 , H01G11/32 , H01G11/34 , H01G11/50 , H01G11/62 , H01G11/84 , H01M4/0447 , H01M4/1395 , H01M4/366 , H01M4/382 , H01M10/052 , H01M10/0566 , H01M10/0568 , H01M12/005 , Y02E60/13 , Y10T29/417
摘要： A lithium-ion capacitor may include a cathode, an anode, a separator disposed between the cathode and the anode, a lithium composite material, and an electrolyte solution. The cathode and anode may be non-porous. The lithium composite material comprises a core of lithium metal and a coating of a complex lithium salt that encapsulates the core. In use, the complex lithium salt may dissolve into and constitute a portion of the electrolyte solution.
摘要翻译：锂离子电容器可以包括阴极，阳极，设置在阴极和阳极之间的隔膜，锂复合材料和电解质溶液。阴极和阳极可以是无孔的。锂复合材料包括锂金属的芯和封装芯的复合锂盐的涂层。在使用中，复合锂盐可以溶解并构成电解质溶液的一部分。

7. 发明授权

US09139574B2 Tumor targeted drug combretastatin A4 derivative 有权
标题翻译：肿瘤靶向药物考布他汀A4衍生物
公开(公告)号：US09139574B2
公开(公告)日：2015-09-22
申请号：US14127847
申请日：2012-07-04
申请人： Yong Wang , Cang Zhang , Xiaorong Liu , Yan Zhang , Yunyun Wang , Wenping Zhang
发明人： Yong Wang , Cang Zhang , Xiaorong Liu , Yan Zhang , Yunyun Wang , Wenping Zhang
IPC分类号： C07D413/04 , C07D233/64 , C07D263/32 , C07D277/24 , C07C251/24 , C07D277/22 , A61K31/53
CPC分类号： C07D413/04 , C07C251/24 , C07D233/64 , C07D263/32 , C07D277/22 , C07D277/24
摘要： The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.
摘要翻译：本发明涉及肿瘤靶向药物考布他汀A4的咪唑，恶唑和噻唑衍生物，以及磷酸酯，磺酸酯或其药学上可接受的盐，糖苷衍生物，溶剂合物，其中A环包含3,5-二甲氧基苯基， 4位的取代基。药理活性试验表明本发明化合物具有良好的体外抗肿瘤活性和优异的微管蛋白抑制作用。

8. 发明申请

US20150133538A1 Deuterated Benzopyran Compounds and Application Thereof 有权
标题翻译：氘代苯并吡喃化合物及其应用
公开(公告)号：US20150133538A1
公开(公告)日：2015-05-14
申请号：US14401600
申请日：2012-08-10
申请人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
发明人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
IPC分类号： C07D311/58
CPC分类号： A61K31/353 , A61K31/382 , A61K31/47 , C07D311/58
摘要： The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
摘要翻译：本发明公开了具有式（I）所示结构特征的氘代苯并吡喃化合物或其药学上可接受的盐或立体异构体或其前药分子。具有优异的抗炎和镇痛作用和抑制肿瘤细胞生长的能力，这些化合物是新型的COX-2选择性抑制剂。本申请公开的化合物及其药学上可接受的盐可用于制备用于治疗或预防肿瘤的抗炎和镇痛药物和药物。

9. 发明申请

US20140146440A1 LITHIUM ION CAPACITORS AND METHODS OF PRODUCTION 有权
标题翻译：锂离子电容器和生产方法
公开(公告)号：US20140146440A1
公开(公告)日：2014-05-29
申请号：US13687161
申请日：2012-11-28
申请人： Kishor Purushottam Gadkaree , Xiaorong Liu
发明人： Kishor Purushottam Gadkaree , Xiaorong Liu
IPC分类号： H01G11/62 , H01G11/32
CPC分类号： H01G11/06 , H01G11/32 , H01G11/34 , H01G11/50 , H01G11/62 , H01G11/84 , H01M4/0447 , H01M4/1395 , H01M4/366 , H01M4/382 , H01M10/052 , H01M10/0566 , H01M10/0568 , H01M12/005 , Y02E60/13 , Y10T29/417
摘要： A lithium-ion capacitor may include a cathode, an anode, a separator disposed between the cathode and the anode, a lithium composite material, and an electrolyte solution. The cathode and anode may be non-porous. The lithium composite material comprises a core of lithium metal and a coating of a complex lithium salt that encapsulates the core. In use, the complex lithium salt may dissolve into and constitute a portion of the electrolyte solution.
摘要翻译：锂离子电容器可以包括阴极，阳极，设置在阴极和阳极之间的隔膜，锂复合材料和电解质溶液。阴极和阳极可以是无孔的。锂复合材料包括锂金属的芯和封装芯的复合锂盐的涂层。在使用中，复合锂盐可以溶解并构成电解质溶液的一部分。

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