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1. 发明授权

US08986692B2 Anti-VEGF monoclonal antibody and pharmaceutical composition comprising said antibody 有权
标题翻译：抗VEGF单克隆抗体和包含所述抗体的药物组合物
公开(公告)号：US08986692B2
公开(公告)日：2015-03-24
申请号：US13393185
申请日：2010-08-27
申请人： Pierre Li , Yaohuang Ke , Yongke Zhang , Weimin Zhu , Guoliang Yu , Fanxin Ma , Xin Fan
发明人： Pierre Li , Yaohuang Ke , Yongke Zhang , Weimin Zhu , Guoliang Yu , Fanxin Ma , Xin Fan
IPC分类号： A61K39/395 , C07K16/22 , A61K39/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides an anti-VEGF monoclonal antibody, which has the variable region of heavy chain comprising the amino acid sequences of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and/or the variable region of light chain comprising the amino acid sequences of SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6. The antibody can be produced by the cell line with the preservation number of CGMCC NO. 3233. The invention also provides the use of said antibody for the manufacture of medicaments for the treatment of a disease that is relevant to VEGF, wherein further provided are pharmaceutical composition, agents, kits and chips comprising said antibody, as well as the cell line with the preservation number of CGMCC NO. 3233.
摘要翻译：本发明提供了抗VEGF单克隆抗体，其具有包含SEQ ID NO：1，SEQ ID NO：2和SEQ ID NO：3的氨基酸序列的重链可变区和/或轻链，其包含SEQ ID NO：4，SEQ ID NO：5和SEQ ID NO：6的氨基酸序列。该抗体可以通过具有CGMCC NO保存数的细胞系产生。本发明还提供了所述抗体用于制备用于治疗与VEGF相关的疾病的药物的用途，其中还提供了包含所述抗体的药物组合物，试剂，试剂盒和切片以及细胞系保存号码为CGMCC NO。 3233。

2. 发明申请

US20130190677A1 PHOTO-STIMULATION METHOD AND KIT WITH AGONIST AGENT 审中-公开
标题翻译：激光治疗方法和试剂盒
公开(公告)号：US20130190677A1
公开(公告)日：2013-07-25
申请号：US13470590
申请日：2012-05-14
申请人： Ming-Chieh TU , Yi-Wei HSIAO , Chung-Pei LEE , Jung-Chien CHANG , Xin-Fan HUANG , Yu-Chia TSAO
发明人： Ming-Chieh TU , Yi-Wei HSIAO , Chung-Pei LEE , Jung-Chien CHANG , Xin-Fan HUANG , Yu-Chia TSAO
IPC分类号： A61M37/00
CPC分类号： A61N5/0616 , A61N5/0624 , A61N2005/0651 , A61N2005/0663
摘要： Disclosed is a photo-stimulation method employing an agonist agent, and a kit for introducing same. The method includes the following steps: providing a light-emitting diode (LED) illuminant which is a yellow, red, green, blue LED or a mixture of two or more kinds thereof, and an agonist agent which contains 0.5% to 2% calcium ion; and adding the agonist agent to a subject and illuminating the subject by the LED illuminant to promote collagen synthesis, to suppress microbial growth, or to inhibit melanin synthesis, wherein the yellow LED is in an illuminance range from 1,000 to 3,500 lux, the red LED is in an illuminance range from 6,000 to 9,500 lux, the green LED is in an illuminance range from 1000 to 5000 lux, and the blue LED is in an illuminance range from 3,000 to 7,000 lux.
摘要翻译：公开了一种使用激动剂的光刺激方法和用于引入其的试剂盒。该方法包括以下步骤：提供黄色，红色，绿色，蓝色LED或其两种或更多种的混合物的发光二极管（LED）发光体，以及含有0.5％至2％钙的激动剂离子; 并将激动剂加入受试者并通过LED照明器照射受试者以促进胶原合成，抑制微生物生长或抑制黑色素合成，其中黄色LED的照度范围为1,000至3,500勒克司，红色LED 在6,000至9,500勒克司的照度范围内，绿色LED的照度范围为1000至5000勒克斯，蓝色LED的照度范围为3,000至7000 lux。

3. 发明申请

US20120093371A1 GENERATING SEARCH REQUESTS FROM MULTIMODAL QUERIES 审中-公开
标题翻译：生成多个查询的搜索请求
公开(公告)号：US20120093371A1
公开(公告)日：2012-04-19
申请号：US13332248
申请日：2011-12-20
申请人： Ming Jing Li , Wei-Ying Ma , Xing Xie , Xin Fan , Zhiwei Li
发明人： Ming Jing Li , Wei-Ying Ma , Xing Xie , Xin Fan , Zhiwei Li
IPC分类号： G06K9/00 , G06K9/54
CPC分类号： G06F16/951 , Y10S707/99945 , Y10S707/99948
摘要： A method and system for generating a search request from a multimodal query that includes a query image and query text is provided. The multimodal query system identifies images of a collection that are textually related to the query image based on similarity between words associated with each image and the query text. The multimodal query system then selects those images of the identified images that are visually related to the query image. The multimodal query system may formulate a search request based on keywords of web pages that contain the selected images and submit that search request to a search engine service.
摘要翻译：提供了一种用于从包含查询图像和查询文本的多模式查询生成搜索请求的方法和系统。多模式查询系统基于与每个图像相关联的单词与查询文本之间的相似度来识别与查询图像文本相关的集合的图像。多模式查询系统然后选择与查询图像视觉相关的识别图像的那些图像。多模式查询系统可以基于包含所选图像的网页的关键词来制定搜索请求，并将该搜索请求提交给搜索引擎服务。

4. 发明授权

US08063699B2 Anti-pop circuit 有权
标题翻译：防爆电路
公开(公告)号：US08063699B2
公开(公告)日：2011-11-22
申请号：US12488438
申请日：2009-06-19
申请人： Xin Fan , Christian Larsen , Lorenzo Crespi
发明人： Xin Fan , Christian Larsen , Lorenzo Crespi
IPC分类号： H03F1/14
CPC分类号： H03F1/305 , H03F3/3022 , H03F3/45183 , H03F2200/144 , H03F2203/45526 , H03F2203/45534 , H03F2203/45674
摘要： Presently many audio chips suffer from pop issues, which is especially serious for single ended audio drivers. An audio pop is a disturbance in the output caused by a sudden transition of chip power, particularly when a chip is powered on or powered off. Furthermore, compensation networks included in the amplifiers on audio chips for stability offer a significant path for transmitting power disturbances to the output. Hence, circuitry is developed to suppress pops in the output stages of an amplifier.
摘要翻译：目前许多音频芯片遭受流行问题，对于单端音频驱动程序来说尤其严重。音频弹奏是由芯片功率的突然转换引起的输出干扰，特别是当芯片通电或断电时。此外，用于稳定性的用于音频芯片的放大器中的补偿网络提供了将功率干扰发送到输出的重要路径。因此，开发电路以抑制放大器的输出级中的弹出。

5. 发明申请

US20070286484A1 Systems and Methods for Enhanced Image Adaptation 审中-公开
标题翻译：用于增强图像适应的系统和方法
公开(公告)号：US20070286484A1
公开(公告)日：2007-12-13
申请号：US11841080
申请日：2007-08-20
申请人： Xing Xie , Wei-Ying Ma , Hong-Jiang Zhang , Liqun Chen , Xin Fan
发明人： Xing Xie , Wei-Ying Ma , Hong-Jiang Zhang , Liqun Chen , Xin Fan
IPC分类号： G06K9/34
CPC分类号： G06K9/3233 , G06K9/4671 , G06T7/00 , G06T11/60 , G06T2200/16
摘要： Systems and methods for adapting images for substantially optimal presentation by heterogeneous client display sizes are described. In one aspect, an image is modeled with respect to multiple visual attentions to generate respective attention objects for each of the visual attentions. For each of one or more image adaptation schemes, an objective measure of information fidelity (IF) is determined for a region R of the image. The objective measures are determined as a function of a resource constraint of the display device and as a function of a weighted sum of IF of each attention object in the region R. A substantially optimal adaptation scheme is then selected as a function of the calculated objective measures. The image is then adapted via the selected substantially optimal adaptation scheme to generate an adapted image as a function of at least the target area of the client display.
摘要翻译：描述了用于通过异构客户端显示大小适配图像以实现基本最佳呈现的系统和方法。在一个方面，针对多个视觉注意来建模图像，以产生每个视觉注意的各自的注意对象。对于一个或多个图像适配方案中的每一个，针对图像的区域R确定信息保真度（IF）的客观测量。根据显示设备的资源约束来确定客观度量，并且根据区域R中每个关注对象的IF的加权和的函数来确定目标度量。然后根据计算出的目标选择基本上最佳的适应方案措施。然后，经由所选择的基本上最佳的自适应方案来适配图像以根据至少客户端显示的目标区域生成适配图像。

6. 发明授权

US07260261B2 Systems and methods for enhanced image adaptation 有权
标题翻译：增强图像适应的系统和方法
公开(公告)号：US07260261B2
公开(公告)日：2007-08-21
申请号：US10371125
申请日：2003-02-20
申请人： Xing Xie , Wei-Ying Ma , Hong-Jiang Zhang , Liqun Chen , Xin Fan
发明人： Xing Xie , Wei-Ying Ma , Hong-Jiang Zhang , Liqun Chen , Xin Fan
IPC分类号： G06K9/34
CPC分类号： G06K9/3233 , G06K9/4671 , G06T7/00 , G06T11/60 , G06T2200/16
摘要： Systems and methods for adapting images for substantially optimal presentation by heterogeneous client display sizes are described. In one aspect, an image is modeled with respect to multiple visual attentions to generate respective attention objects for each of the visual attentions. For each of one or more image adaptation schemes, an objective measure of information fidelity (IF) is determined for a region R of the image. The objective measures are determined as a function of a resource constraint of the display device and as a function of a weighted sum of IF of each attention object in the region R. A substantially optimal adaptation scheme is then selected as a function of the calculated objective measures. The image is then adapted via the selected substantially optimal adaptation scheme to generate an adapted image as a function of at least the target area of the client display.
摘要翻译：描述了用于通过异构客户端显示大小适配图像以实现基本最佳呈现的系统和方法。在一个方面，针对多个视觉注意来建模图像，以产生每个视觉注意的各自的注意对象。对于一个或多个图像适配方案中的每一个，针对图像的区域R确定信息保真度（IF）的客观测量。根据显示设备的资源约束来确定客观度量，并且根据区域R中每个注意对象的IF的加权和的函数确定目标度量。然后根据计算出的目标选择基本上最佳的适应方案措施。然后，经由所选择的基本上最佳的自适应方案来适配图像以根据至少客户端显示的目标区域生成适配图像。

7. 发明授权

US5169962A Preparation of epoxysilicon compounds using rhodium catalysts 失效
标题翻译：使用铑催化剂制备环氧化合物
公开(公告)号：US5169962A
公开(公告)日：1992-12-08
申请号：US583524
申请日：1990-09-17
申请人： James V. Crivello , Ming-Xin Fan
发明人： James V. Crivello , Ming-Xin Fan
IPC分类号： B01J31/20 , B01J31/22 , B01J31/24 , B01J31/30 , C07B61/00 , C07F7/08 , C07F7/21 , C08G59/20 , C08G59/30 , C08G77/38 , C08L83/06
CPC分类号： C08G77/38 , C07F7/0879 , C08L83/06
摘要： A method for making an epoxyfunctional organosilicon compound is provided, comprising the step of reacting at a temperature of from about 25.degree. to about 100.degree. C. a mixture comprising (A) an ethylenically unsaturated epoxide; (B) an organohydrogenpolysiloxane or organohydrogensilane; and (C) a rhodium complex catalyst selected from the group consisting of:(i) RhX.sub.3 (SR.sub.2).sub.3 ;(ii) RhX.sub.3 .multidot.xH.sub.2 O;(iii) [RhX(norbornadiene)].sub.2 ;(iv) RhX(CO)(R.sub.3 P).sub.3 ;(v) RhX(R.sub.3 P).sub.3 ; and(vi) [RhCl(cyclooctadiene)].sub.2 ;wherein X is a halogen atom, x is a number equal to 3 or 4, and R is an alkyl radical having from 1 to 8 inclusive carbon atoms, aryl, aralkyl, or alkaryl radical or the R.sub.3.sup.1 SiQ-- group in which Q represents a divalent aliphatic hydrocarbon radical having from 1 to 6 inclusive carbon atoms and R.sup.1 represents an alkyl radical having from 1 to 8 inclusive carbon atoms, aryl, aralkyl, or alkaryl radical or a (CH.sub.3).sub.3 Si-- radical.

8. 发明授权

US08446216B2 Anti-pop circuit 有权
标题翻译：防爆电路
公开(公告)号：US08446216B2
公开(公告)日：2013-05-21
申请号：US13300012
申请日：2011-11-18
申请人： Xin Fan , Christian Larsen , Lorenzo Crespi
发明人： Xin Fan , Christian Larsen , Lorenzo Crespi
IPC分类号： H03F1/14
CPC分类号： H03F1/305 , H03F3/3022 , H03F3/45183 , H03F2200/144 , H03F2203/45526 , H03F2203/45534 , H03F2203/45674
摘要： Presently many audio chips suffer from pop issues, which is especially serious for single ended audio drivers. An audio pop is a disturbance in the output caused by a sudden transition of chip power, particularly when a chip is powered on or powered off. Furthermore, compensation networks included in the amplifiers on audio chips for stability offer a significant path for transmitting power disturbances to the output. Hence, circuitry is developed to suppress pops in the output stages of an amplifier.
摘要翻译：目前许多音频芯片遭受流行问题，对于单端音频驱动程序来说尤其严重。音频弹奏是由芯片功率的突然转换引起的输出干扰，特别是当芯片通电或断电时。此外，用于稳定性的用于音频芯片的放大器中的补偿网络提供了将功率干扰发送到输出的重要路径。因此，开发电路以抑制放大器的输出级中的弹出。

9. 发明申请

US20130073516A1 Extracting Incremental Data 审中-公开
标题翻译：提取增量数据
公开(公告)号：US20130073516A1
公开(公告)日：2013-03-21
申请号：US13574162
申请日：2012-06-22
申请人： Xin Fan
发明人： Xin Fan
IPC分类号： G06F17/30
CPC分类号： G06F11/1402 , G06F16/254 , G06F16/273
摘要： The present disclosure introduces a method, an apparatus, and a system for extracting incremental data. Primary key information of incremental data is obtained from a backup database. The incremental data is inquired based on the primary key information from a main database that synchronizes with the backup database. The found incremental data is then inserted into a target data warehouse. The present techniques not only save a lot of time and system resources but also improve the efficiency of incremental data extraction.
摘要翻译：本公开引入了用于提取增量数据的方法，装置和系统。从备份数据库获取增量数据的主键信息。根据与备份数据库同步的主数据库的主键信息查询增量数据。然后将找到的增量数据插入目标数据仓库。目前的技术不仅节省了大量的时间和系统资源，而且提高了增量数据提取的效率。

10. 发明授权

US08081824B2 Generating search requests from multimodal queries 有权
标题翻译：从多模态查询生成搜索请求
公开(公告)号：US08081824B2
公开(公告)日：2011-12-20
申请号：US12247958
申请日：2008-10-08
申请人： Ming Jing Li , Wei-Ying Ma , Xing Xie , Xin Fan , Zhiwei Li
发明人： Ming Jing Li , Wei-Ying Ma , Xing Xie , Xin Fan , Zhiwei Li
IPC分类号： G06K9/46
CPC分类号： G06F17/30864 , Y10S707/99945 , Y10S707/99948
摘要： A method and system for generating a search request from a multimodal query that includes a query image and query text is provided. The multimodal query system identifies images of a collection that are textually related to the query image based on similarity between words associated with each image and the query text. The multimodal query system then selects those images of the identified images that are visually related to the query image. The multimodal query system may formulate a search request based on keywords of web pages that contain the selected images and submit that search request to a search engine service.
摘要翻译：提供了一种用于从包含查询图像和查询文本的多模式查询生成搜索请求的方法和系统。多模式查询系统基于与每个图像相关联的单词与查询文本之间的相似度来识别与查询图像文本相关的集合的图像。多模式查询系统然后选择与查询图像视觉相关的识别图像的那些图像。多模式查询系统可以基于包含所选图像的网页的关键词来制定搜索请求，并将该搜索请求提交给搜索引擎服务。

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