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1. 发明申请

US20110069905A1 SYSTEM AND METHOD FOR DETECTING AND ELIMINATING ONE OR MORE DEFOCUSED OR LOW CONTRAST-TO-NOISE RATIO IMAGES 有权
标题翻译：用于检测和消除一个或多个偏差或低对比度噪声比例图像的系统和方法
公开(公告)号：US20110069905A1
公开(公告)日：2011-03-24
申请号：US12993180
申请日：2009-05-29
申请人： Umesha Adiga , Ali Can , Xudong Li , Dirk r. Padfield , Jens Rittscher , Elizabeth P. Roquemore
发明人： Umesha Adiga , Ali Can , Xudong Li , Dirk r. Padfield , Jens Rittscher , Elizabeth P. Roquemore
IPC分类号： G06K9/36
CPC分类号： G06T7/0012 , G01N15/1475 , G06T7/42 , G06T2207/10016 , G06T2207/10056 , G06T2207/20064 , G06T2207/30024 , G06T2207/30168
摘要： This invention, which provides a method for detecting a corruption in an image acquired from a biological sample, includes: providing at least one image of at least one cell; generating the image of the at least one cell over a period of time; determining if the at least one image of the at least one cell is corrupted; applying a wavelet transform, Fourier transform, or other frequency decomposing transform to the at least one image to decompose the at least one image into a plurality of sub-images, wherein the plurality of sub-images have a plurality of low frequency channels, a plurality of middle frequency channels and a plurality of high frequency channels; calculating a ratio based on an energy level of the plurality of low frequency channels and the plurality of middle frequency channels; and removing the at least one image of at least one cell if the at least one image is corrupted.
摘要翻译：本发明提供一种用于检测从生物样品获得的图像中的破坏的方法，包括：提供至少一个单元的至少一个图像; 在一段时间内产生所述至少一个小区的图像; 确定所述至少一个小区的所述至少一个图像是否被破坏; 对所述至少一个图像应用小波变换，傅里叶变换或其他频率分解变换，以将所述至少一个图像分解为多个子图像，其中所述多个子图像具有多个低频信道，多个中频信道和多个高频信道; 基于所述多个低频信道和所述多个中频信道的能级计算比率; 以及如果所述至少一个图像被破坏，则移除所述至少一个单元的所述至少一个图像。

2. 发明申请

US20060120603A1 Method of, and apparatus and computer software for, implementing image analysis protocols 有权
标题翻译：用于实现图像分析协议的方法，以及设备和计算机软件
公开(公告)号：US20060120603A1
公开(公告)日：2006-06-08
申请号：US11019326
申请日：2004-12-07
申请人： Xudong Li , Louis Dagenais , William Durksen , Del Archer
发明人： Xudong Li , Louis Dagenais , William Durksen , Del Archer
IPC分类号： G06K9/00
CPC分类号： G06K9/00127
摘要： A computer-based method for the development of an image analysis protocol for analyzing image data, the image data containing images including image objects, in particular biological image objects such as biological cells. The image analysis protocol, once developed, is operable in an image analysis software system to report on one or more measurements conducted on selected ones of the image objects. The development process includes providing functions for selecting predetermined image analysis procedures, the functions allowing the user to define: at least one first target identification setting for identifying a first target set of image objects in the image data; at least one second target identification setting for identifying a second target set of image objects in the image data; a relationship between the first and second set of image objects; and one or more measurements which are to be reported for the image data, the measurements being conducted using the defined relationship.
摘要翻译：一种用于开发用于分析图像数据的图像分析协议的基于计算机的方法，所述图像数据包含包括图像对象的图像，特别是生物图像对象，例如生物细胞。一旦开发出图像分析协议，在图像分析软件系统中可操作以报告对所选择的图像对象进行的一个或多个测量。开发过程包括提供用于选择预定图像分析过程的功能，允许用户定义的功能：用于识别图像数据中的图像对象的第一目标集合的至少一个第一目标识别设置; 用于识别图像数据中的图像对象的第二目标集合的至少一个第二目标识别设置; 第一和第二组图像对象之间的关系; 以及要针对图像数据报告的一个或多个测量值，使用定义的关系进行测量。

3. 发明授权

US5888887A Trenchless buried contact process technology 失效
标题翻译：无沟埋式接触工艺技术
公开(公告)号：US5888887A
公开(公告)日：1999-03-30
申请号：US990697
申请日：1997-12-15
申请人： Xudong Li , Xuechun Dai , Guangping Hua , Kei Tee Tiew
发明人： Xudong Li , Xuechun Dai , Guangping Hua , Kei Tee Tiew
IPC分类号： H01L21/285 , H01L21/768 , H01L21/28
CPC分类号： H01L21/76895 , H01L21/28525
摘要： A method of forming a buried contact junction without forming a buried contact trench and without a disconnection gap in the current path by using a tapered polysilicon profile and a large angle tilt buried contact implant is described. A layer of gate silicon oxide is provided over the surface of a semiconductor substrate. A first polysilicon layer is deposited overlying the gate silicon oxide layer. The first polysilicon layer is etched away where it is not covered by a buried contact mask to provide an opening to the semiconductor substrate wherein the first polysilicon layer is tapered such that the bottom of the opening has a width the size of the planned buried contact and wherein the top of the opening has a width larger than the size of the planned buried contact. Ions are implanted at a tilt angle into the substrate within the opening whereby the ions penetrate the substrate laterally underlying with said first polysilicon layer to form the buried contact. A second layer of polysilicon is deposited over the first polysilicon layer and over the semiconductor substrate within the opening and patterned to form a polysilicon contact overlying the buried contact junction to complete formation of a buried contact in the fabrication of an integrated circuit.
摘要翻译：描述了通过使用锥形多晶硅轮廓和大角度倾斜埋入式接触植入物而形成掩埋接触结而不形成埋入接触沟槽并且在电流路径中没有断开间隙的方法。在半导体衬底的表面上设置一层栅极氧化硅。沉积在栅极氧化硅层上的第一多晶硅层。第一多晶硅层被蚀刻掉，其中它没有被掩埋的接触掩模覆盖，以提供到半导体衬底的开口，其中第一多晶硅层是锥形的，使得开口的底部具有预定埋入接触的尺寸的宽度，其中所述开口的顶部具有大于所述计划的埋入接触件的尺寸的宽度。离子以倾斜角度注入到开口内的衬底中，由此离子穿透衬底，横向于所述第一多晶硅层的下方，以形成掩埋接触。第二层多晶硅沉积在第一多晶硅层上方并且在开口内的半导体衬底上并且被图案化以形成覆盖在掩埋接触结上的多晶硅接触，从而在集成电路的制造中完成掩埋接触的形成。

4. 发明授权

US08588503B2 System and method for detecting and eliminating one or more defocused or low contrast-to-noise ratio images 有权
标题翻译：用于检测和消除一个或多个散焦或低对比度噪声比图像的系统和方法
公开(公告)号：US08588503B2
公开(公告)日：2013-11-19
申请号：US12993180
申请日：2009-05-29
申请人： Umesha Adiga , Ali Can , Xudong Li , Dirk R. Padfield , Jens Rittscher , Elizabeth P. Roquemore
发明人： Umesha Adiga , Ali Can , Xudong Li , Dirk R. Padfield , Jens Rittscher , Elizabeth P. Roquemore
IPC分类号： G06K9/00 , G06K9/78
CPC分类号： G06T7/0012 , G01N15/1475 , G06T7/42 , G06T2207/10016 , G06T2207/10056 , G06T2207/20064 , G06T2207/30024 , G06T2207/30168
摘要： This invention, which provides a method for detecting a corruption in an image acquired from a biological sample, includes: providing at least one image of at least one cell; generating the image of the at least one cell over a period of time; determining if the at least one image of the at least one cell is corrupted; applying a wavelet transform, Fourier transform, or other frequency decomposing transform to the at least one image to decompose the at least one image into a plurality of sub-images, wherein the plurality of sub-images have a plurality of low frequency channels, a plurality of middle frequency channels and a plurality of high frequency channels; calculating a ratio based on an energy level of the plurality of low frequency channels and the plurality of middle frequency channels; and removing the at least one image of at least one cell if the at least one image is corrupted.
摘要翻译：本发明提供一种用于检测从生物样品获得的图像中的破坏的方法，包括：提供至少一个单元的至少一个图像; 在一段时间内产生所述至少一个小区的图像; 确定所述至少一个小区的所述至少一个图像是否被破坏; 对所述至少一个图像应用小波变换，傅里叶变换或其他频率分解变换，以将所述至少一个图像分解为多个子图像，其中所述多个子图像具有多个低频信道，多个中频信道和多个高频信道; 基于所述多个低频信道和所述多个中频信道的能级计算比率; 以及如果所述至少一个图像被破坏，则移除所述至少一个单元的所述至少一个图像。

5. 发明申请

US20100046823A1 SYSTEM AND METHOD FOR TRACKING THE MOVEMENT OF BIOLOGICAL MATERIALS 有权
标题翻译：跟踪生物材料运动的系统和方法
公开(公告)号：US20100046823A1
公开(公告)日：2010-02-25
申请号：US12523100
申请日：2008-01-30
申请人： Joseph O Ruanaidh , Marcin Swiatek , Xudong Li , Geert Kalusche
发明人： Joseph O Ruanaidh , Marcin Swiatek , Xudong Li , Geert Kalusche
IPC分类号： G06K9/00
CPC分类号： G06K9/00134 , G06T7/246 , G06T7/277 , G06T2200/24 , G06T2207/10056 , G06T2207/20016 , G06T2207/30024
摘要： This invention provides an automated system and method that allows a user to track the movement of an object, such as at least one cell amongst a plurality of cells as it moves from one point to another over time in order for the user to determine how the at least one cell functions. The user is able to track the movement of the at least one cell and determine if the at least one cell structure has changed, such as the at least one cell experiencing cell division or if two or more cells merge together. This user is able to optimally track the at least one cell to find an approximate location of at least one the cell as it moves in time and distance. Thus, this invention provides the user with a means to track cell movement to study the cell function.
摘要翻译：本发明提供了一种自动化系统和方法，其允许用户跟踪物体的移动，诸如当多个单元中的至少一个单元随着时间从一个点移动到另一个单元时，以便用户确定如何至少有一个单元格功能。用户能够跟踪至少一个小区的移动并且确定至少一个小区结构是否已经改变，诸如经历小区划分的至少一个小区或者如果两个或更多个小区合并在一起。当用户在时间和距离上移动时，该用户能够最佳地跟踪至少一个单元以找到至少一个单元的大致位置。因此，本发明为用户提供了跟踪细胞运动以研究细胞功能的手段。

6. 发明授权

US08463015B2 System and method for tracking the movement of biological materials 有权
标题翻译：跟踪生物材料运动的系统和方法
公开(公告)号：US08463015B2
公开(公告)日：2013-06-11
申请号：US12523100
申请日：2008-01-30
申请人： Joseph O Ruanaidh , Marcin Swiatek , Xudong Li , Geert Kalusche
发明人： Joseph O Ruanaidh , Marcin Swiatek , Xudong Li , Geert Kalusche
IPC分类号： G06K9/00
CPC分类号： G06K9/00134 , G06T7/246 , G06T7/277 , G06T2200/24 , G06T2207/10056 , G06T2207/20016 , G06T2207/30024
摘要： This invention provides an automated system and method that allows a user to track the movement of an object, such as at least one cell amongst a plurality of cells as it moves from one point to another over time in order for the user to determine how the at least one cell functions. The user is able to track the movement of the at least one cell and determine if the at least one cell structure has changed, such as the at least one cell experiencing cell division or if two or more cells merge together. This user is able to optimally track the at least one cell to find an approximate location of at least one the cell as it moves in time and distance. Thus, this invention provides the user with a means to track cell movement to study the cell function.
摘要翻译：本发明提供了一种自动化系统和方法，其允许用户跟踪物体的移动，诸如当多个单元中的至少一个单元随着时间从一个点移动到另一个单元时，以便用户确定如何至少有一个单元格功能。用户能够跟踪至少一个小区的移动并且确定至少一个小区结构是否已经改变，诸如经历小区划分的至少一个小区或者如果两个或更多个小区合并在一起。当用户在时间和距离上移动时，该用户能够最佳地跟踪至少一个单元以找到至少一个单元的大致位置。因此，本发明为用户提供了跟踪细胞运动以研究细胞功能的手段。

7. 发明申请

US20120057752A1 METHOD OF, AND APPARATUS AND COMPUTER SOFTWARE FOR, IMPLEMENTING IMAGE ANALYSIS PROTOCOLS 有权
标题翻译：用于实施图像分析协议的方法和装置和计算机软件
公开(公告)号：US20120057752A1
公开(公告)日：2012-03-08
申请号：US13277324
申请日：2011-10-20
申请人： XUDONG LI , LOUIS ERNEST DAGENAIS , WILLIAM MARK DURKSEN , DEL ARCHER
发明人： XUDONG LI , LOUIS ERNEST DAGENAIS , WILLIAM MARK DURKSEN , DEL ARCHER
IPC分类号： G06K9/00
CPC分类号： G06K9/00127
摘要： A computer-based method for the development of an image analysis protocol for analyzing image data, the image data containing images including image objects, in particular biological image objects such as biological cells. The image analysis protocol, once developed, is operable in an image analysis software system to report on one or more measurements conducted on selected ones of the image objects. The development process includes defining target identification settings to identify at least two different target sets of image objects, defining target identification settings to identify at least two different target sets of image objects, and defining one or more measurements to be performed using said pair-wise linking relationship(s).
摘要翻译：一种用于开发用于分析图像数据的图像分析协议的基于计算机的方法，所述图像数据包含包括图像对象的图像，特别是生物图像对象，例如生物细胞。一旦开发出图像分析协议，在图像分析软件系统中可操作以报告对所选择的图像对象进行的一个或多个测量。开发过程包括定义目标识别设置以识别图像对象的至少两个不同的目标集合，定义目标识别设置以识别图像对象的至少两个不同目标集合，以及使用所述成对方式来定义要执行的一个或多个测量链接关系。

8. 发明授权

US08045782B2 Method of, and apparatus and computer software for, implementing image analysis protocols 有权
标题翻译：用于实现图像分析协议的方法，以及设备和计算机软件
公开(公告)号：US08045782B2
公开(公告)日：2011-10-25
申请号：US11019326
申请日：2004-12-07
申请人： Xudong Li , Louis Ernest Dagenais , William Mark Durksen , Del Archer
发明人： Xudong Li , Louis Ernest Dagenais , William Mark Durksen , Del Archer
IPC分类号： G06K9/00
CPC分类号： G06K9/00127
摘要： A computer-based method for the development of an image analysis protocol for analyzing image data, the image data containing images including image objects, in particular biological image objects such as biological cells. The image analysis protocol, once developed, is operable in an image analysis software system to report on one or more measurements conducted on selected ones of the image objects. The development process includes providing functions for selecting predetermined image analysis procedures, the functions allowing the user to define: at least one first target identification setting for identifying a first target set of image objects in the image data; at least one second target identification setting for identifying a second target set of image objects in the image data; a relationship between the first and second set of image objects; and one or more measurements which are to be reported for the image data, the measurements being conducted using the defined relationship.
摘要翻译：一种用于开发用于分析图像数据的图像分析协议的基于计算机的方法，所述图像数据包含包括图像对象的图像，特别是生物图像对象，例如生物细胞。一旦开发出图像分析协议，在图像分析软件系统中可操作以报告对所选择的图像对象进行的一个或多个测量。开发过程包括提供用于选择预定图像分析过程的功能，允许用户定义的功能：用于识别图像数据中的图像对象的第一目标集合的至少一个第一目标识别设置; 用于识别所述图像数据中的图像对象的第二目标集合的至少一个第二目标识别设置; 第一和第二组图像对象之间的关系; 以及要针对图像数据报告的一个或多个测量值，使用定义的关系进行测量。

9. 发明授权

US08885911B2 Method of, and apparatus and computer software for, implementing image analysis protocols 有权
标题翻译：用于实现图像分析协议的方法，以及设备和计算机软件
公开(公告)号：US08885911B2
公开(公告)日：2014-11-11
申请号：US13277324
申请日：2011-10-20
申请人： Xudong Li , Louis Ernest Dagenais , William Mark Durksen , Del Archer
发明人： Xudong Li , Louis Ernest Dagenais , William Mark Durksen , Del Archer
IPC分类号： G06K9/00
CPC分类号： G06K9/00127
摘要： A computer-based method for the development of an image analysis protocol for analyzing image data, the image data containing images including image objects, in particular biological image objects such as biological cells. The image analysis protocol, once developed, is operable in an image analysis software system to report on one or more measurements conducted on selected ones of the image objects. The development process includes defining target identification settings to identify at least two different target sets of image objects, defining target identification settings to identify at least two different target sets of image objects, and defining one or more measurements to be performed using said pair-wise linking relationship(s).
摘要翻译：一种用于开发用于分析图像数据的图像分析协议的基于计算机的方法，所述图像数据包含包括图像对象的图像，特别是生物图像对象，例如生物细胞。一旦开发出图像分析协议，在图像分析软件系统中可操作以报告对所选择的图像对象进行的一个或多个测量。开发过程包括定义目标识别设置以识别图像对象的至少两个不同的目标集合，定义目标识别设置以识别图像对象的至少两个不同目标集合，以及使用所述成对方式来定义要执行的一个或多个测量链接关系。

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