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1. 发明申请

US20090208533A1 NEISSERIA MENINGITIDIS SEROGROUP A CAPSULAR POLYSACCHARIDE ACETYLTRANSFERASE, METHODS AND COMPOSITIONS 失效
标题翻译： IA IS IS IS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS TIONS
公开(公告)号：US20090208533A1
公开(公告)日：2009-08-20
申请号：US11943326
申请日：2007-11-20
申请人： David S. Stephens , Seshu K. Gudlavalleti , Yih-Ling Tzeng , Anup K. Datta , Russell W. Carlson
发明人： David S. Stephens , Seshu K. Gudlavalleti , Yih-Ling Tzeng , Anup K. Datta , Russell W. Carlson
IPC分类号： A61K39/095 , C12N9/10 , C12P19/04 , A61P31/04
CPC分类号： A61K39/095 , A61K39/00 , C12N9/1029 , C12P19/44
摘要： Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using the recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
摘要翻译：提供了用于重组生产O-乙酰转移酶的方法和使用重组O-乙酰转移酶乙酰化荚膜多糖的方法，特别是使用血清组织A脑膜炎奈瑟氏球菌的方法，以及包含乙酰化荚膜多糖的免疫原性组合物。

2. 发明授权

US07883876B2 Neisseria meningitidis serogroup A capsular polysaccharide acetyltransferase, methods and compositions 失效
标题翻译：脑膜炎奈瑟菌血清群A荚膜多糖乙酰转移酶，方法和组成
公开(公告)号：US07883876B2
公开(公告)日：2011-02-08
申请号：US11943326
申请日：2007-11-20
申请人： David S. Stephens , Seshu K. Gudlavalleti , Yih-Ling Tzeng , Anup K. Datta , Russell W. Carlson
发明人： David S. Stephens , Seshu K. Gudlavalleti , Yih-Ling Tzeng , Anup K. Datta , Russell W. Carlson
IPC分类号： C12P19/04 , A61K39/095
CPC分类号： A61K39/095 , A61K39/00 , C12N9/1029 , C12P19/44
摘要： Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using the recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
摘要翻译：提供了用于重组生产O-乙酰转移酶的方法和使用重组O-乙酰转移酶乙酰化荚膜多糖的方法，特别是使用血清组织A脑膜炎奈瑟氏球菌的方法，以及包含乙酰化荚膜多糖的免疫原性组合物。

3. 发明申请

US20060073168A1 Neisseria meningitidis serogroup a capsular polysaccharide acetyltransferase, methods and compositions 审中-公开
标题翻译：脑膜炎奈瑟氏球菌血清群荚膜多糖乙酰转移酶，方法和组成
公开(公告)号：US20060073168A1
公开(公告)日：2006-04-06
申请号：US11201774
申请日：2005-08-11
申请人： David Stephens , Seshu Gudlavalleti , Yih-Ling Tzeng , Anup Datta , Russell Carlson
发明人： David Stephens , Seshu Gudlavalleti , Yih-Ling Tzeng , Anup Datta , Russell Carlson
IPC分类号： A61K39/095 , C07H21/04 , C12P21/06 , C12N9/10 , C12N15/74 , C12P19/04 , C12N1/21
CPC分类号： A61K39/095 , A61K39/00 , C12N9/1029 , C12P19/44
摘要： Provided are recombinant DNA molecules that do not occur in nature encoding an O-acetyltransferase, vectors that direct expression of an O-acetyltransferase, recombinant host cells which express an O-acetyltransferase, methods for recombinant production of an O-acetyltransferase, methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using a recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
摘要翻译：提供在编码O-乙酰转移酶的自然界中不发生的重组DNA分子，直接表达O-乙酰转移酶的载体，表达O-乙酰转移酶的重组宿主细胞，O-乙酰转移酶的重组生产方法，乙酰化的方法荚膜多糖，特别是使用重组O-乙酰转移酶的血清组A脑膜炎奈瑟菌的那些，以及包含乙酰化荚膜多糖的免疫原性组合物。

4. 发明授权

US07807181B2 Neisseria mutants, lipooligosaccharides and immunogenic compositions 有权
标题翻译：奈瑟氏球菌突变体，脂寡糖和免疫原性组合物
公开(公告)号：US07807181B2
公开(公告)日：2010-10-05
申请号：US10508309
申请日：2003-03-20
申请人： David S. Stephens , Yih-Ling Tzeng , Susu Zughaier , Shanta Zimmer
发明人： David S. Stephens , Yih-Ling Tzeng , Susu Zughaier , Shanta Zimmer
IPC分类号： A61K39/02 , A61K39/095 , A61K39/38 , A01N43/04 , C07H1/00
CPC分类号： C12N15/52 , A61K39/095 , A61K2039/522 , A61K2039/523 , A61K2039/53 , C07K14/22 , C07K2319/23
摘要： Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetically stable mutation which inactivates a gene selected from the group consisting of genes encoding arabinose-5-phosphate isomerase, CMP-Kdo synthetase and CMP-Kdo transferase. N. meningitidis NMB206 is a specifically exemplified strain which harbors a stable insertion mutation in the gene (kpsF) encoding A5P isomerase; strain NMB-249 is a specifically exemplified strain with a stable insertion mutation in the gene (kdtA) encoding CMP-Kdo synthetase, and strain NMB259 is specifically exemplified strain with a stable insertion mutation in the gene (kdsB) encoding CMP-Kdo transferase. Also provided by the present invention are methods for the production of Lipid A flee of 3-keto-3-deoxyoctanoic acid using these genetically stable N. meningitidis mutants. Also describes is pYT250, a plasmid functional in neisseriae and in enterics such as Escherichia coli.
摘要翻译：本文提供脑膜炎奈瑟球菌的突变菌株，其产生不含Kdo的脂质A以及不含Kdo的脂质A分子和含有来自包含基因稳定突变的不含Kdo的脂质A分子的免疫脂质A分子的灭活组合，所述遗传稳定突变使选择的基因失活来自编码阿拉伯糖-5-磷酸异构酶，CMP-Kdo合成酶和CMP-Kdo转移酶的基因组。脑膜炎奈瑟球菌NMB206是在编码A5P异构酶的基因（kpsF）中具有稳定插入突变的特异性例证菌株; 菌株NMB-249是编码CMP-Kdo合成酶的基因（kdtA）中具有稳定插入突变的特异性例证菌株，并且菌株NMB259具体示例是在编码CMP-Kdo转移酶的基因（kdsB）中具有稳定插入突变的菌株。本发明还提供了使用这些遗传稳定的脑膜炎奈瑟球菌突变体生产3-酮-3-脱氧辛酸脂质A的方法。还描述了pYT250，一种在奈瑟氏菌中和在诸如大肠杆菌等肠道中功能的质粒。

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