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1. 发明授权

US09493436B2 Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis 有权
标题翻译：酪氨酸磷酸酶抑制剂及其用于调节参与结核分枝杆菌病理学的酶的活性的用途
公开(公告)号：US09493436B2
公开(公告)日：2016-11-15
申请号：US14114077
申请日：2012-04-25
申请人： Zhong-Yin Zhang , Yantao He , Li-Fan Zeng
发明人： Zhong-Yin Zhang , Yantao He , Li-Fan Zeng
IPC分类号： C07D417/12 , C07D413/12 , C07D407/06 , C07D307/80 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/06 , C07D209/42 , C07D307/84
CPC分类号： C07D307/80 , C07D209/42 , C07D307/84 , C07D401/12 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/12 , C07D417/12
摘要： A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological pH and have good bioavailability characteristics. These compounds exhibit selective or at least preferential affinity for the active sites of various sub-sets of protein tyrosine phosphatases. Some of these compounds are excellent inhibitors of Mycobacterium protein tyrosine phosphatase B (mPTPB) a protein tyrosine phosphatase expressed in Mycobacterium tuberculosis and characterized as a virulence factor in the causal agent of tuberculosis. Accordingly, many of these compounds and pharmaceutically acceptable salts thereof are useful for the treatment of diseases such as tuberculosis.
摘要翻译：本文公开了一些具有炔基接头的各种苯并呋喃和吲哚衍生物。这些化合物在生理pH下没有高度充电并且具有良好的生物利用度特性。这些化合物对蛋白酪氨酸磷酸酶的各种亚组的活性位点表现出选择性或至少优先亲和力。这些化合物中的一些是分枝杆菌蛋白酪氨酸磷酸酶B（mPTPB）在结核分枝杆菌中表达的蛋白酪氨酸磷酸酶的优异抑制剂，其特征在于结核病致病因子中的毒力因子。因此，这些化合物和其药学上可接受的盐中的许多可用于治疗疾病如结核病。

2. 发明授权

US09444684B2 Method and system for detecting network upgrades 有权
标题翻译：检测网络升级的方法和系统
公开(公告)号：US09444684B2
公开(公告)日：2016-09-13
申请号：US12887830
申请日：2010-09-22
申请人： Jia Wang , Zihui Ge , Ajay Mahimkar , Aman Shaikh , Jennifer Yates , Yin Zhang , Joanne Emmons
发明人： Jia Wang , Zihui Ge , Ajay Mahimkar , Aman Shaikh , Jennifer Yates , Yin Zhang , Joanne Emmons
IPC分类号： G06F15/177 , H04L12/24
CPC分类号： H04L41/0853 , H04L41/0869 , H04L41/142
摘要： A system and method identify a network upgrade from a data set including a plurality of configuration sessions. The system performs the method by receiving a plurality of configuration sessions. Each of the configuration sessions comprises a plurality of configuration commands. The configuration commands are generated by a same user identifier and within a time threshold. The method further includes identifying one of the configuration sessions as a network upgrade session. The identification is based on a rareness of the configuration session or a skewness of the configuration session.
摘要翻译：系统和方法从包括多个配置会话的数据集中识别网络升级。系统通过接收多个配置会话来执行该方法。每个配置会话包括多个配置命令。配置命令由相同的用户标识符和时间阈值生成。该方法还包括将配置会话之一识别为网络升级会话。该标识基于配置会话的稀有性或配置会话的偏度。

3. 发明授权

US08943081B2 User-powered recommendation system 有权
标题翻译：用户推荐系统
公开(公告)号：US08943081B2
公开(公告)日：2015-01-27
申请号：US12616892
申请日：2009-11-12
申请人： Kadangode K. Ramakrishnan , Divesh Srivastava , Tae Won Cho , Yin Zhang
发明人： Kadangode K. Ramakrishnan , Divesh Srivastava , Tae Won Cho , Yin Zhang
IPC分类号： G06F17/30 , G11B27/10 , H04N21/475 , H04N21/466
CPC分类号： G06N7/005 , G06F17/30038 , G06F17/30412 , G06F17/3097 , G11B27/105 , H04N21/4661 , H04N21/4668 , H04N21/4756
摘要： Recommendation systems are widely used in Internet applications. In current recommendation systems, users only play a passive role and have limited control over the recommendation generation process. As a result, there is often considerable mismatch between the recommendations made by these systems and the actual user interests, which are fine-grained and constantly evolving. With a user-powered distributed recommendation architecture, individual users can flexibly define fine-grained communities of interest in a declarative fashion and obtain recommendations accurately tailored to their interests by aggregating opinions of users in such communities. By combining a progressive sampling technique with data perturbation methods, the recommendation system is both scalable and privacy-preserving.
摘要翻译：推荐系统广泛应用于互联网应用。在目前的推荐系统中，用户只能发挥被动的作用，对推荐生成过程的控制有限。因此，这些系统提出的建议和实际用户兴趣之间经常存在很大的不匹配，这些建议是细粒度和不断发展的。通过用户分配的推荐体系结构，个人用户可以灵活地定义精细的社区，并以声明方式定义感兴趣的社区，通过汇总用户在这些社区的意见，获得准确定制的兴趣建议。通过将逐行采样技术与数据扰动方法相结合，推荐系统既可扩展又保密。

4. 发明授权

US08774023B2 Method and system for detecting changes in network performance 有权
标题翻译：检测网络性能变化的方法和系统
公开(公告)号：US08774023B2
公开(公告)日：2014-07-08
申请号：US12887903
申请日：2010-09-22
申请人： Jia Wang , Zihui Ge , Ajay Mahimkar , Aman Shaikh , Jennifer Yates , Yin Zhang , Joanne Emmons
发明人： Jia Wang , Zihui Ge , Ajay Mahimkar , Aman Shaikh , Jennifer Yates , Yin Zhang , Joanne Emmons
IPC分类号： H04L12/26
CPC分类号： H04L43/16 , H04L41/082 , H04L43/0829 , H04L43/0852
摘要： A system and method are provided for identifying a change point in a set of data. The system performs the method by receiving a set of data. The data indicates a plurality of performance measurements from a measurement point in a network. Each of the plurality of measurements represents a single type of performance measurement made at the measurement point at each of a corresponding plurality of points in time. The method also includes dividing the set of data into a plurality of data points in a chronological order. Each data point has a value corresponding to the performance measurements. The method also includes ranking the data points in an ascending order, calculating a cumulative sum for each of the data points, calculating a change score for the set of data points. A change point is identified in the data set if the change score exceeds a predetermined confidence level.
摘要翻译：提供了用于识别一组数据中的变化点的系统和方法。系统通过接收一组数据来执行该方法。数据表示来自网络中的测量点的多个性能测量。多个测量中的每一个表示在相应的多个时间点的每一个处的测量点进行的单一类型的性能测量。该方法还包括按照时间顺序将数据集合划分成多个数据点。每个数据点都具有对应于性能测量值。该方法还包括以升序对数据点进行排序，计算每个数据点的累积和，计算该组数据点的改变得分。如果改变得分超过预定的置信水平，则在数据集中识别变化点。

5. 发明授权

US08477597B2 Method and system for resilient routing reconfiguration 失效
标题翻译：弹性路由重配置方法和系统
公开(公告)号：US08477597B2
公开(公告)日：2013-07-02
申请号：US12787411
申请日：2010-05-26
申请人： Yin Zhang , Lili Qiu
发明人： Yin Zhang , Lili Qiu
IPC分类号： G01R31/08
CPC分类号： H04L45/22 , H04L45/02 , H04L45/28 , H04L45/50
摘要： A method and system for resilient routing reconfiguration, which provides provably congestion-free rerouting under a large number of failure scenarios and achieves efficiency and flexibility in accommodating different performance requirements, is disclosed. The method of embodiments comprises an offline precomputation phase and an online reconfiguration phase. Embodiments of the present invention also provide a number of useful functionalities, including (i) coping with traffic variations, (ii) supporting realistic failure scenarios, (iii) accommodating prioritized traffic with different protection levels, and (iv) balancing the trade-off between performance and resilience.
摘要翻译：公开了一种用于弹性路由重配置的方法和系统，其在大量故障场景下提供可证明的无拥塞重新路由，并且实现了适应不同性能要求的效率和灵活性。实施例的方法包括离线预计算阶段和在线重新配置阶段。本发明的实施例还提供了许多有用的功能，包括（i）应对流量变化，（ii）支持现实的失败情况，（iii）容纳具有不同保护等级的优先级流量，以及（iv）平衡权衡性能与弹性之间。

6. 发明授权

US08295203B2 Methods and systems to store state used to forward multicast traffic 有权
标题翻译：存储用于转发组播流量的状态的方法和系统
公开(公告)号：US08295203B2
公开(公告)日：2012-10-23
申请号：US12060709
申请日：2008-04-01
申请人： Kadangode K. Ramakrishnan , Divesh Srivastava , Tae W. Cho , Yin Zhang , Michael Rabinovich
发明人： Kadangode K. Ramakrishnan , Divesh Srivastava , Tae W. Cho , Yin Zhang , Michael Rabinovich
IPC分类号： H04L12/28
CPC分类号： H04L12/1886 , H04L45/16 , H04L45/48
摘要： Methods and systems are described to store state used to forward multicast traffic. The system includes a receiving module to receive request to add a first node to a membership tree. The membership tree includes a first plurality of nodes associated with a multicast group. The system further includes a processing module to identify a second node in the first plurality of nodes and to communicate a node identifier that identifies the first node over a network to the second node. The node identifier is to be stored at the second node to add the first node to the membership tree. The node identifier is further to be stored in the membership tree exclusively at the second node to enable the second node to forward the multicast traffic to the first node.
摘要翻译：描述了用于存储用于转发组播流量的状态的方法和系统。该系统包括接收模块，用于接收向成员树添加第一个节点的请求。隶属树包括与多播组相关联的第一多个节点。所述系统还包括处理模块，用于识别所述第一多个节点中的第二节点，并将通过网络识别所述第一节点的节点标识符传送到所述第二节点。节点标识符将存储在第二个节点，以将第一个节点添加到成员树中。节点标识符进一步被存储在专属于第二节点的成员树中，以使得第二节点能够将多播业务转发到第一节点。

7. 发明申请

US20110281942A1 Tautomycetin and Tautomycetin Analog Biosynthesis 有权
标题翻译： Tautomycetin和Tautomycetin模拟生物合成
公开(公告)号：US20110281942A1
公开(公告)日：2011-11-17
申请号：US13101612
申请日：2011-05-05
申请人： Ben Shen , Zhong-Yin Zhang
发明人： Ben Shen , Zhong-Yin Zhang
IPC分类号： A61K31/365 , A61P35/00 , A61P19/00 , A61P9/00 , A61K31/225 , C07D307/02 , A61P35/04
CPC分类号： C07D307/58 , A61K31/225 , A61K31/365 , A61K45/06 , A61K2300/00
摘要： The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function.
摘要翻译：本发明涉及抗菌素（TTN）及其类似物。还提供了使用TTN及其类似物治疗与SHP2功能有关的各种疾病的方法。

8. 发明授权

US08005328B2 Optical add/drop module 有权
标题翻译：光分插模块
公开(公告)号：US08005328B2
公开(公告)日：2011-08-23
申请号：US10724426
申请日：2003-11-26
申请人： Johnny Zhong , Steve Wang , Yin Zhang
发明人： Johnny Zhong , Steve Wang , Yin Zhang
IPC分类号： G02B6/28
CPC分类号： G02B6/29361 , G02B6/29383 , G02B6/29386 , G02B6/32
摘要： A WDM add/drop module. The drop portion of the add/drop module is accomplished by using thin film filters or thin film interleavers. The add portion of the add/drop module uses fused fiber interleavers for the less critical stages of the multiplexing process. In a final stage, fused fiber interleavers can be placed in series. A thin film intervleaver having a flattop frequency response may also be used for the critical stage where the multiplexed channels are more closely spaced. The frequency response of the thin film interleaver is relatively constant across a bandwith of a channel while having a drop off at the channel edge to reduce cross talk.
摘要翻译： WDM添加/删除模块。通过使用薄膜滤波器或薄膜交织器来实现加/减模块的下降部分。加/减模块的添加部分使用融合光纤交织器用于复用过程的不太关键的阶段。在最后阶段，熔融纤维交织器可以串联放置。具有平顶频率响应的薄膜间隔器也可以用于多路复用通道更紧密间隔的关键阶段。薄膜交织器的频率响应在通道的带宽上相对恒定，同时在通道边缘处下降以减少串扰。

9. 发明申请

US20110164562A1 Vehicular Content Distribution 失效
标题翻译：车载内容分布
公开(公告)号：US20110164562A1
公开(公告)日：2011-07-07
申请号：US12983884
申请日：2011-01-03
申请人： Lili Qiu , Yin Zhang
发明人： Lili Qiu , Yin Zhang
IPC分类号： H04W4/02
CPC分类号： H04W72/1236 , H04W48/04 , H04W72/1252
摘要： A system and method provides an electronic content to a vehicle from access point(s) within a network using a controller. The controller divides the electronic content into one or more files wherein each file contains at least one packet, and generates two or more random linear combinations of the packets within each file. For each file, each random linear combination of the packets is replicated to a different access point within the network. The electronic content is provided to the vehicle using at least one of the different access points. The controller can also determine a set of nearest trajectories for the vehicle in a location database that match a recent location history for the vehicle. For each determined nearest trajectory, one or more mobility trajectories are determined for the vehicle, and a set of access points are determined that correspond to the determined mobility trajectories for the vehicle.
摘要翻译：系统和方法使用控制器从网络内的接入点向车辆提供电子内容。控制器将电子内容分成一个或多个文件，其中每个文件包含至少一个分组，并且生成每个文件内的分组的两个或多个随机线性组合。对于每个文件，分组的每个随机线性组合被复制到网络内的不同接入点。电子内容使用不同接入点中的至少一个提供给车辆。控制器还可以确定位置数据库中与车辆的最近位置历史相匹配的车辆的一组最近轨迹。对于每个确定的最近轨迹，为车辆确定一个或多个移动轨迹，并且确定与确定的车辆的移动轨迹相对应的一组接入点。

10. 发明授权

US07898976B2 Methods and apparatus for detection of hierarchical heavy hitters 有权
标题翻译：用于检测分级重击锤的方法和装置
公开(公告)号：US07898976B2
公开(公告)日：2011-03-01
申请号：US12236369
申请日：2008-09-23
申请人： Nicholas Duffield , Carsten Lund , Subhabrata Sen , Yin Zhang , Sumeet Singh
发明人： Nicholas Duffield , Carsten Lund , Subhabrata Sen , Yin Zhang , Sumeet Singh
IPC分类号： G06F11/30 , G06F12/00
CPC分类号： H04L63/1425 , H04L29/12801 , H04L61/6004 , H04L63/1441 , H04L63/1458 , Y10S707/99945 , Y10S707/99948
摘要： An efficient streaming method and apparatus for detecting hierarchical heavy hitters from massive data streams is disclosed. In one embodiment, the method enables near real time detection of anomaly behavior in networks.
摘要翻译：公开了一种用于从海量数据流检测分层重击打者的有效的流传输方法和装置。在一个实施例中，该方法能够近似实时地检测网络中的异常行为。

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