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1. 发明授权

US08222895B2 Displacement sensing device 有权
标题翻译：位移传感装置
公开(公告)号：US08222895B2
公开(公告)日：2012-07-17
申请号：US12523214
申请日：2008-01-11
申请人： Norimi Asahara , Yukiko Nishida , Masahisa Niwa
发明人： Norimi Asahara , Yukiko Nishida , Masahisa Niwa
IPC分类号： G01B7/30
CPC分类号： G01B7/30 , F16H15/38 , G01B7/046 , G01D5/2013 , G01P3/44 , G01P3/488 , G01P3/50
摘要： A compact sensing device capable of sensing a rotational angle and a rotational velocity, or a rectilinear moving distance and a moving velocity. A displacement sensing device that senses a rotational angle of a moving member rotation and a distance of a linear movement of the moving member, or senses an angular velocity of the moving member rotation and a velocity of a linear movement of the moving member, includes: a first movable member, moved together with the moving member by a linear movement of the moving member; a second movable member holding the first movable member in a rotatable manner, and rotated together with the moving member by rotation of the moving member; a first sensor outputting a signal in accordance with a linear movement of the first movable member; and a second sensor outputting a signal in accordance with a rotation of the second movable member.
摘要翻译：能够感测旋转角度，旋转速度或直线移动距离和移动速度的小型感测装置。检测移动构件旋转的旋转角度和移动构件的线性运动的距离，或感测移动构件旋转的角速度和移动构件的直线运动的速度的位移感测装置包括：第一可动构件，通过移动构件的线性移动与移动构件一起移动; 第二可动构件，其以可旋转的方式保持所述第一可动构件，并且通过所述移动构件的旋转与所述移动构件一起旋转; 第一传感器，根据第一可动件的直线运动输出信号; 以及第二传感器，其根据第二可动构件的旋转输出信号。

2. 发明授权

US09334331B2 Bispecific antibodies 有权
标题翻译：双特异性抗体
公开(公告)号：US09334331B2
公开(公告)日：2016-05-10
申请号：US13885421
申请日：2011-11-17
申请人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
发明人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
IPC分类号： C07K16/40 , C07K16/36
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译：各种双特异性抗体特异性结合血液凝固因子IX /活化血液凝固因子IX和血液凝固因子X，并功能取代血液凝固因子VIII的辅因子功能，即促进凝血因子X活化的功能活化血液凝固因子IX。从这些抗体中，成功发现了具有高功能取代凝血因子VIII活性的多特异性抗原结合分子。

3. 发明申请

US20140080153A1 METHOD FOR IMPROVING PHYSICAL PROPERTIES OF ANTIBODY 审中-公开
标题翻译：改善抗体物理性质的方法
公开(公告)号：US20140080153A1
公开(公告)日：2014-03-20
申请号：US13978232
申请日：2012-01-06
申请人： Tomoyuki Igawa , Yukiko Nishida
发明人： Tomoyuki Igawa , Yukiko Nishida
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , A61K39/39591 , A61K2039/505 , C07K16/36 , C07K2317/31 , C07K2317/56 , C07K2317/94
摘要： The present inventors discovered that physicochemical properties of a polypeptide can be improved by reducing the extracellular matrix-binding activity of the polypeptide.
摘要翻译：本发明人发现通过降低多肽的细胞外基质结合活性可以改善多肽的物理化学性质。

4. 发明申请

US20080290861A1 DISPLACEMENT SENSOR 有权
标题翻译：位移传感器
公开(公告)号：US20080290861A1
公开(公告)日：2008-11-27
申请号：US12120411
申请日：2008-05-14
申请人： Masahisa NIWA , Yukiko NISHIDA , Kunitaka OKADA
发明人： Masahisa NIWA , Yukiko NISHIDA , Kunitaka OKADA
IPC分类号： G01B7/02
CPC分类号： G01D5/202
摘要： An oscillator circuit outputs an oscillator signal with a frequency corresponding to an inductance of a displacement detector coil. An oscillation cycle measurement circuit measures a cycle of the oscillator signal output from the oscillator circuit, and outputs a signal corresponding to the measured cycle. A squaring circuit calculates and outputs a square of the signal output from the oscillation cycle measurement circuit. By the calculation and output of the square of the oscillator signal cycle, a square root component of the product of inductance and capacitance components is eliminated, so that the output signal changes linearly relative to the displacement of a displacement body. As a result, the linearity of the output signal relative to the displacement of the displacement body can be improved.
摘要翻译：振荡器电路输出具有对应于位移检测器线圈的电感的频率的振荡器信号。振荡周期测量电路测量从振荡器电路输出的振荡器信号的周期，并输出与测量周期对应的信号。平方电路计算并输出从振荡周期测量电路输出的信号的平方。通过振荡器信号周期的平方的计算和输出，消除了电感和电容分量乘积的平方根分量，使得输出信号相对于位移体的位移线性变化。结果，能够提高输出信号相对于位移体的位移的线性。

5. 发明申请

US20130330345A1 MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 有权
标题翻译：具有替代功能的多特异性抗原结合分子对血液凝血因子VIII的功能
公开(公告)号：US20130330345A1
公开(公告)日：2013-12-12
申请号：US13885421
申请日：2011-11-17
申请人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
发明人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译：各种双特异性抗体特异性结合血液凝固因子IX /活化血液凝固因子IX和血液凝固因子X，并功能取代血液凝固因子VIII的辅因子功能，即促进凝血因子X活化的功能活化血液凝固因子IX。从这些抗体中，成功发现了具有高功能取代凝血因子VIII活性的多特异性抗原结合分子。

6. 发明授权

US08164325B2 Displacement sensor 有权
标题翻译：位移传感器
公开(公告)号：US08164325B2
公开(公告)日：2012-04-24
申请号：US12120411
申请日：2008-05-14
申请人： Masahisa Niwa , Yukiko Nishida , Kunitaka Okada
发明人： Masahisa Niwa , Yukiko Nishida , Kunitaka Okada
IPC分类号： G01B7/00 , G01B7/14
CPC分类号： G01D5/202
摘要： An oscillator circuit outputs an oscillator signal with a frequency corresponding to an inductance of a displacement detector coil. An oscillation cycle measurement circuit measures a cycle of the oscillator signal output from the oscillator circuit, and outputs a signal corresponding to the measured cycle. A squaring circuit calculates and outputs a square of the signal output from the oscillation cycle measurement circuit. By the calculation and output of the square of the oscillator signal cycle, a square root component of the product of inductance and capacitance components is eliminated, so that the output signal changes linearly relative to the displacement of a displacement body. As a result, the linearity of the output signal relative to the displacement of the displacement body can be improved.
摘要翻译：振荡器电路输出具有对应于位移检测器线圈的电感的频率的振荡器信号。振荡周期测量电路测量从振荡器电路输出的振荡器信号的周期，并输出与测量周期对应的信号。平方电路计算并输出从振荡周期测量电路输出的信号的平方。通过振荡器信号周期的平方的计算和输出，消除了电感和电容分量乘积的平方根分量，使得输出信号相对于位移体的位移线性变化。结果，能够提高输出信号相对于位移体的位移的线性。

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