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1. 发明申请

US20210299625A1 Microparticle for Bioanalytical Investigations and Method for Producing Such a Microparticle 有权
公开(公告)号：US20210299625A1
公开(公告)日：2021-09-30
申请号：US17211139
申请日：2021-03-24
申请人： AVA Lifescience GmbH
发明人： Marcus Dühren- von Minden , Holger Klapproth
IPC分类号： B01J13/02 , G01N33/543
摘要： The invention relaters to a microparticle for bioanalytical investigations and a method for its production. The microparticle is suitable for being transported through a flow cell of a flow cytometer in a fluid stream. The microparticle has a solid particle core and at least one nucleic acid sense biomolecule that is binding-specific for an antisense biomolecule. A layer composed of a water-soluble conjugate is arranged on the particle core, which layer includes at least one linear polymer and/or copolymer, which has at least one first group, by means of which the polymer and/or copolymer can be cross-linked by means of irradiation with an optical radiation having a discrete wavelength, has at least one second group, to which the at least one nucleic acid sense biomolecule is conjugated, and has at least one third group that is bound to the surface of the particle core by way of a functional linker group, wherein the linker group is not capable of binding to the at least one nucleic acid sense biomolecule.

2. 发明授权

US11634487B2 Diagnostic method 有权
公开(公告)号：US11634487B2
公开(公告)日：2023-04-25
申请号：US16625754
申请日：2018-07-05
申请人： AVA Lifescience GmbH
发明人： Ulrich Birsner , Hassan Jumaa , Holger Klapproth , Marc A. Kessemeier
IPC分类号： C07K16/28 , A61P35/02 , C07K16/30 , G01N33/574
摘要： The present invention relates to the field of production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to diagnostic procedures using them in the diagnosis of cancers, in particular malignant B-cell neoplasia. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.

3. 发明授权

US11591391B2 Biological binding molecule 有权
公开(公告)号：US11591391B2
公开(公告)日：2023-02-28
申请号：US16625756
申请日：2018-07-05
申请人： AVA Lifescience GmbH
发明人： Ulrich Birsner , Hassan Jumaa , Holger Klapproth , Marc A. Kessemeier
IPC分类号： C07K16/28 , A61P35/02 , C07K16/30 , G01N33/574
摘要： The present invention relates to the field of the production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to their use in the therapy and prophylaxis of cancer diseases, such as, in particular, malignant B-cell neoplasia.
The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.

4. 发明申请

US20220137077A1 Flow Cytometry Measurement Method and Kit for Carrying Out Same 有权
公开(公告)号：US20220137077A1
公开(公告)日：2022-05-05
申请号：US17435160
申请日：2019-03-01
申请人： AVA Lifescience GmbH
发明人： Holger Klapproth , Ulrich Birsner , Marc Kessemeier
IPC分类号： G01N33/96 , G01N33/543 , G01N33/544 , G01N33/58 , G01N33/50 , G01N15/14
摘要： In a flow cytometry measurement method, an analysis medium is provided, which includes a fluid and biological cells contained therein. A labeling molecule is provided and is brought in contact with the analysis medium in such a way that the labeling molecule can bind specifically to a target structure located on the surface of the cell if the cell has said cell structure. For the individual cells, flow cytometry measured values are captured for a first and a second physical parameter. The first parameter is fluorescence radiation emitted by the labeling molecule when the labeling molecule is excited. The cells are classified on the basis of the flow cytometry measured values. A first calibrator and a second calibrator are provided, which have solid particles matching in shape, size and material. A target structure matching the target structure of the cells is immobilized on the surface of the first calibrator. The second calibrator does not have said target structure. The calibrators are mixed with the analysis medium before the flow cytometry measured values are captured. Corresponding first and second flow cytometry measured values are captured for the calibrators as well as for the cells. A normalized first flow cytometry measured value for the cell is formed from the first flow cytometry measured value of the first calibrator, the first flow cytometry measured value of the second calibrator and the first flow cytometry measured value of the cell.

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